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ABSTRACT Enhanced recovery after surgery (ERAS) pathways have been shown to improve patient outcomes, increase patient satisfaction, and decrease costs. First created and implemented in the adult population, these pathways are now commonplace and continue to expand in the pediatric realm. While there are many proven benefits to ERAS pathways, there continue to be challenges to their proper implementation and long‐term success. This article aims to explore common challenges in pediatric ERAS development and implementation, along with strategies to avoid potential pitfalls. Key themes include departmental and institutional support, stakeholder engagement, awareness of pathways, data management and dissemination, and long‐term maintenance including Plan‐Do‐Study‐Act (PDSA) cycles. Pathway development teams should be aware of these considerations and potential pitfalls, and focusing on them can promote long‐term success for a well‐designed pathway. [ABSTRACT FROM AUTHOR]

The enstatite chondrite class is known to have complex thermal histories, often interpreted to include impact melting and shock metamorphism. Highly equilibrated (type 6) EH group enstatite chondrites are rare and thought to have formed through collisional heating. We studied two EH6 chondrites, NWA 7976 and NWA 12945, for their textural, chemical, and mineralogical characteristics. The samples we studied contain subhedral to anhedral grains of enstatite and plagioclase, suggesting solid‐state recrystallization. They show low degrees of shock and no evidence of shock melting. Additionally, the ubiquitous occurrence of daubréelite exsolution lamellae in troilite and the Ni content of schreibersite suggest slow cooling at greater burial depths in the parent body, rather than rapid cooling as a result of an impact event. Based on the characteristics and scarcity of type 6 EH chondrites, and the ubiquitous shock effects and melt rocks in the enstatite chondrite class, we conclude that the unshocked NWA 7976 and NWA 12945 were formed by heat derived from impact melt sheets, analogous to contact metamorphism. [ABSTRACT FROM AUTHOR]

This study examines the characteristics of patients with giant cell arteritis (GCA), the utilization of imaging in GCA diagnosis, and variations in GCA management among specialties. Subjects were identified from the Dallas VAMC database spanning 2010 to 2021 using ICD-9/10 codes for GCA and polymyalgia rheumatica, and a list of temporal artery biopsies (TAB). Patients lacking sufficient data to meet the ACR 1990 classification criteria for GCA were excluded. Categorical variables were compared using Fisher's exact test. Continuous variables were analyzed with the Kruskal–Wallis test. Among 209 identified patients, 41 were excluded due to insufficient data for ACR classification. The cohort comprised 91.9% males with a median age of 69. Of the remaining 168 patients, 42 received a final diagnosis of GCA, and 15 of these were confirmed with a positive TAB. The most reported initial symptoms were visual disturbances (75.5%) and headaches (67.7%). Ophthalmology was the initial physician for 46% of patients. GCA correlated with co-existing autoimmune diseases, glucocorticoid-sparing treatments, and consultation with a rheumatologist (p < 0.05). There were no significant differences in clinical features or management of the positive and negative TAB GCA groups. GCA presents with heterogeneous symptoms making diagnosis challenging. Scalp tenderness and headaches were significantly higher in GCA patients, but sub-group analysis revealed no significant differences among GCA patients. Vascular assessments and adjunct imaging modalities are underutilized. The establishment of multidisciplinary or fast-track clinics may enhance the optimization of GCA management. Key Points • The most common presenting symptoms were blurry vision/visual loss (75.5%), headache (67.7%), and scalp tenderness (35.9%) in descending order. • In sub-group analysis, no significant differences were found between GCA sub-groups, but when compared to the non-GCA group, were found to have significantly higher rates of headache and scalp tenderness. • Compared to other specialties, rheumatologists were more likely to use advanced imaging, and to prescribe glucocorticoid-sparing treatments. • Systematic and comprehensive assessment and multidisciplinary approach could improve diagnosis and management. [ABSTRACT FROM AUTHOR]

