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A patent application has been filed by James A. Kaslik for a device that can transform toilet paper in real time to improve its effectiveness at cleaning residue off the skin and body hair. The device is pocket-sized and can be carried anywhere. It uses liquid, a mold, and pressure to transform the texture, density, and wetness of the paper. The transformed paper provides superior cleaning and decomposes in water without causing harm to sewage and septic systems. Various variations of the device are also described in the patent application. [Extracted from the article]

A patent has been issued for a manufacturing process of intermittent coating release paper by Foshan XinFei Hygiene Materials Co. Ltd. The patent addresses the technical problems associated with the production of release paper used in sanitary napkins and other similar products. The process involves steps such as undercoating, primary drying, printing optical marks, coating silicone oil, and accurately coating heat-sealing material. The patent provides specific details about the viscosity of the silicone oil and heat-sealing material, as well as the alignment and precision of the coating rollers. The process aims to solve technical defects and meet the actual needs of the industry. [Extracted from the article]

A patent application by Philip Morris USA Inc. has been made available online, detailing the invention of banded papers and smoking articles. The application explains that the invention aims to reduce the incidence of accidental fires caused by untended smoking articles. The invention focuses on reducing the Ignition Propensity (IP) value and increasing the Self-Extinction (SE) value of smoking articles. The application describes the testing methods for IP and SE values and discusses the use of an aqueous starch solution with an anti-wrinkling agent to achieve the desired results. The invention also includes patterns and characteristics for the add-on material used in the wrapper paper. [Extracted from the article]

A recent study conducted by researchers at Amrita Vishwa Vidyapeetham in Kerala, India, has shed light on the deceptive practices of predatory journals. The study analyzed three datasets of calls for papers from potential predatory journals and legitimate journals using text mining and programming language. The researchers found that most potential predatory journals use similar language and templates in their calls for papers, often using flattering and positive words that are rarely seen in emails from legitimate journals. Based on these findings, the researchers developed a toolkit for detecting unsolicited calls for papers from potential predatory journals. This research provides valuable insights and tools for distinguishing between predatory and legitimate journals, ultimately helping researchers deal with predatory journals more effectively. [Extracted from the article]

HanxBio has published a research paper titled "Narazaciclib, a novel multikinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models" in the journal Scientific Reports. The paper describes the preclinical evaluation of Narazaciclib (HX301) for the treatment of acute myeloid leukemia (AML). The researchers conducted comprehensive pharmacology characterization of HX301 using various preclinical experimental AML models, demonstrating its strong anti-leukemia activity and potential mechanisms of action. The study also investigated the pharmacodynamics and pharmacokinetics of HX301, providing valuable information for clinical dosage selection. The results of this study will guide the clinical development strategies for HX301 in the treatment of AML. [Extracted from the article]

Brondell, a leading manufacturer of bidets in North America, has announced the consolidation of Omigo, a direct-to-consumer bidet startup. Brondell plans to leverage its retailer partnerships to launch Omigo into the mass market, expanding its customer reach and reducing the environmental impact of toilet paper. Brondell is committed to sustainability and is a 1% for the Planet product partner, donating one percent of sales on partnership products to environmental nonprofits. The consolidation of Brondell and Omigo aims to make bidets the standard in North American bathrooms and reduce toilet paper waste. [Extracted from the article]

Therefore, we explain PK concepts of biodistribution of AAV-based therapies and place key terminologies related to drug exposure and PD in the proper context. Keywords for this news article include: Philadelphia, Pennsylvania, United States, North and Central America, Bioengineering, Biopharmaceutical Companies, Biotechnology, Business, Drugs and Therapies, Gene Therapy, Genetics, Healthcare Biotechnology Companies, Technology, Therapy, Spark Therapeutics Inc. Keywords: Philadelphia; State:Pennsylvania; United States; North and Central America; Bioengineering; Biopharmaceutical Companies; Biotechnology; Business; Drugs and Therapies; Gene Therapy; Genetics; Healthcare Biotechnology Companies; Technology; Therapy EN Philadelphia State:Pennsylvania United States North and Central America Bioengineering Biopharmaceutical Companies Biotechnology Business Drugs and Therapies Gene Therapy Genetics Healthcare Biotechnology Companies Technology Therapy 919 919 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Research findings on Biotechnology - Gene Therapy are discussed in a new report. [Extracted from the article]

