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Layered transition‐metal oxides (NaxTMO2) are one of the most promising cathode materials for sodium‐ion batteries due to their high theoretical specific capacities, good conductivity, and environmental friendliness. However, several key scientific issues of NaxTMO2 cathode materials still persist in practical applications: i) complex phase transitions during the charge/discharge process owing to the slip of the transition‐metal layer; ii) the tendency for the interface to react with the electrolyte, resulting in structure degradation, and iii) reactions between active materials and H2O as well as CO2 on exposure to air in the environment to form alkaline substances on the surface. To understand electrochemical storage mechanisms and solve these problems, several modification strategies of NaxTMO2 have been reported recently, including bulk doping, concentration gradient structure design, interface regulation, and intergrowth structure construction. This review focuses on reversible phase transitions, stable interface regulation, and multifunctional intergrowth structure of the NaxTMO2 material from the inside to the outside. The future research directions for NaxTMO2 are also analyzed, providing guidance for the development of commercial layered oxides for next‐generation energy storage systems. [ABSTRACT FROM AUTHOR]

316 L steel-based human implants play an important role in the biomedical field. In order to address the problem of immune rejection of 316 L steel-based human implants and further improve the machining efficiency, the surface roughness (SR) and hydrophilicity of 316 L workpieces are improved by electrical discharge machining milling (EDM-milling) instead of die-sinking electrical discharge machining (EDM) and by the incorporation of nano hydroxyapatite (NHAP) powder into the dielectric. The effects of powder concentration of NHAP, reference voltage, peak current, pulse width, and pulse interval on the material removal rate (MRR), electrode wear rate (EWR), SR, and contact angle (CA) of 316 L workpiece processed by powder mixed EDM-milling with NHAP (NHAP-PMEDM-milling) are investigated by single-factor experiment, and comparisons are done with the powder mixed die-sinking electrical discharge machining with NHAP (NHAP-PMEDM). According to the results, the MRR, EWR, SR, and CA of 316 L by NHAP-PMEDM-milling are varied regularly with the variation of experiment parameters. The addition of NHAP powder into deionized water (DW) can reduce the CA of the surface of 316 L steel workpiece to a great extent, with a maximum reduction of 27.9%, while affecting MRR, EWR, and SR very little. In addition, NHAP-PMEDM-milling can increase MRR by 115.5% and reduce EWR, SR, and CA by 43.2%, 13.2%, and 15.9%, respectively, compared with NHAP-PMEDM. [ABSTRACT FROM AUTHOR]

Existing separation technologies struggle to recover oil and water concurrently from surfactant-stabilized emulsions to achieve the goal of near-zero liquid discharge. We present a Janus channel of membranes (JCM) that features a confined architecture constructed of a pair of hydrophilic and hydrophobic membranes, which allows for concurrent, highly efficient recovery of oil and water from surfactant-stabilized emulsions. The confined Janus channel can amplify the interplay of the membrane pair through a feedback loop that involves enrichment and demulsification. Our JCM achieves exceptional oil and water recoveries of up to 97 and 75%, respectively, with near 99.9% purities. Moreover, its versatility in handling diverse emulsions may enable near-zero liquid discharge for a range of separations. [ABSTRACT FROM AUTHOR]

AbstractIn the rapidly evolving wireless communication landscape, achieving full-dimensional coverage poses a gamut of challenges such as intricacy, high hardware costs and energy consumption. In addressing these issues, reconfigurable metasurfaces are being considered as a potential solution. However, traditional methods of producing reconfigurable metasurfaces via printed circuit board (PCB) technologies possess limitations such as high cost and extended production cycles. Particularly, in the context of large-scale communication scenarios, reconfigurable metasurfaces can also present high energy consumption issues. Therefore, this paper proposes a novel type of intelligent reflection surface (IRS) characterized by lower production costs, reduced energy consumption, enhanced flexibility, ease of manufacture, and superior electromagnetic wave modulation capabilities. The proposed reconfigurable smart metasurface is a paper-based metasurface printed with conductive ink, which uses conductive ink to draw base metal blocks on a flexible substrate, and uses silver-tin as a metal patch between the metal blocks, and the phase response is reconstructed with silver ink. By adjusting the distribution of these metallic patches, we tailor the phase and amplitude distributions to generate specific scattering effects. This paper presents designs of six patterns that yield single-beam and dual-beam, with experimental results aligning closely with simulated results, validating the feasibility of the proposed method. This low-power, low-cost, and efficient IRS is expected to pave a new path for advanced 5 G/6G wireless communication technologies. [ABSTRACT FROM AUTHOR]

This review explores calixarenes, a prominent family of third-generation supramolecules celebrated for their distinct hollow, cavity-shaped structures. These macrocycles are intricately assembled by linking multiple phenolic units orthogonally through methylene (–CH2–), sulfur (–S–), or sulfonyl (–SO2–) bridges. This structural framework plays a pivotal role in the intricate assembly of nanoclusters, significantly advancing the field of cluster chemistry. A key focus of current research is the remarkable ability of calixarenes to stabilize titanium-oxo clusters. Our review details the application of calixarenes in constructing titanium-oxo cluster structures, emphasizing how these clusters, when encapsulated within calixarenes, exploit flexible coordination sites for structural modifications and serve as foundational units for more complex assemblies. Additionally, we investigate how these calixarene-stabilized metal-oxo clusters function as versatile scaffolds for catalytically active metal ions, facilitating the creation of bimetallic nanoclusters. These clusters not only exhibit unique structural diversity but also demonstrate exceptional catalytic efficiency. This review aims to inspire ongoing exploration and innovation in the use of calixarenes for the synthesis and application of advanced cluster materials. [ABSTRACT FROM AUTHOR]

In this paper, we propose a dynamic authorizable ciphertext image retrieval scheme based on secure neural network inference that effectively enhances the security of image retrieval while preserving privacy. To ensure the privacy of the original image and enable feature extraction without decryption operations, we employ a secure neural network for feature extraction during the index construction stage of encrypted images. Additionally, we introduce a dynamic authenticatable ciphertext retrieval algorithm to enhance system flexibility and security by enabling users to quickly and flexibly retrieve authorized images. Experimental results demonstrate that our scheme guarantees data image privacy throughout the entire process from upload to retrieval compared to similar literature schemes. Furthermore, our scheme ensures data availability while maintaining security, allowing users to conveniently perform image retrieval operations. Although overall efficiency may not be optimal according to experimental results, our solution satisfies practical application needs in cloud computing environments by providing an efficient and secure image retrieval solution. [ABSTRACT FROM AUTHOR]

[Display omitted] • Ultrathin CoNS containing surface oxygen is prepared via in-situ electrochemical reconstruction. • Ultrathin CoNS electrocatalyzed ∼100 % nitrate removal with 99 % ammonia selectivity from low-level nitrate. • Surface oxygen promoted intrinsic activity of ultrathin CoNS for nitrate reduction. • Solar-driven electrolyzer with ultrathin CoNS realized 99.6% total nitrogen removal. Electrocatalytic nitrate removal offers a sustainable approach to alleviate nitrate pollution and to boost the anthropogenic nitrogen cycle, but it still suffers from limited removal efficiency at high rates, especially at low levels of nitrate. Herein, we report the near-complete removal of low-level nitrate (10–200 ppm) within 2 h using ultrathin cobalt-based nanosheets (CoNS) containing surface oxygen, which was fabricated from in-situ electrochemical reconstruction of conventional nanosheets. The average nitrate removal of 99.7 % with ammonia selectivity of 98.2 % in 9 cyclic runs ranked in the best of reported catalysts. Powered by a solar cell under the winter sun, the full-cell nitrate electrolysis system, equipped with ultrathin CoNS, achieved 100 % nitrogen gas selectivity and 99.6 % total nitrogen removal. The in-situ Fourier Transform Infrared included experiments and theoretical computations revealed that in-situ electrochemical reconstruction not only increased electrochemical active surface area but also constructed surface oxygen in active sites, leading to enhanced stabilization of nitrate adsorption in a symmetry breaking configuration and charge transfer, contributing to near-complete nitrate removal on ultrathin CoNS. This work provides a strategy to design ultrathin nanocatalysts for nitrate removal. [ABSTRACT FROM AUTHOR]

