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Despite the key role of start-ups in economic development and job creation, one of the biggest problems of these start-up businesses is their legendary failure rate. One of the main reasons for the failure of these businesses is marketing limitations in the form of lack of financial resources, time, market knowledge and marketing expertise. Also, these companies lack strategic plans and their management is based on personal experience and business intuition. Entrepreneurial networking is one of the solutions that have been proposed to solve these limitations, because networking is considered to be the factor of restructuring the world trade architecture. The current research was conducted with the aim of explaining the role of entrepreneurial networking ability on the marketing performance of start-ups, taking into account the role of entrepreneurial orientation and market knowledge. The statistical population was 550 start-ups and fledgling businesses in Isfahan. The sample size was calculated using the Krejci and Morgan table of 225 companies that were selected by simple random sampling. A standard questionnaire was used to collect research data. Validity of the questionnaire was confirmed by experts and reliability using Cronbach's alpha coefficient. Data analysis was done using structural equation modeling with partial least squares approach and SmartPLS software to test fit and relationships between variables. According to the research results, entrepreneurial networking ability plays an important role in improving the marketing performance of start-up businesses; Therefore, managers who want to increase their marketing performance must identify and form strategic alliances faster than competitors. [ABSTRACT FROM AUTHOR]

The critical Crack Tip Opening Angle (CTOAc) is considered as a convenient parameter to characterize the crack arrest toughness of natural gas pipeline. Load-displacement curve is a comprehensive reflection of geometry, mechanical property and fracture behavior of a loaded specimen, so it would be highly advantageous to deduce (CTOAc) from loaddisplacement curve directly. From force-displacement curves, maximum force of 209kN and 207kN were obtained for experimental and numerical data, respectively. In this article, a combination of load-displacement and deformation of the drop weight tear test specimen was used to calculate the critical crack tip opening angle. For this purpose, the simplified single-specimen test method was used. The (CTOAc) is dependent on the slope of the steady-state crack growth region and the plastic rotation factor. Firstly, based on the fact that load decreases linearly with the increment of displacement during steady-state crack growth, the slope of the experimental load-displacement curve of API X65 steel in the steady-state crack growth region was obtained as 21.583. Secondly, by modeling the drop weight tear test in Abaqus software and using two methods of mises stress and neutral axis, the plastic rotation factor was obtained as 0.5688 and 0.5651, respectively. Finally, these parameters were used and the critical crack tip opening angle was determined as 12.00 and 12.08 degrees. [ABSTRACT FROM AUTHOR]

Background and Aim: The FoxO1 gene is a substantial regulator of cellular metabolism in heart tissue. Therefore, the present study aimed to investigate the effect of Kelussia extract and exercise on FoxO1 expression in cardiac tissue. Materials and Methods: In the present study, A total of 30 adult male Wistar rats weighing 180 to 200 g were selected and divided into five groups of control, negative control, a group of obese rats with exercise (rats became obese in 6 weeks and were trained 5 days a week for one hour and the extract was given to them for 6 weeks) and two treatment groups with doses of 400 and 800 mg/Kg of Kelussia extract. Molecular tests were performed on the hearts of 30 rats using Real-Time RT PCR. Finally, Statistical analysis of results was performed by SPSS software and ANOVA TEST with a significance level of P<0.05. Results: Kelussia extract at doses of 400 and 800 mg/kg can significantly reduce FoxO1 expression level (0.61 ± 0.14) and (0.70 ± 0.25), respectively, compared to the obese group (P<0.05). Also, in the group of rats with exercise, gene expression was significantly reduced compared to that of the obese group (0.54 ± 0.13). Furthermore, the results of biochemical tests confirmed the reduction of cholesterol, sugar, LDL, and triglyceride in the hearts of obese rats treated with 400 and 800 mg/kg of Kelussia. Conclusion: Exercise as well as Kelussia extract can reduce FoxO1 expression level and, could be used as a therapeutic target in heart disease if confirmed in further studies. [ABSTRACT FROM AUTHOR]

Introduction: One of the approaches that influences the decisionmaking and management of universities is evidence-based management. Evidence-based management requires managerial and organizational decisions and informed actions using the best available evidence in which the best evidence is used as norms and standards. Therefore, in line with the importance of this issue, the present study aimed to determine the sources of evidence used in decision making of staff managers in Iran University of Medical Sciences. Methods: The present descriptive-analytical study was conducted in 2019 among 71 managers of Iran University of Medical Sciences. The research tool was a standard evidence-based management questionnaire. In this study, the sampling was not carried out and all managers participated in it. Spearman test and SPSS-24 software were also used to analyze the data. Results: The findings of the study on the sources of evidence used by managers in organizational decisions and programs showed that the highest source of evidence was socio-political development program and the lowest was the use of sources of scientific research evidence. Conclusion: Any decision that is made without evidence-based management cannot be considered evidence-based and can have negative outcomes in any decision-making organization. Therefore, it is necessary that the relevant officials and policy makers provide a suitable platform by formulating specialized policies and providing the necessary infrastructure to reduce the gap between the current situation and the evidence-based management model. [ABSTRACT FROM AUTHOR]

Incremental forming method with lower cost and more flexibility can be a suitable alternative for traditional methods of the hole-flanging. In this study, the possibility of square hole-flanging of AL1050 aluminum sheet using incremental forming method has been investigated and the quality of the pyramid flange has been compared with conical flange. The final shape of the flange is defined so that wall angle increases with raising height. The process simulation was performed using Abaqus software and an experimental test was done to validate the simulation results. After performing the experimental tests, flange features such as the final size of the hole, flange height, and wall thickness were measured. The results showed that at the created flange around the circular hole, there is less spring back and more dimensional accuracy, however, it can be flanged a square hole by incremental approach with consideration of the height and hole size. The dimensional measurements showed that the final size of the hole will increase after the hole-flanging. By investigation of the various holes, it was found that in the larger initial hole, increasing the hole size after the flanging will be lower. [ABSTRACT FROM AUTHOR]