One often learns the opinions of others without getting to hear the evidence behind them. How should you revise your own opinions in such cases? Dietrich (2010) shows that, for opinions about objective chance, the method known as upco effectively adds your interlocutor's evidence to your own. We provide a simple way of viewing upco that makes properties like Dietrich's easy to appreciate, and we do three things with it. First, we unify Dietrich's motivation for upco with another motivation due to Easwaran et al. (2016). Second, we show that laypeople can sometimes use upco to resolve expert disagreements. And third, we use it to cricitize the social argument for the uniqueness thesis. [ABSTRACT FROM AUTHOR]

Anxiety is highly prevalent, but undertreated, in primary care. Brief, non-pharmacological interventions are needed. Modular Anxiety Skills Training (MAST), a cognitive-behavioral anxiety intervention, was developed for primary care and tailored for a Veteran sample (MAST-V). The purpose of this mixed methods pilot study was to evaluate MAST-V's feasibility, acceptability, and implementation potential, and preliminarily examine its effectiveness compared to Primary Care Behavioral Health (PCBH) usual care. This hybrid I randomized controlled trial (conducted 2019–2021) assigned 35 primary care patients (M age = 47, 17 % female, 27 % racial/ethnic minority) with clinically significant anxiety symptoms to receive MAST-V or PCBH usual care. Participants completed validated measures of anxiety symptoms and functional impairment at 0, 4, 8, 12, and 16 weeks. Participants attended more sessions in MAST-V than usual care. After necessary adjustments to reduce session duration, MAST-V will likely fit within PCBH practice parameters. Participants in both conditions valued treatment, but treatment satisfaction, credibility, and therapeutic alliance were higher for MAST-V. Study therapists achieved high treatment fidelity and rated MAST-V as highly feasible, acceptable, and appropriate for PCBH. They identified ways to address potential barriers to implementation. MAST-V was more effective than usual care in reducing anxiety symptoms and impairment. This was a small pilot study at a single site using study therapists. Results should be considered preliminary until replicated in a full-scale clinical trial. This brief modular anxiety intervention, which was designed with implementation in mind, may help to address the anxiety treatment gap in primary care. • Brief nonpharmacological anxiety interventions feasible in primary care are needed. • We conducted a pilot RCT of a modular cognitive-behavioral anxiety intervention. • The intervention was feasible and highly acceptable for patients and therapists. • Clinical outcomes improved more than with usual care (primarily supportive therapy). • The intervention's potential for implementation in routine primary care is high. [ABSTRACT FROM AUTHOR]

The objective of this study was to develop a U-net capable of generating highly accurate 3D models of knee bones, in particular the femur. As part of the approach, a U-net was designed, trained, and validated. In order to achieve these goals, a novel architecture was proposed, including an architecture that reduces encoder parameters and incorporates transfer learning, in order to enhance the attention U-net. Additionally, an extra depth layer was added to extract more salient information. Moreover, the model includes a classifier unit to reduce false positives, as well as a Tversky focal loss function, which is an innovative loss function. The proposed architecture achieved a Dice coefficient of 98.05. By using these enhanced tools, clinicians can visualize and analyze knee structures more accurately, improve surgical intervention effectiveness, and improve patient care quality overall. [ABSTRACT FROM AUTHOR]

Type 3 chondrites are subdivided into 3.0–3.9. Subtype 3.0 chondrites nearly preserve all of their primitive features. Many criteria have been proposed to distinguish such primitive chondrites. Here, we compiled mineral data and reconsider the petrologic classification criteria for subtype 3.0. Chondrites are classified into subtypes by the minor element distribution of olivine and textural and chemical features of Fe‐Ni metal. The []Si4O8 and MgO components of feldspar also distinguish subtype 3.0 from subtypes ≥3.1. Other features, such as the occurrence of near pure chromite, are also indicators of subtype 3.0. It is difficult to distinguish between subtypes 3.0 and ≤2.9 based on mineral chemistry. Therefore, we propose the following criteria to distinguish between subtypes 3.0 and ≤2.9. In type 3.0 chondrites, major silicate (olivine, pyroxene, and plagioclase), oxide, metal, and sulfide minerals do not show aqueous alteration features. Melilite, anorthite, and glass show no or mild aqueous alteration features. Subtype 3.0 has not been identified in all chondrite groups. The absence of subtype 3.0 from some groups mainly reflects differences in the degrees of secondary parent body processes among the chondrite groups. [ABSTRACT FROM AUTHOR]

