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In this paper, we review the main features of modified theories of gravity containing higher-order curvature invariants in the action. After summarizing the main features of these theories, we consider their applications to cosmology, pointing out the differences with respect to general relativity that can eventually solve issues exhibited by the latter at low and high energy scales. Specifically, we explore a gravitational action that incorporates both the Ricci scalar R and the topological Gauss–Bonnet term, denoted as . Our investigation revolves around the cosmological properties of a specific category of modified gravity theories, chosen upon symmetry considerations. Within the framework of a spatially flat, homogeneous and isotropic cosmic background, we demonstrate that it is possible to account for the presently observed acceleration of the Universe by means of the extra geometric terms carried by the selected f (R ,) model. This approach offers a way to address the issues associated with the cosmological constant. To achieve this, we first examine the energy conditions and find that, under certain choices for the values of the cosmographic parameters, these conditions are all violated. In the second part of the work, to assess the feasibility of the selected f (R ,) model, we place observational constraints on its free parameters through a Bayesian Monte Carlo technique applied to late-time cosmic data. Our findings reveal that the f (R ,) model can effectively reproduce observations at low redshifts, providing an alternative to the standard Λ CDM scenario. [ABSTRACT FROM AUTHOR]

We modify the symmetric-teleparallel dark energy through the addition of a further Yukawa-like term, in which the non-metricity scalar, Q, is non-minimally coupled to a scalar field Lagrangian where the phion acts as quintessence, describing dark energy. We investigate regions of stability and find late-time attractors. To do so, we conduct a stability analysis for different types of physical potentials describing dark energy, namely the power-law, inverse power-law, and exponential potentials. Within these choices, we furthermore single out particular limiting cases, such as the constant, linear and inverse potentials. For all the considered scenarios, regions of stability are calculated in terms of the signs of the coupling constant and the exponent, revealing a clear degeneracy among coefficients necessary to ensure stability. We find that a generic power-law potential with α > 0 is not suitable as a non-minimal quintessence potential and we put severe limits on the use of inverse potential, as well. In addition, the equations of state of each potential have been also computed. We find the constant potential seems to be favored than other treatments, since the critical point appears independent of the non-minimal coupling. [ABSTRACT FROM AUTHOR]

We address the galaxy rotation curves through the Yukawa gravitational potential emerging as a correction of the Newtonian potential in extended theories of gravity. On the one hand, we consider the contribution of the galactic bulge, galactic disk, and the dark matter halo of the Navarro–Frenk–White profile, in the framework of the standard Λ CDM model. On the other hand, we use modified Yukawa gravity to show that the rotational velocity of galaxies can be addressed successfully without the need for dark matter. In Yukawa gravity, we recover MOND and show that dark matter might be seen as an apparent effect due to the modification of the law of gravitation in terms of two parameters: the coupling constant α and the characteristic length λ . We thus test our theoretical scenario using the Milky Way and M31 rotation velocity curves. In particular, we place observational constraints on the free parameters of Yukawa cosmology through the Monte Carlo method and then compare our results with the predictions of the Λ CDM paradigm by making use of Bayesian information criteria. Specifically, we find that λ is constrained to be of the order of kpc, while cosmological data suggest λ of the order of Gpc. To explain this discrepancy, we argue that there is a fundamental limitation in measuring λ due to the role of quantum mechanics on cosmological scales. [ABSTRACT FROM AUTHOR]

