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Traditionally, the place-pitch 'tonotopically' organized auditory neural pathway was considered to be hard-wired. Cochlear implants restore hearing by arbitrarily mapping frequency-amplitude information. This study shows that recipients, after a long period of sound deprivation, preserve a level of auditory plasticity, enabling them to swiftly and concurrently learn speech understanding with two alternating, distinct frequency maps. During rehabilitation, subjects switched maps randomly on a daily basis, serving as their own control. After stating their preference, on average, subjects maintained their hearing performance with the non-preferred, legacy map over time. In addition, subjects continued to learn and improve with their map of preference. Being able to train and process the auditory information from two maps did not seem to be a competition over neural resources, such as would be the case in a typical zero-sum game. This shows a new level of flexibility in learning and long-term adaptation of the auditory system. Practically, the required novel study design halves the sample size while mitigating order effects associated with neural plasticity, benefitting sensory-oriented trials. [ABSTRACT FROM AUTHOR]

This study reports the outcomes of a speaker evaluation experiment conducted in a higher educational context in Flanders, in which we investigated the influence of language variety (Standard vs. Colloquial Dutch), accent (Flemish vs. Eastern European) and name (Flemish vs. Eastern European) on students' perceptions of a female university instructor. The results suggest that participants exhibited a relatively high level of tolerance toward both non-conforming speech and non-conforming speakers. Whereas Colloquial Dutch scored lower than Standard Dutch on standardness, we observed no negative effects of Colloquial Dutch on the teacher's didactic competence, status, or social attractiveness. We did not find any evidence of a negative bias triggered by an Eastern European name. Whereas the Eastern European accent did have a negative impact on the teacher's social attractiveness, we did not find any evidence of an accent bias affecting judgements of the teacher's didactic competence and status. [ABSTRACT FROM AUTHOR]

• The isolated anti-CASPR2 antibodies all selectively bind the discoidin domain. • Monoclonal anti-CASPR2 antibodies block the interaction of CASPR2 with contactin 2. • Anti-CASPR2 antibodies cause increased afterpotentials and hyperexcitability in vivo. • Anti-CASPR2 antibodies reduce functional connectivity in resting-state fMRI in vivo. Anti-contactin associated protein receptor 2 (CASPR2) encephalitis is a severe autoimmune encephalitis with a variable clinical phenotype including behavioral abnormalities, cognitive decline, epileptic seizures, peripheral nerve hyperexcitability and neuropathic pain. The detailed mechanisms of how CASPR2 autoantibodies lead to synaptic dysfunction and clinical symptoms are largely unknown. Aiming for analyses from the molecular to the clinical level, we isolated antibody-secreting cells from the cerebrospinal fluid of two patients with CASPR2 encephalitis. From these we cloned four anti-CASPR2 human monoclonal autoantibodies (mAbs) with strong binding to brain and peripheral nerves. All were highly hypermutated and mainly of the IgG4 subclass. Mutagenesis studies determined selective binding to the discoidin domain of CASPR2. Surface plasmon resonance revealed affinities with dissociation constants K D in the pico- to nanomolar range. CASPR2 mAbs interrupted the interaction of CASPR2 with its binding partner contactin 2 in vitro and were internalized after binding to CASPR2-expressing cells. Electrophysiological recordings of rat hippocampal slices after stereotactic injection of CASPR2 mAbs showed characteristic afterpotentials following electrical stimulation. In vivo experiments with intracerebroventricular administration of human CASPR2 mAbs into mice and rats showed EEG-recorded brain hyperexcitability but no spontaneous recurrent seizures. Behavioral assessment of infused mice showed a subtle clinical phenotype, mainly affecting sociability. Mouse brain MRI exhibited markedly reduced resting-state functional connectivity without short-term structural changes. Together, the experimental data support the direct pathogenicity of CASPR2 autoantibodies. The minimally invasive EEG and MRI techniques applied here may serve as novel objective, quantifiable tools for improved animal models, in particular for subtle neuropsychiatric phenotypes or repeated measurements. [ABSTRACT FROM AUTHOR]

The catalytic deoxyamination of readily available 2‐arylethanols offers an appealing, simple, and straightforward means of accessing β‐(hetero)arylethylamines of biological interest. Yet, it currently represents a great challenge to synthetic chemistry. In most cases, the alcohol has to be either pre‐activated in situ or converted into a reactive carbonyl intermediate, limiting the substrate scope for some methods. Examples of direct dehydrative amination of 2‐arylethanols are thus still scarce. Here, we describe a catalytic protocol based on the synergy of triflic acid and hexafluoroisopropanol, which enables the direct and stereospecific amination of a broad array of 2‐arylethanols, and does not require any pre‐activation of the alcohol. This approach yields high value‐added products incorporating sulfonamide, amide, urea, and aniline functionalities. In addition, this approach was applied to the sulfidation of 2‐arylethanols. Mechanistic experiments and DFT computations indicate the formation of phenonium ions as key intermediates in the reaction. [ABSTRACT FROM AUTHOR]

Supplemental Digital Content is Available in the Text. The science of learning (learning science) is an interprofessional field that concerns itself with how the brain learns and remembers important information. Learning science has compiled a set of evidence-based strategies, such as distributed practice, retrieval practice, and interleaving, which are quite relevant to continuing professional development (CPD). Spreading out study and practice separated by cognitive breaks (distributed practice), testing oneself to check mastery and memory of previously learned information (retrieval practice), and mixing the learning of distinct but related material (interleaving) represent strategies that are underutilized in CPD. Participants and planners alike can benefit from learning science recommendations to inform their decisions. Sleep, the subject of this article and critical to distributed practice, is the ideal circumstance for the brain to process priority information. The authors make the case for sleep as a legitimate part of a learning activity and worthy of consideration in the award of CPD credits. [ABSTRACT FROM AUTHOR]

Supplemental Digital Content is Available in the Text. The science of learning (learning science) is an interprofessional field that concerns itself with how the brain learns and remembers important information. Learning science has compiled a set of evidence-based strategies, such as distributed practice, retrieval practice, and interleaving, which are quite relevant to continuing professional development. Spreading out study and practice separated by cognitive breaks (distributed practice), testing oneself to check mastery and memory of previously learned information (retrieval practice), and mixing the learning of distinct but related material (interleaving) represent strategies that are underutilized in continuing professional development. Participants and planners alike can benefit from learning science recommendations to inform their decisions. The common intervention of the educational meeting provides an opportunity to illustrate the benefits of these three learning-science strategies in continuing professional development. [ABSTRACT FROM AUTHOR]