Spatial navigation is more difficult and effortful for older than younger individuals, a shift which occurs for a variety of neurological, physical, and cognitive reasons associated with aging. Despite a large body of evidence documenting age-related deficits in spatial navigation, comparatively less research addresses how to facilitate more effective navigation behavior for older adults. Since navigation challenges arise for a variety of reasons in old age, a one-size-fits-all solution is unlikely to work. Here, we introduce a framework for the variety of spatial navigation challenges faced in aging, which we call LOST-Location, Orientation, Spatial mapping, and Transit. The LOST framework builds on evidence from the cognitive neuroscience of spatial navigation, which reveals distinct components underpinning human wayfinding. We evaluate research on navigational aids--devices and depictions--which help people find their way around; and we reflect on how navigation aids solve (or fail to solve) specific wayfinding difficulties faced by older adults. In summary, we emphasize a bespoke approach to improving spatial navigation in aging, which focuses on tailoring navigation solutions to specific navigation challenges. Our hope is that by providing precise support to older navigators, navigation opportunities can facilitate independence and exploration, while minimizing the danger of becoming lost. We conclude by delineating critical knowledge gaps in how to improve older adults' spatial navigation capacities that the novel LOST framework could guide to address. [ABSTRACT FROM AUTHOR]

Anthropogenic warming is altering species abundance, distribution, physiology, and more. How changes observed at the species level alter emergent community properties is an active and urgent area of research. Trait‐based ecology and regime shift theory provide complementary ways to understand climate change impacts on communities, but these two bodies of work are only rarely integrated. Lack of integration handicaps our ability to understand community responses to warming, at a time when such understanding is critical. Therefore, we advocate for merging trait‐based ecology with regime shift theory. We propose a general set of principles to guide this merger and apply these principles to research on marine communities in the rapidly warming North Atlantic. In our example, combining trait distribution and regime shift analyses at the community level yields greater insight than either alone. Looking forward, we identify a clear need for expanding quantitative approaches to collecting and merging trait‐based and resilience metrics in order to advance our understanding of climate‐driven community change. [ABSTRACT FROM AUTHOR]

Ehlers-Danlos syndrome comprises 13 hereditary connective tissue disorders associated with skin hyperelasticity, joint hypermobility, atrophic scarring, and blood vessel fragility. Hypermobile EDS, the most common subtype, has no clear genetic or molecular source. When presented with wide-ranging clinical symptoms, it requires effective clinical diagnosis. A 31-year-old female with hypermobile EDS underwent an abdominal Computed Tomography (CT) scan displaying a 2.9 cm soft-tissue mass possibly arising from the terminal ileum, which was revealed to be a desmoid fibromatosis. It is believed that Gastrointestinal (GI) manifestations may be associated with EDS, specifically the hypermobile subtype. The patient demonstrated manifestations commonly seen throughout the literature on hypermobile EDS, including abdominal pain, nausea, and diarrhoea. With symptoms worsening, a follow-up CT disclosed an enlargement of the ileocecal desmoid tumour, measuring 5.1 cm. Because all the subtypes of EDS share features such as tissue fragility, joint hypermobility, and skin hyperextensibility, and many of the manifestations are insufficient to establish a diagnosis, imaging modalities are essential for proper identification and patient management. Given the patient's medical history and the involvement of EDS and desmoid tumours with connective tissue, there is a strong linkage between desmoid fibromatosis and the patient's hypermobile Ehlers-Danlos diagnosis. The available literature does not clearly attribute such a tumour to the syndrome. This patient's symptoms represent a possible association between hypermobile EDS and desmoid fibromatosis, warranting future research in this area. The patient is now stable and was recently discharged. [ABSTRACT FROM AUTHOR]