Vascular calcification (VC) arises from the accumulation of calcium salts in the intimal or tunica media layer of the aorta, contributing to higher risk of cardiovascular events and mortality. Despite this, the mechanisms driving VC remain incompletely understood. We previously described that nesfatin-1 functioned as a switch for vascular smooth muscle cells (VSMCs) plasticity in hypertension and neointimal hyperplasia. In this study, we sought to investigate the role and mechanism of nesfatin-1 in VC. The expression of nesfatin-1 was measured in calcified VSMCs and aortas, as well as in patients. Loss- and gain-of-function experiments were evaluated the roles of nesfatin-1 in VC pathogenesis. The transcription activation of nesfatin-1 was detected using a mass spectrometry. We found higher levels of nesfatin-1 in both calcified VSMCs and aortas, as well as in patients with coronary calcification. Loss-of-function and gain-of-function experiments revealed that nesfatin-1 was a key regulator of VC by facilitating the osteogenic transformation of VSMCs. Mechanistically, nesfatin-1 promoted the de-ubiquitination and stability of BMP-2 via inhibiting the E3 ligase SYTL4, and the interaction of nesfatin-1 with BMP-2 potentiated BMP-2 signaling and induced phosphorylation of Smad, followed by HDAC4 phosphorylation and nuclear exclusion. The dissociation of HDAC4 from RUNX2 elicited RUNX2 acetylation and subsequent nuclear translocation, leading to the transcription upregulation of OPN, a critical player in VC. From a small library of natural compounds, we identified that Curculigoside and Chebulagic acid reduced VC development via binding to and inhibiting nesfatin-1. Eventually, we designed a mass spectrometry-based DNA-protein interaction screening to identify that STAT3 mediated the transcription activation of nesfatin-1 in the context of VC. Overall, our study demonstrates that nesfatin-1 enhances BMP-2 signaling by inhibiting the E3 ligase SYTL4, thereby stabilizing BMP-2 and facilitating the downstream phosphorylation of SMAD1/5/9 and HDAC4. This signaling cascade leads to RUNX2 activation and the transcriptional upregulation of MSX2, driving VC. These insights position nesfatin-1 as a potential therapeutic target for preventing or treating VC, advancing our understanding of the molecular mechanisms underlying this critical cardiovascular condition. [ABSTRACT FROM AUTHOR]

Remanufacturing has become one of the most important research topics in the manufacturing industry as it can effectively save costs, reduce environmental pollution and extend the lifecycle of products. The correct selection of remanufacturing mode is the key for enterprise. Previous studies usually constructed game models from the dynamic changes of single influencing factors, which may ignore the influence of interests among decision makers (DMs) and DMs' non-cooperative behavior under group decision-making circumstances. The non-cooperative behavior processing method that comprehensively considers multiple-attribute and group consensus to help enterprise to select the correct remanufacturing mode is a subject worthy of study. In this paper, we first propose the concept of fuzzy distributed preference relation. It combines the fuzzy set theory and DPR, which is more suitable to express fuzzy and uncertain assessments in complex decision situations. Then, a consensus reaching model to analyze non-cooperative behaviors is proposed. The non-cooperative degrees on attribute, alternative and individual levels are constructed to identify and manage non-cooperative behaviors of DMs. Thirdly, DM's reliability measurement method is proposed based on the consensus reaching model, and a suitable decision support procedure of remanufacturing mode selection is constructed. Finally, a case study of remanufacturing mode selection is provided to illustrate the effectiveness and validity of the proposed method. [ABSTRACT FROM AUTHOR]

We investigated fasting hypertriglyceridemia as predictors of all‐cause, cardiovascular, and non‐cardiovascular mortality in an elderly male Chinese population, while accounting for various conventional cardiovascular risk factors. Our participants were elderly men recruited from residents living in a suburban town of Shanghai (≥60 years of age, n = 1583). Hypertriglyceridemia was defined as a fasting serum triglycerides concentration ≥1.70 mmol/L. Subgroup analyses were performed according to current smoking (yes vs. no), alcohol intake (yes vs. no), and the presence and absence of hypertension and hyperglycemia. During a median of 7.9 years follow‐up, all‐cause, cardiovascular, and non‐cardiovascular deaths occurred in 279, 112, and 167 participants, respectively. After adjustment for confounding factors, fasting hypertriglyceridemia was not significantly (p ≥.33) associated with the risk of all‐cause, cardiovascular, and non‐cardiovascular mortality. However, there was significant (p =.03) interaction between hypertriglyceridemia and the presence and absence of hypertension in relation to all‐cause mortality. In normotensive, but not hypertensive individuals, hypertriglyceridemia was significantly associated with a higher risk of all‐cause mortality (hazard ratio 1.57, 95% confidence interval 1.06–2.31). In further non‐parametric analyses in normotensive individuals, the age‐standardized rate for all‐cause mortality increased from 18.9 in quartile 1 to 20.0, to 24.7, and to 39.9 per 1000 person‐years in quartiles 2, 3, and 4 of serum triglycerides concentration, respectively (ptrend =.0004). Similar results were observed for cardiovascular mortality. Our study in elderly male Chinese showed that fasting hypertriglyceridemia was associated with a higher risk of all‐cause and cardiovascular mortality in patients with normotension but not those with hypertension. [ABSTRACT FROM AUTHOR]

A new three‐dimensional (3D) coordination polymer, namely, poly[diaqua[μ5‐2,2′‐(1,3,5,7‐tetraoxo‐1,2,3,5,6,7‐hexahydropyrrolo[3,4‐f]isoindole‐2,6‐diyl)diacetato]barium(II)], [Ba(C14H6N2O8)(H2O)2]n, (I), has been synthesized by the microwave‐irradiated reaction of Ba(NO3)2 with N,N′‐bis(glycinyl)pyromellitic diimide {BGPD, namely, 2,2′‐(1,3,5,7‐tetraoxo‐1,2,3,5,6,7‐hexahydropyrrolo[3,4‐f]isoindole‐2,6‐diyl)diacetatic acid, H2L}. The title compound was structurally characterized by single‐crystal X‐ray diffraction analysis and powder X‐ray diffraction analysis, as well as IR spectroscopy. In the crystal structure of (I), the BaII ion is nine‐coordinated by six carboxylate O atoms from five symmetry‐related L2− dianions and one imide O atom, as well as two water O atoms. The coordination geometry of the central BaII ion can be described as a spherical capped square antiprism. One carboxylate group of the ligand serves as a μ3‐bridge linking the BaII cations into a one‐dimensional polynuclear secondary building unit (SBU). Another carboxylate group of the ligand acts as a μ2‐bridge connecting the 1D SBUs, thereby forming a two‐dimensional (2D) SBU. The resulting 2D SBUs are extended into a 3D framework via the pyromellitic diimide moiety of the ligand as a spacer. The 3D Ba framework can be simplified as a 5‐connected hexagonal boron nitride net (bnn) topology. The intermolecular interactions in the 3D framework were further investigated by Hirshfeld surface analysis and the results show that the prominent interactions are H...O (45.1%), Ba...O (11.1%) and C...H (11.1%), as well as H...H (11.1%) contacts. The thermal stability, photoluminescence properties and UV–Vis absorption spectra of (I) were also investigated. The coordination polymer exhibits a fluorescence emission with a quantum yield of 0.071 and high thermal stability. [ABSTRACT FROM AUTHOR]

Elastomers with high strength and toughness, excellent self-healing properties, and biocompatibility have broad application prospects in wearable electronics and other fields, but preparing it remains a challenge. In this work, we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine (TEA) to the poly thioctic acid (PTA) chains and preparing the PAxEy elastomers using a simple synthesis step. This strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks, endowing materials with excellent strength and toughness (tensile strength of 288 kPa, toughness of 278.2 kJ/m3), admirable self-healing properties (self-healing efficiency of 121.6% within 7 h at 70 °C), and good biocompatibility. The PAxEy elastomers can also be combined with MWNTs to become flexible strain sensors, which can be used to monitor human joint movements with high sensitivity, repeatable responses, and stability. [ABSTRACT FROM AUTHOR]

