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Effective information systems require the existence of explicit process models. A completely specified process design needs to be developed in order to enact a given business process. This development is time consuming and often subjective and incomplete. We propose a method that constructs the process model from process log data, by determining the relations between process tasks. To predict these relations, we employ machine learning technique to induce rule sets. These rule sets are induced from simulated process log data generated by varying process characteristics such as noise and log size. Tests reveal that the induced rule sets have a high predictive accuracy on new data. The effects of noise and imbalance of execution priorities during the discovery of the relations between process tasks are also discussed. Knowing the causal, exclusive, and parallel relations, a process model expressed in the Petri net formalism can be built. We illustrate our approach with real world data in a case study. [ABSTRACT FROM AUTHOR]

Protein domains are the structural and functional units of proteins. The ability to parse protein chains into different domains is important for protein classification and for understanding protein structure, function, and evolution. Here we use machine learning algorithms, in the form of recursive neural networks, to develop a protein domain predictor called DOMpro. DOMpro predicts protein domains using a combination of evolutionary information in the form of profiles, predicted secondary structure, and predicted relative solvent accessibility. DOMpro is trained and tested on a curated dataset derived from the CATH database. DOMpro correctly predicts the number of domains for 69% of the combined dataset of single and multi-domain chains. DOMpro achieves a sensitivity of 76% and specificity of 85% with respect to the single-domain proteins and sensitivity of 59% and specificity of 38% with respect to the two-domain proteins. DOMpro also achieved a sensitivity and specificity of 71% and 71% respectively in the Critical Assessment of Fully Automated Structure Prediction 4 (CAFASP-4) (Fisher et al., 1999; Saini and Fischer, 2005) and was ranked among the top ab initio domain predictors. The DOMpro server, software, and dataset are available at http://www.igb.uci.edu/servers/psss.html. [ABSTRACT FROM AUTHOR]