We here propose a new model-independent technique to overcome the circularity problem affecting the use of gamma-ray bursts (GRBs) as distance indicators through the use of E p−Eiso correlation. We calibrate the E p −E iso correlation and find the GRB distance moduli that can be used to constrain dark energy models. We use observational Hubble data to approximate the cosmic evolution through Bézier parametric curve obtained through the linear combination of Bernstein basis polynomials. In doing so, we build up a new data set consisting of 193 GRB distance moduli. We combine this sample with the supernova JLA data set to test the standard ΛCDM model and its w CDM extension. We place observational constraints on the cosmological parameters through Markov Chain Monte Carlo numerical technique. Moreover, we compare the theoretical scenarios by performing the Akaike and Deviance Information statistical criteria.the 2σ level, while for the w CDM model we obtain |$\Omega _m=0.34^{+0.13}_{-0.15}$| and |$w=-0.86^{+0.36}_{-0.38}$| at the 2σ level. Our analysis suggests that ΛCDM model is statistically favoured over the w CDM scenario. No evidence for extension of the ΛCDM model is found. [ABSTRACT FROM AUTHOR]

In the framework of metric-affine gravity, we consider the role of the boundary term in Symmetric Teleparallel Gravity assuming f(Q, B) models where f is a smooth function of the non-metricity scalar Q and the related boundary term B. Starting from a variational approach, we derive the field equations and compare them with respect to those of f(Q) gravity in the limit of B → 0 . It is possible to show that f (Q , B) = f (Q - B) models are dynamically equivalent to f(R) gravity as in the case of teleparallel f (B ~ - T) gravity (where B ≠ B ~ ). Furthermore, conservation laws are derived. In this perspective, considering boundary terms in f(Q) gravity represents the last ingredient towards the Extended Geometric Trinity of Gravity, where f(R), f (T , B ~) , and f(Q, B) can be dealt under the same standard. In this perspective, we discuss also the Gibbons–Hawking–York boundary term of General Relativity comparing it with B in f(Q, B) gravity. [ABSTRACT FROM AUTHOR]

Different astrophysical methods can be combined to detect possible deviations from General Relativity. In this work, we consider a class of f(R) gravity models selected by the existence of Noether symmetries. In this framework, it is possible to determine a set of static and spherically symmetric black hole solutions, encompassing small departures from the Schwarzschild geometry. In particular, when gravity is the only dominating interaction, we exploit the ray-tracing technique to reconstruct the image of a black hole, the epicyclic frequencies, and the black hole shadow profile. Moreover, when matter dynamics is also affected by an electromagnetic radiation force, we take into account the general relativistic Poynting–Robertson effect. In light of the obtained results, the proposed strategy results to be robust and efficient: on the one hand, it allows to investigate gravity from strong to weak field regimes; on the other hand, it is capable of detecting small departures from General Relativity, depending on the current observational sensitivity. [ABSTRACT FROM AUTHOR]

Patients with progressive supranuclear palsy (PSP) often have blinking abnormalities. In this study we examined the kinematic features of voluntary, spontaneous and reflex blinking in 11 patients with PSP and healthy control subjects. Patients were asked to blink voluntarily as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. During voluntary blinking the closing and opening phases lasted longer in patients than in healthy subjects. Furthermore, the peak velocity of the closing phase of voluntary blinking was lower in patients than healthy subjects. During spontaneous blinking the blink rate was markedly lower in patients than in control subjects. Patients recordings also showed kinematic abnormalities of spontaneous (reduced peak velocity of both closing and opening phases) and reflex (reduced peak velocity and increased duration of the opening phase) blinking. Recordings during reflex blinking disclosed an enhanced excitability of the interneuronal pool mediating the closing and opening blink phases. Finally, the pause, a neurophysiological marker of the switching processes between the closing and opening phases, was prolonged in all the three types of blinking. The abnormal kinematic variables correlated with patients’ clinical and kinematic features. Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease. [ABSTRACT FROM AUTHOR]