A Gram-stain-negative, short rod-shaped strain, MDT2-1-1T, was isolated from cryoconite samples collected from the Midui glacier in Tibet, China. It grew aerobically from 7 to 40 °C, within a pH range of 6.0–10.0, and in NaCl concentration of 0 to 1.0% (w/v). The pairwise 16S rRNA gene sequence similarity, average nucleotide identity and digital DNA-DNA hybridization values between strains MDT2-1-1T and Sabulicella rubraurantiaca SYSU D01096T were 99.4%, 89.7% and 38.9%, respectively. Considering the results from phylogeny, phenotypic and genotypic data, strain MDT2-1-1T (=CGMCC 1.11170T = NBRC 110485T) was suggested to represent a novel species of the genus Sabulicella, for which the name Sabulicella glaciei sp. nov. is proposed. Furthermore, based on the phylogenomic analysis, it is recommended that Roseomonas rubea, Roseomonas ponticola and Roseomonas oleicola be reclassified as Neoroseomonas rubea comb. nov., Falsiroseomonas ponticola comb. nov. and Falsiroseomonas oleicola comb. nov., respectively. Considering the illegitimate status of the genera names Pararoseomonas and Pseudoroseomonas, the species within the genera Pararoseomonas and Pseudoroseomonas should be transferred to Muricoccus and Teichococcus, respectively. Therefore, we proposed the following new combinations: Muricoccus aeriglobus comb. nov., Muricoccus aerilatus comb. nov., Muricoccus harenae comb. nov., Muricoccus nepalensis comb. nov., Muricoccus pecuniae comb. nov., Muricoccus radiodurans comb. nov., Muricoccus vinaceus comb. nov., Teichococcus aerofrigidensis comb. nov., Teichococcus aerophilus comb. nov., Teichococcus aestuarii comb. nov., Teichococcus cervicalis comb. nov., Teichococcus coralli comb. nov., Teichococcus deserti comb. nov., Teichococcus globiformis comb. nov., Teichococcus hibiscisoli comb. nov., Teichococcus musae comb. nov., Teichococcus oryzae comb. nov., Teichococcus rhizosphaerae comb. nov., Teichococcus ruber comb. nov., Teichococcus suffuscus comb. nov., Teichococcus vastitatis comb. nov., and Teichococcus wenyumeiae comb. nov. [ABSTRACT FROM AUTHOR]

In this study, we dynamically monitored the glomerular filtration rate and other assessment of renal function and markers of injury in various mice models of acute kidney injury. Male C57BL/6 mice were utilized to establish acute kidney injury models of sepsis, ischemia reperfusion, cisplatin, folic acid, aristolochic acid and antibiotic. In addition to the real time glomerular filtration rate, renal LCN-2 and HAVCR-1 mRNA expression levels, and serum creatinine, urea nitrogen and cystatin c levels were also used to evaluate renal function. In addition, the protein levels of LCN-2 and HAVCR-1 in renal, serum and urine were measured. Our results demonstrated that the changes in biomarkers always lagged the real time glomerular filtration rate during the progression and recovery of renal injury. Cystatin-c can reflect renal injury earlier than other markers, but it remains higher in the recovery stage. Perhaps the glomerular filtration rate does not reflect the greater injury caused by vancomycin plus piperacillin. [ABSTRACT FROM AUTHOR]

The core-shell structure is crucial for enhancing the electrochemical and electrocatalytic performance of supercapacitor electrode materials. To maximize the potential of NiCo 2 O 4 as an electrode material, this study combines NiCo 2 O 4 with CoFe-LDH. Forming a NiCo 2 O 4 @CoFe LDH core-shell structured electrode material. Using NF as the substrate, NiCo 2 O 4 @CoFe-LDH electrode materials are prepared via a hydrothermal method. The phase structure and microstructure of the electrode material are investigated through X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), and transmission electron microscope (TEM) analyses. The electrode materials undergo electrochemical and electrocatalytic tests using an electrochemical workstation. This study shows that the NiCo 2 O 4 @CoFe-LDH achieves a specific capacitance of 5384.47 mF cm−2 at 1 mA cm−2. After assembling the NiCo 2 O 4 @CoFe-LDH electrode material into a supercapacitor, it exhibits an excellent energy density. Both the power density and the energy density are 758.17 μW cm−2 and 55.81 μWh cm−2, respectively. As an electrocatalyst, the NiCo 2 O 4 @CoFe-LDH electrode material also demonstrates excellent performance. The overpotential is 183 mV at 20 mA cm−2 in Hydrogen Evolution Reaction (HER). Furthermore, the NiCo 2 O 4 @CoFe-LDH electrode material demonstrates outstanding performance in overall water splitting. The voltage is 1.7 V at 25 mA cm−2, which shows strong cyclic stability. This material provides a reliable guarantee for the continuous and stable operation of various application scenarios. • The NiCo 2 O 4 @CoFe-LDH composite electrode is synthesized via hydrothermal-calcination method. • The NiCo 2 O 4 @CoFe-LDH achieves a high specific capacitance of 5384.47 mF cm−2 at 1 mA cm−2. • The capacitance retention of the assembled NiCo 2 O 4 @CoFe-LDH//AC after 10,000 cycles is close to 70%. • Performing HER testing on NiCo 2 O 4 @CoFe-LDH. The overpotential is 183 mV at 20 mA cm−2. [ABSTRACT FROM AUTHOR]

Carbon nanotube fibers (CNTFs) are considered an ideal candidate as next‐generation conducting wires due to their high conductivity and low density. However, the orientation and compaction of the nanotubes in a CNTF need to be further improved to achieve even higher conductivity and ampacity. Here the fabrication of double‐wall CNTFs (DWCNTFs) is reported by a dry‐jet wet spinning method, which significantly improves the orientation and compaction of the carbon nanotubes (CNTs). As a result, the obtained DWCNTFs have a record high electrical conductivity of 1.1 × 107 S m−1 and ampacity of 8.0 × 108 A m−2. The fibers also have a high tensile strength of 1.65 GPa and a toughness of 130.9 MJ m−3, among the highest for wet‐spun CNTFs. The DWCNTFs preserve their integrity and conductivity after more than 5000 bending cycles. Theoretical calculations indicate that in a dry‐jet wet‐spinning process, gravity promotes the orientation of the CNTs along the axial direction of the fiber. [ABSTRACT FROM AUTHOR]

Two-dimensional (2D) ferromagnetic and antiferromagnetic second-order topological insulators (SOTIs) coexisting with valley polarization have received increasing attention recently, while 2D valley-polarized ferrimagnetic (ferri-valley) SOTI has not been reported yet. In this work, we propose an effective six-band tight-binding model based on structural symmetry to confirm the possibility of coexistence of ferrimagnetism, second-order topological corner states, and valley polarization in 2D systems, and predict Mo2CSCl monolayer as the robust 2D ferri-valley SOTI with good structural stability, considerable Curie temperature estimated to be 100 K, and distinct valley polarization up to 109 meV under out-of-plane exchange field based on our model and first-principles calculations. Also, we find that the spin polarization direction of corner states combined with valley polarization can be controlled by switching the direction of the magnetization direction using an external magnetic field. These findings of the combination of intrinsic ferrimagnetism, second-order topological properties, and valley polarization in single 2D materials provide an ideal platform for practical applications in multifield-control spintronic devices. [ABSTRACT FROM AUTHOR]

The digital competence of TVET (technical and vocational education and training) teacher is the key to the digital development of TVET. Improving the digital competence of TVET teachers is of great significance to accelerate the digital transformation process of TVET. However, there are still few researches on digital competence of TVET. The aim of this study is to describe the self-cognition of digital competence of Chinese teachers for TVET. For this purpose, based on the development characteristics of China's TVET, a standard system for digital competence of TVET teachers in China was established, including digital mindset and attitude, digital knowledge and skills, digital education and teaching, digital care and support, and digital collaboration and development. Based on this, an assessment tool was developed to investigate the current situation of competence of 2,514 in-service TVET teachers in China. The results show that the competency system is an effective tool to measure the digital competence of Chinese TVET teachers, and other internal and external factors except gender have different degrees of influence on the digital competence of teachers. According to the results of this study, different suggestions are put forward to train the digital competence of TVET teachers. [ABSTRACT FROM AUTHOR]