NWA 8785 is a remarkable EL3 chondrite with a high abundance (~34 vol%) of an Fe‐rich matrix. This is the highest matrix abundance known among enstatite chondrites (ECs) and more similar to the matrix abundances in some carbonaceous and Rumuruti chondrites. X‐ray diffraction and TEM data indicate that the fine‐grained portion of the NWA 8785 matrix consists of nanoscale magnetite mixed with a noncrystalline silicate material and submicron‐sized enstatite and plagioclase grains. This is the first report of magnetite nanoparticles in an EL3. The Si content of the metal (0.7 wt%), presence of ferroan alabandite, and its O isotopic composition indicate NWA 8785 is EL3‐related. Having more abundant matrix than in other ECs, and that the matrix is rich in magnetite nanoparticles, which are not present in any other EC, suggest classification as an EL3 anomalous. Although we cannot completely exclude any of the mechanisms or environments for formation of the magnetite, we find a secondary origin to be the most compelling. We suggest that the magnetite formed due to hydrothermal activity in the meteorite parent body. Although ECs are relatively dry and likely formed within the nebular snow line, ices may have drifted inward from just beyond the snow line to the region where the EL chondrites were accreting, or more likely the snow line migrated inward during the early evolution of the solar system. This may have resulted in the condensation of ices and provided an ice‐rich region for accretion of the EL3 parent body. Thus, the EL3 parent body may have had hydrothermal activity and if Earth formed near the EC accretion zone, similar bodies may have contributed to the Earth's water supply. NWA 8785 greatly extends the range of known characteristics of ECs and EC parent body processes. [ABSTRACT FROM AUTHOR]

Online peer groups are a popular channel for mental health support, but the evidence for their effectiveness is mixed. The present study focused on empathy to better identify which supporters' comments regulated seekers' distress. We also explored how seekers' emotions may shape supporters' empathy. Posts (N = 7,646) published on an online peer support platform ("Emotional first aid [ERAN]") were sourced. Supporters' empathy (empathic concern, personal distress, exploration, and interpretation) and seekers' emotional expressions (soft negative, hard negative, and positive) were coded. We hypothesized that (1) empathic concern, exploration, and interpretation (but not personal distress) would predict better seekers' emotions (lower negative emotions and greater positive ones); (2) support seekers' soft negative and positive emotions would predict supporters' empathic concern and cognitive empathy (i.e., exploration and interpretation); but that (3) hard negative emotions would predict supporters' personal distress. A set of cumulative mixed models revealed that empathic concern predicted more seekers' positive emotions. However, cognitive empathy predicted more negative seekers' emotions. Seekers' soft negative emotions predicted greater expressions of supporters' empathy (of all types). Finally, seekers' positive emotions predicted more supporters' empathic concern and less personal distress, but also predicted less cognitive empathy (i.e., exploration). A secondary analysis found that this pattern of results differed to some extent as a function of the supporters' role as anonymous peers or the professional moderator. These findings suggest that empathy is a key component in online mental support platforms and that it may make online interactions more effective through emotional regulation. Public Significance Statement: Supporters' empathy was associated with seekers' emotional states in an online mental support platform. Seekers' emotional expressions shaped supporters' empathy. The bidirectional associations between seekers' emotions and supporters' empathy differed between anonymous peers versus professional moderators, but that overall, empathy may make online interactions more effective through emotional regulation. [ABSTRACT FROM AUTHOR]

Community science involves scientists and community members co-creating and coexecuting scientific research. Given their deep engagement of non-scientists, these projects have great potential to improve their participants' scientific knowledge and pro-environmental attitudes, as well as to collect first-order data on issues of local and scientific concern. To investigate this potential, we implemented a community science project to monitor an endemic species of sea lion in the Galápagos Islands and empirically assessed its impacts on the community scientists (local high-school students). We discovered that our community scientists increased their understanding of the nature of science, knowledge of sea lion biology, and intrinsic motivations for conservation as a result of their participation. These results provide empirical evidence that community science initiatives can be effective tools for helping community members to increase both their scientific knowledge and their environmental awareness. [ABSTRACT FROM AUTHOR]