Recent studies have highlighted the importance of ordinality skills in early numerical development. Here, we investigate individual differences in ordering sets of items and suggest that children might also differ in their tendency to spontaneously recognize and use numerical order in everyday situations. This study investigated the individual differences in 3- to 4-year-old children's tendency to spontaneously focus on numerical order (SFONO), and their association with early numerical skills. One hundred fifty children were presented with three SFONO tasks designed as play-like activities, where numerical order was one aspect that could be focused on. In addition, the children were administered tasks addressing spontaneous focusing on numerosity (SFON), numerical ordering, cardinality recognition, and number sequence production. Our results showed that children had substantial individual differences in all measures, including SFONO tendency. Children's SFONO tendency was associated with their early numerical skills. To further investigate the association between SFONO tendency and numerical ordering skills, a hierarchical regression was conducted for a group of children who could successfully order sets from one to three at a minimum and were regarded as likely having the requisite skills to spontaneously focus on numerical order. The findings reveal that SFONO tendency had a unique contribution to children's numerical ordering skills, even after controlling for age, cardinality recognition, and number sequence production. The results suggest that SFONO tendency potentially plays a relevant role in children's numerical development. [ABSTRACT FROM AUTHOR]

For many, search engines are crucial gateways to (political) information. While extant research is concerned with algorithmic bias, user choices had been largely neglected. Yet, search queries are the key way in which searchers explicate their information need. Building on framing theory and selective exposure, we argue that queries are ingrained with (political) predispositions: issue frames in mind of searchers manifest themselves in search terms and queries. Using Dutch survey data (N = 1994), and manual coding and latent class analysis, we explore how types of people formulate search queries about immigration and climate change (RQ1). A regression analysis shows how these searcher types relate to political attitudes and socio-demographic characteristics (RQ2). Notably, searchers formulate queries in ways that are related to their political positions, but this differs for different issues. These findings imply systematic differences in user choices which future research needs to consider when auditing search engines. [ABSTRACT FROM AUTHOR]

The article discusses the use of co-constructive patient simulation (CCPS) in two international child and adolescent psychiatry conferences to foster active learning and reflection through real-time human simulations. Topics include innovative educational formats, international collaboration, and the impact of simulation on clinical training.

Background: Research has shown that mathematics anxiety negatively correlates with primary school mathematics performance, including fraction knowledge. However, recently no significant correlation was found between fraction arithmetic performance and state anxiety measured after the fraction task. One possible explanation is the natural number bias (NNB), a tendency to apply natural number reasoning in fraction tasks, even when this is inappropriate. Students with the NNB may not realize they are answering incorrectly. Aims: The aim is to examine whether a misconception, namely the NNB, can influence students' fraction state anxiety. Sample: The participants were 119 fifth‐ and sixth‐grade students categorized as belonging to an NNB group (n = 60) or a No‐NNB group (n = 59), according to their NNB‐related answering profile on a fraction arithmetic task. Methods: Group differences were examined for state anxiety and performance on a fraction and a whole number arithmetic task and self‐reported trait mathematics anxiety. Results: The NNB group reported lower fraction state anxiety than the No‐NNB group, but there was no significant difference in trait mathematics anxiety. Furthermore, the NNB group reported lower fraction state anxiety than whole number state anxiety, while the opposite was true for the No‐NNB group. Conclusion: The present study suggests that students' perceptions of their own performance influence their state anxiety responses, and students with a NNB may not be aware of their misconception and poor performance. Not taking into account qualitative differences in low performance, such as misconceptions, may lead to misinterpretations in state anxiety‐performance relations. [ABSTRACT FROM AUTHOR]

Processing rational numbers is difficult for many children. The natural number bias is one possible explanation for why children struggle with rational numbers. It refers to the tendency to overgeneralize the properties of natural numbers. In this study, it is argued that in order to be successful in rational number tasks, individuals need to inhibit or suppress their unwanted impulses (in this case the tendency to apply natural number properties). It was investigated whether inhibition plays a role in the occurrence of the natural number bias among primary school children by administering two rational number tasks, two Stroop tasks and a questionnaire measuring inhibitory skills. The results indicated that primary school children were hampered by the natural number bias both in terms of accuracy rates and response times. Additionally, the results did not yield strong evidence for a relationship between inhibition and the occurrence of the natural number bias. [ABSTRACT FROM AUTHOR]

AIM The aim of this study was to determine the status of retrieval practice in original research of nursing education. BACKGROUND The science of learning is an emerging interdisciplinary field that offers evidence-based strategies to improve learning. One of the most highly effective strategies is retrieval practice, which involves recalling previously learned information from long-term memory prior to additional study. METHOD Searching PubMed, CINAHL, Scopus, Psych INFO, and ERIC, an interprofessional team followed a formal scoping review framework and utilized the PRISMA Extension for Scoping Reviews to report the findings. RESULTSThe review included 25 research studies, with all but one at the prelicensure level. Quantitative designs were most common, and outcomes reflected objective and subjective measures. If present, terms were varied and inconsistent with supporting research. Documentation of many characteristics was lacking. CONCLUSION Retrieval practice is an increasingly common strategy being studied at the prelicensure level. Opportunities for improvement include consistent use of standard terminology, documentation of important characteristics, and more attention to subjective outcomes and to graduate and continuing education levels. [ABSTRACT FROM AUTHOR]

We present high-angular-resolution observations of Sakurai's object using the Atacama Large Millimeter Array, shedding new light on its morpho-kinematical structure. The millimetre continuum emission observed at an angular resolution of 20 milliarcsec (corresponding to 70 AU) reveals a bright compact central component whose spectral index indicates that it is composed of amorphous carbon dust. Based on these findings, we conclude that this emission traces the previously suggested dust disc observed in mid-infrared observations, and therefore our observations provide the first direct imaging of this disc. The H12CN(J = 4 → 3) line emission observed at an angular resolution of 300 milliarcsec (corresponding to 1000 AU) displays a bipolar structure with a north–south velocity gradient. From the position–velocity diagram of this emission, we identify the presence of an expanding disc and a bipolar molecular outflow. The inclination of the disc is determined to be i = 72°. The derived values for the de-projected expansion velocity and the radius of the disc are vexp = 53 km s−1 and R = 277 AU, respectively. On the other hand, the de-projected expansion velocity of the bipolar outflow detected in the H12CN(J = 4 → 3) emission is of approximately 1000 km s−1. We propose that the molecular outflow has an hourglass morphology with an opening angle of around 60°. Our observations unambiguously show that an equatorial disc and bipolar outflows formed in Sakurai's object during the 30 years following the occurrence of the born-again event, providing important constraints for future modelling efforts of this phenomenon. [ABSTRACT FROM AUTHOR]

