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Objective: To develop and validate a questionnaire to evaluate missed nursing care (MNC) in a home care setting. Design: A new instrument was developed and tested performing a preliminary analysis of a multicenter cross‐sectional study in Italy. Reporting was performed according to COnsensus‐based Standards for the selection of health status Measurement INstruments (COSMIN) guidelines. Sample: Eight hundred out of a total of 2549 home care nurses enrolled in AIDOMUS‐IT were considered for the validation of the Missed Nursing Care in Home Care (MNC_HC). Measurements: The MNC_HC instrument was developed by a panel of experts and underwent content and face validation. Exploratory (EFA) and confirmatory factor analyses (CFA) were conducted. Results: EFA revealed a one‐factor solution, explaining 56% of the total variance for MNC_HC. CFA confirmed excellent structural validity, with a one‐factor model showing an exceptional fit (χ2 (27) = 141.39, p <.001, RMSEA = 0.04, SRMR = 0.04, CFI = 0.99, TLI = 0.99, factor loadings > 0.5). MNC_HC also demonstrated high reliability (Cronbach's α = 0.92). The activity with the highest rate of missed care was the documentation of nursing care (77%), while activities related to nursing techniques (e.g., injections, dressings, etc.) were reported to be missed less (33.63%). Conclusions: MNC_HC is a quick‐filling, valid, reliable, and psychometrically sound instrument for measuring MNC in home care useful for future research. [ABSTRACT FROM AUTHOR]

Background. Caregivers are crucial in ensuring that their relatives with heart failure (HF) reach proper self-care levels. Despite this, the demanding nature of caring for others can lead to poor outcomes and the compromise of own needs, which raises the need for perceived social support. Prior research does not offer a thorough knowledge of how caregivers of people with HF regarded social support and the characteristics that went along with it. Purpose. The aim of this study was to develop a comprehensive understanding of perceived social support and its associated factors among caregivers of individuals with heart failure. Methods. This is a secondary analysis of a convergent mixed-methods design study. The perception of social support, mutuality, anxiety, depression, and quality of life were assessed in 158 heart failure patients and their caregivers (physical and mental dimensions). In 50 caregivers, we also performed semistructured interviews. Results. The mixed analysis and integration of qualitative and quantitative inferences revealed two main factors affecting perceived social support. First, caregivers with strong familial network and greater number of caregivers available for tangible caregiving support and moral support perceived increased sense of social support. Second, caregivers with enhanced mental health had increased sense of social support. Conclusions. Caregiver perception of social support might be influenced by mental well-being status. To improve caregivers' perceptions of social support and community belonging, it is necessary to create and assess community- and individual-based mental health promotion interventions. To strengthen the perception of support in the heart failure caring process, more dyadic strategies should be established to improve patient-caregiver mutuality. [ABSTRACT FROM AUTHOR]

Interferon-gamma (IFNγ) is one of the central cytokines produced by the innate and adaptive immune systems. IFNγ directly favors tumor growth control by enhancing the immunogenicity of tumor cells, induces IP-10 secretion facilitating (CXCR3+) immune cell infiltration, and can prime macrophages to an M1-like phenotype inducing proinflammatory cytokine release. We had previously reported that the targeted delivery of IFNγ to neoplastic lesions may be limited by the trapping of IFNγ-based products by cognate receptors found in different organs. Here we describe a novel fusion protein consisting of the L19 antibody, specific to the alternatively spliced extra-domain B of fibronectin (EDB), fused to a variant of IFNγ with reduced affinity to its cognate receptor. The product (named L19-IFNγ KRG) selectively localized to tumors in mice, showed favorable pharmacokinetic profiles in monkeys and regained biological activity upon antigen binding. The fusion protein was investigated in two murine models of cancer, both as monotherapy and in combination with therapeutic modalities which are frequently used for cancer therapy. L19-IFNγ KRG induced tumor growth retardation and increased the intratumoral concentration of T cells and NK cells in combination with anti-PD-1. [ABSTRACT FROM AUTHOR]

Purpose of review: Continuous progress in cancer care has led to its increased use in oral anticancer agents that are easily managed by patients at home with fewer costs and hospitalizations. However, correct self-care behaviors are needed for the safe use of these medications. This review aimed to synthesize studies on self-care behaviors in patients treated with oral anticancer agents. Methods: This systematic review used a convergent qualitative synthesis design for mixed studies. Studies on adult patients with cancer using any kind of oral anticancer agent and describing self-care maintenance, self-care monitoring, and/or self-care management behaviors were searched on PubMed, EMBASE, and CINAHL. After data extraction, the findings were retained for qualitative synthesis. Findings: Of 3419 records, 19 studies were included in this review. From the qualitative synthesis, all the retrieved behaviors were synthesized in the three self-care dimensions. Five themes and 18 subthemes were identified. Self-care maintenance included "adherence to the medications" and "prevention." Self-care monitoring consisted of "health surveillance and recognition of illness changes." Self-care management included "seeking help" and "autonomous management of side effects." Overall, most of the behaviors described focused only on adherence. Conclusion: The findings of this systematic review could guide future studies on self-care and drive future interventions aimed at improving self-care in this vulnerable population. Nurses and other healthcare professionals should provide self-care support to patients taking oral anticancer agents. In particular, they should promote behaviors aimed at improving well-being, preserving health, or managing side effects. [ABSTRACT FROM AUTHOR]