Neurodevelopmental disorders are currently one of the major complications faced by patients with congenital heart disease (CHD). Chronic hypoxia in the prenatal and postnatal preoperative brain may be associated with neurological damage and impaired long-term cognitive function, but the exact mechanisms are unknown. In this study, we find that delayed neuronal migration and impaired synaptic development are attributed to altered Atoh1 under chronic hypoxia. This is due to the fact that excessive Atoh1 facilitates expression of Kif21b, which causes excess in free-state α-tubulin, leading to disrupted microtubule dynamic stability. Furthermore, the delay in neonatal brain maturation induces cognitive disabilities in adult mice. Then, by down-regulating Atoh1 we alleviate the impairment of cell migration and synaptic development, improving the cognitive behavior of mice to some extent. Taken together, our work unveil that Atoh1 may be one of the targets to ameliorate hypoxia-induced neurodevelopmental disabilities and cognitive impairment in CHD. Atoh1 hinders neuronal dendritic branching, cell migration and long-term cognitive functions by modulating Kif21b to disrupt microtubule's dynamic stability under perinatal chronic hypoxia. [ABSTRACT FROM AUTHOR]

New stimulus‐responsive scaffolds are of interest as constituents of hierarchical supramolecular ensembles. 1,3,5–2,4,6‐Functionalized, facially segregated benzene moieties have a time‐honored role as building blocks for host molecules. However, their user as switchable motifs in the construction of multi‐component supramolecular structures remains poorly explored. Here, we report a molecular cage 1, which consists of a bent anthracene dimer 3 paired with 1,3,5‐tris(aminomethyl)‐2,4,6‐triethylbenzene 2. As the result of the pH‐induced ababab↔bababa isomerization of the constituent‐functionalized benzene units derived from 2, this cage can reversibly convert between an open state and a closed form, both in solution and in the solid state. Cage 1 was used to create stimuli‐responsive hierarchical superstructures, namely Russian doll‐like complexes with [K⊂18‐crown‐6⊂1]+ and [K⊂cryptand‐222⊂1]+. The reversible assembly and disassembly of these superstructures could be induced by switching cage 1 from its open to closed form. The present study thus provides an unusual example where pH‐triggered conformation motion within a cage‐like scaffold is used to control the formation and disassociation of hierarchical ensembles. [ABSTRACT FROM AUTHOR]

New stimulus‐responsive scaffolds are of interest as constituents of hierarchical supramolecular ensembles. 1,3,5–2,4,6‐Functionalized, facially segregated benzene moieties have a time‐honored role as building blocks for host molecules. However, their user as switchable motifs in the construction of multi‐component supramolecular structures remains poorly explored. Here, we report a molecular cage 1, which consists of a bent anthracene dimer 3 paired with 1,3,5‐tris(aminomethyl)‐2,4,6‐triethylbenzene 2. As the result of the pH‐induced ababab↔bababa isomerization of the constituent‐functionalized benzene units derived from 2, this cage can reversibly convert between an open state and a closed form, both in solution and in the solid state. Cage 1 was used to create stimuli‐responsive hierarchical superstructures, namely Russian doll‐like complexes with [K⊂18‐crown‐6⊂1]+ and [K⊂cryptand‐222⊂1]+. The reversible assembly and disassembly of these superstructures could be induced by switching cage 1 from its open to closed form. The present study thus provides an unusual example where pH‐triggered conformation motion within a cage‐like scaffold is used to control the formation and disassociation of hierarchical ensembles. [ABSTRACT FROM AUTHOR]

The paper was to investigate the effects of sunflower straw replacing corn stover on the digestive performance, lactation performance, rumen fermentation indexes, and serum biochemical indexes of dairy cows. Eighty Chinese Holstein cows with no significant differences in parity, body weight, and milk yield were selected and randomly divided into four groups of 20 replicates each, with each head as a replicate. The control group was fed a basal diet, and unflower straw in the experimental groups was replaced with 20% (Group I), 50% (Group II), and 100% (Group III) corn stover in the basal diet, respectively. The experiment lasted for 100 days, including 10 days of pre-test and 90 days of formal experiment. The results showed that compared with the control group, the dry matter intake of the three experimental groups was significantly increased (P<0.05), the apparent digestibility of dry matter was significantly increased (P<0.05), the apparent digestibility of crude protein in all experimental groups was extremely increased (P<0.01). The somatic cell count in the milk of Group II was significantly reduced (P<0.05), the microbial protein content in Group III was significantly decreased (P<0.05). GroupsII and III showed a significant increase in the levels of total protein and albumin in serum at 60 and 90 days (P<0.05). The production efficiency of Group I increased by 4.51 yuan/head per day. The study shows that replacing corn stover with 20% sunflower stalks can increase dairy cows' feed intake, improve digestion and absorption of nutrients, and improve milk production and quality, with no adverse effects on the rumen environment and liver and kidney function, and with better economic benefits. [ABSTRACT FROM AUTHOR]

Background: The ectopic superior parathyroid in the tracheoesophageal groove and paraesophageal region is rare. Hyperparathyroidism results when these glands become hyperfunctioning. That may necessitate surgical intervention in the form of parathyroidectomy, which requires a transsternal or transthoracic approach due to a deeply seated mediastinal parathyroid gland. Minimally invasive strategies have emerged recently as an alternative approach with less morbidity. Case presentation: We present a case of the paraesophageal ectopic parathyroid gland in the superior posterior mediastinum, which was successfully treated with thoracoscopic resection. Conclusion: The current imaging tools improve the thoracoscopic management of mediastinal parathyroid glands. Video-assisted thoracoscopic surgery (VATS) can provide access and exposure to ectopic parathyroid adenoma with low morbidity and financial burden. [ABSTRACT FROM AUTHOR]

Objective: Advancements in neuroimaging technologies have significantly deepened our understanding of the neural physiopathology associated with stroke. Nevertheless, the majority of studies ignored the characteristics of dynamic changes in brain networks. The relationship between dynamic changes in brain networks and the severity of motor dysfunction after stroke needs further investigation. From the perspective of multilayer network module reconstruction, we aimed to explore the dynamic reorganization of the brain and its relationship with motor function in subcortical stroke patients. Methods: We recruited 35 healthy individuals and 50 stroke patients with unilateral limb motor dysfunction (further divided into mild-moderate group and severe group). Using dynamic multilayer network modularity analysis, we investigated changes in the dynamic modular reconfiguration of brain networks. Additionally, we assessed longitudinal clinical scale changes in stroke patients. Correlation and regression analyses were employed to explore the relationship between characteristic dynamic indicators and impairment and recovery of motor function, respectively. Results: We observed increased temporal flexibility in the Default Mode Network (DMN) and decreased recruitment of module reconfiguration in the Attention Network (AN), Sensorimotor Network (SMN), and DMN after stroke. We also observed reduced module loyalty following stroke. Additionally, correlation analysis showed that hyper-flexibility of the DMN was associated with better lower limb motor function performance in stroke patients with mild-to-moderate impairment. Regression analysis indicated that increased flexibility within the DMN and decreased recruitment coefficient within the AN may predict good lower limb function prognosis in patients with mild to moderate motor impairment. Conclusions: Our study revealed more frequent modular reconfiguration and hyperactive interaction of brain networks after stroke. Notably, dynamic modular remodeling was closely related to the impairment and recovery of motor function. Understanding the temporal module reconfiguration patterns in multilayer networks after stroke can provide valuable information for more targeted treatments. [ABSTRACT FROM AUTHOR]