A patent application has been published for a device called the "Cigarette Roller" by Koopeh Designs Inc. The device is designed to roll papers into cigarettes, offering an all-in-one system for grinding, blending, wrapping, and filling the cigarettes. It includes features such as a rolling assembly, a paperfeed, a wetting assembly, and a retainer. The device can be used with various smokeable materials, including tobacco, cannabis, and herbs. The patent application provides detailed descriptions and claims for the device. [Extracted from the article]

When in use, the cylindrical cigarette is placed in the heating cavity, the tobacco and the cigarette paper are disposed in the heating cavity, and the filter rod is disposed outside the heating cavity. The cigarette paper is a poor thermal conductor, that is, the cigarette paper has very poor thermal conductivity, so it is very difficult to quickly transfer the heat generated by the heating rod to the tobacco, resulting in slow heating speed of the tobacco. After the power supply is turned on, the heating wire is energized to generate heat, and the heat generated by the heating wire is transferred to the heating cavity. [Extracted from the article]

Leadway (Hk) Limited has submitted a patent application for a test device and test paper that can be used for point-of-care testing (POCT). The test strip includes a positioning hole and a positioning column to ensure accurate placement in a test cassette. The positioning hole is slightly larger than the positioning column, making insertion easier and reducing misalignment. This invention aims to improve the success rate of mounting the test strip and reduce scrap rates during production. Library patrons conducting research can rely on Leadway (Hk) Limited's reports for factual and reliable information on various topics worldwide. [Extracted from the article]

A patent application has been submitted for a gas and water vapor barrier laminate by inventors ONISHI, Tokiharu and YAMASAKI, Naoaki. The patent's assignee is Asahi Kasei Kabushiki Kaisha. The inventors aim to provide a laminate that has excellent heat sealability, yellowing resistance, and recyclability, in addition to having barrier properties against gas and water vapor. The laminate consists of a paper support and a halogenated vinyl polymer layer with a specific coverage efficiency. The patent application also includes claims for packaging materials or containers and a production method for the laminate. [Extracted from the article]

Punjab, India, Asia, Business, Emerging Technologies, Nanoparticles, Nanotechnology Keywords: Punjab; India; Asia; Business; Emerging Technologies; Nanoparticles; Nanotechnology EN Punjab India Asia Business Emerging Technologies Nanoparticles Nanotechnology 2576 2576 1 10/16/23 20231020 NES 231020 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Nanotechnology - Nanoparticles. [Extracted from the article]

A patent application has been filed for an apparatus that manufactures eco-friendly straws using wood as a raw material. The invention aims to prevent environmental pollution by creating straws that are easy to recycle and dispose of. The apparatus includes a supply unit, a processing unit, and a transfer unit to transport the raw material. It also features a polishing unit and a foreign matter removal device to improve hygiene by removing any foreign matter from the inside of the straw. The invention seeks to address the problem of single-use plastic straws and provide a cost-effective solution. [Extracted from the article]

Keywords: Business; Newell Brands; Newell Rubbermaid Inc.; Social Media EN Business Newell Brands Newell Rubbermaid Inc. Social Media 3425 3425 1 05/08/23 20230511 NES 230511 2023 MAY 12 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- Paper Mate, a #1 Teacher Choice brand and part of the Newell Brands global portfolio of brands, announced its partnership with actor and children's book author, Max Greenfield, alongside its non-profit partner, AdoptAClassroom.org, to kick off the brand's Thanks to Teachers initiative. Max Greenfield and Paper Mate are encouraging everyone to thank their teachers, past and present, for their hard work and dedication, and encourage the use of the hashtag #ThankstoTeachers when sharing on social media. [Extracted from the article]

Keywords: Business; Cannabinoids; Marijuana/Cannabis; Republic Technologies (North America) LLC; Tetrahydrocannabinol EN Business Cannabinoids Marijuana/Cannabis Republic Technologies (North America) LLC Tetrahydrocannabinol N.PAG N.PAG 1 07/17/23 20230718 NES 230718 2023 JUL 18 (NewsRx) -- By a News Reporter-Staff News Editor at Cannabis & Marijuana News -- Republic Technologies (North America) LLC (Glenview, Illinois, United States) has been issued patent number 11684081, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. Business, Cannabinoids, Marijuana/Cannabis, Republic Technologies (North America) LLC, Tetrahydrocannabinol The process according to claim 1, wherein the cannabinoid is oil-free broad-spectrum cannabidiol (CBD) and wherein the cannabinoid is heated to 70° C. with or without oil before introduction in said water. [Extracted from the article]

