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Background and Objectives Corona is caused by a viral infection called acute respiratory syndrome corona virus 2 which spreads rapidly, causing irreparable damage and death. In order to predict and develop treatment algorithms, the study of biomarkers is important in determining the severity of the disease. Therefore, we investigated the correlation of Interleukin 6 IL-6, Lactate dehydrogenase LDH, C reactive protein CRP and disease severity in COVID-19 patients. Materials and Methods In this descriptive and analytical cross-sectional study, the information of 365 coronavirus hospitalized patients randomly selected in Sina Hamadan hospital during 2019 was entered into SPSS 26. The severity of the disease was also measured according to the defined reference and clinical symptoms and classified into two levels. The data were analyzed with gamma correlation instability test, Somers' D at significance level of p value <0.05. Results It was found that IL-6 with a correlation coefficient of 0.506, LDH with a correlation coefficient of 0.291 and CRP with a correlation coefficient of 0.23, all at the level of 0.01 (p value = 0.01), have a positive effect on the severity of Corona disease and the amount of this positive effect is based on Somers' effect coefficient d 0.839, 0.458 and 0.358, respectively. Conclusions Patients with severe COVID-19 have significantly higher serum levels of CRP, LDH and IL-6. Baseline levels of IL-6, CRP, and LDH were closely related to the severity of COVID-19 disease. These laboratory markers can be used as clinical indicators of disease exacerbation and prognosis of COVID-19. [ABSTRACT FROM AUTHOR]