Background and Purpose: The benefit of remote ischaemic conditioning (RIC) in acute moderate ischaemic stroke has been demonstrated by the Remote Ischaemic Conditioning for Acute Moderate Ischaemic Stroke (RICAMIS) study. This prespecified exploratory analysis aimed to determine whether there was a difference of RIC efficacy in anterior versus posterior circulation stroke based on RICAMIS data. Methods: In this analysis, eligible patients presenting within 48 h of stroke onset were divided into two groups: anterior circulation stroke (ACS) and posterior circulation stroke (PCS) groups. The primary endpoint was an excellent functional outcome, defined as a modified Rankin Scale (mRS) score 0–1 at 90 days. Results: In all, 1013 patients were included in the final analysis, including 642 with ACS and 371 with PCS. Compared with the control group, RIC was significantly associated with an increased proportion of mRS scores 0–1 within 90 days in the PCS group (unadjusted odds ratio 1.6, 95% confidence interval 1.0–2.4, p = 0.04; adjusted odds ratio 2.0, 95% confidence interval 1.2–3.3, p = 0.005), but not in the ACS group (p = 0.29). Similar results were found regarding secondary outcomes including mRS score 0–2 at 90 days, mRS distribution at 90 days and change in National Institutes of Health Stroke Scale score at day 12 from baseline. However, there was no significant interaction effect between stroke location and intervention on the primary outcome (pinteraction = 0.21). Conclusion: Amongst patients with acute PCS who are not candidates for reperfusion treatment, RIC may be associated with a higher probability of improved functional outcomes. These findings need to be validated in prospective trials. [ABSTRACT FROM AUTHOR]

Context: Coix [Coix lacryma-jobi L. var. mayuen (Roman.) Stapf (Poaceae)], a crop of medicinal and edible significance, contains coixol, which has demonstrated anticancer properties. however, the limited solubility of coixol restricts its potential therapeutic applications. Objective: this study prepared a water-soluble coixol-β-cyclodextrin polymer (CDP) inclusion compound and evaluated its anticancer effect. Materials and methods: the coixol-CDP compound was synthesized through a solvent-stirring and freeze-drying technique. its coixol content was quantified using HPLC, and its stability was tested under various conditions. the anticancer effects of the coixol-CDP compound (4.129, 8.259, 16.518, and 33.035 mg/L for 24, 48, and 72 h) on the proliferation of non-small cell lung cancer (NSCLC) a549 cells were evaluated using an MTT assay; cell morphology was examined by hoechst nuclear staining; apoptosis and cell cycle was detected by flow cytometry; and the expression of apoptosis-related proteins was assessed by Western blots. Results: the water-soluble coixol-CDP inclusion compound was successfully prepared with an inclusion ratio of 86.6% and an inclusion yield rate of 84.1%. the coixol content of the compound was 5.63% and the compound remained stable under various conditions. compared to coixol alone, all 24, 48, and 72 h administrations with the coixol-CDP compound exhibited lower IC50 values (33.93 ± 2.28, 16.80 ± 1.46, and 6.93 ± 0.83 mg/L) in a549 cells; the compound also showed stronger regulatory effects on apoptosis-related proteins. Discussion and conclusions: these findings offer a new perspective for the potential clinical application of Coix in NSCLC therapy and its future research. [ABSTRACT FROM AUTHOR]

The nonreciprocity between two signal fields is regarded as a key function in future quantum networks and modern communication technologies. Here, we theoretically propose a scheme of nonreciprocal devices between signal fields in two different arbitrarily frequency domains in a hybrid cavity opto-electromechanical system. The model consists of a microwave cavity and an optical cavity, respectively, coupled with two different mechanical oscillators, which are coupled together by the tunable Coulomb interaction and driven by the external electrical fields. We study the nonreciprocal response between two different frequency fields. Nonreciprocal transmission is based on multichannel quantum interference to break time-reversal symmetry. The perfect nonreciprocity is shown in the certain conditions. By adjusting the Coulomb interaction, the phase differences, and strength of the electrically driven fields on the mechanical oscillators, we find that nonreciprocity can be modulated and even transformed into perfect nonreciprocity and reciprocity. These results provide a new insight into the design of nonreciprocal devices and present the potential applications in quantum information processing and quantum networks. [ABSTRACT FROM AUTHOR]

Electrocatalytic water splitting, powered by clean energy sources, represents a sustainable method for hydrogen (H2) production. Although extensive research has concentrated on performance indicators like current density and faradaic efficiency, the widespread adoption of electrocatalytic water splitting encounters challenges primarily due to high cell voltages and electricity costs. These issues stem from the sluggish kinetics of the anodic oxygen evolution reaction (OER). Various efforts to replace sluggish OER with thermodynamically more favorable anodic reactions have been demonstrated as pathbreaking strategies for energy‐efficient H2 evolution. In this concept, we aim to comprehensively explore alternative electrochemical oxidation reactions combined with H2 evolution and propose insights for the future development of cost‐effective integrated electrolysis for H2 production. [ABSTRACT FROM AUTHOR]

The self-supported Co–Fe LDH@Ni(OH)2 material is successfully prepared on a foam nickel substrate through two hydrothermal processes. The phase structure and microstructure of the electrode material are investigated through X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), and transmission electron microscope (TEM) analyses. The electrode materials undergo electrochemical and electrocatalytic tests using an electrochemical workstation. This study demonstrates that the specific capacitance of the Co–Fe LDH@Ni(OH)2 is 2626 mF cm−2 at 1 mA cm−2. Supercapacitors made of LDH@Ni(OH)2 electrode material operate exceptionally well. Both the power density and the energy density are 0.755 mW cm−2 and 32.5 μWh cm−2, respectively. As a catalyst material for electrochemical splitting of water, CoFe-LDH@Ni(OH)2 exhibits distinguished electrocatalytic properties. The overpotential is 242 mV at 50 mA cm−2 in HER, while that is 149 mV at 20 mA cm−2 in OER. Meanwhile, the CoFe-LDH@Ni(OH)2 electrocatalytic material also performs extremely well in the overall water electrolysis testing. The voltage is 1.65 V at 25 mA cm−2, which shows strong cyclic stability. The material provides a reliable guarantee for sustained and stable operation in various application scenarios. [ABSTRACT FROM AUTHOR]

Cobalt‐free and spinel LiNi0.5Mn1.5O4 (LNMO) cathodes commonly suffer from undesirable solvent decomposition, serious transition‐metal dissolution, and unstable cathode electrolyte interphase (CEI) layers, incurring rapid capacity decay at high voltages and low temperatures. Herein, these issues are well addressed by utilizing fluorinated solvents with a low coordination number and ethyl propionate with a low melting point. A Li2CO3/LiF‐rich heterostructured CEI layer, which possesses good electron blocking capability of LiF, fast Li+ transport kinetics of Li2CO3 and good mechanical stability, is generated by the synergistic decomposition of hybrid solvents. The robust, homogeneous, and well‐balanced CEI layers subsequently prevent catalyzed parasitic side reactions, prohibit transition‐metal dissolution, and ensure fast interfacial reaction kinetics crossover to the LNMO cathode, thus improving its cycling stability. Consequently, the LNMO cathode delivers a high‐capacity retention of 95.8% over 500 cycles at 25 °C and 97.5% after 180 cycles at −20 °C. This work provides an encouraging alternative to design the high‐voltage and low‐temperature electrolyte for pushing the ongoing research to stabilize Co‐free LNMO materials toward practical applications. [ABSTRACT FROM AUTHOR]

Seeking high‐performance photoresists is an important item for semiconductor industry due to the continuous miniaturization and intelligentization of integrated circuits. Polymer resin containing carbonate group has many desirable properties, such as high transmittance, acid sensitivity and chemical formulation, thus serving as promising photoresist material. In this work, a series of aqueous developable CO2‐sourced polycarbonates (CO2‐PCs) were produced via alternating copolymerization of CO2 and epoxides bearing acid‐cleavable cyclic acetal groups in the presence of tetranuclear organoborane catalyst. The produced CO2‐PCs were investigated as chemical amplification resists in deep ultraviolet (DUV) lithography. Under the catalysis of photogenerated acid, the acetal (ketal) groups in CO2‐PC were hydrolysed into two equivalents of hydroxyl groups, which change the exposed area from hydrophobicity to hydrophilicity, thus enabling the exposed area to be developed with water. Through normalized remaining thickness analysis, the optimal CO2‐derived resist achieved a remarkable sensitivity of 1.9 mJ/cm2, a contrast of 7.9, a favorable resolution (750 nm, half pitch), and a good etch resistance (38 % higher than poly(tert‐butyl acrylate)). Such performances outperform commercial KrF and ArF chemical amplification resists (i.e. polyhydroxystyrene‐derived and polymethacrylate‐based resists), which endows broad application prospects in the field of DUV (KrF and ArF) and extreme ultraviolet (EUV) lithography for nanomanufacturing. [ABSTRACT FROM AUTHOR]