Acupath LABORATORIES INC., Biomarkers, Bladder Cancer, Business, Cancer, Cancer Biomarkers, Carcinoma Biomarkers, Cytology, Diagnostics and Screening, Health and Medicine, Oncology, Risk and Prevention Keywords: Acupath LABORATORIES INC.; Biomarkers; Bladder Cancer; Business; Cancer; Cancer Biomarkers; Carcinoma Biomarkers; Cytology; Diagnostics and Screening; Health and Medicine; Oncology; Risk and Prevention EN Acupath LABORATORIES INC. Biomarkers Bladder Cancer Business Cancer Cancer Biomarkers Carcinoma Biomarkers Cytology Diagnostics and Screening Health and Medicine Oncology Risk and Prevention 69 69 1 09/19/23 20230919 NES 230919 2023 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Acupath Labs released a white paper highlighting the impressive results of a large-scale internal study analyzing the clinical utility of its Acu-UR017 bladder cancer biomarker. [Extracted from the article]

A report from KEDGE Business School in Talence, France discusses research on organization management and the impact of psychological contracts (PC) on employment relationships. The research was conducted by a group of PC and sustainability scholars from around the world. The paper explores how PC scholars can enhance the beneficial influence of PC knowledge on employment relationships through research, practice and society, and students. The research also contributes to the debate on sustainable PCs by integrating PCs with an 'ethics of care' perspective. The paper has been peer-reviewed and is available for further reading. [Extracted from the article]

"In the conventional GA-based biosensor, folding and/or twisting of alkane chains leads to crosslinking amongst the aldehyde itself, and thereby limits the sensitivity of the biosensor over time. Protein Sensing Platform With A Combination Of Conducting Polymers, Aromatic And Conjugated Aldehydes On A Cellulose Paper Base. Keywords: Acyclic Hydrocarbons; Aldehydes; Alkenes; Biosensors; Biotechnology; Business; COVID-19; Coronavirus; Emerging Technologies; Ethylenes; Nanotechnology; Nanowires; Opteev Technologies Inc.; Organic Chemicals; RNA Viruses; SARS-CoV-2; Severe Acute Respiratory Syndrome Coronavirus 2; Viral; Virology; Viruses EN Acyclic Hydrocarbons Aldehydes Alkenes Biosensors Biotechnology Business COVID-19 Coronavirus Emerging Technologies Ethylenes Nanotechnology Nanowires Opteev Technologies Inc. Organic Chemicals RNA Viruses SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 Viral Virology Viruses 1351 1351 1 08/14/23 20230820 NES 230820 2023 AUG 20 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- A patent application by the inventors BESSEMER, Conrad (Millersville, MD, US); CHATTERJEE, Sauvik (Dist-Hooghly, IN); CHATTERJEE, Soumyo (Kolkata, IN); PAL, Biplab (Ellicot City, MD, US), filed on January 23, 2023, was made available online on July 27, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. [Extracted from the article]

The wrapper of claim 93, wherein the second banded layer includes, a first layer adjacent to the second base side, and a second layer adjacent to an exposed surface of the first layer; the first layer includes a first starch, a first chalk, the second anti-wrinkling agent, or any combination thereof; the second layer includes a second starch, a second chalk, the second anti-wrinkling agent, or any combination thereof; the first starch is same as or different from the second starch; and the first chalk is same as or different from the second chalk. The wrapper of claim 93, wherein the first banded layer includes, a first layer adjacent to the first base side, and a second layer disposed adjacent to an exposed surface of the first layer; the first layer includes a first starch, a first chalk, the first anti-wrinkling agent, or any combination thereof; the second layer includes a second starch, a second chalk, the first anti-wrinkling agent, or any combination thereof; the first starch is same as or different from the second starch; and the first chalk is same as or different from the second chalk. [Extracted from the article]

Such displays using solid electro-optic materials may hereinafter for convenience be referred to as "solid electro-optic displays" or "solid electro-optic devices". The invention enables the authentication of the manufacturing source and the identification of the manufacturing lot of the electro-optic device and its components at any time during the life of the electro-optic device. [Extracted from the article]

