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In 2018, the position paper 'Imaging the adult with congenital heart disease: a multimodality imaging approach' was published. The paper highlights, in the first part, the different imaging modalities applied in adult congenital heart disease patients. In the second part, these modalities are discussed more detailed for moderate to complex anatomical defects. Because of the length of the paper, simple lesions were not touched on. However, imaging modalities to use for simple shunt lesions are still poorly known. One is looking for structured recommendations on which they can rely when dealing with an (undiscovered) shunt lesion. This information is lacking for the initial diagnostic process, during repair and at follow-up. Therefore, this paper will focus on atrial septal defect, ventricular septal defect, and persistent arterial duct. Pre-, intra-, and post-procedural imaging techniques will be systematically discussed. This position paper will offer algorithms that might help at a glance. The document is prepared for general cardiologists, trainees, medical students, imagers/technicians to select the most appropriate imaging modality and to detect the requested information for each specific lesion. It might serve as reference to which researchers could refer when setting up a (imaging) study. [ABSTRACT FROM AUTHOR]

The article focuses on a study which seeks to validate aerosol optical thickness (AOT) and Ångström exponent acquired with the Satellite Aerosol Retrieval (SAER) algorithm for Moderate resolution Imaging Spectroradiometer (MODIS) Aqua and Terra data over land surfaces in Europe. It performs an inter-comparison of the diverse algorithm. It explores the impact of aerosols on climate AOT.

Objectives Comprehensive smokefree laws, as recommended by the WHO Framework Convention of Tobacco Control (WHO FCTC), are the most effective tool to protect the population from secondhand smoke (SHS) and to ensure healthy environments. Studies evaluating how laws govern SHS protection are scarce. This study assessed the level of protection from SHS of laws from countries belonging to the WHO European Region. Methods A new methodology system was developed to evaluate the smokefree legislation according to the principles provided by the WHO guidelines for the correct implementation of Article 8 of the FCTC. For each law, six main sectors and 28 facilities were evaluated. Results Overall 68 laws from 48 countries from the WHO European Region were reviewed. 'Education' and 'Public transport' were the most protected sectors from SHS. Many WHO European laws do not provide protection from SHS across all public sectors. For example, 48.5% of general health facilities and 71.2% of restaurants are unprotected from SHS. The level of protection provided in the 28 facilities studied was low; many WHO European laws still allow smoking under certain conditions, permitting smoking in designated and/or ventilated areas. Conclusions Nine years after the adoption of the WHO FCTC there are still legal formulas in which smoking is allowed in several facilities, through the inclusion of separated areas, ventilated areas and other conditions. Tobacco control efforts still face the challenge of eradicating the legal clauses that prevent 100% smokefree environments. [ABSTRACT FROM AUTHOR]

This paper examines the ethical and legal challenges encountered during the GATEKEEPER Project and how these challenges informed the development of a comprehensive framework for future Large-Scale Pilot (LSP) projects. GATEKEEPER is a LSP Project with 48 partners conducting 30 implementation studies across Europe with 50,000 target participants grouped into 9 Reference Use Cases. The project underscored the complexity of obtaining ethical approval across various jurisdictions with divergent regulations and procedures. Through a detailed analysis of the issues faced and the strategies employed to navigate these challenges, this study proposes an ethical and legal framework. This framework, derived from a comparative analysis of ethical application forms and regulations, aims to streamline the ethical approval process for future LSP research projects. By addressing the hurdles encountered in GATEKEEPER, the proposed framework offers a roadmap for more efficient and effective project management, ensuring smoother implementation of similar projects in the future. [ABSTRACT FROM AUTHOR]

Algorithmic decision-making and other types of artificial intelligence (AI) can be used to predict who will commit crime, who will be a good employee, who will default on a loan, etc. However, algorithmic decision-making can also threaten human rights, such as the right to non-discrimination. The paper evaluates current legal protection in Europe against discriminatory algorithmic decisions. The paper shows that non-discrimination law, in particular through the concept of indirect discrimination, prohibits many types of algorithmic discrimination. Data protection law could also help to defend people against discrimination. Proper enforcement of non-discrimination law and data protection law could help to protect people. However, the paper shows that both legal instruments have severe weaknesses when applied to artificial intelligence. The paper suggests how enforcement of current rules can be improved. The paper also explores whether additional rules are needed. The paper argues for sector-specific – rather than general – rules, and outlines an approach to regulate algorithmic decision-making. [ABSTRACT FROM AUTHOR]

New propulsion systems in aircrafts must meet strict regulations and emission limitations. The Flightpath 2050 goals set by the Advisory Council for Aviation Research and Innovation in Europe (ACARE) include reductions of 75%, 90%, and 65% in CO2, NOx, and noise, respectively. These goals are not fully satisfied by marginal improvements in gas turbine technology or aircraft design. A novel control design procedure for the next generation of turbofan engines is proposed in this paper to improve Full Authority Digital Engine Control (FADEC) systems and reduce the emission levels to meet the Flightpath 2050 regulations. Hence, an Adaptive Network–based Fuzzy Inference System (ANFIS), nonlinear autoregressive network with exogenous inputs (NARX) techniques, and the block-structure Hammerstein–Wiener approach are used to develop a model for a turbofan engine. The Min–Max control structure is chosen as the most widely used practical control algorithm for gas turbine aero engines. The objective function is considered to minimize the emission level for the engine in a pre-defined maneuver while keeping the engine performance in different aspects. The Genetic Algorithm (GA) is applied to find the optimized control structure. The results confirm the effectiveness of the proposed approach in emission reduction for the next generation of turbofan engines. [ABSTRACT FROM AUTHOR]

The article presents a study which examines the retrieval and validation of the aerosol optical thickness (AOT) land product at the infrared channel of Spinning Enhanced Visible and InfraRed Imager (SEVIRI) sensor aboard EUMETSAT's Meteosat Second Generation (MSG) meteorological satellite. It analyzes the validity of the algorithm using ground-based measurements (AERONET) for stations in Europe. It further explores the capability of the SEVIRI product to follow the aerosol diurnal cycle.