Seeking high‐performance photoresists is an important item for semiconductor industry due to the continuous miniaturization and intelligentization of integrated circuits. Polymer resin containing carbonate group has many desirable properties, such as high transmittance, acid sensitivity and chemical formulation, thus serving as promising photoresist material. In this work, a series of aqueous developable CO2‐sourced polycarbonates (CO2‐PCs) were produced via alternating copolymerization of CO2 and epoxides bearing acid‐cleavable cyclic acetal groups in the presence of tetranuclear organoborane catalyst. The produced CO2‐PCs were investigated as chemical amplification resists in deep ultraviolet (DUV) lithography. Under the catalysis of photogenerated acid, the acetal (ketal) groups in CO2‐PC were hydrolysed into two equivalents of hydroxyl groups, which change the exposed area from hydrophobicity to hydrophilicity, thus enabling the exposed area to be developed with water. Through normalized remaining thickness analysis, the optimal CO2‐derived resist achieved a remarkable sensitivity of 1.9 mJ/cm2, a contrast of 7.9, a favorable resolution (750 nm, half pitch), and a good etch resistance (38 % higher than poly(tert‐butyl acrylate)). Such performances outperform commercial KrF and ArF chemical amplification resists (i.e. polyhydroxystyrene‐derived and polymethacrylate‐based resists), which endows broad application prospects in the field of DUV (KrF and ArF) and extreme ultraviolet (EUV) lithography for nanomanufacturing. [ABSTRACT FROM AUTHOR]

Due to their excellent biocompatibility and biodegradability, aliphatic polyesters are widely used in the biomedical, packaging and agricultural fields, which are usually accessed by the ring-opening polymerization (ROP) of lactones and the catalysts particularly play an important role. Herein a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and characterized. In combination with 7-methyl-1, 5, 7-triazabicyclo[4,4,0]dec-5-ene (MTBD) as a cocatalyst and benzyl alcohol (BnOH) as an initiator, 1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea (3-QU) was observed to be most active for the ROP of δ-valerolactone (δ-VL). The polymerization conditions were optimized by varying the type of organic base, catalyst concentration and reaction temperature. By changing the ratio of [M]0/[I], linear polyvalerolactones (PVLs) with different molecular weights and narrow molecular weight distribution were prepared. The kinetic and chain extension experiments were carried out to prove the "living"/controllable feature. And the NMR experiments were used to support the proposal of possible mechanism. [ABSTRACT FROM AUTHOR]

The diversity of cyclodextrins and their derivatives is increasing with continuous research. In addition to monomolecular cyclodextrins with different branched chains, cyclodextrin-based polymers have emerged. The aim of this review is to summarize these innovations, with a special focus on the study of applications of cyclodextrins and their derivatives in nano-delivery systems. The areas covered include nanospheres, nano-sponges, nanogels, cyclodextrin metal–organic frameworks, liposomes, and emulsions, providing a comprehensive and in-depth understanding of the design and development of nano-delivery systems. [ABSTRACT FROM AUTHOR]

To investigate the etiology, pathogens, treatment, and prognosis of endogenous endophthalmitis (EE). Patients diagnosed with EE over three decades at Peking Union Medical College Hospital were retrospectively reviewed and analyzed. A total of 97 eyes from 81 patients were included. Diabetes was the most common predisposing medical condition (34.6%). Klebsiella pneumoniae (31.3%) and Candida albicans (32.8%) were the most common pathogens. Liver abscess (20.6%) was the predominant cause EE due to liver abscess had a worse initial visual acuity (P < 0.05). Patients who initially underwent pars plana vitrectomy (PPV)+silicone oil tamponade underwent fewer total treatments (P < 0.05). In the past 10 years, the proportion of Gram-positive cocci, Gram-negative bacilli, and Candida showed an upward trend. Over the past 15 years, EE after liver abscess and immunosuppression has increased, while EE from genitourinary systems has decreased. EE was a devastating intraocular disease with a poor visual prognosis. The initial condition and prognosis of EE after liver abscess were the worst. PPV+silicone oil tamponade as an initial treatment may reduce additional therapy. [ABSTRACT FROM AUTHOR]

Central nervous system Infections (CNSIs) is a disease characterized by complex pathogens, rapid disease progression, high mortality rate and high disability rate. Here, we evaluated the clinical value of metagenomic next generation sequencing (mNGS) in the diagnosis of central nervous system infections and explored the factors affecting the results of mNGS. We conducted a retrospective study to compare mNGS with conventional methods including culture, smear and etc. 111 suspected CNS infectious patients were enrolled in this study, and clinical data were recorded. Chi-square test were used to evaluate independent binomial variables, taking p < 0.05 as statistically significant threshold. Of the 111 enrolled cases, 57.7% (64/111) were diagnosed with central nervous system infections. From these cases, mNGS identified 39.6% (44/111) true-positive cases, 7.2% (8/111) false-positive case, 35.1% (39/111) true-negative cases, and 18.0% (20/111) false-negative cases. The sensitivity and specificity of mNGS were 68.7% (44/64) and 82.9% (39/47), respectively. Compared with culture, mNGS provided a higher pathogen detection rate in CNSIs patients (68.7% (44/64) vs. 26.5% (17/64), p < 0.0001). Compared to conventional methods, positive percent agreement and negative percent agreement was 84.60% (44/52) and 66.1% (39/59) separately. At a species-specific read number (SSRN) ≥ 2, mNGS performance in the diagnosis of definite viral encephalitis and/or meningitis was optimal (area under the curve [AUC] 0.758, 95% confidence interval [CI] 0.663–0.854). In bacterial CNSIs patients with significant CSF abnormalities (CSF WBC > 300*106/L), the positive rate of CSF mNGS is higher. To sum up, conventional microbiologic testing is insufficient to detect all neuroinvasive pathogens, and mNGS exhibited satisfactory diagnostic performance in CNSIs and with an overall detection rate higher than culture (p < 0.0001). [ABSTRACT FROM AUTHOR]

We reported hitherto the most extensive isomeric, interconversion and decomposition landscape of the pentanitrogen cation (N5+) at the CCSD(T)_CBS//MP2/cc-pVTZ, CBS-QB3 and CCSD(T)_CBS//CCSD/cc-pVTZ levels. A maximum number of eleven isomers and fourteen transition states were located, among which three and eight were reported for the first time. Moreover, the counterion stabilisation effect by the model BF4− anion as well as the solvation effect in anhydrous HF solvent at different temperatures were investigated. Notably, although 01 is rather well known, a new type of N2-extrusion process for the 01 salt (with BF4− counterion) was identified. [ABSTRACT FROM AUTHOR]

Key points The central histaminergic system has a pivotal role in emotional regulation and psychiatric disorders, including anxiety, depression and schizophrenia. However, the effect of histamine on neuronal activity of the centrolateral amygdala (CeL), an essential node for fear and anxiety processing, remains unknown. Here, using immunostaining and whole‐cell patch clamp recording combined with optogenetic manipulation of histaminergic terminals in CeL slices prepared from histidine decarboxylase (HDC)‐Cre rats, we show that histamine selectively suppresses excitatory synaptic transmissions, including glutamatergic transmission from the basolateral amygdala, on both PKC‐δ‐ and SOM‐positive CeL neurons. The histamine‐induced effect is mediated by H3 receptors expressed on VGLUT1‐/VGLUT2‐positive presynaptic terminals in CeL. Furthermore, optoactivation of histaminergic afferent terminals from the hypothalamic tuberomammillary nucleus (TMN) also significantly suppresses glutamatergic transmissions in CeL via H3 receptors. Histamine neither modulates inhibitory synaptic transmission by presynaptic H3 receptors nor directly excites CeL neurons by postsynaptic H1, H2 or H4 receptors. These results suggest that histaminergic afferent inputs and presynaptic H3 heteroreceptors may hold a critical position in balancing excitatory and inhibitory synaptic transmissions in CeL by selective modulation of glutamatergic drive, which may not only account for the pathophysiology of psychiatric disorders but also provide potential psychotherapeutic targets. Histamine selectively suppresses the excitatory, rather than inhibitory, synaptic transmissions on both PKC‐δ‐ and SOM‐positive neurons in the centrolateral amygdala (CeL). H3 receptors expressed on VGLUT1‐ or VGLUT2‐positive afferent terminals mediate the suppression of histamine on glutamatergic synaptic transmission in CeL. Optogenetic activation of hypothalamic tuberomammillary nucleus (TMN)–CeL histaminergic projections inhibits glutamatergic transmission in CeL via H3 receptors. [ABSTRACT FROM AUTHOR]