General Mills Inc. has been issued a patent for a system and method for coating soft and sticky food cores. The patent describes a process for manufacturing food products with a coating on the core, specifically addressing the challenges of coating sticky and soft food materials. The system involves using conveyor belts and a carrier sheet to support the core material and maintain its shape during the coating process. The patent also mentions the use of parchment paper and a thin layer of coating material to prevent the core from sticking to the conveyor. The invention aims to provide an efficient and effective system for producing food products with soft and sticky cores in a commercial manufacturing setting. [Extracted from the article]

Nestle Purina Petcare Company has filed a trademark application for the name "STOUFFER'S." The application includes a wide range of goods and services, such as rice, pasta, noodles, frozen entrees, sauces, preserved vegetables and fruit, meat and seafood, soups, and baking paper. The application was made public on January 31, 2024. The owner of the application is Andrea K. Cannon, and the company is located in St. Louis, MO. [Extracted from the article]

A patent has been issued for an image forming apparatus by Canon Kabushiki Kaisha. The patent describes a configuration that notifies the user of the position of a recording medium remaining in the apparatus. The invention includes a conveyance unit with sensors and light sources that determine the position of a paper jam and control the corresponding light source to turn on. The apparatus also includes a capacitor to reduce voltage fluctuation and a shut-off mechanism when the conveyance unit is pulled out. The invention aims to provide a less expensive configuration for notifying paper jams in an image forming apparatus. [Extracted from the article]

A new editorial paper titled "The double-edge sword of CRISPR application for in vivo studies" discusses the challenges and potential of using CRISPR technology for in vivo cancer studies. The paper highlights a previous study that demonstrated the ability to generate cancer in mice using CRISPR, but notes that few studies have utilized this method in the past decade. The imperfection of mutations introduced by CRISPR is identified as a challenge, as it can result in clone-to-clone variation and tumors with different mutation profiles. However, the paper concludes that despite these challenges, the in vivo application of CRISPR is likely to become more common in the future. [Extracted from the article]

A recent article from GlaxoSmithKline plc discusses the use of machine learning in drug and vaccine safety. The researchers conducted an analysis of 393 papers from a literature search between 2000 and 2021, focusing on industry contributions. The findings revealed that industry is interested in applying machine learning to enhance safety monitoring in pharmacovigilance. The study concludes that although progress has been uneven, there is potential for machine learning to improve patient safety. For more information, readers can refer to the article "An industry perspective on the use of machine learning in drug and vaccine safety" published in Frontiers in Drug Safety and Regulation. [Extracted from the article]

The method of claim 1, further comprising triggering the knife assembly to cut in-between a first puck and a second puck to provide the first puck and the second puck on a first sheet of paper and a second sheet of paper, respectively. The method of claim 9, further comprising triggering the knife assembly not to cut in-between the second puck and a third puck to provide the second puck and the third puck on the second sheet of paper. In some embodiments, the knife assembly is triggered not to cut in-between the second puck and a third puck to provide the second puck and the third puck on the second sheet of paper. [Extracted from the article]

The beverage container packaging assembly of claim 1, wherein at least one of the beverage container support cavities include a semi-circular shape and at least one of the beverage container support cavities include a fully circular shape. The beverage container packaging assembly of claim 1, wherein a first set of the beverage container support cavities are configured to fully encapsulate the beverage container and a second set of the beverage container support cavities are configured to partially encapsulate the beverage container. The beverage container packaging assembly of claim 18, wherein a first set of the beverage container support cavities are configured to fully encapsulate the beverage container and a second set of the beverage container support cavities are configured to partially encapsulate the beverage container. [Extracted from the article]

A cover element is arranged above the strip housing element and including a machine-readable test identifier on an upper surface, and a removably attached filtering element is arranged on the hydrophobic paper-based strip housing element. The one or more testing strips received by the hydrophobic paper-based strip housing element display colorimetric results, and at least one of the machine-readable test identifier or the color reference information area identifies the test being performed. The testing strip device according to claim 1, wherein: the removably attached filtering element is adhered to the upper surface of the cover element, and the filtering element is configured to filter the sample. [Extracted from the article]

A new research perspective published in Oncoscience presents the rationale for adding five already approved and marketed generic drugs to the current standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC). The regimen, called IPIAD, includes an angiotensin receptor blocker, an antimicrobial drug, an antifungal drug, a broad-spectrum antibiotic, and an antibiotic. The researcher suggests that this augmentation regimen may slow the growth of PDAC and provide clinical benefit. The full paper provides more detailed information on the drugs and their potential impact on PDAC. [Extracted from the article]