Over the centuries, Grotius's writings on onderzetting (rights of hypothec) have been widely cited, particularly in the Netherlands and South Africa. This article investigates the originality and lasting impact of Grotius's contributions to this field. The article follows the layout of the chapter on hypothecs of Grotius's Inleiding tot de Hollandsche Rechts-geleertheyd. It examines Grotius's translation of hypotheca as onderzetting , the structure of his Inleiding , the distinctions between various kinds of hypothec, and contemporary requirements for the creation of hypothecs. It then explores the right to follow encumbered assets into the hands of third parties and analyses the enforcement of hypothecs, priority issues in cases of competing hypothecs, and reflects on Grotius's influence on Dutch security rights. In summary, although Grotius's insights were largely derivative, often echoing interpretations of earlier scholars, they illustrate Grotius's deep understanding of the influence of Germanic and Roman law on Roman-Dutch security rights. Grotius had a lasting impact on legal scholarship and practice because he was the first to provide a scholarly systematization of Roman-Dutch law within the framework of Justinian's Institutes and firmly placed the rights of hypothec in the book on property rights of his Inleiding. [ABSTRACT FROM AUTHOR]

Background: Limited recent data exists regarding discospondylitis in dogs. Hypothesis/Objectives: (i) Describe the signalment, clinical and imaging findings, etiologic agents, treatment, and outcome of dogs with discospondylitis, (ii) determine diagnostic agreement between radiographs, CT, and MRI with regard to the presence of discospondylitis and its location, and (iii) determine risk factors for relapse and progressive neurological deterioration. Animals: Three hundred eighty‐six dogs. Methods: Multi‐institutional retrospective study. Data extracted from medical records were: signalment, clinical and examination findings, diagnostic results, treatments, complications, and outcome. Potential risk factors were recorded. Breed distribution was compared to a control group. Agreement between imaging modalities was assessed via Cohen's kappa statistic. Other analyses were performed on categorical data, using cross tabulations with chi‐squared and Fisher's exact tests. Results: Male dogs were overrepresented (236/386 dogs). L7‐S1 (97/386 dogs) was the most common site. Staphylococcus species (23/38 positive blood cultures) were prevalent. There was a fair agreement (κ = 0.22) between radiographs and CT, but a poor agreement (κ = 0.05) between radiographs and MRI with regard to evidence of discospondylitis. There was good agreement between imaging modalities regarding location of disease. Trauma was associated with an increased risk of relapse (P =.01, OR: 9.0, 95% CI: 2.2‐37.0). Prior steroid therapy was associated with an increased risk of progressive neurological dysfunction (P =.04, OR: 4.7, 95% CI: 1.2‐18.6). Conclusions and Clinical Importance: Radiograph and MRI results could be discrepant in dogs with discospondylitis. Prior trauma and corticosteroids could be associated with relapse and progressive neurological dysfunction, respectively. [ABSTRACT FROM AUTHOR]

tRNA splicing endonuclease (TSEN) has a well-characterized role in transfer RNA (tRNA) splicing but also other functions. For yeast TSEN, these other functions include degradation of a subset of mRNAs that encode mitochondrial proteins and an unknown essential function. In this study, we use yeast genetics to characterize the unknown tRNA-independent function(s) of TSEN. Using a high-copy suppressor screen, we found that sen2 mutants can be suppressed by overexpression of SEN54. This effect was seen both for tRNA-dependent and tRNA-independent functions indicating that SEN54 is a general suppressor of sen2, likely through structural stabilization. A spontaneous suppressor screen identified mutations in the intron-debranching enzyme, Dbr1, as tRNA splicing-independent suppressors. Transcriptome analysis showed that sen2 mutation activates the Gcn4 stress response. These Gcn4 target transcripts decreased considerably in the sen2 dbr1 double mutant. We propose that Dbr1 and TSEN may compete for a shared substrate, which TSEN normally processes into an essential RNA, while Dbr1 initiates its degradation. These data provide further insight into the essential function(s) of TSEN. Importantly, single amino acid mutations in TSEN cause the generally fatal neuronal disease pontocerebellar hypoplasia (PCH). The mechanism by which defects in TSEN cause this disease is unknown, and our results reveal new possible mechanisms. [ABSTRACT FROM AUTHOR]

The Nenitzescu reaction is a condensation reaction between an enamine and a quinone, which can give rise to a wide variety of reaction products depending on the nature of the starting material and the reaction conditions. The most commonly observed products are 5-hydroxyindoles and 5-hydroxybenzofurans. Both classes are of interest since they are known to possess a variety of promising bioactivities. Despite the high chemodivergency for this reaction, it remains an interesting synthetic strategy thanks to the mild reaction conditions, easily accessible starting materials and simple reaction procedures. For these reasons, our research group investigated the Nenitzescu reaction of piperazinone enaminoesters, resulting in the unexpected formation of rearranged 2-imidazolidinone benzofurans. In this work, we aimed to develop reaction conditions that favor the formation of 5-hydroxyindoles via an extensive, multivariate optimization study. This led to valuable insights into the parameters that influence regio- and chemoselectivity. Furthermore, two novel products were obtained, a pyrrolo[2,3-f]indole and a benzofuranone, both of which are rarely reported in the literature. [ABSTRACT FROM AUTHOR]

Introduction: Clinically, recording hearing detection thresholds and representing them in an audiogram is the most common way of evaluating hearing loss and starting the fitting of hearing devices. As an extension, we present the loudness audiogram, which does not only show auditory thresholds but also visualizes the full course of loudness growth across frequencies. The benefit of this approach was evaluated in subjects who rely on both electric (cochlear implant) and acoustic (hearing aid) hearing. Methods: In a group of 15 bimodal users, loudness growth was measured with the cochlear implant and hearing aid separately using a loudness scaling procedure. Loudness growth curves were constructed, using a novel loudness function, for each modality and then integrated in a graph plotting frequency, stimulus intensity level, and loudness perception. Bimodal benefit, defined as the difference between wearing a cochlear implant and hearing aid together versus wearing only a cochlear implant, was assessed for multiple speech outcomes. Results: Loudness growth was related to bimodal benefit for speech recognition in noise and to some aspects of speech quality. No correlations between loudness and speech in quiet were found. Patients who had predominantly unequal loudness input from the hearing aid, gained more bimodal benefit for speech recognition in noise compared to those patients whose hearing aid provided mainly equivalent input. Conclusion: Results show that loudness growth is related to bimodal benefit for speech recognition in noise and to some aspects of speech quality. Subjects who had different input from the hearing aid compared to CI, generally gained more bimodal benefit compared to those patients whose hearing aid provided mainly equivalent input. This suggests that bimodal fitting to create equal loudness at all frequencies may not always be beneficial for speech recognition. [ABSTRACT FROM AUTHOR]