The aim of this study was to adapt the National Aeronautics and Space Administration Task Load Index (NASA‐TLX) to the home care setting and translate and validate it in Italian. An online questionnaire containing the Italian version of the NASA‐TLX adapted to the home care setting was administered to home care nurses to measure workload. Content Validity Index, Exploratory, and Confirmatory Factor Analyses were used to measure the psychometric characteristics of the modified NASA‐TLX. The modified Italian version of NASA‐TLX_HC‐IT showed good psychometric characteristics in measuring the workload of home care nurses, with excellent fit indices. The reliability, calculated with Cronbach's alpha, was 0.73, indicating adequate reliability. A negative correlation between workload and job satisfaction among home care nurses, as well as a positive association between high workload and intention to leave the workplace, was verified. The modified Italian version of the NASA‐TLX_HC‐IT was confirmed to be a valid and reliable instrument to measure workload in home care nursing. Furthermore, the correlation between workload and the intention to leave the workplace among home care nurses was an important result that community nursing managers should consider preventing the shortage of home care nurses. [ABSTRACT FROM AUTHOR]

The ever‐wider spread of distributed generation in distribution systems feeds the increasing demand for voltage regulation in low‐voltage networks. For these distribution grids, characterised by simpler structures than medium voltage systems but with a larger number of buses and feeders, voltage control devices have to guarantee fast and reliable operation, as well as economic and simple implementation. A key issue is ensuring adequate voltage amplitude for the active users, which present both load and generation. Variations of active power injections/absorptions by active users can produce long‐duration variations of the voltage amplitudes that exceed normal operating ranges admitted for the feeders, thus causing distributed generation tripping and poor power quality for the loads. This work is intended as 'concept proof' to demonstrate the possibility of obtaining a simple, compact, and cheap device that guarantees adequate voltage amplitudes at low‐voltage user's premises. The device consists of a transformer that can vary its winding arrangements using controlled static switches. A summary of the construction aspects is recalled focussing attention on the control logic and operating characteristics. Various laboratory tests on a prototype are reported, under various operating conditions, highlighting the pros and cons of the considered solution and the margins of improvement. [ABSTRACT FROM AUTHOR]

The migratory issues need to be deepened, not only from the human point of view, but also with regard to legal discipline. Asylum, a term of Greek origin aσuλov (iερov), literally means without capture; in the Latin terminology asylum indicates a temple where there is no right of capture and is strictly bound to the Institute of Hospitality, defined by the Romans Hospitium Publicum (one of the first forms of public hospitality). Asylum and refugee status represent, therefore, two institutions that go back to the Greco-Roman age and that will be deepened juridically from the origins and their practical applications. The different interpretations regarding the discipline that have been developed in modern and contemporary history will be analyzed later, and in addition, it will be observed how these have finally been reinterpreted since the First and the Second World Conflicts and moreover since the Universal Declaration of Human Rights of 1948. [ABSTRACT FROM AUTHOR]

Background: Advanced cancer patients often die in hospital after receiving needless, aggressive treatment. Although palliative care improves symptom management, barriers to accessing palliative care services affect its utilisation, and such disparities challenge the equitable provision of palliative care. This study aimed to identify which factors are associated with inequitable palliative care service utilisation among advanced cancer patients by applying the Andersen Behavioural Model of Health Services Use. Material and methods: This was a retrospective cohort study using administrative healthcare data. A total of 13,656 patients residing in the Lazio region of Italy, who died of an advanced cancer-related cause—either in hospital or in a specialised palliative care facility—during the period of 2012–2016 were included in the study. Potential predictors of specialised palliative service utilisation were explored by grouping the following factors: predisposing factors (i.e., individuals' characteristics), enabling factors (i.e., systemic/structural factors) and need factors (i.e., type/severity of illness). Results: The logistic hierarchical regression showed that older patients (odds ratio [OR] = 1.45; <0.0001) of Caucasian ethnicity (OR = 4.17; 0.02), with a solid tumour (OR = 1.87; <0.0001) and with a longer survival time (OR = 2.09; <0.0001) were more likely to be enrolled in a palliative care service. Patients who lived farther from a specialised palliative care facility (OR = 0.13; <0.0001) and in an urban area (OR = 0.58; <0.0001) were less likely to be enrolled. Conclusion: This study found that socio-demographic (age, ethnicity), clinical (type of tumour, survival time) and organisational (area of residence, distance from service) factors affect the utilisation of specialised palliative care services. The fact that service utilisation is not only a function of patients' needs but also of other aspects demonstrates the presence of inequity in access to palliative care among advanced cancer patients. [ABSTRACT FROM AUTHOR]

Abstract The isotopic distribution of nuclei produced in the 50Ti + 249Cf reaction has been studied at the gas-filled recoil separator TASCA at GSI Darmstadt, which separates ions according to differences in magnetic rigidity. The bombardment was performed at an energy around the Bass barrier and with the TASCA magnetic fields set for collecting fusion-evaporation reaction products. Fifty-three isotopes located “north-east” of 208Pb were identified as recoiling products formed in non-fusion channels of the reaction. These recoils were implanted with energies in two distinct ranges; besides one with higher energy, a significant low-energy contribution was identified. The latter observation was not expected to occur according to kinematics of the known types of reactions, namely quasi-elastic, multi-nucleon transfer, deep-inelastic collisions or quasifission. The present observations are discussed within the framework of two-body kinematics passing through the formation of a composite system. [ABSTRACT FROM AUTHOR]