A research perspective published in Oncoscience discusses the use of blood-based liquid biopsies for prostate cancer management. The paper provides an overview of three types of liquid biopsies: circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor-derived exosomes. The authors highlight the advances in molecular characterization of these biopsies and their potential to predict recurrence, improve treatment responses, and evaluate prognosis in prostate cancer patients. While there is currently full clinical validation for only one CTC-based and one ctDNA-based liquid biopsy, the adoption of additional methods is expected as they undergo standardization and validation. The paper also outlines the advantages and disadvantages of different blood-based liquid biopsy approaches and suggests that the utilization of these biopsies, with the assistance of artificial intelligence, will enhance patient stratification and facilitate timely therapeutic decision-making. [Extracted from the article]

Business, Health and Medicine, Imaging Technology Companies, Olympus, Olympus Corporation, Surgery, Technology Keywords: Business; Health and Medicine; Imaging Technology Companies; Olympus; Olympus Corporation; Surgery; Technology EN Business Health and Medicine Imaging Technology Companies Olympus Olympus Corporation Surgery Technology 2023 FEB 12 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Olympus announced the availability of several Experience Papers focused on the benefits of advancements in electrosurgical devices. [Extracted from the article]

A research paper titled "Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia" was recently published in Oncotarget's Volume 15. The paper investigates the potential of the growth hormone-releasing hormone (GHRH) receptor antagonist MIA-602 as a treatment for Doxorubicin-resistant acute myeloid leukemia (AML). The study found that MIA-602 significantly reduced cell viability in both wild-type AML cells and Doxorubicin-resistant clones. In an in vivo experiment using xenografted mice, MIA-602 treatment resulted in a reduction in tumor volume compared to the control group. The researchers suggest that GHRH antagonists like MIA-602 may offer an alternative treatment approach for AML and drug-resistant AML, potentially avoiding the side effects associated with standard chemotherapy. [Extracted from the article]

A research paper published in Aging suggests that chlorogenic acid, a major polyphenol found in Du-Zhong, a herb used in Traditional Chinese Medicine, may be a promising candidate for the treatment of osteoporosis. The study found that chlorogenic acid enhanced osteoblast functions and suppressed osteoclast formation, effectively preventing bone loss in ovariectomized rats. The researchers concluded that chlorogenic acid could potentially be developed into a novel anti-osteoporosis treatment. [Extracted from the article]

A research paper titled "Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort" explores the relationship between prenatal vitamins and metals and epigenetic aging biomarkers. The study found that essential and non-essential metals in the intrauterine environment can affect epigenetic aging biomarkers throughout a person's life. The researchers investigated the association between first-trimester folate, B12, essential metals, and non-essential metals in maternal circulation with epigenetic gestational age acceleration (EGAA) at birth and epigenetic age acceleration (EAA) in childhood. The study suggests that prenatal metals, including essential metals and arsenic, are associated with epigenetic aging in early life, which may have implications for future health. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 on February 22, 2024, titled "Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas," explores the potential of combining sacituzumab govitecan (SG) with platinum-based chemotherapeutics in treating triple-negative breast cancer (TNBC), urinary bladder carcinoma (UBC), and small-cell lung carcinoma (SCLC). The study found that combining SG with carboplatin or cisplatin produced additive growth-inhibitory effects in vitro and significant antitumor effects in mice bearing TNBC, UBC, and SCLC tumors. The researchers suggest that further clinical investigation is warranted to explore the benefits of this combination therapy. [Extracted from the article]

A patent has been issued for a mass spectrometry ionization-based assay that can detect enzyme activity and/or presence. The apparatus includes a spray material, a sample containing specific enzymes, a solvent to hydrate the sample and extract analytes of interest, an enzyme substrate, a power supply to create charged droplets of the analytes, and a mass spectrometer to identify the analytes and determine the presence of enzymes. The spray material can be porous or solid, and the solvent can be a single or multi-solvent. The method can be used with various samples such as blood, urine, and plasma. The patent was filed in October 2021 and published in February 2024. [Extracted from the article]

A research paper titled "The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut" explores the role of the vitamin D/vitamin D receptor (VitD/VDR) pathway in maintaining intestinal homeostasis and extending life expectancy. The study, conducted by researchers from Pusan National University and Korea Food Research Institute, used a Drosophila midgut model to investigate the protective role of VitD/VDR in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging. The findings suggest that vitamin D treatment reduces age- and oxidative stress-induced ISC proliferation and centrosome amplification, providing direct evidence of the anti-aging role of the VitD/VDR pathway. This study contributes valuable insights into the molecular mechanisms underlying healthy aging in Drosophila. [Extracted from the article]