To assess the safety and efficacy of an experimental large-diameter vascular graft externally sealed with an elastomeric polymer when used as an interposition graft in the descending aorta of sheep. The experimental vascular grafts as well as control gelatin sealed interposition grafts were inserted into the descending aorta of juvenile sheep. The grafts were assessed by time to hemostasis and blood loss during surgery and hematology and biochemistry panels at distinct time points. Magnetic resonance imaging (MRI) was performed at 3 and at 6 mo after surgery, after which the animals were euthanized and necropsies were carried out including macroscopic and microscopic examination of the grafts, anastomoses, and distal organs. All animals survived the study period. There was no perceivable difference in the surgical handling of the grafts. The median intraoperative blood loss was 27.5 mL (range 10.0-125.0 mL) in the experimental group and 50.0 mL (range 10.0-75.0 mL) in the control group. The median time to hemostasis was 5.0 min (range 2.0-16.0 min) minutes in the experimental group versus 6.0 min (range 4.0-6.0 min) in the control group. MRI showed normal flow and graft patency in both groups. Healing and perianastomotic endothelialization was similar in both groups. The experimental graft has a similar safety and performance profile and largely comparable necropsy results, in comparison to a commonly used prosthetic vascular graft, with the experimental grafts eliciting a nonadherent external fibrous capsule as the major difference compared to the control grafts that were incorporated into the periadventitia. Survival, hemostatic sealing, and hematologic and radiologic results were comparable between the study groups. • The RUA vascular graft is externally sealed with an Elast-Eon polymer. • No animal-derived sealing products such as gelatin are needed. • Safety and performance of the experimental graft was tested in a large animal model. • Similar results were obtained in the experimental group and the control group. • The experimental graft elicited a nonadherent external fibrous capsule. [ABSTRACT FROM AUTHOR]

Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold hopping, a pyrido[3,4-d]pyrimidine analogue as a promising CXCR2 antagonist with an IC50 value of 0.11 µM in a kinetic fluorescence-based calcium mobilization assay. This study aims at exploring the structure–activity relationship (SAR) and improving the CXCR2 antagonistic potency of this pyrido[3,4-d]pyrimidine via systematic structural modifications of the substitution pattern. Almost all new analogues completely lacked the CXCR2 antagonism, the exception being a 6-furanyl-pyrido[3,4-d]pyrimidine analogue (compound 17b) that is endowed with similar antagonistic potency as the original hit. [ABSTRACT FROM AUTHOR]

Extracellular vesicles (EVs) are cell-derived structures surrounded by a lipid bilayer that carry RNA and DNA as potential templates for molecular diagnostics, e.g., in cancer genotyping. While it has been established that DNA templates appear on the outside of EVs, no consensus exists on which nucleic acid species inside small EVs (<200 nm, sEVs) are sufficiently abundant and accessible for developing genotyping protocols. We investigated this by extracting total intravesicular nucleic acid content from sEVs isolated from the conditioned cell medium of the human NCI-H1975 cell line containing the epidermal growth factor (EGFR) gene mutation T790M as a model system for non-small cell lung cancer. We observed that mainly short genomic DNA (<35–100 bp) present in the sEVs served as a template. Using qEV size exclusion chromatography (SEC), significantly lower yield and higher purity of isolated sEV fractions were obtained as compared to exoEasy membrane affinity purification and ultracentrifugation. Nevertheless, we detected the EGFR T790M mutation in the sEVs' lumen with similar sensitivity using digital PCR. When applying SEC-based sEV separation prior to cell-free DNA extraction on spiked human plasma samples, we found significantly higher mutant allele frequencies as compared to standard cell-free DNA extraction, which in part was due to co-purification of circulating tumor DNA. We conclude that intravesicular genomic DNA can be exploited next to ctDNA to enhance EGFR T790M mutation detection sensitivity by adding a fast and easy-to-use sEV separation method, such as SEC, upstream of standard clinical cell-free DNA workflows. [ABSTRACT FROM AUTHOR]

Introduction: Involving patients in decision making adds value in the context of pharmacovigilance (PV). This added value goes beyond participation in spontaneous reporting systems for adverse drug reactions. However, there is a gap between allowing patients to report and actual patient involvement. Views regarding best practices from regulators, patient organizations and pharmaceutical companies could help increase and improve patient involvement in PV.Objective: The aim of this study was to investigate the factors contributing to best practices for patient involvement in PV and to develop a definition of patient involvement based on a qualitative multistakeholder study across Europe.Methods: A literature review was conducted to map the field of study and obtain insights for the elaboration of an interview guide. Subsequently, patient representatives, members of the pharmaceutical industry and regulators were invited to participate in interviews. These interviews were analyzed using NVIVO® software and employing reflective thematic analysis.Results: A total of 20 interviews were conducted with representatives at both the national and European levels. The best practices identified were engagement from the start, face-to-face communication, a full circle of feedback, same-level partners, structured involvement and guidelines, establishing common goals, patient education and empowerment, and developing trust and balance. These activities can be implemented via deep collaboration among stakeholders. A definition of patient involvement was constructed in accordance with the input of all stakeholder groups, which reflects the involvement of all types of patients at all levels of the decision-making process.Conclusion: In this study, we developed a definition for patient involvement based on qualitative interviews. The factors contributing to best practices for patient involvement were mentioned across stakeholder groups and aimed to stimulate patient involvement in PV. Patients are eager to become equal partners and to engage effortlessly in the same manner as other stakeholders. [ABSTRACT FROM AUTHOR]

Supplemental Digital Content is Available in the Text. Interleaving is an evidence-based, learning-science strategy that is relevant to the planning and implementation of continuing professional development (CPD). Mixing related but different areas of study forces the brain to reconcile the relationship between the areas while understanding each area well. By doing so, interleaving increases the likelihood of mastery and memory. Research from cognitive psychology and neuroscience provides the rationale for interleaving, and examples of its implementation in health profession education have begun to appear in the literature. If utilized appropriately, some common CPD interventions can leverage interleaving. Through increased understanding, CPD participants can benefit from interleaving by making more-informed educational choices, and CPD planners can benefit in efforts to improve educational activities. [ABSTRACT FROM AUTHOR]

A green multicomponent synthesis of previously unreported octahydropyrimido[4,5-g]quinazoline-5,6-diones was developed from simple building blocks. These highly symmetrical compounds show strong propensity to self-assembled molecular network (SAMN) formation on highly oriented pyrolytic graphite. The SAMN type is easily tunable by changing molecular characteristics. The redox behavior was studied by cyclic voltammetery. [ABSTRACT FROM AUTHOR]