The dynamics of the fission process is expected to affect the evaporation residue cross section because of the fission hindrance due to the nuclear viscosity. Systems of intermediate fissility constitute a suitable environment for testing such hypothesis since they are characterized by evaporation residue cross sections comparable or larger than the fission ones. Observables related to emitted charged particles, due to their relatively high emission probability, can be used to put stringent constraints on models describing the excited nucleus decay and to recognize the effects of fission dynamics. In this work model simulations are compared with the experimental data collected via the S 32 + 100 Mo reaction at E lab = 200  MeV . Consequently we pointed out, exploring an extended set of evaporation channel observables, the limits of the statistical model and the large improvement obtained with a dynamical model. Moreover we stress the importance of using an apparatus covering a large fraction of 4 π to extract observables. Finally, we discuss the opportunity to measure more sensitive observables by a new detection device in operation at LNL. [ABSTRACT FROM AUTHOR]

The laboratory modelling of a rotating turbulent flow subjected to a β-effect by means of laboratory experiments is considered. In particular the focus has been put on the emergence and the evolution of zonal jet-like structures due to the anisotropization of the upscale energy transfer that can be observed in geophysical flows. The experimental setup consists of a rotating tank in which a turbulent flow is reproduced by electromagnetically forcing a shallow layer of saline solution; this model then reproduces the dynamics in the polar regions simulating the so-called γ-plane by the parabolic surface of the rotating fluid. Several experiments have been performed by changing the main external parameters in order to investigate if the setup is suitable for reproducing the basic dynamics associated with a banded configuration analogous to large scale atmospheric and oceanic circulations. Velocity measurements performed by image analysis have allowed characterization of the flow in terms of mean azimuthal velocity, degree of anisotropy, distribution of energy, and characteristic scales. As expected, zonal jets have been found to dominate the dynamics when the β-effect is stronger. [ABSTRACT FROM AUTHOR]

Light charged-particle multiplicities in the evaporation residue (ER) and fission (FF) channels from the reaction 200MeV 32S + 100Mo as well as ER and FF channel cross-sections have been measured and compared to the predictions of the statistical model (SM) to estimate the fission time scale. The statistical model fails in reproducing the whole set of data and no convincing estimate is possible. In particular, while pre-scission multiplicities can be reproduced, the model strongly overestimates proton and alpha particle multiplicities in the ER channel, irrespective of the SM input parameters and prescriptions used for the level density and the transmission coefficients. Same calculations performed on data from literature in the A $ \approx$ 150 and excitation energy Ex $ \approx$ 100-200 MeV region, for the ER channel, provide similar conclusions. These findings repropose the problem of the reliability of the SM in describing the compound-nucleus decay and have a relevant impact on the extraction of the fission delay time through the use of the SM. [ABSTRACT FROM AUTHOR]

Interleukin-21 (IL21) is a pleiotropic cytokine involved in the modulation of both innate and adaptive immunity. IL21 is mainly secreted by natural killer (NK) and activated CD4+ T-cells. The biology of this cytokine can be associated to proinflammatory responses reflecting its potent stimulatory activity of NK and CD8+ T-cells. Here we describe four formats of novel IL21-based antibody–cytokine fusion proteins, targeting the extra domain A (EDA) of fibronectin and explore their potential for cancer treatment. The fusion proteins were designed, expressed, and characterized. F8 in single-chain diabody (scDb) format fused to IL21 at its C-terminus exhibited a promising profile in size exclusion chromatography (SEC) and SDS-PAGE. The lead candidate was further characterized in vitro. A cell-based activity assay on murine cytotoxic T-cells showed that human IL21, compared to murine IL21 partially cross-reacted with the murine receptor. The prototype was able to recognize EDA as demonstrated by immunofluorescence analysis on tumor sections. In an in vivo quantitative biodistribution experiment, F8(scDb)-murine IL21 did not preferentially accumulate at the site of disease after intravenous injection, suggesting that additional protein engineering would be required to improve the tumor-homing properties of IL21-based product. [ABSTRACT FROM AUTHOR]

Since the code LILITA was presented in 1981 by Gomez Del Campo and Stockstad (1981) [1] and used to simulate the emission of light particles in the decay of a compound nucleus, relevant improvements have been made. Revisions leading to LILITA_N97 were begun by G. La Rana (Naples), M. Kaplan (CMU, Pittsburgh, PA), J.M. Alexander (Stony Brook, NY) and continued by the Naples Group (Moro et al., 2012) [2]. In this work new key features of the code consisting of the implementation of transmission coefficients based on global parametrization of the optical model potential, a description of the nuclear shape based on the nuclear stratosphere model, the parallelization of the code and a graphical user interface are presented. We expect that the new code version, LILITA_N21, makes it possible a better reproduction of wide data set from literature. In order to illustrate how this could be achieved, the standard statistical model predictions have been compared with those obtained with the new code features. A single set of parameters of the new code simultaneously well reproduces the neutron, proton and α -particle energy spectra, angular distributions, and multiplicities in the fusion–evaporation channel. By way of example, here the calculations are compared with experimental data of the reaction 60Ni+100Mo at the excitation energy of about 280 MeV (Charity et al., 2003) [3]. The capability to reduce the execution time by exploiting the code parallelization is also discussed. [ABSTRACT FROM AUTHOR]