In this paper, we consider a gravitational action containing a combination of the Ricci scalar, R, and the topological Gauss-Bonnet term, G. Specifically, we study the cosmological features of a particular class of modified gravity theories selected by symmetry considerations, namely the f (R , G) = R n G 1 - n model. In the context of a spatially flat, homogeneous and isotropic background, we show that the currently observed acceleration of the Universe can be addressed through geometry, hence avoiding de facto the shortcomings of the cosmological constant. We thus present a strategy to numerically solve the Friedmann equations in presence of pressureless matter and obtain the redshift behavior of the Hubble expansion rate. Then, to check the viability of the model, we place constraints on the free parameters of the theory by means of a Bayesian Monte Carlo method applied to late-time cosmic observations. Our results show that the f(R, G) model is capable of mimicking the low-redshift behavior of the standard Λ CDM model. Finally, we investigate the energy conditions and show that, under suitable choices for the values of the cosmographic parameters, they are all violated when considering the mean value of n obtained from our analysis, as occurs in the case of a dark fluid. [ABSTRACT FROM AUTHOR]

We heal the cosmological constant problem by means of a cancellation mechanism that adopts a phase transition during which quantum fluctuations are eliminated. To this purpose, we propose that a generalized scalar (dark) matter field with a non-vanishing pressure term can remove the vacuum energy contribution, if its corresponding thermodynamics is written in terms of a quasi-quintessence representation. In such a picture, pressure differs from quintessence as it shows a zero kinetic contribution. Using this field, we investigate a metastable transition phase, in which the Universe naturally passes through an inflationary phase. To reach this target, we single out a double exponential potential, describing the metastable inflationary dynamics by considering suitable boundaries and thermodynamic conditions. We analyze stability investigating saddle, stable and unstable points and we thus predict a chaotic inflation that mimics the Starobinsky exponential potential. Consequently, the role of the proposed dark matter field is investigated throughout the overall Universe evolution. To do so, we provide a physical explanation on unifying the dark sector with inflation by healing the cosmological constant problem. [ABSTRACT FROM AUTHOR]

Objective: Extrauterine growth restriction (EUGR) among very preterm infants is related to poor neurodevelopment, but lack of consensus on EUGR measurement constrains international research. Our aim was to compare EUGR prevalence in a European very preterm cohort using commonly used measures.Design: Population-based observational study.Setting: 19 regions in 11 European countries.Patients: 6792 very preterm infants born before 32 weeks' gestational age (GA) surviving to discharge.Main Outcome Measures: We investigated two measures based on discharge-weight percentiles with (1) Fenton and (2) Intergrowth (IG) charts and two based on growth velocity (1) birth weight and discharge-weight Z-score differences using Fenton charts and (2) weight-gain velocity using Patel's model. We estimated country-level relative risks of EUGR adjusting for maternal and neonatal characteristics and associations with population differences in healthy newborn size, measured by mean national birth weight at 40 weeks' GA.Results: About twofold differences in EUGR prevalence were observed between countries for all indicators and these persisted after case-mix adjustment. Discharge weight <10th percentile using Fenton charts varied from 24% (Sweden) to 60% (Portugal) and using IG from 13% (Sweden) to 43% (Portugal), while low weight-gain velocity ranged from 35% (Germany) to 62% (UK). Mean term birth weight strongly correlated with both percentile-based measures (Spearman's rho=-0.90 Fenton, -0.84 IG, p<0.01), but not Patel's weight-gain velocity (rho: -0.38, p=0.25).Conclusions: Very preterm infants have a high prevalence of EUGR, with wide variations between countries in Europe. Variability associated with mean term birth weight when using common postnatal growth charts complicates international benchmarking. [ABSTRACT FROM AUTHOR]