Homogeneous electrocatalysts can indirect oxidate the high overpotential substrates through single‐electron transfer on the electrode surface, enabling efficient operation of organic electrosynthesis catalytic cycles. However, the problems of this chemistry still exist such as high dosage, difficult recovery, and low catalytic efficiency. Single‐atom catalysts (SACs) exhibit high atom utilization and excellent catalytic activity, hold great promise in addressing the limitations of homogeneous catalysts. In view of this, we have employed Fe‐SA@NC as an advanced redox mediator to try to change this situation. Fe‐SA@NC was synthesized using an encapsulation‐pyrolysis method, and it demonstrated remarkable performance as a redox mediator in a range of reported organic electrosynthesis reactions, and enabling the construction of various C−C/C−X bonds. Moreover, Fe‐SA@NC demonstrated a great potential in exploring new synthetic method for organic electrosynthesis. We employed it to develop a new electro‐oxidative ring‐opening transformation of cyclopropyl amides. In this new reaction system, Fe‐SA@NC showed good tolerance to drug molecules with complex structures, as well as enabling flow electrochemical syntheses and gram‐scale transformations. This work highlights the great potential of SACs in organic electrosynthesis, thereby opening a new avenue in synthetic chemistry. [ABSTRACT FROM AUTHOR]

Homogeneous electrocatalysts can indirect oxidate the high overpotential substrates through single‐electron transfer on the electrode surface, enabling efficient operation of organic electrosynthesis catalytic cycles. However, the problems of this chemistry still exist such as high dosage, difficult recovery, and low catalytic efficiency. Single‐atom catalysts (SACs) exhibit high atom utilization and excellent catalytic activity, hold great promise in addressing the limitations of homogeneous catalysts. In view of this, we have employed Fe‐SA@NC as an advanced redox mediator to try to change this situation. Fe‐SA@NC was synthesized using an encapsulation‐pyrolysis method, and it demonstrated remarkable performance as a redox mediator in a range of reported organic electrosynthesis reactions, and enabling the construction of various C−C/C−X bonds. Moreover, Fe‐SA@NC demonstrated a great potential in exploring new synthetic method for organic electrosynthesis. We employed it to develop a new electro‐oxidative ring‐opening transformation of cyclopropyl amides. In this new reaction system, Fe‐SA@NC showed good tolerance to drug molecules with complex structures, as well as enabling flow electrochemical syntheses and gram‐scale transformations. This work highlights the great potential of SACs in organic electrosynthesis, thereby opening a new avenue in synthetic chemistry. [ABSTRACT FROM AUTHOR]

Purpose: The study object was to determine the relationship between leptin and diabetes. Methods: We searched for the literature on the relationship between leptin and diabetes from PubMed, EMBASE, Cochrane Library, and CNKI databases. We carried out the meta‐analysis by calculating the Std. Mean Difference (SMD) and 95% confidence intervals (CIs) to study the relationship between leptin and diabetes. We performed the Chi‐square‐based Q test and I2 statistics to evaluate the potential heterogeneity, and the sensitivity analysis was performed to evaluate the stability of our results. Moreover, Begg's test was performed to evaluate the publication bias. Results: There are 10 studies in this study for meta‐analysis, which include 1879 patients (diabetic (n = 1024); and nondiabetic patients (n = 855)). The results indicated that the levels of serum leptin were significantly increased in patients with diabetes (SMD = 1.78, 95% CI [0.81, 2.76]), especially those with gestational diabetes mellitus compared with controls (SMD = 3.03, 95% CI [1.21, 4.86]). However, the results showed that there was no difference in serum leptin levels between type 2 diabetes and controls (SMD = 0.34, 95% CI [−1.06, 1.74]). Conclusions: Our analysis indicated that the levels of serum leptin were significantly elevated in patients with diabetes especially those with gestational diabetes mellitus compared with controls. [ABSTRACT FROM AUTHOR]

The pathogenesis of Alzheimer's disease (AD) remains unclear, but revealing individual differences in functional connectivity (FC) may provide insights and improve diagnostic precision. A hierarchical clustering-based autoencoder with functional connectivity was proposed to categorize 82 AD patients from the Alzheimer's Disease Neuroimaging Initiative. Compared to directly performing clustering, using an autoencoder to reduce the dimensionality of the matrix can effectively eliminate noise and redundant information in the data, extract key features, and optimize clustering performance. Subsequently, subtype differences in clinical and graph theoretical metrics were assessed. Results indicate a significant inter-subject heterogeneity in the degree of FC disruption among AD patients. We have identified two neurophysiological subtypes: subtype I exhibits widespread functional impairment across the entire brain, while subtype II shows mild impairment in the Limbic System region. What is worth noting is that we also observed significant differences between subtypes in terms of neurocognitive assessment scores associations with network functionality, and graph theory metrics. Our method can accurately identify different functional disruptions in subtypes of AD, facilitating personalized treatment and early diagnosis, ultimately improving patient outcomes. [ABSTRACT FROM AUTHOR]

The oxidative esterification of aldehydes under mild conditions remains a significant challenge. This study introduces a unique defective UiO-66 to achieve gold nanoclusters (AuNCs) for efficient aldehyde oxidation under mild conditions. The construction and characterization of these materials are thoroughly investigated by techniques of XRD, SEM and TEM images, FT-IR, Raman, and XPS spectrum, emphasizing the unique microporous in defective UiO-66 are conducive to the fabrication of AuNCs. The catalytic performance of the prepared materials in aldehyde oxidation reactions is systematically evaluated, demonstrating the remarkable efficiency of dispersed Au@UiO-66-25 with high-content (9.09 wt%) Au-loading and ultra-small size (~2.7 nm). Moreover, mechanistic insights into the catalytic process under mild conditions (70 °C for 1 h) are provided, elucidating the determination of defective UiO-66 in the confined fabrication of AuNCs and subsequent furfural adsorption, which underlie the principles governing the observed enhancements. This study establishes the groundwork for the synthesis of highly dispersed and catalytically active metal nanoparticles using defective MOFs as a platform, advancing the catalytic esterification reaction of furfural to the next level. [ABSTRACT FROM AUTHOR]

Diabetic corneal neuropathy (DCN) is a common diabetic ocular complication with limited treatment options. In this study, we investigated the effects of topical and oral fenofibrate, a peroxisome proliferator-activated receptor-α agonist, on the amelioration of DCN using diabetic mice (n = 120). Ocular surface assessments, corneal nerve and cell imaging analysis, tear proteomics and its associated biological pathways, immuno-histochemistry and western blot on PPARα expression, were studied before and 12 weeks after treatment. At 12 weeks, PPARα expression markedly restored after topical and oral fenofibrate. Topical fenofibrate significantly improved corneal nerve fibre density (CNFD) and tortuosity coefficient. Likewise, oral fenofibrate significantly improved CNFD. Both topical and oral forms significantly improved corneal sensitivity. Additionally, topical and oral fenofibrate significantly alleviated diabetic keratopathy, with fenofibrate eye drops demonstrating earlier therapeutic effects. Both topical and oral fenofibrate significantly increased corneal β-III tubulin expression. Topical fenofibrate reduced neuroinflammation by significantly increasing the levels of nerve growth factor and substance P. It also significantly increased β-III-tubulin and reduced CDC42 mRNA expression in trigeminal ganglions. Proteomic analysis showed that neurotrophin signalling and anti-inflammation reactions were significantly up-regulated after fenofibrate treatment, whether applied topically or orally. This study concluded that both topical and oral fenofibrate ameliorate DCN, while topical fenofibrate significantly reduces neuroinflammation. [ABSTRACT FROM AUTHOR]