During the workshop, the six partner universities worked towards acquiring the necessary skills to design and analyse surveys and to establish a portfolio of competences, which will be the basis of updated and new MSc programmes. The project will result in two new MSc programmes in Ecuador and the update of three MSc programmes in both Ecuador and Peru. CORRIENTE XXI aims to raise the level of the MSc programmes, increase graduate employability, and raise awareness of the importance of aquatic sciences and management. [Extracted from the article]

The article discusses the issues and challenges in open-world software development. The authors reflect that the closed-world assumption that the boundary between environment and system is known and unchanging has been the basis of traditional software development. This basis of assumption is no longer suited to the present's unpredictable open-world settings. Open-world settings demand techniques that let software react to changes by self-adapting its behavior and self-organizing its structure. The authors suggest that research must be directed to provide techniques and tools to realize this open-world software. They mention that polymorphism and dynamic binding offers the first step in developing system that runs in an open-world.

E-learning has the potential to offer significant advantages over traditional classroom learning. However, it requires a complete redefinition of the dynamics of interaction between the various actors of a classroom. Moreover, in this context, the authoring of instructional material requires much more time than in traditional learning. Therefore, special care has to be posed to the definition of proper authoring approaches where educators can reuse and easily assemble existing materials. In this scenario, a comprehensive learning platform addressing the various interrelated aspects of authoring and fruition of instructional material is needed. Such a platform should enable reusability of materials, so that it is possible to make efficient use of preexisting experiences, and interoperability with existing platforms so that it is possible to take advantage of their strengths. The SCORM standard offers, among other features, a rich data model that can be used to define and share Learning Objects through different e-learning platforms. We argue that, despite the fact that it is the most emerging and promising standard, SCORM does not address some key issues properly, such as specification of metadata and LO composition. In this paper we focus on these issues and propose some extensions to SCORM that aim to address the above issues. [ABSTRACT FROM AUTHOR]

The article offers information on the complexities of Intimate Partner Violence (IPV) and the importance of tailored care for victims. Topics include the mechanisms by which women prioritize their children's health even in IPV situations, the role of healthcare providers within national anti-violence networks, and the biases healthcare providers may have when approaching IPV victims.

[Display omitted] • GO-FmocPhe 3 hydrogel composites were synthesized by an enzymatic reverse hydrolysis reaction. • The addition of GO implied a redistribution of the peptides in the composite. • Hydrogel composites did not alter cell viability nor produced inflammatory responses in vitro. Hydrogels based on short peptide molecules are interesting biomaterials with wide present and prospective use in biotechnologies. A well-known possible drawback of these materials can be their limited mechanical performance. In order to overcome this problem, we prepared Fmoc-Phe 3 self-assembling peptides by a biocatalytic approach, and we reinforced the hydrogel with graphene oxide nanosheets. The formulation here proposed confers to the hydrogel additional physicochemical properties without hampering peptide self-assembly. We investigated in depth the effect of nanocarbon morphology on hydrogel properties (i.e. morphology, viscoelastic properties, stiffness, resistance to an applied stress). In view of further developments towards possible clinical applications, we have preliminarily tested the biocompatibility of the composites. Our results showed that the innovative hydrogel composite formulation based on FmocPhe3 and GO is a biomaterial with improved mechanical properties that appears suitable for the development of biotechnological applications. [ABSTRACT FROM AUTHOR]

Simple Summary: The use of oral anticancer agents (OAAs) is increasing, and even more people need to monitor and manage their treatment pathway. A clear map of self-care outcomes studied so far can provide insights for clinical practice and future studies. The study revealed that all included articles considered, as intervention, treatment adherence and, as outcomes, mortality, survival, disease recurrence and quality of life. Adherence to OAA treatment has been found to reduce mortality and increase survival. However, important outcomes such as economic, social or psychological outcomes should be assessed in future studies to provide a complete picture of improvements that can be derived from self-care behaviours. Background/Objectives: The use of oral anticancer agents (OAA) dates to the late 20th century in cancer treatment. It is crucial that patients implement self-care behaviours to keep their disease stable and manage their OAA treatment. The three dimensions of self-care according to Riegel et al., self-care maintenance, self-care monitoring, and self-care management, may be implemented to avoid negative outcomes. This paper seeks to identify outcomes associated with self-care in breast cancer patients during treatment with OAA and to compare which of these outcomes fall into the core outcome categorizations in oncology (minimal set of outcomes that research on a given health issue should measure). Methods: A systematic review with narrative synthesis was conducted. This study included patients with breast cancer taking any kind of OAA and described outcomes of self-care. The search was performed on MEDLINE, Web of Science and CINAHL/PsycINFO; Results: Of 4173 records, eight studies were selected and reviewed. The core outcomes mainly considered were mortality, survival, disease recurrence and quality of life. All studies focused only on pharmacological adherence outcome; none of them focused on other dimensions of self-care. Conclusions: This systematic review highlighted that there is a great lack of research on outcomes related to self-care in patients with breast cancer taking OOA. Even though pharmacological adherence to OAA is important, other behaviours are also important to improve patients' outcomes, but they have not been studied. Further research is needed to study how self-care behaviours can impact patients' outcomes. [ABSTRACT FROM AUTHOR]