Objective: To determine whether the variation in neurodevelopmental disability rates between populations persists after adjustment for demographic, maternal and infant characteristics for an international very preterm (VPT) birth cohort using a standardised approach to neurodevelopmental assessment at 2 years of age.Design: Prospective standardised cohort study.Setting: 15 regions in 10 European countries.Patients: VPT births: 22+0-31+6 weeks of gestation.Data Collection: Standardised data collection tools relating to pregnancy, birth and neonatal care and developmental outcomes at 2 years corrected age using a validated parent completed questionnaire.Main Outcome Measures: Crude and standardised prevalence ratios calculated to compare rates of moderate to severe neurodevelopmental impairment between regions grouped by country using fixed effects models.Results: Parent reported rates of moderate or severe neurodevelopmental impairment for the cohort were: 17.3% (ranging 10.2%-26.1% between regions grouped by country) with crude standardised prevalence ratios ranging from 0.60 to 1.53. Adjustment for population, maternal and infant factors resulted in a small reduction in the overall variation (ranging from 0.65 to 1.30).Conclusion: There is wide variation in the rates of moderate to severe neurodevelopmental impairment for VPT cohorts across Europe, much of which persists following adjustment for known population, maternal and infant factors. Further work is needed to investigate whether other factors including quality of care and evidence-based practice have an effect on neurodevelopmental outcomes for these children. [ABSTRACT FROM AUTHOR]

Background Hospitalized neonates receive the highest number of drugs compared to all other age groups, but consumption rates vary between studies depending on patient characteristics and local practices. There are no large-scale international studies on drug use in neonatal units. Objective We aimed to describe drug use in European neonatal units and characterize its associations with geographic region and gestational age. Setting A one-day point prevalence study was performed as part of the European Study of Neonatal Exposure to Excipients from January to June 2012. Method All neonatal prescriptions and demographic data were registered in a web-based database. The impact of gestational age and region on prescription rate were analysed with logistic regression. Main outcome measure The number and variety of drugs prescribed to hospitalized neonates in different gestational age groups and geographic regions. Results In total, 21 European countries with 89 neonatal units participated. Altogether 2173 prescriptions given to 726 neonates were registered. The 10 drugs with the highest prescription rate were multivitamins, vitamin D, caffeine, gentamicin, amino acids for parenteral nutrition, phytomenadione, ampicillin, benzylpenicillin, fat emulsion for parenteral nutrition and probiotics. The six most commonly prescribed ATC groups (alimentary tract and metabolism, blood and blood-forming organs, systemic anti-infectives, nervous, respiratory and cardiovascular system) covered 98% of prescriptions. Gestational age significantly affected the use of all commonly used drug groups. Geographic region influenced the use of alimentary tract and metabolism, blood and blood-forming organs, systemic anti-infectives, nervous and respiratory system drugs. Conclusion While gestational age-dependent differences in neonatal drug use were expected, regional variations (except for systemic anti-infectives) indicate a need for cooperation in developing harmonized evidence-based guidelines and suggest priorities for collaborative work. [ABSTRACT FROM AUTHOR]

2051Cosmography can be considered as a sort of a model-independent approach to tackle the dark energy/modified gravity problem. In this review, the success and the shortcomings of the Λ CDM model, based on General Relativity (GR) and standard model of particles, are discussed in view of the most recent observational constraints. The motivations for considering extensions and modifications of GR are taken into account, with particular attention to f (R) and f (T) theories of gravity where dynamics is represented by curvature or torsion field, respectively. The features of f (R) models are explored in metric and Palatini formalisms. We discuss the connection between f (R) gravity and scalar–tensor theories highlighting the role of conformal transformations in the Einstein and Jordan frames. Cosmological dynamics of f (R) models is investigated through the corresponding viability criteria. Afterwards, the equivalent formulation of GR (Teleparallel Equivalent General Relativity (TEGR)) in terms of torsion and its extension to f (T) gravity is considered. Finally, the cosmographic method is adopted to break the degeneracy among dark energy models. A novel approach, built upon rational Padé and Chebyshev polynomials, is proposed to overcome limits of standard cosmography based on Taylor expansion. The approach provides accurate model-independent approximations of the Hubble flow. Numerical analyses, based on Monte Carlo Markov Chain integration of cosmic data, are presented to bound coefficients of the cosmographic series. These techniques are thus applied to reconstruct f (R) and f (T) functions and to frame the late-time expansion history of the universe with no a priori assumptions on its equation-of-state. A comparison between the Λ CDM cosmological model with f (R) and f (T) models is reported. [ABSTRACT FROM AUTHOR]