Proposal of a risk analysis model to diminish negative impact on patient care by preanalytical errors in blood gas analysis (BGA). Here we designed a Failure Mode and Effects Analysis (FMEA) risk assessment template for BGA, based on literature references and expertise of an international team of laboratory and clinical health care professionals. The FMEA identifies pre-analytical process steps, errors that may occur whilst performing BGA (potential failure mode), possible consequences (potential failure effect) and preventive/corrective actions (current controls). Probability of failure occurrence (OCC), severity of failure (SEV) and probability of failure detection (DET) are scored per potential failure mode. OCC and DET depend on test setting and patient population e.g., they differ in primary community health centres as compared to secondary community hospitals and third line university or specialized hospitals. OCC and DET also differ between stand-alone and networked instruments, manual and automated patient identification, and whether results are automatically transmitted to the patient's electronic health record. The risk priority number (RPN = SEV × OCC × DET) can be applied to determine the sequence in which risks are addressed. RPN can be recalculated after implementing changes to decrease OCC and/or increase DET. Key performance indicators are also proposed to evaluate changes. This FMEA model will help health care professionals manage and minimize the risk of preanalytical errors in BGA. [ABSTRACT FROM AUTHOR]

This study reports on a contextualized speaker evaluation experiment exploring the effects of language variation (standard vs. colloquial varieties), ethnic identity (Flemish vs. Maghrebi) and wearing a headscarf on students' evaluation of a female university instructor in Flanders. 314 participants evaluated a single lecture of the instructor on professionalism, comprehensibility, authority, standardness, social attractiveness and physical attractiveness. The results suggest that when measured indirectly, colloquial Dutch is no less acceptable than Standard Dutch in higher education. No general downgrading of the Maghrebi identity was observed. When wearing a headscarf, the standard-speaking Maghrebi instructor was upgraded for professionalism. • Standard language ideological beliefs are weak in a contextualized experiment. • Standard-speaking Maghrebi instructors are not downgraded compared to Flemings. • The standard-speaking instructor with hijab excelled in professionalism. [ABSTRACT FROM AUTHOR]

Purpose: Although Hartmann's procedure is commonly performed, subsequent reversal is less frequent. The most common reasons for reversal surgery are advanced age, comorbidities, and perceived surgical difficulties. The main objective of this study was to investigate if the length of the rectal stump influences the outcome of Hartmann's reversal surgery. Method: We conducted a retrospective case study analyzing data from 105 patients who underwent Hartmann's reversal procedure between 2007 and 2019 in two centers. We evaluated patient demographics, length of rectal stump, intraoperative surgical details, short-term and long-term outcomes. Results: From 2007 to 2019, 105 patients underwent Hartmann's reversal surgery. Short-term morbidity rate was 58% (61 patients), including 16% (17 patients) with severe postoperative complication (Clavien-Dindo ≥ 3). Anastomotic leakage rate was 2.9% (3 patients). Long-term complications were present in 41% (43 patients) of which abdominal wall defect was the most frequent complication. The mean length of the rectal stump was 15 cm. In almost 1 out of 5 patients (17%) the rectal stump was shorter than 10 cm. The three anastomotic leakages appeared in the long rectal stump group (3.6% vs. 0%, p = 0.273). The complication rate for patients with a short rectal stump was similar to those with a longer rectal stump (50% vs. 63%, p = 0.275). Smoking, high ASA score, obesity, and advanced age did not influence the outcomes of the reversal procedure either. Conclusion: Length of the rectal stump is not a predictive factor for postoperative complications after Hartmann's reversal surgery. [ABSTRACT FROM AUTHOR]

Background: A vestibular implant can partially restore vestibular function by providing motion information through implanted electrodes. During vestibular implantation, various obstructions of the semicircular canals, such as protein deposits, fibrosis, and ossification, can be encountered. The objective was to explore the relationship between preoperative imaging and intraoperative findings of semicircular canal obstruction and to develop surgical strategies for dealing with obstructions of the semicircular canal(s) in patients eligible for vestibular implantation. Methods: Patients undergoing vestibulocochlear implantation (in an active clinical trial) were included in the current study when preoperative imaging indicated an obstruction in the semicircular canal. Preoperative imaging consisted of CT and MRI scans. During surgery, the bony semicircular canals were skeletonized ("bluelined") to identify the course of the canals and create a fenestration to insert the electrodes. The aim was to place the electrodes in the semicircular canal ampullae. Surgical strategies were developed to deal with the soft tissue obstructions. These procedures were evaluated intraoperatively with microscopic visualization, postoperatively with CT imaging. Results: The three included patients suffered from bilateral vestibulopathy and hearing loss due to autosomal dominant nonsyndromic sensorineural deafness 9 (DFNA9). A soft tissue obstruction was predicted in one semicircular canal (2 patients) or two semicircular canals (1 patient), based on preoperative imaging. Intraoperatively, bluelining the semicircular canals aided in identifying these locations, by revealing a "whiteline" instead of blueline. Depending on the nature and location of the obstruction, different surgical procedures were employed to facilitate proper electrode insertion. These were as follows: a dummy electrode was used to probe the soft tissue, the obstructive tissue was removed, and/or a bypass fenestration was created. In all patients, the electrodes could be implanted in the semicircular canal ampullae. Based on these first experiences, a diagnostic and surgical guide to deal with obstructions of the semicircular canals during vestibular implantation was developed. Conclusions: Preoperative imaging can indicate locations of obstructions in the SCCs. Different surgical procedures can be applied to enable appropriate electrode positioning in the SCC ampulla. This article describes the first experiences with obstructions of the semicircular canals during intralabyrinthine vestibular implantation and presents a diagnostic and surgical guide. Trial registration: ABR NL73492.068.20, METC20-087 (Maastricht University Medical Center) and NAC 11-080 (Geneva University Hospitals). [ABSTRACT FROM AUTHOR]

AIM The aim of this study was to describe the status of distributed practice in research of nursing education. BACKGROUND The science of learning has compiled evidence-based strategies that should be integral to nursing education. One long-standing strategy, distributed practice, involves spacing, placing cognitive breaks between study or practice sessions with priority information. METHOD Reviewing literature published over 20 years at every level of nursing education, the authors conducted a scoping review to determine the extent to which research of nursing education includes attention to distributed practice. RESULTS In the 13 articles meeting criteria, distributed practice was most common in continuing professional development, with an emphasis in learning psychomotor skills. Study authors used a variety of terms and descriptions in referring to the strategy. CONCLUSION By way of research, distributed practice appears underutilized in nursing education, especially at prelicensure and graduate levels, and could benefit from clear and consistent use of terminology. [ABSTRACT FROM AUTHOR]