Determining contingency aware dispatch decisions by solving a security-constrained optimal power flow (SCOPF) is challenging for real-world power systems, as the high problem dimensionality often leads to impractical computational requirements. This problem becomes more severe when the SCOPF has to be solved not only for a single instance, but for multiple periods, e.g. in the context of electricity market analyses. This paper proposes an algorithm that identifies the minimal set of constraints that exactly define the space of feasible nodal injections for a given network and contingency scenarios. By internalizing the technical limits of the nodal injections and enforcing a minimal worst-case impact of contingencies to line flows, computational effort can be further improved. The case study applies and analyzes the methods on the IEEE 118 and A&M 2000 bus systems, as well as the German and European transmission systems. In all tested cases the proposed algorithm identifies at least 95% of the network and security constraints as redundant, leading to significant SCOPF solve time reductions. Scalability and practical implementation are explicitly discussed. The code and input data of the case study is published supplementary to the paper under an open-source license. [ABSTRACT FROM AUTHOR]

Editorial. Highlights the Design and Test in Europe Conference. Discussion of research on technologies for electronic and embedded systems engineering; Design, verification, algorithms and tools for design automation of electronic circuits and systems for wireless communications; Submission of manuscripts for peer-reviewing.

Individual tree detection algorithms (ITD) are used to obtain accurate information about trees. Following the process of individual tree detection, it is possible to use additional processing tools to determine tree parameters such as tree height, crown base height, crown volume, or stem volume. However, many of the methods developed so far have focused on parameterising the algorithms based on the study area, height structure or tree species analysed. Applying the parameters of the method can be challenging in areas with dense and heterogeneous forests with a diverse stand structure. Therefore, this work aimed to develop a method to correct the results of ITD algorithms to identify individual trees more reliably, taking into account different ITD methods based on the Canopy Height Model. In the present study, we proposed a three-step approach to correct segmentation errors. In the first step, erroneous (under- and over-segmentation errors) and correct segments were classified. After classification, the second step was to refine the under-segmentation errors. The final step was to merge segments from the over-segmentation class with correct segments based on the specified conditions. The study was conducted in one of the most complex and diverse forest communities in Europe, making tree identification a major challenge. The accuracy of the segmentation improvements varied depending on the method applied and tree species group examined. Thus, based on the results, the paper advocates for the correction method due to its efficiency in mixed forest stands. Therefore, the present study offers a possible solution to reduce segmentation errors by considering different forest types and different CHM-based ITD methods for identifying individual trees. [ABSTRACT FROM AUTHOR]

In more or less noticeable ways, algorithms are pervading every sector of life. As algorithm-related activities multiply around us, it is reasonable to predict that so will accidents and, consequently, compensation claims framed as torts. Against this background, the paper investigates from a comparative perspective how legal systems in three regions of the world--the U.S., (continental) Europe, and China--could approach the rise of algorithmic torts. First, the paper sketches out the main features that might be associated with algorithm-related torts and the specific challenges that they might bring to current legal frameworks. It then presents the state-of-the-art of the legal debate about algorithmic liability in U.S., Europe, and China. Finally, the paper delves into the ways in which tort laws in these three regions might address injuries associated with algorithmic activities, reviewing in particular the criteria for grounding jurisdiction, the procedural devices applying to tort law claims, the liability regimes under which claims could be framed, the mechanisms for damage attribution and apportionment, and the type and amount of potential recoverable losses. [ABSTRACT FROM AUTHOR]

Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems. [ABSTRACT FROM AUTHOR]

Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems. [ABSTRACT FROM AUTHOR]

Atmospheric inversions are used to derive constraints on the net sources and sinks of CO 2 and other stable atmospheric tracers from their observed concentrations. The resolution and accuracy that the fluxes can be estimated with depends, among other factors, on the quality and density of the observational coverage, on the precision and accuracy of the transport model used by the inversion to relate fluxes to observations, and on the adaptation of the statistical approach to the problem studied. In recent years, there has been an increasing demand from stakeholders for inversions at higher spatial resolution (country scale), in particular in the framework of the Paris agreement. This step up in resolution is in theory enabled by the growing availability of observations from surface in situ networks (such as ICOS in Europe) and from remote sensing products (OCO-2, GOSAT-2). The increase in the resolution of inversions is also a necessary step to provide efficient feedback to the bottom-up modeling community (vegetation models, fossil fuel emission inventories, etc.). However, it calls for new developments in the inverse models: diversification of the inversion approaches, shift from global to regional inversions, and improvement in the computational efficiency. In this context, we developed LUMIA, the Lund University Modular Inversion Algorithm. LUMIA is a Python library for inverse modeling built around the central idea of modularity: it aims to be a platform that enables users to construct and experiment with new inverse modeling setups while remaining easy to use and maintain. It is in particular designed to be transport-model-agnostic, which should facilitate isolating the transport model errors from those introduced by the inversion setup itself. We have constructed a first regional inversion setup using the LUMIA framework to conduct regional CO 2 inversions in Europe using in situ data from surface and tall-tower observation sites. The inversions rely on a new offline coupling between the regional high-resolution FLEXPART Lagrangian particle dispersion model and the global coarse-resolution TM5 transport model. This test setup is intended both as a demonstration and as a reference for comparison with future LUMIA developments. The aims of this paper are to present the LUMIA framework (motivations for building it, development principles and future prospects) and to describe and test this first implementation of regional CO 2 inversions in LUMIA. [ABSTRACT FROM AUTHOR]

Many countries have some kind of energy-system transformation either planned or ongoing for various reasons, such as to curb carbon emissions or to compensate for the phasing out of nuclear energy. One important component of these transformations is the overall reduction in energy demand. It is generally acknowledged that the domestic sector represents a large share of total energy consumption in many countries. Increased energy efficiency is one factor that reduces energy demand, but behavioral approaches (known as “sufficiency”) and their respective interventions also play important roles. In this paper, we address citizens’ heterogeneity regarding both their current behaviors and their willingness to realize their sufficiency potentials—that is, to reduce their energy consumption through behavioral change. We collaborated with three Swiss cities for this study. A survey conducted in the three cities yielded thematic sets of energy-consumption behavior that various groups of participants rated differently. Using this data, we identified four groups of participants with different patterns of both current behaviors and sufficiency potentials. The paper discusses intervention types and addresses citizens’ heterogeneity and behaviors from a city-based perspective. [ABSTRACT FROM AUTHOR]

