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This paper presents the Hybrid and Self-Adaptive Differential Evolution algorithms (HSADE) to solve an egg distribution problem in Thailand. We introduce and formalize a model for a multi-product, multi-depot vehicle routing problem with a time window, a heterogeneous fleet and inventory restrictions. The goal of the problem is to minimize the total cost. The multiple products comprise customers' demands with different egg sizes. This paper presents a Mixed Integer Linear Programming (MILP) model, an initial solution-based constructive heuristic, a new self-adaptive mutation strategy, and a neighborhood search structure with the probability to improve DE. The two measurements of criteria are the heuristic performance (HP) compared with the solution obtained by MILP and the relative improvement (RI) of the solution compared with Thailand's current egg distribution practice. The computational results show that the performance of HSADE is better than the current practice, and HSADE can provide on average a 14.13% improvement in total cost. Additionally, our proposed algorithm can be applied to similar agriculture logistics in Thailand and worldwide. [ABSTRACT FROM AUTHOR]