We derive the weak field limit for a gravitational Lagrangian density L g = (R + a 0 R 2 + ∑ k = 1 p a k R □ k R) − g , where higher-order derivative terms in the Ricci scalar R are taken into account. The interest for this kind of effective theories comes out from the consideration of the infrared and ultraviolet behaviors of gravitational field and, in general, from the formulation of quantum field theory in curved spacetimes. Here, we obtain solutions in weak field regime both in vacuum and in the presence of matter and derive gravitational waves considering the contribution of R □ k R terms. By using a suitable set of coefficients a k , it is possible to find up to (p + 2) normal modes of oscillation with six polarization states with helicity 0 or 2. Here p is the higher-order term in the □ operator appearing in the gravitational Lagrangian. More specifically: the mode ω 1 , with k 2 = 0 , has transverse polarizations 𝜖 μ ν (+) and 𝜖 μ ν (×) with helicity 2; the (p + 1) modes ω m , with k 2 ≠ 0 , have transverse polarizations 𝜖 μ ν (1) and non-transverse ones 𝜖 μ ν (TT) , 𝜖 μ ν (TS) , 𝜖 μ ν (L) with helicity 0. [ABSTRACT FROM AUTHOR]

We propose a model-independent formalism to numerically solve the modified Friedmann equations in the framework of f( T) teleparallel cosmology. Our strategy is to expand the Hubble parameter around the redshift $$z=0$$ up to a given order and to adopt cosmographic bounds as initial settings to determine the corresponding $$f(z)\equiv f(T(H(z)))$$ function. In this perspective, we distinguish two cases: the first expansion is up to the jerk parameter, the second expansion is up to the snap parameter. We show that inside the observed redshift domain $$z\le 1$$ , only the net strength of f( z) is modified passing from jerk to snap, whereas its functional behavior and shape turn out to be identical. As first step, we set the cosmographic parameters by means of the most recent observations. Afterwards, we calibrate our numerical solutions with the concordance $$\Lambda $$ CDM model. In both cases, there is a good agreement with the cosmological standard model around $$z\le 1$$ , with severe discrepancies outer of this limit. We demonstrate that the effective dark energy term evolves following the test-function: $$f(z)={\mathcal {A}}+{\mathcal {B}}{z}^2e^{{\mathcal {C}}{z}}$$ . Bounds over the set $$\left\{ {\mathcal {A}}, {\mathcal {B}}, {\mathcal {C}}\right\} $$ are also fixed by statistical considerations, comparing discrepancies between f( z) with data. The approach opens the possibility to get a wide class of test-functions able to frame the dynamics of f( T) without postulating any model a priori. We thus re-obtain the f( T) function through a back-scattering procedure once f( z) is known. We figure out the properties of our f( T) function at the level of background cosmology, to check the goodness of our numerical results. Finally, a comparison with previous cosmographic approaches is carried out giving results compatible with theoretical expectations. [ABSTRACT FROM AUTHOR]

In this study, a gas-chromatography mass spectrometry (GC-MS) metabolomics study was applied to examine urine metabolite profiles of different classes of neonates under different nutrition regimens. The study population included 35 neonates, exclusively either breastfed or formula milk fed, in a seven-day timeframe. Urine samples were collected from intrauterine growth restriction (IUGR), large for gestational age (LGA), and appropriate gestational age (AGA) neonates. At birth, IUGR and LGA neonates showed similarities in their urine metabolite profiles that differed from AGA. When neonates started milk feeding, their metabolite excretion profile was strongly characterized by the different diet regimens. After three days of formula milk nutrition, urine had higher levels of glucose, galactose, glycine and myo-inositol, while up-regulated aconitic acid, aminomalonic acid and adipic acid were found in breast milk fed neonates. At seven days, neonates fed with formula milk shared higher levels of pseudouridine with IUGR and LGA at birth. Breastfed neonates shared up-regulated pyroglutamic acid, citric acid, and homoserine, with AGA at birth. The role of most important metabolites is herein discussed. [ABSTRACT FROM AUTHOR]