A recent study on gene therapy has been published, focusing on the use of biotherapeutic modalities such as cell therapies, gene therapies, nucleic acids, and proteins for neurodegenerative disorders. The research, conducted by Sanofi, highlights the challenges and limited guidance in evaluating the biological consequences of these treatments. The study suggests expanding screening methods and neurohistological procedures to assess possible neural effects. This paper serves as a practical reference for preclinical safety testing and risk assessment of novel biologics. [Extracted from the article]

A recent editorial paper published in Oncoscience discusses the challenges of developing novel therapeutics for metastatic tumors. The author highlights that tumors that have spread to distant locations, such as the brain, are difficult to treat and cure. While immunotherapeutic approaches have shown success in some tumor types, there is evidence that they may cause hyper-progression in certain patients. The paper emphasizes the need for combination therapies targeting key signaling pathways to effectively control tumor growth and survival. [Extracted from the article]

Guardant Health, Inc., a precision oncology company, has reported its financial results for the fourth quarter and full year of 2023. In the fourth quarter, the company saw a 22% increase in revenue compared to the same period in 2022, with reported tests to clinical and biopharmaceutical customers increasing by 29% and 16% respectively. For the full year of 2023, revenue increased by 25% compared to 2022, with reported tests to clinical and biopharmaceutical customers increasing by 39% and 15% respectively. The company also improved its operating expenses and free cash flow compared to the previous year and ended the year with $1.2 billion in cash, cash equivalents, and marketable debt securities. Additionally, Guardant Health achieved improved average selling prices with its Guardant360 LDT CMS reimbursement and published a paper demonstrating improved adherence with blood-based colorectal cancer screening. The company also collaborated with the US Oncology Network and community oncology practices to increase the use of biomarker testing for identifying patients who would benefit from therapies. Terilyn Juarez Monroe was appointed as the chief people officer. [Extracted from the article]

Tetra Laval Holdings & Finance S.A. has been issued a patent for a liquid food packaging material, system, and method for applying an opening to the packaging material. The patent addresses the issue of improperly applied opening devices on containers, particularly on non-white colored packaging material or packaging material with a film. The invention involves using a first contrast area printed in a first color adjacent to the pre-laminated hole to achieve high contrast and improve detection. The patent provides detailed claims and descriptions of the laminated packaging material, system, and method. [Extracted from the article]

The device, which contains a liquid absorbent material (water or alcohol), is of sufficient length to accommodate the entire length of the endoscope channels. To use water indicator paper, compressed air is supplied to an opening on the endoscope and a piece of water indicator paper is used to catch/detect expelled liquid/moisture at the compressed air exit location. For examination of the internal channels of an endoscope, the borescope is typically inserted into the instrument channel opening at the distal tip of the endoscope. "There is currently no direct and sensitive method available for assessing endoscope channel dryness of all flexible endoscope internal channels.". [Extracted from the article]

A new editorial paper published in Oncotarget's Volume 15 discusses the challenges and setbacks in the process of drug discovery in academia. The researchers highlight the time-consuming and expensive nature of drug discovery, as many drug candidates fail to progress beyond the research bench. The lack of synergy between academia and industry, as well as the lack of streamlining the drug development process, contribute to this issue. The paper explores possible solutions to overcome these challenges. [Extracted from the article]

Chundo Pharm Co. Ltd. has been issued a patent for a method of producing a test strip for detecting calcium levels in a biological fluid sample. The test strip is based on a colorimetric change and can be used to measure calcium concentrations in blood, urine, or saliva. Calcium plays a crucial role in various bodily functions, and abnormal calcium levels can indicate medical conditions such as cancer, muscle dysfunction, and bone diseases. The test strip provides an easy, inexpensive, and fast way to measure calcium levels, allowing for early detection and prevention of conditions like osteoporosis. [Extracted from the article]

A new editorial paper published in Oncotarget discusses acute myeloid leukemia (AML), a type of aggressive cancer. The paper highlights recent advancements in understanding AML biology and the potential for developing novel drug therapies. The researchers suggest exploring reductive carboxylation as a possible drug target to weaken tumor cell survival mechanisms and improve patient outcomes. The paper provides further information on this topic and can be accessed through the provided DOI link. [Extracted from the article]