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Monitoring glucose concentration in the blood is essential in the therapy of diabetes, a pathology which affects about 350 million people around the World (three million in Italy), causes more than four million deaths per year and consumes a significant portion of the budget of national health systems (10% in Italy). In the last 15 years, several sensors with different degree of invasiveness have been proposed to monitor glycemia in a quasi-continuous way (up to 1 sample/min rate) for relatively long intervals (up to 7 consecutive days). These continuous glucose monitoring (CGM) sensors have opened new scenarios to assess, off-line, the effectiveness of individual patient therapeutic plans from the retrospective analysis of glucose time-series, but have also stimulated the development of innovative on-line applications, such as hypo/hyper-glycemia alert systems and artificial pancreas closed-loop control algorithms. In this review, we illustrate some significant Italian contributions, both from industry and academia, to the growth of the CGM sensors research area. In particular, technological, algorithmic and clinical developments performed in Italy will be discussed and put in relation with the advances obtained in the field in the wider international research community. [ABSTRACT FROM AUTHOR]

In this study, performed on a set of twenty-two earthquakes that occurred in central Italy between 2019 and 2020, we will explore the possibility to locate the hypocenter of local events by using a ring laser gyroscope observing the vertical ground rotation and a standard broadband seismometer. A picking algorithm exploiting the four components (4C) polarization properties of the wavefield is used to identify the first shear onset transversely polarized (SH). The wavefield direction is estimated by correlation between the vertical rotation rate and the transverse acceleration. The picked times for Pg and Sg onsets are compared to the ones obtained after manual revision on the GIGS station seismometer. The results are compared with the location provided by the national monitoring service of the INGV. [ABSTRACT FROM AUTHOR]