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The exploitation and transportation of deep-sea and remote oil and gas fields have risen to become important components of national energy strategies. The gas–liquid separation and gas blocking caused by the large density difference between the gas and liquid phases are the primary influencing factors for the safe and reliable operation of gas–liquid mixed transportation pump systems. This paper takes the independently designed single-stage helical axial-flow mixed transportation pump compression unit as the research object. Through numerical simulation, the internal flow of the mixed transportation pump is numerically calculated to study the aggregation and conglomeration of small gas clusters in the flow passage hub caused by gas–liquid phase separation, influenced by the shear flow of phase separation, forming axial vortices at the outlet where gas clusters gather in the flow passage. The work performed by the impeller on the gas clusters is insufficient to overcome the adverse pressure gradient formed at the outlet of the flow passage due to the gathering of the liquid phase in adjacent flow passages, resulting in the phenomenon of gas blocking, with vortex gas clusters lingering near the hub wall of the flow passage. [ABSTRACT FROM AUTHOR]