Purpose: The use of medicines among newborns admitted to intensive care units is characterized by a high prevalence of off-label/unlicensed use and a wide variability in the absence of international guidelines. A prospective cross-sectional study was organized with the aim to analyse drug prescriptions among all 107 Italian level III neonatal intensive care units. Methods: An online questionnaire was used to collect detailed information for each newborn, and a classification was made about the license status of all prescriptions. In addition, prescriptions were analysed taking into account a practical guide prepared by the Italian Society of Neonatology (ISN). Results: The 1-day survey (May-July 2014) regarded 220 newborn infants admitted to 36/107 Italian neonatal intensive care units: 191 prematures and 29 born at term. In total, 720 prescriptions (corresponding to 79 different drugs) were analysed: 191 (26.5 %) followed the terms of the product license, 529 (73.5 %) were off-label or unlicensed: 193/220 newborns (87.7 %) received at least one off-label/unlicensed prescription. Antiinfectives were the most common medicine used, followed by respiratory drugs and antianaemics; in an off-label manner, the most common was cardiovascular and central nervous system (CNS) drugs, gastrointestinals and antiinfectives. The most common categories of off-label use were age (34.4 %) and dosing frequency (20.6 %). Compared to ISN practical guide, prescriptions adhered more frequently to indications (100 % for ampicillin/sulbactam, >80 % for ampicillin, fluconazole, fentanyl, ranitidine and vancomicin). Conclusions: Our results confirm the high prevalence of off-label/unlicensed drug use in the neonatal population and underline a better adherence to indications based on clinical practice, suggesting the need to update information contained in the data sheets of medicines. [ABSTRACT FROM AUTHOR]

Objectives We aimed to describe administration of eight potentially harmful excipients of interest (EOI)-- parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol, ethanol and benzalkonium chloride--to hospitalised neonates in Europe and to identify risk factors for exposure. Methods All medicines administered to neonates during 1 day with individual prescription and demographic data were registered in a web-based point prevalence study. Excipients were identified from the Summaries of Product Characteristics. Determinants of EOI administration (geographical region, gestational age (GA), active pharmaceutical ingredient, unit level and hospital teaching status) were identified using multivariable logistical regression analysis. Results Overall 89 neonatal units from 21 countries participated. Altogether 2095 prescriptions for 530 products administered to 726 neonates were recorded. EOI were found in 638 (31%) prescriptions and were administered to 456 (63%) neonates through a relatively small number of products (n=142; 27%). Parabens, found in 71 (13%) products administered to 313 (43%) neonates, were used most frequently. EOI administration varied by geographical region, GA and route of administration. Geographical region remained a significant determinant of the use of parabens, polysorbate 80, propylene glycol and saccharin sodium after adjustment for the potential covariates including anatomical therapeutic chemical class of the active ingredient. Conclusions European neonates receive a number of potentially harmful pharmaceutical excipients. Regional differences in EOI administration suggest that EOI-free products are available and provide the potential for substitution to avoid side effects of some excipients. [ABSTRACT FROM AUTHOR]

