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Background and Objectives Corona is caused by a viral infection called acute respiratory syndrome corona virus 2 which spreads rapidly, causing irreparable damage and death. In order to predict and develop treatment algorithms, the study of biomarkers is important in determining the severity of the disease. Therefore, we investigated the correlation of Interleukin 6 IL-6, Lactate dehydrogenase LDH, C reactive protein CRP and disease severity in COVID-19 patients. Materials and Methods In this descriptive and analytical cross-sectional study, the information of 365 coronavirus hospitalized patients randomly selected in Sina Hamadan hospital during 2019 was entered into SPSS 26. The severity of the disease was also measured according to the defined reference and clinical symptoms and classified into two levels. The data were analyzed with gamma correlation instability test, Somers' D at significance level of p value <0.05. Results It was found that IL-6 with a correlation coefficient of 0.506, LDH with a correlation coefficient of 0.291 and CRP with a correlation coefficient of 0.23, all at the level of 0.01 (p value = 0.01), have a positive effect on the severity of Corona disease and the amount of this positive effect is based on Somers' effect coefficient d 0.839, 0.458 and 0.358, respectively. Conclusions Patients with severe COVID-19 have significantly higher serum levels of CRP, LDH and IL-6. Baseline levels of IL-6, CRP, and LDH were closely related to the severity of COVID-19 disease. These laboratory markers can be used as clinical indicators of disease exacerbation and prognosis of COVID-19. [ABSTRACT FROM AUTHOR]

Background and Objectives Change in the age structure of the population affects many activities and processes, and most countries are expected to enter the old population phase by 2050. Today, for various reasons, the consumption of blood and blood products has increased. The aim of this study was to investigate the age change in donor population during the years 1390 to 1397 and compare it with the society's age change algorithm to determine if the latter affects the former. Materials and Methods In this cross-sectional descriptive study, demographic information of 329631 blood donors from 1390 to 1397 from Blood Transfusion Software (Negareh software version 5/9) was extracted and the latest demographic information of the province was achieved using the website of the Statistics Center of Iran. Results Of the population of Yazd and Ardakan cities, 64.7% and 65.38% are within the appropriate age range for blood donation. The donor population of 18-30 years decreased by 30.7% in 2016 and 32.3% in 2018 compared with the year 2011 while other age groups almost increased. Mean age of donors in 2014 and 2017 were 44.2 and 40.05 years, respectively. Conclusions Due to the aging population, and the reduction of the population under the age of 30, it is necessary to take effective programs to maintain and attract 18-30 year old population for blood donation. [ABSTRACT FROM AUTHOR]