This paper shifts discussion on social diversity from ethnic diversity to broader social diversity. We explore spatial social diversity and assess opportunities to encounter diversity in an urban context. In doing so, we prepared a description of diversity in the residential communities of two cities, Leeds and Warsaw, using census data for small areas (UK 2001, Poland 2002). Selected variables were used to represent the key social dimensions of difference: demographic, socioeconomic, ethnic, and disability. A cluster analysis using a k-means algorithm was implemented for each city separately and for the two cities combined using harmonized indicators. We selected eight cluster solutions for each city which had diff erent profiles and spatial distributions. A combined cluster analysis showed that there was little overlap in community types across the two cities. The paper illustrates that Leeds and Warsaw residents experience very different opportunities to encounter difference which need to be taken into account when local diversity policies are implemented. [ABSTRACT FROM AUTHOR]

This paper aims to provide insights into the phenomenon of knowledge flows. We study one of the main mechanisms through which these flows occur, namely, the mobility of highly-skilled individuals. We focus on the geographical mobility of inventors across European regions. Thus, patent data are used to trace the pattern of inventors' mobility across European regions, to track down focuses of attraction of talent throughout the continent, and to study their distribution across the space. To do so, we gather information from PCT patent documents and we first match the names which seemed to belong to the same inventor and then we create a new algorithm to decide whether each patent applied for under each name belongs to the same inventor. [ABSTRACT FROM AUTHOR]

The research field of crisis informatics examines, amongst others, the potentials and barriers of social media use during conflicts and crises. Social media allow emergency services to reach the public easily in the context of crisis communication and receive valuable information (e.g. pictures) from social media data. However, the vast amount of data generated during large-scale incidents can lead to issues of information overload and quality. To mitigate these issues, this paper proposes the semi-automatic creation of alerts including keyword, relevance and information quality filters based on cross-platform social media data. We conducted empirical studies and workshops with emergency services across Europe to raise requirements, then iteratively designed and implemented an approach to support emergency services, and performed multiple evaluations, including live demonstrations and field trials, to research the potentials of social media-based alerts. Finally, we present the findings and implications based on semi-structured interviews with emergency services, highlighting the need for usable configurability and white-box algorithm representation. [ABSTRACT FROM AUTHOR]

Assessing the performance of transit systems operating under different regulatory regimes is a topic of considerable interest in the literature. The goal of this paper is to investigate the performance characteristics and factors affecting this performance for European transit systems operating in vastly different regulatory environments. The initial results of data envelopment analysis application indicate that privately operated systems tend to be more efficient while publicly operated systems tend to be more effective; transport operators in cities where open entry form of competition has been introduced were found to perform both efficiently and effectively. Further, as the Tobit regressions focused on the effect of ownership indicate, most systems in the sample demonstrate a positive trend in both efficiency and effectiveness, a finding with important practical implications for financially strained systems. [ABSTRACT FROM AUTHOR]

Regulatory frameworks for artificial intelligence (AI) are needed to mitigate risks while ensuring the ethical, secure, and effective implementation of AI technology in healthcare and population health. In this article, we present a synthesis of 141 binding policies applicable to AI in healthcare and population health in the EU and 10 European countries. The EU AI Act sets the overall regulatory framework for AI, while other legislations set social, health, and human rights standards, address the safety of technologies and the implementation of innovation, and ensure the protection and safe use of data. Regulation specifically pertaining to AI is still nascent and scarce, though a combination of data, technology, innovation, and health and human rights policy has already formed a baseline regulatory framework for AI in health. Future work should explore specific regulatory challenges, especially with respect to AI medical devices, data protection, and data enablement. [ABSTRACT FROM AUTHOR]

Background: Elevated rates of suicidal behavior were reported during the COVID-19 pandemic. However, information is scarce on patients' profiles during this period. Studies evoke the potential adverse effects of the mandatory lockdown, but they remain relatively speculative. Methods: We monitored fluctuations in suicide attempts (SA) in six European countries. We gathered data, retrospectively for under 18-year-old SA episodes (1 January 2018 to 31 December 2021), through records of psychiatric emergency services. We collected clinical profiles individually. We extracted environmental indicators by month, as provided by Oxford COVID-19 Government Response Tracker (OxCGRT). We used the Pruned Exact Linear Time (PELT) method to identify breakpoints in SA episodes reported for each country, and logistic regressions to estimate changes in patients' characteristics after the breakpoints. Finally, we used a univariate and multivariate negative binomial model to assess the link between SA and OxCGRT indicators, accounting for the delay (lag) between the interventions and their impact on SA. Results: The study comprised 2,833 children and adolescents (mean age = 15.1 years (SD 1.6); M: F sex-ratio = 1:5.4). A significant increase in SA was found either 6 or 10 months after the beginning of the pandemic, varying by country. Patients were more likely to be girls (aOR = 1.77 [1.34; 2.34]) and used SA methods "other than self-poisoning" (aOR = 1.34 [1.05; 1.7]). In the multivariate model, an association was found between SA and the contact tracing indicator with an 11 months delay, and the number of COVID-19 deaths with a 3-months delay. Conclusions: Findings confirmed a delayed increase in SA during the COVID-19 pandemic in children and adolescents as well as changes in patients' profiles. The duration and severity of the pandemic emerged as the strongest predictor in the rise of SA. If faced with a similar pandemic in the future, the gap between the onset of pandemic and the increase in suicide attempts presents an opportunity for prevention. [ABSTRACT FROM AUTHOR]

