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The aim of the present study was to perform the accurate prognosis of different molecular types breast cancer (BC) by using the partitioning calculation method of the Ki-67 index. Partitioning calculation was used to judge the Ki-67 index and the molecular type was classified according to the 2019 Chinese Society of Clinical Oncology guidelines in 199 cases of BC. The association between the Ki-67 index and overall survival (OS), disease-free survival (DFS) and molecular types was analyzed using the Chi-squared test. Survival analysis was performed using the Kaplan-Meier method with statistical SPSS 18.0 software. The results revealed that the 5-year survival rate of patients with BC was 18.60% (8/43), the 6-year survival rate was 38.24% (26/68), while the 10-year survival rate of patients with BC was 73.08% (133/182); the results indicated that almost 80% patients succumbed during the 5 years following diagnosis. Marked differences were found between the OS of patients with BC and the Ki-67 index (between 50 to 54%) (χ2=4.83, P=0.028; χ2=4.60, P=0.032 respectively). All 14 cases of luminal A subtype BC with a Ki-67 index ≤4% survived at the end of follow-up time (69-156 months). At the same time, there was a marked difference between two groups of patients with overexpression HER-2 while using 50% as a cut-off point of Ki-67 (χ2=5.54, P=0.019). On the whole, the present study demonstrates that the partitioning calculation of the Ki-67 index can be used to judge the prognosis of patients with BC accurately. The prognosis of patients with different molecular subtypes of BC may be associated with the different Ki-67 index. [ABSTRACT FROM AUTHOR]