Background: In the last two decades, the use of oral anticancer agents (OAAs) has increased in cancer patients. Despite this, patients and their caregivers face some challenging issues (side effects, drug-to-drug interactions, etc.) related to OAA administration. The three dimensions of self-care by Riegel et al., self-care maintenance (i.e., stability of patient condition), self-care monitoring (i.e., detection of side effects), and self-care management (i.e., management of side effects), may be implemented to avoid negative outcomes. However, knowledge of self-care determinants is necessary to recognise people at risk of poor self-care behaviours. Aims: Determine which are the predictors of self-care maintenance, self-care monitoring and self-care management in patients with cancer taking OAA. Methods: A systematic review with narrative synthesis was conducted. We included studies on adult patients with cancer using any kind of oral anticancer agent and describing a predictor of self-care. The search was performed on PubMed, CINAHL/PsycINFO, and Web of Science. Results: Of 3,061 records, 45 studies were included in this review. Forty-six predictors organised into 14 categories were identified. In general, all studies focused only on adherence, considered as a self-care maintenance component, and none of them focused on other dimensions of self-care. The predictors of OAA adherence most reported were age, side effects, and socioeconomic factors (e.g., insurance status, and annual income). Conclusions: This systematic review highlighted the literature gap on the analysis of determinants of self-care behaviours in patients taking OAAs. This element could be a starting point for future research that can provide elements to support the oncology nursing research agenda, aimed at recognising patients at risk of poor self-care. [ABSTRACT FROM AUTHOR]

Introduction Design Method Results Conclusion Clinical relevance The uptake of research evidence on staffing issues in nursing by nursing leadership, management and into organizational policies seems to vary across Europe. This study wants to assess this uptake of research evidence.Scoping survey.The presidents of twelve country specific Sigma Chapters within the European Region answered written survey questions about work organisation, national staffing levels, national skill mix levels, staff characteristics, and education.Seven of the 12 chapters could not return complete data, reported that data was unavailable, there was no national policy or only guidance related to some settings.Enhancing the awareness of nursing research and of nursing leaders and managers regarding staffing level evidence is not enough. It seems necessary to encourage nurse leaders to lobby for staffing policies.Research evidence on staffing issues in nursing and how it benefits health care is available. In Europe this evidence should be used more to lobby for change in staffing policies. [ABSTRACT FROM AUTHOR]

Introduction: The aging of the population requires an appropriate knowledge of the type of care that needs to be provided to inform healthcare policies. In Italy, neither home care nursing, nor the patient experiences have ever been described. Objectives: To describe the characteristics of nurses and care recipients involved in home care. Methods: A descriptive cross‐sectional study conducted in 18 Italian Regions. Between April and October 2023, data from nurses and patients involved in home care were collected through two surveys. Psychosocial conditions in workplaces, missed care, and care experiences were assessed using validated tools. Descriptive statistics and Pearson's correlations were performed. Results: A total of 46 local healthcare units were included in this study, with a total of 2549 nurses and 4709 care recipients. Nurses (mean age 46.60; 79.48% female; 44.68% regional nursing diploma as the highest qualification) reported good working conditions (42.37; SD = 12.25; range = 0–100) and a high mean number of missed care activities (5.11; SD = 3.19; range 0–9). Most nurses (83.41%) reported high levels of job satisfaction, while 20.28% intended to leave their job. Patients (mean age 75.18; 57.57% female; 36.95% primary school), on the other hand, rated positively the care they had received (8.23; range = 0–10). Conclusions: Despite the perception of critical issues at work and some missed care, satisfaction in nurses and patients was high. These data constitute a preliminary snapshot of the studied phenomena, which will be investigated through more in‐depth analyses. [ABSTRACT FROM AUTHOR]

The analysis of the concept of the subject of law and the concept of citizenship presupposes a historical-legal excursus that allows us to understand the birth of two statuses that inevitably refer to the vital concept of person, thus allowing us to understand the transformations to which they have been subjected, from their beginnings to the present day, trying to observe their impact on the European panorama. The law, created by man and constituted ad hoc in its function, is regulated within it by human rights, with the Universal Declaration of Human Rights of 10 December 1948, defined as human goods, which, guaranteed by law, allow personal fulfillment and recognize the protection of the human person. [ABSTRACT FROM AUTHOR]