Background: Tier 1 exposure tools recommended for use under REACH are designed to easily identify situations that may pose a risk to health through conservative exposure predictions. However, no comprehensive evaluation of the performance of the lower tier tools has previously been carried out. The ETEAM project aimed to evaluate several lower tier exposure tools (ECETOC TRA, MEASE, and EMKG-EXPO-TOOL) as well as one higher tier tool (STOFFENMANAGER®). This paper describes the results of the external validation of tool estimates using measurement data. Methods: Measurement data were collected from a range of providers, both in Europe and United States, together with contextual information. Individual measurement and aggregated measurement data were obtained. The contextual information was coded into the tools to obtain exposure estimates. Results were expressed as percentage of measurements exceeding the tool estimates and presented by exposure category (non-volatile liquid, volatile liquid, metal abrasion, metal processing, and powder handling). We also explored tool performance for different process activities as well as different scenario conditions and exposure levels. Results: In total, results from nearly 4000 measurements were obtained, with the majority for the use of volatile liquids and powder handling. The comparisons of measurement results with tool estimates suggest that the tools are generally conservative. However, the tools were more conservative when estimating exposure from powder handling compared to volatile liquids and other exposure categories. In addition, results suggested that tool performance varies between process activities and scenario conditions. For example, tools were less conservative when estimating exposure during activities involving tabletting, compression, extrusion, pelletisation, granulation (common process activity PROC14) and transfer of substance or mixture (charging and discharging) at nondedicated facilities (PROC8a; powder handling only). With the exception of STOFFENMANAGER® (for estimating exposure during powder handling), the tools were less conservative for scenarios with lower estimated exposure levels. Conclusions: This is the most comprehensive evaluation of the performance of REACH exposure tools carried out to date. The results show that, although generally conservative, the tools may not always achieve the performance specified in the REACH guidance, i.e. using the 75th or 90th percentile of the exposure distribution for the risk characterisation. Ongoing development, adjustment, and recalibration of the tools with new measurement data are essential to ensure adequate characterisation and control of worker exposure to hazardous substances. [ABSTRACT FROM AUTHOR]

We propose a novel decomposition approach that breaks down the levels and trends of lifespan inequality as the sum of cause-of-death contributions. The suggested method shows whether the levels and changes in lifespan inequality are attributable to the levels and changes in (1) the extent of inequality in the cause-specific age-at-death distribution (the "Inequality" component), (2) the total share of deaths attributable to each cause (the "Proportion" component), or (3) the cause-specific mean age at death (the "Mean" component). This so-called Inequality–Proportion–Mean (or IPM) method is applied to 10 low-mortality countries in Europe. Our findings suggest that the most prevalent causes of death (in our setting, "circulatory system" and "neoplasms") do not necessarily contribute the most to overall levels of lifespan inequality. In fact, "perinatal and congenital" causes are the strongest drivers of lifespan inequality declines. The contribution of the IPM components to changes in lifespan inequality varies considerably across causes, genders, and countries. Among the three components, the Mean one explains the least lifespan inequality dynamics, suggesting that shifts in cause-specific mean ages at death alone contributed little to changes in lifespan inequality. [ABSTRACT FROM AUTHOR]

In the academic year 2010–2011, Spain finished the process of introducing the regulatory changes derived from the Bologna Declaration and the new European Space for Higher Education (ESHE). These changes have implied the updating of university degrees’ structure as well as the inclusion of the European Credit Transfer System (ECTS). This paper describes the process of adaptation of two basic first-semester core subjects of computer engineering to one of the basic aspects of the ESHE, the adoption of the ECTS. The process described in the paper was developed in the framework of the pilot plan undertaken by the Universitat Autònoma de Barcelona between 2005 and 2010. The proposed course design implies a better coordination and integration of the contents of two different subjects that students follow simultaneously, and it is based on the combination of project-based learning and cooperative learning. After the experience finished, an extended quantitative and qualitative analysis of the academic results over the five-year period has shown an improvement in the students’ learning outcomes. [ABSTRACT FROM AUTHOR]

Manuscript Type: Conceptual. Research Question/Issue: Shareholding structures are sometimes so complex that it can be difficult to know who are the actual owners and controllers of a firm. In particular, in continental Europe and Asia, control tunnelling appears frequently through pyramidal structures. Different methods exist to isolate control from ownership. This paper attempts to better understand these different models and their implications. Research Findings/Results: After describing ownership structure through a graph association, this paper analyzes the voting game at stake in the race for control. It compares existing methods and algorithms to identify the owners and controllers of a firm in a pyramidal structure without cross-ownership. These different methods are then applied to the case of a Belgian retailer, Colruyt. The results are compared and the influence of a control threshold is analyzed. Furthermore, it shows how the ownership structure allows the Colruyt family to maintain control of the firm even if there is dissension within the family. Theoretical Implications: This study clarifies definitions of ownership structures and provides a better understanding of models that analyze ownership structure and their implications. Practical Implications: In practice, these models can help shareholders achieve a majority of voting rights in the general assembly by identifying who are the influential partners. Furthermore, the models provide a means for external parties to determine whether control of a firm is attainable, and if so, how. Established shareholders may also use these models to ascertain the optimal ownership structure that will preserve their control with a minimum level of investment. [ABSTRACT FROM AUTHOR]

This paper discusses the variation between generic soil screening values (SSV) from 17 countries for 11 volatile organic contaminants (VOC). The variation between SSV was one to four orders-of- magnitude (OOM) depending on the SSV and landuse type. What would be the variation if parameter values are harmonized between member states? The effect of harmonization was visualized by firstly reviewing the technical derivation procedure for SSV for 7 SSV from five countries and collecting all parameter values that are involved in the deviation. The parameters were subdivided in scientific (e.g. algorithm plus its parameter values), political (e.g. toxicological reference) or geographical (e.g. building and soil properties) elements. Secondly, new SSV were calculated with progressively harmonized sets of scientific andlor political parameter values, while the geographical parameters varied. Thirdly, the variation between SSV was compared before and after harmonization. Results show that harmonizing algorithms plus other scientific and political parameters are suited for harmonization. The variation decreases to I OOM, after scientific and political parameters were harmonized. Geographical parameters seem to have less impact on the differences between SSV. So, should we harmonize the procedures for deriving SSV between EU member states? The need for discussing harmonization is also raised by the upcoming EU Soil Framework Directive. Clearly common generic SSV across all of Europe are not appropriate, since countries are allowed to include member state specific geographical and cultural elements and also political decision making. By harmonizing scientific andlor political parameters differences between SSV can be made more transparent between member states and it will encourage convergence in procedures among member states to ensure neutral conditions of competition and a coherent soil protection regime throughout Europe. To promote uniformity it is recommended to construct a toolbox for the calculation of human health risk exposure, carried by a European consensus, that includes different model algorithms for which fixed and flexible input parameters are made available. Fixed algorithm parameters are standardized and applied uniformly by all member states, e.g. physico- chemical parameters, while flexible input parameters permits member states to include region or country specific parameter values and policy decisions. [ABSTRACT FROM AUTHOR]

