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Cryo-electron micrograph images have various characteristics such as varying sizes, shapes, and distribution densities of individual particles, severe background noise, high levels of impurities, irregular shapes, blurred edges, and similar color to the background. How to demonstrate good adaptability in the field of image vision by picking up single particles from multiple types of cryo-electron micrographs is currently a challenge in the field of cryo-electron micrographs. This paper combines the characteristics of the MixUp hybrid enhancement algorithm, enhances the image feature information in the pre-processing stage, builds a feature perception network based on the channel self-attention mechanism in the forward network of the Swin Transformer model network, achieving adaptive adjustment of self-attention mechanism between different single particles, increasing the network's tolerance to noise, Incorporating PReLU activation function to enhance information exchange between pixel blocks of different single particles, and combining the Cross-Entropy function with the softmax function to construct a classification network based on Swin Transformer suitable for cryo-electron micrograph single particle detection model (Swin-cryoEM), achieving mixed detection of multiple types of single particles. Swin-cryoEM algorithm can better solve the problem of good adaptability in picking single particles of many types of cryo-electron micrographs, improve the accuracy and generalization ability of the single particle picking method, and provide high-quality data support for the three-dimensional reconstruction of a single particle. In this paper, ablation experiments and comparison experiments were designed to evaluate and compare Swin-cryoEM algorithms in detail and comprehensively on multiple datasets. The Average Precision is an important evaluation index of the evaluation model, and the optimal Average Precision reached 95.5% in the training stage Swin-cryoEM, and the single particle picking performance was also superior in the prediction stage. This model inherits the advantages of the Swin Transformer detection model and is superior to mainstream models such as Faster R-CNN and YOLOv5 in terms of the single particle detection capability of cryo-electron micrographs. [ABSTRACT FROM AUTHOR]

In the process of Canny edge detection, a large number of high complexity calculations such as Gaussian filtering, gradient calculation, non-maximum suppression, and double threshold judgment need to be performed on the image, which takes up a lot of operation time, which is a great challenge to the real-time requirements of the algorithm. The traditional Canny edge detection technology mainly uses customized equipment such as DSP and FPGA, but it has some problems, such as long development cycle, difficult debugging, resource consumption, and so on. At the same time, the adopted CUDA platform has the problem of poor cross-platform. In order to solve this problem, a fine-grained parallel Canny edge detection method is proposed, which is optimized from three aspects: task partition, vector memory access, and NDRange optimization, and CPU-GPU collaborative parallelism is realized. At the same time, the parallel Canny edge detection methods based on multi-core CPU and CUDA architecture are designed. The experimental results show that OpenCL accelerated Canny edge detection algorithm (OCL_Canny) achieves 20.68 times acceleration ratio compared with CPU serial algorithm at 7452 × 8024 image resolution. At the image resolution of 3500 × 3500, the OCL_Canny algorithm achieves 3.96 times the acceleration ratio compared with the CPU multi-threaded Canny parallel algorithm. At 1024 × 1024 image resolution, the OCL_Canny algorithm achieves 1.21 times the acceleration ratio compared with the CUDA-based Canny parallel algorithm. The effectiveness and performance portability of the proposed Canny edge detection parallel algorithm are verified, and it provides a reference for the research of fast calculation of image big data. [ABSTRACT FROM AUTHOR]