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The search for new active substances against SARS-CoV-2 is still a central challenge after the COVID-19 pandemic. Antiviral agents to complement vaccination are an important pillar in the clinical situation. Selected cannabinoids such as cannabigerol, cannabicyclol, cannabichromene, and cannabicitran from Cannabis sativa and synthetic homologues of cannabigerol and cannabicyclol were evaluated for effects on the cell viability of Vero cells (CC50 of cannabigerol and cannabicyclol 40 resp. 38 µM) and reduced virus entry of vesicular stomatitis pseudotyped viruses with surface-expressed SARS-CoV-2 spike protein at 20 µM. In addition to a reduction of pseudotyped virus entry, a titer reduction assay on Vero cells after preincubation of Wuhan SARS-CoV-2 significantly confirmed antiviral activity. Investigations on the molecular targets addressed by cannabigerol and cannabicyclol indicated that both compounds are inhibitors of SARS-CoV-2 spike protein-mediated membrane fusion, as could be shown by a virus-free reporter fusion inhibition assay (EC50 for cannabigerol 5.5 µM and for cannabicyclol 10.8 µM) and by monitoring syncytia formation in Vero reporter cells. Selectivity indices were calculated as 7.4 for cannabigerol and 3.5 for cannabicyclol. Systematic semisynthetic alterations of cannabigerol and cannabicyclol indicated that the side chains of both compounds do not contribute to the observed anti-membrane fusion activity. [ABSTRACT FROM AUTHOR]

Presents information on the dramatization of the leadership principle Führerprinzip in the Nazi motion pictures. List of characters used by film-makers to project the personality of Nazi leader Adolf Hitler; Background on several films related to the Nazis; Criteria for measuring the relevance of historical films for the Nazis in Germany; Details on how historical films were used to propagate anti-parliamentarianism themes and the concept of an individual leader genius.

Focuses on New York State Governor Mario Cuomo. Claim of Cuomo that he is a progressive reformist; View that Cuomo is not now, and never has been, a liberal; Reasons why Cuomo and his strategists did nothing to discourage press stories that described him as the most attractive and well-spoken liberal in the U.S.; Information on the state budget unveiled by Cuomo; Information on some of the speeches delivered by Cuomo.

The article offers news briefs in Connecticut. Consultancy D. P. Consulting Corp. has filed for bankruptcy voluntarily which is presented by Teresa Sandutto-Carley and Clifford A Katz. Lawsuit was filed against general contractor Anchorage Construction Corp. for delinquent contributions. A fine of $385,251 was imposed on food company Andrew Depoala Mushrooms Inc.

The article announces Christopher R. Cuomo's appointment as an associate in the real estate and real estate finance practice roups of the White Plains, New York office of the national law firm Eckert Seamans Cherin & Mellott LLC.

The article announces Lisamarie Desanto's appointment as project manager and digital strategist at digital marketing and web design company MarkNet.

The article announces Anson Augustine's appointment as partner at New York City accounting firm Marcum LLP.

The article reports on Westchester County (New York) Executive Robert P. Astorino's partnership with the organization Volunteer NY! to host the 9/11: Serve and Remember event, as well as the launch of the Westchester County Diaper Bank in partnership with the Junior League of Central Westchester.

The article reports on a $500,000 funding secured by Attorney General Mark Andrew M. Cuomo to finance clean air projects in several counties in New York. The funds are part of a $9.5 million settlement that Cuomo reached with American Electric Power. Projects in Westchester, Putnam and Dutchess counties will receive an initial disbursement of $500,000 from the settlement to reduce diesel air pollution emissions through truck stop electrification.