As a result of many factors, including the European Union's aim to increase the share of electrical energy from renewable sources, the number of distributed-generation (DG) devices in Europe is significantly increasing. Increasing numbers of DG units may cause problems with power quality (PQ). In this paper, a PQ-management algorithm is presented that reduces or even solves this problem in low-voltage grids. This algorithm will be implemented as one of several software modules in a system for distributed power operation and PQ management in low-voltage grids. PQ management in this context means maintaining PQ within prescribed limits by optimizing the control of generators, storage units, and controllable loads. Significant advantages of the presented approach are that the algorithm is universal and that it adapts its control variables automatically. Therefore, a detailed analysis of the grid in advance is not necessary. Furthermore, local PQ control of distributed resources can work autonomously and continuously without triggering by external signals, which is advantageous in the case of loss of communications. Various simulations to validate the effectiveness and stable operation of the algorithm were performed and results presented that show a marked improvement in PQ. [ABSTRACT FROM AUTHOR]

This paper estimates the readiness of the accession countries of Central and Eastern Europe for EMU or unilateral euroization using a fuzzy clustering algorithm. The variables to which the algorithm is applied are suggested alternately by the criteria in the Maastricht Treaty (nominal convergence) and by Optimum Currency Area theory (real convergence). The algorithm reveals that Estonia and Slovenia are the leaders in both nominal and real convergence, whereas the other countries from the 1998 accession wave have achieved substantial results only in real convergence. Moreover, Poland is excluded from the leading group in the most recent years due to its worsened economic performance. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The paper proposes a fully automatic algorithm approach to map burned areas from remote sensing characterized by human interpretable mapping criteria and explainable results. This approach is partially knowledge-driven and partially data-driven. It exploits active fire points to train the fusion function of factors deemed influential in determining the evidence of burned conditions from reflectance values of multispectral Sentinel-2 (S2) data. The fusion function is used to compute a map of seeds (burned pixels) that are adaptively expanded by applying a Region Growing (RG) algorithm to generate the final burned area map. The fusion function is an Ordered Weighted Averaging (OWA) operator, learnt through the application of a machine learning (ML) algorithm from a set of highly reliable fire points. Its semantics are characterized by two measures, the degrees of pessimism/optimism and democracy/monarchy. The former allows the prediction of the results of the fusion as affected by more false positives (commission errors) than false negatives (omission errors) in the case of pessimism, or vice versa; the latter foresees if there are only a few highly influential factors or many low influential ones that determine the result. The prediction on the degree of pessimism/optimism allows the expansion of the seeds to be appropriately tuned by selecting the most suited growing layer for the RG algorithm thus adapting the algorithm to the context. The paper illustrates the application of the automatic method in four study areas in southern Europe to map burned areas for the 2017 fire season. Thematic accuracy at each site was assessed by comparison to reference perimeters to prove the adaptability of the approach to the context; estimated average accuracy metrics are omission error = 0.057, commission error = 0.068, Dice coefficient = 0.94 and relative bias = 0.0046. [ABSTRACT FROM AUTHOR]

Three algorithm intercomparison experiments have recently been conducted as part of the Global Precipitation Climatology Project with the goal of (a) assessing the skill of current satellite rainfall algorithms, (b) understanding the differences between them, and (c) moving toward improved algorithms. The results of these experiments are summarized and intercompared in this paper. It was found that the skill of satellite rainfall algorithms depends on the regime being analyzed, with algorithms producing very good results in the tropical western Pacific and over Japan and its surrounding waters during summer, but relatively poor rainfall estimates over western Europe during late winter. Monthly rainfall was estimated most accurately by algorithms using geostationary infrared data, but algorithms using polar data [Advanced Very High Resolution Radiometer and Special Sensor Microwave/Imager (SSM/I)] were also able to produce good monthly rainfall estimates when data from two satellites were available. In most eases, SSM/I algorithms showed significantly greater skill than IR-based algorithms in estimating instantaneous rain rates. [ABSTRACT FROM AUTHOR]

Trustworthy medical AI requires transparency about the development and testing of underlying algorithms to identify biases and communicate potential risks of harm. Abundant guidance exists on how to achieve transparency for medical AI products, but it is unclear whether publicly available information adequately informs about their risks. To assess this, we retrieved public documentation on the 14 available CE-certified AI-based radiology products of the II b risk category in the EU from vendor websites, scientific publications, and the European EUDAMED database. Using a self-designed survey, we reported on their development, validation, ethical considerations, and deployment caveats, according to trustworthy AI guidelines. We scored each question with either 0, 0.5, or 1, to rate if the required information was "unavailable", "partially available," or "fully available." The transparency of each product was calculated relative to all 55 questions. Transparency scores ranged from 6.4% to 60.9%, with a median of 29.1%. Major transparency gaps included missing documentation on training data, ethical considerations, and limitations for deployment. Ethical aspects like consent, safety monitoring, and GDPR-compliance were rarely documented. Furthermore, deployment caveats for different demographics and medical settings were scarce. In conclusion, public documentation of authorized medical AI products in Europe lacks sufficient public transparency to inform about safety and risks. We call on lawmakers and regulators to establish legally mandated requirements for public and substantive transparency to fulfill the promise of trustworthy AI for health. [ABSTRACT FROM AUTHOR]