Objective: This study demonstrates a novel method for pulse arrival time (PAT) segmentation into cardiac isovolumic contraction (IVC) and vascular pulse transit time to approximate central pulse wave velocity (PWV). Methods: 10 subjects (38 ± 10 years, 121 ± 12 mmHg SBP) ranging from normotension to hypertension were repeatedly measured at rest and with induced changes in blood pressure (BP), and thus PWV. ECG was recorded simultaneously with ultrasound-based carotid distension waveforms, a photoplethysmography-based peripheral waveform, noninvasive continuous and intermittent cuff BP. Central PAT was segmented into cardiac and vascular time intervals using a fiducial point in the carotid distension waveform that reflects the IVC onset. Central and peripheral PWVs were computed from (segmented) intervals and estimated arterial path lengths. Correlations with Bramwell-Hill PWV, systolic and diastolic BP (SBP/DBP) were analyzed by linear regression. Results: Central PWV explained more than twice the variability (R2) in Bramwell-Hill PWV compared to peripheral PWV (0.56 vs. 0.27). SBP estimated from central PWV undercuts the IEEE mean absolute deviation threshold of 5 mmHg, significantly lower than peripheral PWV or PAT (4.2 vs. 7.1 vs. 10.1 mmHg). Conclusion: Cardiac IVC onset signaled in carotid distension waveforms enables PAT segmentation to obtain unbiased vascular pulse transit time. Corresponding PWV estimates provide the basis for single-site assessment of central arterial stiffness, confirmed by significant correlations with Bramwell-Hill PWV and SBP. Significance: In a small-scale cohort, we present proof-of-concept for a novel method to estimate central PWV and BP, bearing potential to improve the practicality of cardiovascular risk assessment in clinical routines. [ABSTRACT FROM AUTHOR]

Although a good rational number understanding is of crucial importance for learners' general maths achievement, many learners have misconceptions about fractions. An often described misconception is that a fraction's numerical magnitude increases when its denominator, numerator, or both increase. The present intervention study investigated how robust this misconception is, after learners have specifically been instructed on the incorrectness of their idea by means of a refutation text, as opposed to a condition where they received an expository text. Results of 76 fourth graders showed a (long-term) learning effect, but no larger learning gains in the group that received a refutation text compared to the group that received an expository text. Results further pointed to large individual differences in the learning gains. While there is a subgroup of learners that benefits from the refutation text, another subgroup was found that tend to overuse and misapply the information given in this text. [ABSTRACT FROM AUTHOR]

Retrieval practice is an evidence-based, science of learning strategy that is relevant to the planning and implementation of continuing professional development (CPD). Retrieval practice requires one to examine long-term memory to work with priority information again in working memory. Retrieval practice improves learning in two ways. It improves memory for the information itself (direct benefit), and retrieval practice provides feedback about what needs additional effort (indirect). Both benefits contribute significantly to durable learning. Research from cognitive psychology and neuroscience provides the rationale for retrieval practice, and examples of its implementation in health professions education are increasingly available in the literature. Through appropriate utilization, CPD participants can benefit from retrieval practice by making more-informed educational choices, and CPD planners can benefit in efforts to improve educational activities. [ABSTRACT FROM AUTHOR]

Adolescents with substance use disorders are often diagnosed with co-occurring mental disorders. However, it is unknown if adolescent hospital admission for acute alcohol intoxication is also associated with co-occurring mental disorders. Therefore, the primary aim of this study is to estimate the prevalence of co-occurring mental disorders among Dutch adolescents admitted for acute alcohol intoxication. Secondly, this study aims to explore the cross-sectional relationship between the co-occurrence of mental disorders and patient characteristics, such as sex, age and blood alcohol concentration at admittance. Data were retrospectively collected from 726 adolescents admitted for acute alcohol intoxication. Overall, 245 (34%) of the 726 adolescents treated for acute alcohol intoxication were diagnosed with a co-occurring mental health disorder, such as attention-deficit hyperactivity disorder (13%) or autism spectrum disorder (2.1%). Attention-deficit hyperactivity disorder in particular seems to be more prevalent in the study population than in the general Dutch adolescent population. Conclusion: This study demonstrates that among adolescents admitted for acute alcohol intoxication, the prevalence of co-occurring mental disorders is a common and a relevant issue for treatment and prevention strategies. What is Known: • Alcohol consumption among adolescents has been associated with negative psychosocial effect. • Among adolescents admitted for acute alcohol intoxication, risk factors for psychological dysfunction appear to be inadequately assessed, documented and followed up. What is New: • The current study reports on the prevalence of co-occurring mental disorders among a substantial sample of adolescents admitted for acute alcohol intoxication. • Understanding the prevalence of co-occurring mental disorders is clinically relevant for the outpatient follow-up of adolescents admitted for acute alcohol intoxication. [ABSTRACT FROM AUTHOR]

Cultural tightness-looseness represents the degree to which a particular culture possesses strong behavioral norms, and the degree to which members of that culture are likely to sanction individuals who deviate from those norms. While tightness-looseness has been quantified for a large and growing number of countries around the world, there are many countries where a tightness-looseness score has yet to be determined, thus impeding the inclusion of those countries in cross-cultural research with a tightness-looseness focus. There is a dearth of research on cultural tightness-looseness in South America in particular. We report results from a national survey of 1,265 Ecuadorian residents which provided quantification of the relatively tight culture of Ecuador. [ABSTRACT FROM AUTHOR]

Previous research amply showed the importance of a good fraction understanding but also people's lack of fraction understanding. It is therefore important to investigate the cognitive processes that underlie reasoning with fractions. The present study investigated the role of inhibition and switch costs in fraction comparison tasks. Participants solved a fraction comparison task that alternated between 4 items congruent and 4 items incongruent with natural number reasoning. This allowed to not only investigate congruency switch effects, but also inhibition, given that inhibition was experimentally increased by the prolonged exposure to incongruent trials. Based on data of seventh graders, the present study showed that inhibition does not only play a role in learners' general mathematics achievement, but also in specific areas of mathematics, such as fractions. Moreover, a switch cost was found in the lower accuracy rates and higher reaction times needed to correctly solve switch items compared to non-switch items. [ABSTRACT FROM AUTHOR]

Objective. Persistent low back pain (PLBP) is a common and costly health problem worldwide. Better strategies to manage it are required. The purpose of this study was to longitudinally evaluate absenteeism, pain, and disability in nurses with PLBP following a cognitive functional therapy (CFT) intervention. Methods. In this case series pilot study, 33 eligible nurses with PLBP were recruited. During the baseline phase (phase A; no intervention), outcome measures were collected on 2 occasions 6 months apart (A1 and A2). During phase B, participants received an individualized CFT intervention for 14 weeks. During phase C (no intervention), outcomes were measured immediately after the intervention, as well as 3, 6, 9, 12, and 36 months after the intervention (secondary outcomes only until 12 months). LBP-related work absenteeism, pain intensity (numerical pain rating scale) and disability (Oswestry Disability Index) were the primary outcomes. Health care seeking, a range of psychological and lifestyle variables, and global perceived effect were secondary outcomes. Results. Days of absenteeism due to LBP were significantly reduced in the first and second calendar years after the CFT intervention but not the third and fourth. Disability was significantly reduced immediately after (−4.4; 95% CI = −6.5 to −2.2) and at 3 months (−4.3; 95% CI=−6.6 to −2.0), 9 months (−6.0; 95% CI=−8.1 to −3.9), and 12 months (−4.9; 95% CI = −7.0 to −2.8) after the intervention. Pain was significantly reduced immediately after (−1.2; 95% CI = −1.7 to −0.8) and at 3 months (−1.5; 95% CI = −2.0 to −0.9), 9 months (−1.1; 95% CI = −1.9 to −0.3), and 12 months (−0.9; 95% CI = −1.5 to −0.2) after the intervention. Total health care seeking (consults and proportion of participants) was significantly reduced after the intervention. All psychosocial variables, except for 1, demonstrated significant improvements at all follow-up assessments. Conclusions. This case series pilot study demonstrated significant reductions in LBP-related absenteeism, pain intensity, disability, health care seeking, and several psychological and lifestyle behaviors until the 1-year follow-up among nurses with PLBP following an individualized CFT intervention. Further evaluation of the efficacy of CFT in high-quality randomized clinical trials among nurses is recommended. [ABSTRACT FROM AUTHOR]

