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2 results on '"Wenwen, Hu"'

1. Probability Density Functions of the Net Charge Transfer of Saltating Particles in Sand Flux.

Author

Wenwen Hu and Li Xie

Subjects
*PROBABILITY density function, *CHARGE transfer, *FLUX (Metallurgy), *PARTICLE size determination, *COLLISIONS (Physics)
Abstract

We present a model depicting the probability density function of the net charge transfer of the rebound saltating particles from the sand bed in sand-bed collision process. Using DEM simulation, the sand-bed collision process is simulated, and the difference of the contact areas between two collision particles is obtained. The net charge transfer of the rebound saltating particle is related to five variables, such as the particle sizes of both saltating particles and particles in sand bed, the incident velocity and incident angle of the saltating particle, and the contact angle. The probability density functions of the net charge transfer of the rebound saltating particle about five-random variables and two-random variables are demonstrated in this study. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Acid Denaturation Inducing Self-Assembly of Curcumin-Loaded Hemoglobin Nanoparticles.

Author

Kaikai Wang, Juan Wang, Wenwen Hu, Yifan Zhang, Feng Zhi, Zaigang Zhou, Jinhui Wu, and Yiqiao Hu

Subjects
*HEMOGLOBINS, *NANOPARTICLES, *DRUG carriers, *MOLECULAR self-assembly, *HYDROPHOBIC interactions, *THERAPEUTICS
Abstract

Hemoglobin is a promising drug carrier but lacks extensive investigation. The chemical conjugation of hemoglobin and drugs is costly and complex, so we have developed curcumin-loaded hemoglobin nanoparticles (CCM-Hb-NPs) via self-assembly for the first time. Using the acid-denaturing method, we avoid introducing denaturants and organic solvents. The nanoparticles are stable with uniform size. We have conducted a series of experiments to examine the interaction of hemoglobin and CCM, including hydrophobic characterization, SDS-PAGE. These experiments substantiate that this self-assembly process is mainly driven by hydrophobic forces. Our nanoparticles achieve much higher cell uptake efficiency and cytotoxicity than free CCM solution in vitro. The uptake inhibition experiments also demonstrate that our nanoparticles were incorporated via the classic clathrin-mediated endocytosis pathway. These results indicate that hemoglobin nanoparticles formed by self-assembly are a promising drug delivery system for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2015
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