Objectives: Evaluate the performance of a deep learning (DL)–based model for multiple sclerosis (MS) lesion segmentation and compare it to other DL and non-DL algorithms. Methods: This ambispective, multicenter study assessed the performance of a DL-based model for MS lesion segmentation and compared it to alternative DL- and non-DL-based methods. Models were tested on internal (n = 20) and external (n = 18) datasets from Latin America, and on an external dataset from Europe (n = 49). We also examined robustness by rescanning six patients (n = 6) from our MS clinical cohort. Moreover, we studied inter-human annotator agreement and discussed our findings in light of these results. Performance and robustness were assessed using intraclass correlation coefficient (ICC), Dice coefficient (DC), and coefficient of variation (CV). Results: Inter-human ICC ranged from 0.89 to 0.95, while spatial agreement among annotators showed a median DC of 0.63. Using expert manual segmentations as ground truth, our DL model achieved a median DC of 0.73 on the internal, 0.66 on the external, and 0.70 on the challenge datasets. The performance of our DL model exceeded that of the alternative algorithms on all datasets. In the robustness experiment, our DL model also achieved higher DC (ranging from 0.82 to 0.90) and lower CV (ranging from 0.7 to 7.9%) when compared to the alternative methods. Conclusion: Our DL-based model outperformed alternative methods for brain MS lesion segmentation. The model also proved to generalize well on unseen data and has a robust performance and low processing times both on real-world and challenge-based data. Clinical relevance statement: Our DL-based model demonstrated superior performance in accurately segmenting brain MS lesions compared to alternative methods, indicating its potential for clinical application with improved accuracy, robustness, and efficiency. Key Points: • Automated lesion load quantification in MS patients is valuable; however, more accurate methods are still necessary. • A novel deep learning model outperformed alternative MS lesion segmentation methods on multisite datasets. • Deep learning models are particularly suitable for MS lesion segmentation in clinical scenarios. [ABSTRACT FROM AUTHOR]

Background: Over the past half century the global tendency for improvements in longevity has been uneven across countries. This has resulted in widening of inter-country disparities in life expectancy. Moreover, the pattern of divergence appears to be driven in part by processes at the level of country groupings defined in geopolitical terms. A systematic quantitative analysis of this phenomenon has not been possible using demographic decomposition approaches as these have not been suitably adapted for this purpose. In this paper we present an elaboration of conventional decomposition techniques to provide a toolkit for analysis of the inter-country variance, and illustrate its use by analyzing trends in life expectancy in developed countries over a 40-year period. Methods: We analyze trends in the population-weighted variance of life expectancy at birth across 36 developed countries and three country groups over the period 1970-2010. We have modified existing decomposition approaches using the stepwise replacement algorithm to compute age components of changes in the total variance as well as variance between and within groups of Established Market Economies (EME), Central and Eastern Europe (CEE), and the Former Soviet Union (FSU). The method is generally applicable to the decomposition of temporal changes in any aggregate index based on a set of populations. Results: The divergence in life expectancy between developed countries has generally increased over the study period. This tendency dominated from the beginning of 1970s to the early 2000s, and reversed only after 2005. From 1970 to 2010, the total standard deviation of life expectancy increased from 2.0 to 5.6 years among men and from 1.0 to 3.6 years among women. This was determined by the between-group effects due to polarization between the EME and the FSU. The latter contrast was largely fueled by the long-term health crisis in Russia. With respect to age, the increase in the overall divergence was attributable to between-country differences in mortality changes at ages 15-64 years compared to those aged 65 and older. The within-group variance increased, especially among women. This change was mostly produced by growing mortality differences at ages 65 and older. Conclusions: From the early 1970s to the mid-2000s, the strong divergence in life expectancy across developed countries was largely determined by the between-group variance and mortality polarization linked to the East--West geopolitical division. [ABSTRACT FROM AUTHOR]

This paper proposes an enhanced algorithm to estimate the differential code biases (DCB) on three frequencies of the BeiDou Navigation Satellite System (BDS) satellites. By forming ionospheric observables derived from uncombined precise point positioning and geometry-free linear combination of phase-smoothed range, satellite DCBs are determined together with ionospheric delay that is modeled at each individual station. Specifically, the DCB and ionospheric delay are estimated in a weighted least-squares estimator by considering the precision of ionospheric observables, and a misclosure constraint for different types of satellite DCBs is introduced. This algorithm was tested by GNSS data collected in November and December 2013 from 29 stations of Multi-GNSS Experiment (MGEX) and BeiDou Experimental Tracking Stations. Results show that the proposed algorithm is able to precisely estimate BDS satellite DCBs, where the mean value of day-to-day scattering is about 0.19 ns and the RMS of the difference with respect to MGEX DCB products is about 0.24 ns. In order to make comparison, an existing algorithm based on IGG: Institute of Geodesy and Geophysics, China (IGGDCB), is also used to process the same dataset. Results show that, the DCB difference between results from the enhanced algorithm and the DCB products from Center for Orbit Determination in Europe (CODE) and MGEX is reduced in average by 46 % for GPS satellites and 14 % for BDS satellites, when compared with DCB difference between the results of IGGDCB algorithm and the DCB products from CODE and MGEX. In addition, we find the day-to-day scattering of BDS IGSO satellites is obviously lower than that of GEO and MEO satellites, and a significant bias exists in daily DCB values of GEO satellites comparing with MGEX DCB product. This proposed algorithm also provides a new approach to estimate the satellite DCBs of multiple GNSS systems. [ABSTRACT FROM AUTHOR]

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) recommendations for the management of PMR. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology as a framework for the project. Accordingly, the direction and strength of the recommendations are based on the quality of evidence, the balance between desirable and undesirable effects, patients' and clinicians' values and preferences, and resource use. Eight overarching principles and nine specific recommendations were developed covering several aspects of PMR, including basic and follow-up investigations of patients under treatment, risk factor assessment, medical access for patients and specialist referral, treatment strategies such as initial glucocorticoid (GC) doses and subsequent tapering regimens, use of intramuscular GCs and disease modifying anti-rheumatic drugs (DMARDs), as well as the roles of non-steroidal anti-rheumatic drugs and non-pharmacological interventions. These recommendations will inform primary, secondary and tertiary care physicians about an international consensus on the management of PMR. These recommendations should serve to inform clinicians about best practices in the care of patients with PMR. [ABSTRACT FROM AUTHOR]

Breakthrough pain is common in patients with cancer and is a significant cause of morbidity in this group of patients. Breakthrough pain is a heterogeneous condition, and so its management needs to be individualised. This paper describes the management of breakthrough pain and, specifically, the recently published guidelines of the European Oncology Nursing Society. [ABSTRACT FROM AUTHOR]