Mobile genetic elements are key to the evolution of bacteria and traits that affect host and ecosystem health. Here, we use a framework of a hierarchical and modular system that scales from genes to populations to synthesize recent findings on mobile genetic elements (MGEs) of bacteria. Doing so highlights the role that emergent properties of flexibility, robustness, and genetic capacitance of MGEs have on the evolution of bacteria. Some of their traits can be stored, shared, and diversified across different MGEs, taxa of bacteria, and time. Collectively, these properties contribute to maintaining functionality against perturbations while allowing changes to accumulate in order to diversify and give rise to new traits. These properties of MGEs have long challenged our abilities to study them. Implementation of new technologies and strategies allows for MGEs to be analyzed in new and powerful ways. [ABSTRACT FROM AUTHOR]

Teacher education programs play a crucial role in developing teachers' equity/social justice mindsets and technology integration knowledge and expertise. Scholars have advocated for merging these two areas to support common curricular goals and access unique learning benefits. However, little is known about how equity pedagogy and technology integration intersect in preservice teacher (PST) education. This scoping review aims to expand knowledge and understanding at this intersection with the goal of developing a foundation for future research and practice. Findings revealed that relevant studies focused on two main styles of pedagogy: (a) leveraging technology to teach about equity and social justice (i.e., tech-infused equity pedagogy), and (b) adopting a critical stance toward technology's roles in schools and society (i.e., digital equity pedagogy). We provide a detailed description of these pedagogies and present useful systems of classification for related studies. We also present key implications of this work for PST education practice, policy, and scholarship. [ABSTRACT FROM AUTHOR]

Among plant-associated bacteria, agrobacteria occupy a special place. These bacteria are feared in the field as agricultural pathogens. They cause abnormal growth deformations and significant economic damage to a broad range of plant species. However, these bacteria are revered in the laboratory as models and tools. They are studied to discover and understand basic biological phenomena and used in fundamental plant research and biotechnology. Agrobacterial pathogenicity and capability for transformation are one and the same and rely on functions encoded largely on their oncogenic plasmids. Here, we synthesize a substantial body of elegant work that elucidated agrobacterial virulence mechanisms and described their ecology. We review findings in the context of the natural diversity that has been recently unveiled for agrobacteria and emphasize their genomics and plasmids. We also identify areas of research that can capitalize on recent findings to further transform our understanding of agrobacterial virulence and ecology. [ABSTRACT FROM AUTHOR]

Among the numerous innovations implemented in medical education since the beginning of the 21st century, small-group learning experiences have worked well for modern students and the application of computer technology provided access to thousands of lectures, images, and slides via the internet. This has helped to build an electronic foundation on which further educational adaptations have arisen in the current era, coupled with the altered communications landscape represented by Apple's introduction of the iPhone and Google's subsequent entrance onto the playing field. With the advent of smartphone applications (apps), education has taken on an even more personalized approach. Data show that the use of educational apps has been embraced by today's nursing and medical students, notably including radiology students. We survey recent research on the use and desirability of medical apps and offer practical tips for those ready to embark on developing medical, particularly radiology, educational apps including how to assess and hone them for optimal use. [ABSTRACT FROM AUTHOR]

Much modern laboratory research on creative thinking, or in vitro research, is based on the "remote-associates" perspective, which assumes that creative advances arise through bringing together ideas which were previously "remotely associated," that is, not directly linked. That view has provided the foundation for modern theorizing across a broad range of areas, including the role of associative processes in creativity, divergent thinking in creativity, attention in creativity, genius and madness, and the neuroscience of creativity. However, contrary to the remote-associates view, analyses of real-life – in vivo – creative thinking indicate that new ideas arose as variations on or extensions of old ideas, rather than through bringing together unrelated ideas in a far-ranging creative leap. This conflict between the in vitro and in vivo perspectives has resulted in a theoretical quandary for creativity studies – a "creativity quandary." This article examines that quandary. The first section demonstrates the wide reach of the remote-associates view in laboratory research on creativity. The second section examines in vivo creative advances that raise questions for the remote-associates view. The third section presents an alternative conception of creative thinking, based on executive functioning, as a potential resolution of the creativity quandary. Similarities and differences between the present proposal and other recent theoretical analyses of creative thinking are discussed. [ABSTRACT FROM AUTHOR]