In recent years, spatial transcriptomics (ST) research has become a popular field of study and has shown great potential in medicine. However, there are few bibliometric analyses in this field. Thus, in this study, we aimed to find and analyze the frontiers and trends of this medical research field based on the available literature. A computerized search was applied to the WoSCC (Web of Science Core Collection) Database for literature published from 2006 to 2023. Complete records of all literature and cited references were extracted and screened. The bibliometric analysis and visualization were performed using CiteSpace, VOSviewer, Bibliometrix R Package software, and Scimago Graphica. A total of 1467 papers and reviews were included. The analysis revealed that the ST publication and citation results have shown a rapid upward trend over the last 3 years. Nature Communications and Nature were the most productive and most co-cited journals, respectively. In the comprehensive global collaborative network, the United States is the country with the most organizations and publications, followed closely by China and the United Kingdom. The author Joakim Lundeberg published the most cited paper, while Patrik L. Ståhl ranked first among co-cited authors. The hot topics in ST are tissue recognition, cancer, heterogeneity, immunotherapy, differentiation, and models. ST technologies have greatly contributed to in-depth research in medical fields such as oncology and neuroscience, opening up new possibilities for the diagnosis and treatment of diseases. Moreover, artificial intelligence and big data drive additional development in ST fields. Spatial transcriptomics (ST) technologies and application prospects. (1) Imaging-based approaches, including in situ sequencing (ISS)—where transcripts are amplified and sequenced in tissue—and ISH-based approaches—where imaging probes are sequentially hybridized in tissue. (2) NGS-based techniques, in which positional information is encoded onto transcripts prior to NGS sequencing. [ABSTRACT FROM AUTHOR]

Lime is widely used for soft ground treatment, rendering the compressibility of lime-treated soil a crucial factor in deformation analysis in engineering applications. This study investigated the compressibility of three remoulded lime-treated slurries with high water content in Southeast China. Sixty groups of oedometer tests were conducted on lime-treated soils with an initial water content of 1 to 3 times the liquid limit and lime contents between 1 and 3%. The oedometer test results were discussed to examine the remoulded yield stress σ y ′ of lime-treated slurry. Considering the relationships between σ y ′ , the void ratio, lime content, and initial water content were preliminarily discussed and quantitatively established. Research on the normalised compression curve of lime-treated soil revealed that for soil samples containing a lime content of 0–%, the normalised compression curve at σ p ′ > σ y ′ can be represented by a unique line. Furthermore, the log(1 + e) − log σ v ′ compression curve of lime-treated slurry at pre-yield state is analysed, and a prediction method for the modified compression index is proposed. [ABSTRACT FROM AUTHOR]

This experiment was conducted to study the effects of Astragalus polysaccharide (APS) on intestinal antioxidant capacity, immunity, structural integrity, and permeability of hybrid crucian carp (control group, Astragalus polysaccharide stress group (APs), and salt and alkali stress group (SAs)) under saline-alkali environment. The results showed that the CAT activity, MDA activity, and total antioxidant capacity in the APs group was significantly higher than that in the control group (P < 0.05). At 6 h, the activity of intestinal GPX in the SAs group was significantly higher than that in the control group and APs group (P < 0.05). At 48h, the activity of C3 in the APs group was significantly higher than that in the control group (P < 0.05). At 24 h, the content of C4 in the APs group was significantly higher than that in the control group (P < 0.05). At 72 h, the ACP and the AKP activity in the APs group and the SAs group was significantly higher than that in the control group (P < 0.05). Inflammatory cells infiltrated the folds in both the APs and SAs groups. At 72 h, the gene expression levels of claudin 7, claudin 12, claudin c, and ZO-1 in the APs group and SAs group were significantly higher than those in the control group (P < 0.05). At 72 h, the expression of inflammation-related genes in the APs group and SAs group was significantly higher than that in the control group (P < 0.05). In conclusion, APS, as an additive, can alleviate the damage of intestinal physical barrier and immune barrier caused by salt-alkali stress to hybrid crucian carp, including up-regulation of genes for inhibiting inflammation and tight junction and alleviating oxidative stress, thus maintaining the integrity of intestinal structure. [ABSTRACT FROM AUTHOR]

Objectives: To systematically analyze the accuracy of robotic surgery for dental implant placement. Materials and Methods: PubMed, Embase, and Cochrane CENTRAL were searched on October 25, 2023. Model studies or clinical studies reporting the accuracy of robotic surgery for dental implant placement among patients with missing or hopeless teeth were included. Risks of bias in clinical studies were assessed. Meta‐analyses were undertaken. Results: Data from 8 clinical studies reporting on 109 patients and 242 implants and 13 preclinical studies were included. Positional accuracy was measured by comparing the implant plan in presurgery CBCT and the actual implant position in postsurgery CBCT. For clinical studies, the pooled (95% confidence interval) platform deviation, apex deviation, and angular deviation were 0.68 (0.57, 0.79) mm, 0.67 (0.58, 0.75) mm, and 1.69 (1.25, 2.12)°, respectively. There was no statistically significant difference between the accuracy of implants placed in partially or fully edentulous patients. For model studies, the pooled platform deviation, apex deviation, and angular deviation were 0.72 (0.58, 0.86) mm, 0.90 (0.74, 1.06) mm, and 1.46 (1.22, 1.70)°, respectively. No adverse event was reported. Conclusion: Within the limitation of the present systematic review, robotic surgery for dental implant placement showed suitable implant positional accuracy and had no reported obvious harm. Both robotic systems and clinical studies on robotic surgery for dental implant placement should be further developed. [ABSTRACT FROM AUTHOR]

One of the most effective strategies for modifying the surface properties of nano-fillers and enhancing their composite characteristics is through polymer grafting. In this study, a coprecipitation method was employed to modify hydroxyapatite (HAP) with epoxidized soybean oleic acid (ESOA), resulting in ESOA-HAP. Subsequently, oligomeric poly(lactic acid) (OPLA) was grafted onto the surface of ESOA-HAP, yielding OPLA-ESOA-HAP. HAP, ESOA-HAP, and OPLA-ESOA-HAP were comprehensively characterized. The results demonstrate the progressive grafting of ESOA and OPLA onto the surface of HAP, resulting in enhanced hydrophobicity and improved dispersity in organic solvent for OPLA-ESOA-HAP compared to HAP. The vitality and adhesion of Wistar rat mesenchymal stem cells (MSCs) were assessed using HAP and modified HAP materials. Following culture with MSCs for 72 h, the OPLA-ESOA-HAP showed an inhibition rate lower than 23.0% at a relatively high concentration (1.0 mg/mL), which is three times lower compared to HAP under similar condition. The cell number for OPLA-ESOA-HAP was 4.5 times higher compared to HAP, indicating its superior biocompatibility. Furthermore, the mechanical properties of the OPLA-ESOA-HAP/PLLA composite almost remained unaltered ever after undergoing two stages of thermal processing involving melt extrusion and inject molding. The increase in the biocompatibility and relatively high mechanical properties render OPLA-ESOA-HAP/PLLA a potential material for the biodegradable fixation system. [ABSTRACT FROM AUTHOR]

P- and S-wave separation plays an important role in elastic reverse-time migration. It can reduce the artifacts caused by crosstalk between different modes and improve image quality. In addition, P- and Swave separation can also be used to better understand and distinguish wave types in complex media. At present, the methods for separating wave modes in anisotropic media mainly include spatial nonstationary filtering, low-rank approximation, and vector Poisson equation. Most of these methods require multiple Fourier transforms or the calculation of large matrices, which require high computational costs for problems with large scale. In this paper, an efficient method is proposed to separate the wave mode for anisotropic media by using a scalar anisotropic Poisson operator in the spatial domain. For 2D problems, the computational complexity required by this method is 1/2 of the methods based on solving a vector Poisson equation. Therefore, compared with existing methods based on pseudo-Helmholtz decomposition operators, this method can significantly reduce the computational cost. Numerical examples also show that the P and S waves decomposed by this method not only have the correct amplitude and phase relative to the input wavefield but also can reduce the computational complexity significantly. [ABSTRACT FROM AUTHOR]