In this paper, we describe the implementation of the Semi-Analytical Cloud Retrieval Algorithm (SACURA), to obtain scaled cloud optical thickness (SCOT) from satellite imagery acquired with the SEVIRI instrument and surface UV irradiance levels. In estimation of SCOT particular care is given to the proper specification of the background (i.e. cloud-free) spectral albedo and the retrieval of the cloud water phase from reflectance ratios in SEVIRI's 0.6 µm and 1.6 µm spectral bands. The SACURA scheme is then applied to daytime SEVIRI imagery over Europe, for the month of June 2006, at 15-min time increments. The resulting SCOT fields are compared with values obtained by the CloudSat experimental satellite mission, yielding a negligible bias, correlation coefficients ranging from 0.51 to 0.78, a root mean square difference of 1 to 2 SCOT increments. These findings compare favourably to results from similar intercomparison exercises reported in the literature. Based on the retrieved SCOT from SEVIRI and radiative transfer modelling approach, simple parameterisations are proposed to estimate the surface UV-A and UV-B irradiance. The validation of the modelled UV-A and UV-B irradiance against the measurements over two Belgian stations, Redu and Ostend, indicate good agreement with the high correlation, index of agreement and low bias. The SCOT fields estimated by implementing SACURA on imagery from geostationary satellite are reliable and its impact on surface UV irradiance levels is well produced. [ABSTRACT FROM AUTHOR]

This paper describes the algorithms used in a planning and scheduling software tool developed for the European Space Agency in the framework of the Mars Express mission. The planning and scheduling algorithm computes a feasible schedule for the transmission of telecommands (TCs) from the ground segment to the space segment, complying with a number of technical constraints. Owing to the distance between Mars and Earth, it is important that the robustness of the schedule is taken into account because repair operations may be very time consuming or even impossible. For this reason, besides the maximization of the number of TCs transmitted from Earth to Mars, the scheduler is also designed to maximize the number of full confirmations and secondary time windows, which are two special characteristics of the Mars Express schedule explicitly designed for the sake of robustness. Besides the maximization of robustness, the scheduling algorithm that can run with different settings can be used to optimize some secondary figures of merit, such as the average saturation of the memory devices of the space segment and the usage of the time windows available for communication. Computational results on real instances are presented. [ABSTRACT FROM PUBLISHER]

This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe. The ART mechanistic model is based on a conceptual framework that adopts a source receptor approach, which describes the transport of a contaminant from the source to the receptor and defines seven independent principal modifying factors: substance emission potential, activity emission potential, localized controls, segregation, personal enclosure, surface contamination, and dispersion. ART currently differentiates between three different exposure types: vapours, mists, and dust (fumes, fibres, and gases are presently excluded). Various sources were used to assign numerical values to the multipliers to each modifying factor. The evidence used to underpin this assessment procedure was based on chemical and physical laws. In addition, empirical data obtained from literature were used. Where this was not possible, expert elicitation was applied for the assessment procedure. Multipliers for all modifying factors were peer reviewed by leading experts from industry, research institutes, and public authorities across the globe. In addition, several workshops with experts were organized to discuss the proposed exposure multipliers. The mechanistic model is a central part of the ART tool and with advancing knowledge on exposure, determinants will require updates and refinements on a continuous basis, such as the effect of worker behaviour on personal exposure, ‘best practice’ values that describe the maximum achievable effectiveness of control measures, the intrinsic emission potential of various solid objects (e.g. metal, glass, plastics, etc.), and extending the applicability domain to certain types of exposures (e.g. gas, fume, and fibre exposure). [ABSTRACT FROM AUTHOR]

This paper presents hedging strategies for European and exotic options in a Lévy market. By applying Taylor's theorem, dynamic hedging portfolios are constructed under different market assumptions, such as the existence of power jump assets or moment swaps. In the case of European options or baskets of European options, static hedging is implemented. It is shown that perfect hedging can be achieved. Delta and gamma hedging strategies are extended to higher moment hedging by investing in other traded derivatives depending on the same underlying asset. This development is of practical importance as such other derivatives might be readily available. Moment swaps or power jump assets are not typically liquidly traded. It is shown how minimal variance portfolios can be used to hedge the higher order terms in a Taylor expansion of the pricing function, investing only in a risk-free bank account, the underlying asset, and potentially variance swaps. The numerical algorithms and performance of the hedging strategies are presented, showing the practical utility of the derived results. [ABSTRACT FROM AUTHOR]

This paper presents an algorithm necessary when choosing a new location for the operational facilities within European middle-sized and large companies. In this regard, the first part of the paper will present a short analysis of the present tendencies of operational management regarding the choice of a new location. Next, we will underline the importance of choosing a new location within the European Union area, decision that for many companies (more precisely for companies outside the borders of the European Union) can be a difficult step. In the end, we will present two methods that the operational managers can use in order to decide themselves on which location to choose out of the strategic alternatives they have. [ABSTRACT FROM AUTHOR]

This paper presents an alternative approach for time-dependent multimodal transport problem. We describe a new graph structure to abstract multimodal networks, called transfer graph, which adapts to the distributed nature of real information sources of transportation networks. A decomposition of the Shortest Path Problem in transfer graph is proposed to optimize the computation time. This approach was computationally tested in several experimental multimodal networks having different size and complexity. The approach was integrated in the multimodal transport service of the European Carlink platform, where it has been validated in real scenarios. Comparision with other related works is provided. [ABSTRACT FROM AUTHOR]

This paper explores written calculation methods for division used by pupils in England (n = 276) and the Netherlands (n = 259) at two points in the same school year. Informal strategies are analysed and progression identified towards more structured procedures that result from different teaching approaches. Comparison of the methods used by year 5 (Group 6) pupils in the two countries shows greater success in the Dutch approach, which is based on careful progression from informal strategies to more structured and efficient procedures. This success is particularly notable for the girls in the sample. For the English pupils, whose written solutions largely involved the traditional algorithm, the discontinuity between the formal computation procedure and informal solution strategies presents difficulties. [ABSTRACT FROM AUTHOR]