According to Grotius in his Inleiding (2.36.6), the actual use of two houses by the same owner could lead to the implied grant of a servitude if he transferred one of the houses to someone else, 'without any mention either the one way or the other'. Various interpretations of this text exist, but the consensus is lacking. In this article, the author investigates the meaning and influence of Grotius's position on implied servitudes in both his time and the following centuries. This research shows how Grotius's opinion progressed from Bartolus's approach to implied servitudes and sheds new light on the creation of servitudes by means of destinatione patris familias in the Netherlands. [ABSTRACT FROM AUTHOR]

Distributed practice is an evidence-based, learning-science strategy that is relevant to the planning and implementation of continuing professional development (CPD). Spacing-out study or practice over time allows the brain multiple opportunities to process new and complex information in an efficient way, thus increasing the likelihood of mastery and memory. Research from cognitive psychology and neuroscience provide the rationale for distributed practice, and examples of its implementation in health professions education have begun to appear in the literature. If used appropriately or extended creatively, some common CPD interventions can fully leverage distributed practice. Through increased understanding, CPD planners can benefit from distributed practice in efforts to improve educational activities, and CPD participants can benefit by making more informed educational choices. [ABSTRACT FROM AUTHOR]

Faithful degradation of mRNAs is a critical step in gene expression, and eukaryotes share a major conserved mRNA decay pathway. In this major pathway, the two rate-determining steps in mRNA degradation are the initial gradual removal of the poly(A) tail, followed by removal of the cap structure. Removal of the cap structure is carried out by the decapping enzyme, containing the Dcp2 catalytic subunit. Although the mechanism and regulation of mRNA decay is well understood, the consequences of defects in mRNA degradation are less clear. Dcp2 has been reported as either essential or nonessential. Here, we clarify that Dcp2 is not absolutely required for spore germination and extremely slow growth, but in practical terms it is impossible to continuously culture dcp2D under laboratory conditions without suppressors arising. We show that null mutations in at least three different genes are each sufficient to restore growth to a dcp2D, of which kap123D and tl(gag)gD appear the most specific. We show that kap123D and tl(gag)gD suppress dcp2 by mechanisms that are different from each other and from previously isolated dcp2 suppressors. The suppression mechanism for tL(GAG)G is determined by the unique GAG anticodon of this tRNA, and thus likely by translation of some CUC or CUU codons. Unlike previously reported suppressors of decapping defects, these suppressors do not detectably restore decapping or mRNA decay to normal rates, but instead allow survival while only modestly affecting RNA homeostasis. These results provide important new insight into the importance of decapping, resolve previously conflicting publications about the essentiality of DCP2, provide the first phenotype for a tl(gag)g mutant, and show that multiple distinct mechanisms can bypass Dcp2 requirement. [ABSTRACT FROM AUTHOR]

A study into reading behavior and reading compliance among 2,600 students in five universities in Ecuador found that their reading behavior and reading compliance were better than among students in the United States, despite the challenges that exist in Ecuadorian higher education. Suggestions for future research, in particular with regard to improving students' time management skills as a way to enhance their reading compliance, are included. [ABSTRACT FROM AUTHOR]

Although a good rational number understanding is very important, many learners struggle to understand fractions. Recent research attributes many of these difficulties to the natural number bias – the tendency to apply natural number features in rational number tasks where this is inappropriate. Previous correlational dual process studies found evidence for the intuitive nature of the natural number bias in learners' response latencies. However, the reported correlations do not ascertain the causality that is assumed in this ascription. In the present study we therefore experimentally elicited intuitive responses in a fraction comparison task in educated adults by restricting reaction time. Results show that the natural number bias has an intuitive character. Findings also indicate that the detection of conflict between the natural number-based answer and the correct answer seems to work at an intuitive level. [ABSTRACT FROM AUTHOR]

Background: Prospective research in the field of cochlear implants is hampered by methodological issues and small sample sizes. The ELEPHANT study presents an alternative clinical trial design with a daily randomized approach evaluating individualized tonotopical fitting of a cochlear implant (CI).Methods: A single-blinded, daily-randomized clinical trial will be implemented to evaluate a new imaging-based CI mapping strategy. A minimum of 20 participants will be included from the start of the rehabilitation process with a 1-year follow-up period. Based on a post-operative cone beam CT scan (CBCT), mapping of electrical input will be aligned to natural place-pitch arrangement in the individual cochlea. The CI's frequency allocation table will be adjusted to match the electrical stimulation of frequencies as closely as possible to corresponding acoustic locations in the cochlea. A randomization scheme will be implemented whereby the participant, blinded to the intervention allocation, crosses over between the experimental and standard fitting program on a daily basis, and thus effectively acts as his own control, followed by a period of free choice between both maps to incorporate patient preference. With this new approach the occurrence of a first-order carryover effect and a limited sample size is addressed.Discussion: The experimental fitting strategy is thought to give rise to a steeper learning curve, result in better performance in challenging listening situations, improve sound quality, better complement residual acoustic hearing in the contralateral ear and be preferred by recipients of a CI. Concurrently, the suitability of the novel trial design will be considered in investigating these hypotheses.Trial Registration: ClinicalTrials.gov: NCT03892941. Registered 27 March 2019. [ABSTRACT FROM AUTHOR]