The stem cell niche at the perivascular space in human tissue plays a pivotal role in dictating the overall fate of stem cells within it. Mesenchymal stem cells (MSCs) in particular, experience influential microenvironmental conditions, which induce specific metabolic profiles that affect processes of cell differentiation and dysregulation of the immunomodulatory function. Reports focusing specifically on the metabolic status of MSCs under the effect of pathophysiological stimuli – in terms of flow velocities, shear stresses or oxygen tension – do not model heterogeneous gradients, highlighting the need for more advanced models reproducing the metabolic niche. Organ-on-a-chip technology offers the most advanced tools for stem cell niche modelling thus allowing for controlled dynamic culture conditions while profiling tuneable oxygen tension gradients. However, current systems for live cell detection of metabolic activity inside microfluidic devices require the integration of microsensors. The presence of such microsensors poses the potential to alter microfluidics and their resolution does not enable intracellular measurements but rather a global representation concerning cellular metabolism. Here, we present a metabolic toolbox coupling a miniaturised in vitro system for human-MSCs dynamic culture, which mimics microenvironmental conditions of the perivascular niche, with high-resolution imaging of cell metabolism. Using fluorescence lifetime imaging microscopy (FLIM) we monitor the spatial metabolic machinery and correlate it with experimentally validated intracellular oxygen concentration after designing the oxygen tension decay along the fluidic chamber by in silico models prediction. Our platform allows the metabolic regulation of MSCs, mimicking the physiological niche in space and time, and its real-time monitoring representing a functional tool for modelling perivascular niches, relevant diseases and metabolic-related uptake of pharmaceuticals. [ABSTRACT FROM AUTHOR]

The nuclear properties of 48Cr composite α-like nuclei produced at 60 MeV of excitation energy via the 24Mg+24Mg reaction were investigated. This excitation energy corresponds to a resonance with a narrow width (170 keV) observed in the elastic and inelastic channels, which was interpreted as a highly deformed state. To gain insight on the deformation of this state exclusive measurements of light charged particles were carried out with 8πLP apparatus at Laboratori Nazionali di Legnaro and compared to statistical model predictions. The measured of α-particle energy spectra, α-evaporation residues, α-α, and α-α-α correlations indicate the limitation of the rotating liquid drop model in describing the nuclear shape of the compound nucleus along the decay cascade. To reproduce the full set of experimental data very elongated nuclear shapes had to be considered, with an axis ratio 3:1 at the resonance angular momentum. This large deformation is consistent with previous findings for α-like nuclei and with the predictions of the cranked cluster model. [ABSTRACT FROM AUTHOR]

Background: The use of intravenous fluid therapy in patients with major trauma in prehospital settings is still controversial. We conducted an umbrella review to evaluate which is the best volume expansion in the resuscitation of a hemorrhagic shock to support the development of major trauma guideline recommendations. Methods: We searched PubMed, Embase, and CENTRAL up to September 2022 for systematic reviews (SRs) investigating the use of volume expansion fluid on mortality and/or survival. Quality assessment was performed using AMSTAR 2 and the Certainty of the evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Results: We included 14 SRs investigating the effects on mortality with the comparisons: use of crystalloids, blood components, and whole blood. Most SRs were judged as critically low with slight overlapping of primary studies and high consistency of results. For crystalloids, inconsistent evidence of effectiveness in 28- to 30-day survival (primary endpoint) was found for the hypertonic saline/dextran group compared with isotonic fluid solutions with moderate certainty of evidence. Pre-hospital blood component infusion seems to reduce mortality, however, as the certainty of evidence ranges from very low to moderate, we are unable to provide evidence to support or reject its use. The blood component ratio was in favor of higher ratios among all comparisons considered with moderate to very low certainty of evidence. Results about the effects of whole blood are very uncertain due to limited and heterogeneous interventions in studies included in SRs. Conclusion: Hypertonic crystalloid use did not result in superior 28- to 30-day survival. Increasing evidence supports the scientific rationale for early use of high-ratio blood components, but their use requires careful consideration. Preliminary evidence is very uncertain about the effects of whole blood and further high-quality studies are required. [ABSTRACT FROM AUTHOR]

The delivery of specific cytokine payloads to a neoplastic environment employing antibodies able to selectively accumulate at the tumor site represents an attractive strategy to stimulate an immune response to cancer. Whilst conventional antibody–cytokine fusions based on a single payload have shown potent anticancer activity, the concomitant delivery of two cytokine payloads may further improve the therapeutic outcome as the immune system typically adopts multiple signals to reinforce an antitumor strategy. We here describe a potency-matched dual-cytokine antibody fusion protein containing a tumor-targeting antibody fragment specific to human fibroblast activation protein (FAP), simultaneously linked to both interleukin-2 (IL2) and a tumor necrosis factor (TNF) mutant. The resulting fusion protein, termed IL2-7NP2-TNFmut, formed stable non-covalent trimers driven by the interaction of the tumor necrosis factor subunits. Both cytokine payloads retained their biological activity within the fusion protein, as shown by in vitro cellular assays. The tumor-targeting properties and the anticancer activity of IL2-7NP2-TNFmut were investigated in vivo in immunocompromised mice bearing SKRC52 cells transduced with human FAP. The fusion protein preferentially localized to the cancer site and induced partial tumor retardation. [ABSTRACT FROM AUTHOR]