Objectives: To explore differences in approaches to supporting lactation and breastfeeding for very preterm infants in neonatal intensive care units (NICU) in 3 European regions. Design: Qualitative cross-sectional study carried out by means of face-to-face semistructured interviews. Verbatim transcripts were coded using a theoretical framework derived from the literature and supplemented by data-driven concepts and codes. Setting: 4 purposively selected NICUs in each of 3 European regions in 2010 (Ile-de-France in France, Lazio in Italy, and the former Trent region in the UK). Participants: NICU staff members (n=22). Results: Policies and practices for managing mother's own milk for very preterm babies differed between regions, and were much more complex in Ile-de-France than in the Trent or Lazio regions. Staff approaches to mothers to initiate lactation differed by region, with an emphasis on the nutritional and immunological value of human milk in the Trent region and on the 'normalising' effect of breastfeeding on the mother-child relationship in Lazio. French and English staff expressed conflicting opinions about the use of bottles, which was routine in Italy. Italian informants stressed the importance of early maternal milk expression and feeding, but also mentioned discharging infants home before feeding at the breast was established. In Ile-de-France and Trent, successful feeding from the breast was achieved before discharge, although this was seen as a factor that could prolong hospitalisation and discourage continued breastfeeding for some women. Conclusions: Targeted health promotion policies in the NICU are necessary to increase the number of infants receiving their mother's milk and to support mothers with transfer of the infant to the breast. Integrating knowledge about the different approaches to lactation and breastfeeding in European NICUs could improve the relevance of recommendations in multiple cultural settings. [ABSTRACT FROM AUTHOR]

Background: Antibiotic dosing in neonates varies between countries and centres, suggesting suboptimal exposures for some neonates. We aimed to describe variations and factors influencing the variability in the dosing of frequently used antibiotics in European NICUs to help define strategies for improvement. Methods: A sub-analysis of the European Study of Neonatal Exposure to Excipients point prevalence study was undertaken. Demographic data of neonates receiving any antibiotic on the study day within one of three two-week periods from January to June 2012, the dose, dosing interval and route of administration of each prescription were recorded. The British National Formulary for Children (BNFC) and Neofax were used as reference sources. Risk factors for deviations exceeding ±25% of the relevant BNFC dosage recommendation were identified by multivariate logistic regression analysis. Results: In 89 NICUs from 21 countries, 586 antibiotic prescriptions for 342 infants were reported. The twelve most frequently used antibiotics - gentamicin, penicillin G, ampicillin, vancomycin, amikacin, cefotaxime, ceftazidime, meropenem, amoxicillin, metronidazole, teicoplanin and flucloxacillin - covered 92% of systemic prescriptions. Glycopeptide class, GA <32 weeks, 5th minute Apgar score <5 and geographical region were associated with deviation from the BNFC dosage recommendation. While the doses of penicillins exceeded recommendations, antibiotics with safety concerns followed (gentamicin) or were dosed below (vancomycin) recommendations. Conclusions: The current lack of compliance with existing dosing recommendations for neonates needs to be overcome through the conduct of well-designed clinical trials with a limited number of antibiotics to define pharmacokinetics/pharmacodynamics, efficacy and safety in this population and by efficient dissemination of the results. [ABSTRACT FROM AUTHOR]

Extrauterine growth retardation (EUGR) seriously affects premature newborns and is related to the impairment of growth during childhood. There are very limited data available concerning the growth outcome of EUGR children. Our aim was to assess the growth outcome in a cohort of children born before 34 weeks of gestation with severe EUGR. This was a retrospective multicenter study, performed in outpatient endocrinology clinic. A total of 103 premature children with weight and/or length below −2 standard deviation score (SDS) of 'intrauterine' growth expectation at the time of discharge from hospital (within 42 weeks of postmenstrual age) were included in the study. The study participants underwent a thorough anthropometric assessment at a mean age of 3.9 years ± 1.7 SD. Of the EUGR children, 12.6 % showed a height below −2 SDS and 7.7 % even below −2.5 SDS. Growth impairment was more common in males than in females (17 vs. 8 %). The prevalence of subnormal weight (below −2 SDS) was 13.6 %, being higher in males than in females (17 vs. 10 %). BMI values below −2 SDS were found in 18.4 % of our study population (22.7 % in males and 12 % in females). The 19.6 % of EUGR children did not catch up in head circumference during early childhood. Length at term was the major predictor of height in childhood ( P < 0.001). Conclusion: A significant proportion of children born prematurely with severe EUGR show growth retardation in childhood thus suggesting the need for a close clinical follow-up to determine their growth potential and implement effective intervention strategies. [ABSTRACT FROM AUTHOR]