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Researchers at Albert Einstein College of Medicine in Bronx, New York have conducted a study on trogocytosis, a process by which cells acquire molecules from other cells. The study focused on hematopoietic stem cells (HSCs), which are routinely mobilized from the bone marrow for transplantation. The researchers found that a subset of HSCs displayed macrophage-associated markers on their cell surface, suggesting that these HSCs were selectively retained in the bone marrow. The study provides evidence that adult stem cells use trogocytosis to establish and activate molecular mechanisms. [Extracted from the article]

A recent study conducted by researchers at the Albert Einstein College of Medicine in New York City has shed light on the mechanisms that control the fate of hematopoietic stem cells (HSPCs), which are responsible for blood production. The study found that transitory free cytoplasmic iron plays a role in regulating the fate of adult stem cells. The researchers discovered that limited iron availability triggers metabolic and epigenetic events that regulate stemness-conferring gene expression. Additionally, the study found that aging-related iron loading can impair cell fate control in aged stem cells. This research provides insights into potential intervention strategies for dysfunctional aged stem cells. [Extracted from the article]

A recent study conducted by researchers at Albert Einstein College of Medicine has identified a potential therapeutic target for acute myeloid leukemia (AML). The study found that a protein called TMIGD2 is expressed by AML cells and plays a crucial role in the development and maintenance of the disease. Targeting TMIGD2 with monoclonal antibodies was shown to reduce leukemia burden in AML patient-derived xenograft models without affecting normal hematopoietic stem/progenitor cells. These findings provide a promising strategy for the treatment of AML. [Extracted from the article]