BACKGROUND: Upper extremity function (UEF) is often compromised in multiple sclerosis (MS), although its importance is regularly underrecognized relative to ambulation. We explored the concurrent presence of impairment in UEF and ambulation by examining various aspects of UEF across different levels of ambulation. METHODS: The cohort consisted of 247 patients with clinically definite MS or clinically isolated syndrome according to the revised 2010 McDonald criteria. The Nine-Hole Peg Test and the Expanded Disability Status Scale were used to stratify patients into clinically different subgroups. For UEF, cerebellar function (finger-to-nose test), pyramidal function (pronator drift test), and the ability to perform a task of activities of daily living (drinking- from-cup test) were examined. Patient-reported limitations of UEF in daily life were assessed using the Arm Function in Multiple Sclerosis Questionnaire. RESULTS: Patients in more severely impaired ambulation groups displayed poorer performance on all UEF measures. Although most patients had normal to mild (n = 147) or moderate (n = 46) ambulatory impairment, 87.7% exhibited some level of UEF impairment as defined using the Nine-Hole Peg Test. Most patients had mild UEF impairment (n = 174), accounting for the largest proportion in all ambulation groups (51.9%-77.8%). CONCLUSIONS: A distinct pattern of impairment was found for ambulation and multiple aspects of UEF. Independent assessment of multiple aspects of disability may be helpful in treatment decision-making and could support the development of rehabilitation strategies that specifically target UEF impairment [ABSTRACT FROM AUTHOR]

Indirect methods for the indirect estimation of reference intervals are increasingly being used, especially for validation of reference intervals, as they can be applied to routine patient data. In this study, we compare three statistically different indirect methods for the verification and validation of reference intervals in eight laboratories distributed throughout Europe. The RefLim method is a fast and simple approach which calculates the reference intervals by extrapolating the theoretical 95 % of non-pathological values from the central linear part of a quantile-quantile plot. The Truncated Maximum Likelihood (TML) method estimates a smoothed kernel density function for the distribution of the mixed data, for which it is assumed that the "central" part of the distribution represents the healthy population. The refineR utilizes an inverse modelling approach. This algorithm identifies a model that best explains the observed data before transforming the data with the Box-Cox transformation. We show that the different indirect methods each have their advantages but can also lead to inaccurate or ambiguous results depending on the approximation of the mathematical model to real-world data. A combination of different methodologies can improve the informative value and thus the reliability of results. Based on routine measurements of four enzymes alkaline phosphatase (ALP), total amylase (AMY), cholinesterase (CHE) and gamma-glutamyl transferase (GGT) in adult women and men, we demonstrate that some reference limits taken from the literature need to be adapted to the laboratory's particular local and population characteristics. [ABSTRACT FROM AUTHOR]

Growing numbers of asylum seekers across Europe have created heightened pressure on governments to employ technologies to assist immigration systems in meeting humanitarian standards of international law. This article analyses the potential of hybrid intelligence (HI)—a machine learning (ML) utility supervised by and supervising human intelligence—for assisting both asylum seekers and immigration officers in performing fair and just assessments, while addressing theoretical underpinnings of what hybridity entails from the perspective of stakeholders and humanitarian systems. While aspects of ML demonstrate promise in reducing bias in immigration decisions, such technology itself suffers from various inherent biases. In addition, technological mediation poses several unforeseen, unintended, and subtle threats to humanitarian missions. By analysing ML algorithms currently employed in refugee status determination pilot programs and immigration control, this article synthesizes universal complications of using assistive technology in Refugee Status Determinations, with special focus on evaluating resultant theoretical refugee identity reconfigurations. Conceptually, this article expands on the theoretical model of what has been termed 'ID entity' by biometrics researchers and ethnographers by analysing potential latent consequences from technological mediation in asylum cases, while addressing use cases such as German and Canadian immigration services' pilot programs, along with automated pilot border screening projects such as Iborderctrl, among others. In addition, several hypothetical scenarios are presented to concretize and further theoretical inquiry of using HI in asylum seeker interviews, with special focus on the requisite criterion of possessing a well-founded fear of persecution. [ABSTRACT FROM AUTHOR]

Aim: To develop and validate models based on logistic regression and artificial intelligence for prognostic prediction of molar survival in periodontally affected patients. Materials and Methods: Clinical and radiographic data from four different centres across four continents (two in Europe, one in the United States, and one in China) including 515 patients and 3157 molars were collected and used to train and test different types of machine‐learning algorithms for their prognostic ability of molar loss over 10 years. The following models were trained: logistic regression, support vector machine, K‐nearest neighbours, decision tree, random forest, artificial neural network, gradient boosting, and naive Bayes. In addition, different models were aggregated by means of the ensembled stacking method. The primary outcome of the study was related to the prediction of overall molar loss (MLO) in patients after active periodontal treatment. Results: The general performance in the external validation settings (aggregating three cohorts) revealed that the ensembled model, which combined neural network and logistic regression, showed the best performance among the different models for the prediction of MLO with an area under the curve (AUC) = 0.726. The neural network model showed the best AUC of 0.724 for the prediction of periodontitis‐related molar loss. In addition, the ensembled model showed the best calibration performance. Conclusions: Through a multi‐centre collaboration, both prognostic models for the prediction of molar loss were developed and externally validated. The ensembled model showed the best performance in terms of both discrimination and validation, and it is made freely available to clinicians for widespread use in clinical practice. [ABSTRACT FROM AUTHOR]

Digitization in transplantation is not a new phenomenon. Algorithms are being used, for example, to allocate organs based on medical compatibility and priority criteria. However, digitization is accelerating as computer scientists and physicians increasingly develop and use machine learning (ML) models to obtain better predictions on the chances of a successful transplant. The objective of the article is to shed light on the potential threats to equitable access to organs allocated through algorithms, whether these are the consequence of political choices made upstream of digitization or of the algorithmic design, or are produced by self-learning algorithms. The article shows that achieving equitable access requires an overall vision of the algorithmic development process and that European legal norms only partially contribute to preventing harm and addressing equality in access to organs. [ABSTRACT FROM AUTHOR]