We present an experimental/numerical study of a dipolar flow structure in a shallow layer of electrolyte driven by electromagnetic forcing and subjected to background rotation. The aim of this study is to determine the influence of a non-conservative body force on the range of applicability of the classical Ekman boundary layer theory in rapidly rotating systems. To address this question, we study the response of the flow to the three control parameters: the magnitude of the forcing, the rotation rate of the system, and the shallowness of the layer. This response is quantified taking into account the magnitude of the flow velocity (represented by the Reynolds number), the symmetry between both vortex cores, and the vertical profile of the horizontal velocity. As in the case without background rotation, the response of the flow exhibits two scaling regimes (a linear and a nonlinear regime) in which the flow exhibits different vertical profiles of velocity. The transition between the two regimes occurs when the convective acceleration becomes of the same order as the viscous damping. This suggests that the applicability of the Ekman theory depends on the existence of a balance between the forcing and the damping due to the Ekman layers and does not depend solely on the value of the Rossby number as for decaying flows. On the other hand, the cyclone/anticyclone asymmetry is governed exclusively by the Rossby number. [ABSTRACT FROM AUTHOR]

Space missions with humans expose the crews to ionizing radiation, mainly due to the galactic cosmic radiation (GCR). All radiation protection programs in space aim to minimize crews' exposure to radiation. The radiation protection of astronauts can be achieved through the use of shields. The shields could serve as a suit to reduce GCR exposure and, in an emergency, as a radiation shelter to perform necessary interventions outside the space habitat in case of a solar proton event (SPE). A space radiation shielding that is suitable for exploration during space missions requires particular features and a proper knowledge of the radiation type. This study shows the results of numerical simulations performed with the Geant4 toolkit-based code DOSE. Calculations to evaluate the performance of Nomex, an aramidic fiber with high mechanical resistance, in terms of dose reduction to crews, were performed considering the interaction between protons with an energy spectrum ranging from 50 to 1100 MeV and a target slab of 20 g/cm2. This paper shows the properties of secondary products obtained as a result of the interaction between space radiation and a Nomex target and the properties of the secondary particles that come out the shield. The results of this study show that Nomex can be considered a good shield candidate material in terms of dose reductions. We also note that the secondary particles that provide the greatest contribution to the dose are protons, neutrons and, in a very small percentage, α-particles and Li ions. [ABSTRACT FROM AUTHOR]

Background: A structured approach involves systematic management of trauma patients. We aim to conduct an overview of reviews about the clinical efficacy and safety of structured approach (i.e., primary and secondary survey) by guideline checklist compared to non-structured approach (i.e. clinical examination); moreover, routine screening whole-body computer tomography (WBCT) was compared to non-routine WBCT in patients with suspected major trauma. Methods: We systematically searched MEDLINE (PubMed), EMBASE and Cochrane Database of Systematic Reviews up to 3 May 2022. Systematic reviews (SRs) that investigated the use of a structured approach compared to a non-structured approach were eligible. Two authors independently extracted data, managed the overlapping of primary studies belonging to the included SRs and calculated the corrected covered area (CCA). The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results: We included nine SRs investigating two comparisons in stable trauma patients: structured approach vs non-structured approach (n = 1) and routine WBCT vs non-routine WBCT (n = 8). The overlap of included primary studies was generally high across outcomes (CCA ranged between 20.85 and 42.86%) with some discrepancies in the directions of effects across reviews. The application of a structured approach by checklist may improve adherence to guidelines (e.g. Advanced Trauma Life Support) during resuscitation and might lead to a reduction in mortality among severely injured patients as compared to clinical examination (Adjusted OR 0.51; 95% CI 0.30–0.89; p = 0.018; low certainty of evidence). The use of routine WBCT seems to offer little to no effects in reducing mortality and time spent in emergency room or department, whereas non-routine WBCT seems to offer little to no effects in reducing radiation dose, intensive care unit length of stay (LOS) and hospital LOS (low-to-moderate certainty of evidence). Conclusions: The application of structured approach by checklist during trauma resuscitation may improve patient- and process-related outcomes. Including non-routine WBCT seems to offer the best trade-offs between benefits and harm. Clinicians should consider these findings in the light of their clinical context, the volume of patients in their facilities, the need for time management, and costs. [ABSTRACT FROM AUTHOR]

One of the main DevOps practices is the automation of resource provisioning and deployment of complex software. This automation is enabled by the explicit definition of Infrastructure-as-Code (IaC), i.e., a set of scripts, often written in different modeling languages, which defines the infrastructure to be provisioned and applications to be deployed. We introduce the DevOps Modeling Language (DOML), a new Cloud modeling language for infrastructure deployments. DOML is a modeling approach that can be mapped into multiple IaC languages, addressing infrastructure provisioning, application deployment and configuration. The idea behind DOML is to use a single modeling paradigm which can help to reduce the need of deep technical expertise in using different specialized IaC languages. We present the DOML's principles and discuss the related work on IaC languages. Furthermore, the advantages of the DOML for the end-user are demonstrated in comparison with some state-of-the-art IaC languages such as Ansible, Terraform, and Cloudify, and an evaluation of its effectiveness through several examples and a case study is provided. [ABSTRACT FROM AUTHOR]

The system of intermediate fissility 132Ce has been studied experimentally and theoretically to investigate the dissipation properties of nuclear matter. Cross sections of fusion-fission and evaporation-residue channels together with light charged particle multiplicities in both channels, their spectra, light charged particle-evaporation residue angular correlations, and mass-energy distribution of fission fragments have been measured. Theoretical analysis has been performed using a multidimensional stochastic approach coupled with a Hauser-Feshbach treatment of particle evaporation. The main conclusions are that the full one-body shape-dependent dissipation mechanism allows the reproduction of the full set of experimental data and that after a time τd=5×10-21 s from the equilibrium configuration of the compound nucleus, fission decay can occur in a time that can span several orders of magnitude. [ABSTRACT FROM AUTHOR]