In recent years, there has been a growing interest in neuropsychological deficits in patients with Cocaine Use Disorder (CUD) and Alcohol Use Disorder (AUD). Besides deficits in working memory (WM), impulsivity and attention, chronic alcohol and cocaine use have neurotoxic effects on frontostriatal areas in the brain. Individuals with deficits in these brain regions experience motor-timing deficits. It is unclear whether observed temporal processing deficits, in fact, reflect increased sustained attention or WM demands (which are required by timing tasks), or whether motor-timing deficits reflect some other process. The main questions of this were: (i) Can attention and WM be explained by motor-timing performance, and (ii), is impulsivity related to motor timing performance, in an inpatient SUD population? The study sample consisted of 74 abstinent patients who completed selected neuropsychological and motor-timing tasks. No significant correlation was found between performance on motor tasks and impulsivity. With regard to visual and auditory WM, motor timing was a significant predictor but only under conditions that required increased cognitive demands. Motor-timing performance contributed to a small portion of the variance in attention, but only for spatial abilities and only at increased cognitive demands. These preliminary findings suggest that, in line with the literature, millisecond timing engages other cognitive functions, but only minimally. As such motor timing should be regarded as a separate neurocognitive concomitant. Impulsivity was not associated with millisecond motor timing. More research is needed to further investigate these preliminary findings. [ABSTRACT FROM AUTHOR]

In recent years, there has been a growing interest in neuropsychological deficits in patients with Cocaine Use Disorder (CUD) and Alcohol Use Disorder (AUD). Besides deficits in working memory (WM), impulsivity and attention, chronic alcohol and cocaine use have neurotoxic effects on frontostriatal areas in the brain. Individuals with deficits in these brain regions experience motor-timing deficits. It is unclear whether observed temporal processing deficits, in fact, reflect increased sustained attention or WM demands (which are required by timing tasks), or whether motor-timing deficits reflect some other process. The main questions of this were: (i) Can attention and WM be explained by motor-timing performance, and (ii), is impulsivity related to motor timing performance, in an inpatient SUD population? The study sample consisted of 74 abstinent patients who completed selected neuropsychological and motor-timing tasks. No significant correlation was found between performance on motor tasks and impulsivity. With regard to visual and auditory WM, motor timing was a significant predictor but only under conditions that required increased cognitive demands. Motor-timing performance contributed to a small portion of the variance in attention, but only for spatial abilities and only at increased cognitive demands. These preliminary findings suggest that, in line with the literature, millisecond timing engages other cognitive functions, but only minimally. As such motor timing should be regarded as a separate neurocognitive concomitant. Impulsivity was not associated with millisecond motor timing. More research is needed to further investigate these preliminary findings. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate discrepancies in potassium measurements between point-of-care testing (POCT) and central laboratory (CL) methods, focusing on the impact of hemolysis on these measurements and its impact in the clinical practice in the emergency department (ED). A retrospective analysis was conducted using data from three European university hospitals: Technische Universitat München (Germany), Hospital Universitario La Paz (Spain), and Erasmus University Medical Center (The Netherlands). The study compared POCT potassium measurements in EDs with CL measurements. Data normalization was performed in categories for potassium levels (kalemia) and hemolysis. The severity of discrepancies between POCT and CL potassium measurements was assessed using the reference change value (RCV). The study identified significant discrepancies in potassium between POCT and CL methods. In comparing POCT normo- and mild hypokalemia against CL results, differences of −4.20 % and +4.88 % were noted respectively. The largest variance in the CL was a +4.14 % difference in the mild hyperkalemia category. Additionally, the RCV was calculated to quantify the severity of discrepancies between paired potassium measurements from POCT and CL methods. The overall hemolysis characteristics, as defined by the hemolysis gradient, showed considerable variation between the testing sites, significantly affecting the reliability of potassium measurements in POCT. The study highlighted the challenges in achieving consistent potassium measurement results between POCT and CL methods, particularly in the presence of hemolysis. It emphasised the need for integrated hemolysis detection systems in future blood gas analysis devices to minimise discrepancies and ensure accurate POCT results. [ABSTRACT FROM AUTHOR]

Introduction: Intraoperative cardiac arrest (ICA) is a feared complication during liver transplantation (LTx), typically occurring during reperfusion. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been used for post-reperfusion cardiac arrest. Case report: We present a case of successful resuscitation after hyperkalemic ICA during the pre-anhepatic phase of a second liver transplantation by converting veno-venous bypass (VVB) to VA-ECMO. Discussion: While this technique has been recommended for ICA during reperfusion, it has never been reported during the pre-anhepatic phase. VA-ECMO can be a lifesaving extension to cardiopulmonary resuscitation for ICA during LTx with beneficial neurological outcome by providing perfusion while the cause of ICA is reversed. Conclusion: Conversion of VVB to VA-ECMO should be considered in all patients who suffer from ICA during LTx with use of VVB. With VVB installed, conversion to VA-ECMO is fast and effective. If VVB is not used, early VA-ECMO should be considered for ICA. [ABSTRACT FROM AUTHOR]

We develop ancestral Gumbel-Top-k sampling: a generic and efficient method for sampling without replacement from discrete-valued Bayesian networks, which includes multivariate discrete distributions, Markov chains and sequence models. The method uses an extension of the Gumbel-Max trick to sample without replacement by finding the top k of perturbed log-probabilities among all possible configurations of a Bayesian network. Despite the exponentially large domain, the algorithm has a complexity linear in the number of variables and sample size k. Our algorithm allows to set the number of parallel processors m, to trade off the number of iterations versus the total cost (iterations times m) of running the algorithm. For m = 1 the algorithm has minimum total cost, whereas for m = k the number of iterations is minimized, and the resulting algorithm is known as Stochastic Beam Search.¹ We provide extensions of the algorithm and discuss a number of related algorithms. We analyze the properties of Gumbel-Top-k sampling and compare against alternatives on randomly generated Bayesian networks with different levels of connectivity. In the context of (deep) sequence models, we show its use as a method to generate diverse but high-quality translations and statistical estimates of translation quality and entropy. [ABSTRACT FROM AUTHOR]

The science of learning (learning science) is an emerging interdisciplinary field that concerns itself with how the brain learns and remembers important information. The authors describe an innovative extracurricular program that introduced first-year undergraduate students in engineering to learning science, specifically the biological steps in the learning process and study strategies consistent with that process. The evaluation of the first two years of the program included data about attendance, satisfaction, grade point average, retention, and learning approach. This article describes the program and its evaluation findings, and the authors offer a critique in light of expert opinion and relevant research in order to improve program evaluation, recruitment, retention, and possibly effectiveness. [ABSTRACT FROM AUTHOR]

A novel numerical methodology is proposed to simulate thermal spray coating process on 3D objects with a focus on the prediction of the footprint shape and thickness. The method is based on the level set approach to capture the evolution of the deposited layer interface during the coating process. The shadowing effects that strongly affect the final footprint on 3D objects are considered. The method allows for the imposition of complex source trajectory and orientation evolution which are requested to tailor the final footprint on complex 3D objects. The capabilities and limitations of the proposed numerical tools are assessed using an aeronautic test case: the thermal spray coating of a part of aircraft engine (seal teeth). [ABSTRACT FROM AUTHOR]