A detailed analysis of Lagrangian tracer dispersion is performed on datasets obtained from laboratory experiments that simulate rotating turbulence in the presence of a β effect. Compatible with the limitations of the experimental apparatus, a relatively wide range of the zonostrophy index R β, a parameter used to characterize flow regimes in β-plane turbulence, is explored. The considered range spans from values ~ O(10−1), for which the flow is nearly isotropic, to values ~ O(1), corresponding to the so-called transitional range in which the flow gradually leaves the friction-dominated regime to enter the full zonostrophic regime. The degree of anistropy and the characteristic scales of the flow have been estimated by means of a Lagrangian approach based on the reconstruction of tracer trajectories and on the measure of the finite-scale Lyapunov exponents (FSLE). The FSLE analysis allows one to identify the regimes of two-particle dispersion and to relate them to the physical parameters of the system. Moreover, a Lagrangian anisotropy index (LAI) is introduced and defined in terms of the FSLE zonal and radial components, in order to describe the onset of anisotropy and to check if it is consistent with the theoretical predictions. It is remarkable that the finite-scale dispersion rates are very sensitive to the degree of anistropy of turbulence, more so than other indicators defined in terms of Eulerian quantities. Furthermore, they offer an effective diagnostic tool of the degree of anisotropy that can be used even prior to attaining a fully developed regime of zonostrophic turbulence. [ABSTRACT FROM AUTHOR]

Background: The Caregiver Contribution to Self-Care of Heart Failure (CC-SCHFI) is a theoretically driven instrument to measure the extent to which caregivers support heart failure (HF) patients to perform self-care. The CC-SCHFI measures caregivers' contribution to self-care maintenance and self-care management and caregiver confidence in contributing to heart failure patients' self-care. To date, the CC-SCHFI has never been tested in Spanish-speaking populations. Purpose: To translate the CC-SCHFI from English into Spanish and to test its psychometric characteristics. Method: CC-SCHFI translation and back-translation were performed according to the Beaton et al. methodology. Data from a cross-sectional study conducted in an outpatient clinic in Spain were used for the analysis. Psychometric analysis was performed with exploratory factor analysis (EFA) with oblique rotation. Results: Caregivers had a mean age of 60.5 years (SD 14,9) and the majority were female (85%). Data from 220 caregivers were analyzed. From EFA, using the principal axis factoring method, we extracted two factors in the self-care maintenance subscale ("treatment adherence behaviors" and "symptom control and maintenance behaviors"), two in the self-care monitoring subscale ("illness behaviors" and "prevention behaviors") and one factor for the self-efficacy subscale. The Pearson's rank correlation coefficients between SCHFI and CCSCHFI showed significant correlation in each subdimension. [ABSTRACT FROM AUTHOR]

The dynamic provisioning of virtualized resources offered by cloud computing infrastructures allows applications deployed in a cloud environment to automatically increase and decrease the amount of used resources. This capability is called auto-scaling and its main purpose is to automatically adjust the scale of the system that is running the application to satisfy the varying workload with minimum resource utilization. The need for auto-scaling is particularly important during workload peaks, in which applications may need to scale up to extremely large-scale systems. Both the research community and the main cloud providers have already developed auto-scaling solutions. However, most research solutions are centralized and not suitable for managing large-scale systems, moreover cloud providers' solutions are bound to the limitations of a specific provider in terms of resource prices, availability, reliability, and connectivity. In this paper we propose DEPAS, a decentralized probabilistic auto-scaling algorithm integrated into a P2P architecture that is cloud provider independent, thus allowing the auto-scaling of services over multiple cloud infrastructures at the same time. Our experiments (simulations and real deployments), which are based on real service traces, show that our approach is capable of: (i) keeping the overall utilization of all the instantiated cloud resources in a target range, (ii) maintaining service response times close to the ones obtained using optimal centralized auto-scaling approaches. [ABSTRACT FROM AUTHOR]

Abstract: One-dimensional and three-dimensional dynamical fission calculations based on Langevin equations are performed for the compound nuclei 194Pb, 200Pb, 206Pb, 182Hg, and 204Hg to investigate the influence of the compound nucleus isospin on the prescission particle multiplicities and on the fission fragment mass–energy distribution. It is found that the prescission neutron, proton, and alpha particle multiplicities have approximately the same sensitivity to the dissipation strength for a given nucleus. This is at variance with conclusions of recent papers. The sensitivity of the calculated prescission particle multiplicities to the dissipation strength becomes higher with decreasing isospin of fissioning compound nucleus, and the increase of prescission particle multiplicities could reach 200%, when the reduction coefficient of one-body viscosity increases from 0.1 to 1, for the most neutron deficient nuclei considered. The variances of fission fragment mass and kinetic energy distributions are less sensitive to the change of dissipation strength than the prescission light particle multiplicities. A comparison to experimental data concerning 200Pb nucleus is also presented. [Copyright &y& Elsevier]