Globalization has made agricultural commodities more accessible, available, and affordable. However, their global movement increases the potential for invasion by pathogens and necessitates development and implementation of sensitive, rapid, and scalable surveillance methods. Here, we used 35 strains, isolated by multiple diagnostic laboratories, as a case study for using whole genome sequence data in a plant disease diagnostic setting. Twenty-seven of the strains were isolated in 2022 and identified as Xanthomonas hortorum pv. pelargonii. Eighteen of these strains originated from material sold by a plant breeding company that had notified clients following a release of infected geranium cuttings. Analyses of whole genome sequences revealed epidemiological links among the 27 strains from different growers that confirmed a common source of the outbreak and uncovered likely secondary spread events within facilities that housed plants originating from different plant breeding companies. Whole genome sequencing data were also analyzed to reveal how preparatory and analytical methods can impact conclusions on outbreaks of clonal pathogenic strains. The results demonstrate the potential power of using whole genome sequencing among a network of diagnostic labs and highlight how sharing such data can help shorten response times to mitigate outbreaks more expediently and precisely than standard methods. [ABSTRACT FROM AUTHOR]

The number of structural studies of peptoids has grown dramatically over the past 20 years. To date, over 100 high‐resolution structures have been reported for peptoids, which are typically defined as N‐substituted glycine oligomers. We have collected these structures and standardized their sequence representations to facilitate structural analysis as the dataset continues to grow. These structures are presented online as The Peptoid Data Bank (databank.peptoids.org), which also provides persistent links to the published structural data. This review analyzes the present collection of structures and finds extensive support for grouping side chains by their chemistry at the position adjacent to the backbone nitrogen. Groups of side chains with similar chemistry at this position show similar influences on the conformational preferences of the backbone. We also observe a relationship between the side chain and backbone conformations for many monomers that has not previously attracted significant discussion: the values of the χ1 and ϕ dihedrals are correlated. We outline a general design strategy for attaining a specific backbone conformation based on the patterns seen in the collected structures. [ABSTRACT FROM AUTHOR]

Relying on shared tasks and stimuli to conduct research can enhance the replicability of findings and allow a community of researchers to collect large data sets across multiple experiments. This approach is particularly relevant for experiments in spatial navigation, which often require the development of unfamiliar large-scale virtual environments to test participants. One challenge with shared platforms is that undetected technical errors, rather than being restricted to individual studies, become pervasive across many studies. Here, we discuss the discovery of a software bug in a virtual environment platform used to investigate individual differences in spatial navigation: Virtual Silcton. The bug, which was difficult to detect for several reasons, resulted in storing the absolute value of a direction in a pointing task rather than the signed direction and rendered the original sign of the direction unrecoverable. To assess the impact of the bug on published findings, we collected a new data set for comparison. Results revealed that although the bug caused suppression in pointing errors and had different effects across people (less accurate navigators had more suppression), the effect of the bug on published data is small, partially explaining the difficulty in detecting the bug. We also used the new data set to develop a tool that allows researchers who have previously used Virtual Silcton to evaluate the impact of the bug on their findings. We summarize the ways that shared open materials, shared data, and collaboration can pave the way for better science to prevent errors in the future. [ABSTRACT FROM AUTHOR]

Among the numerous innovations implemented in medical education since the beginning of the 21st century, small-group learning experiences have worked well for modern students and the application of computer technology provided access to thousands of lectures, images, and slides via the internet. This has helped to build an electronic foundation on which further educational adaptations have arisen in the current era, coupled with the altered communications landscape represented by Apple's introduction of the iPhone and Google's subsequent entrance onto the playing field. With the advent of smartphone applications (apps), education has taken on an even more personalized approach. Data show that the use of educational apps has been embraced by today's nursing and medical students, notably including radiology students. We survey recent research on the use and desirability of medical apps and offer practical tips for those ready to embark on developing medical, particularly radiology, educational apps including how to assess and hone them for optimal use. [ABSTRACT FROM AUTHOR]

It is not that unusual to find that Americans are unaware that Puerto Rico is a territory of the United States, and, like them, Puerto Ricans are U.S citizens enjoying the same liberties, freedoms, and rights. It may be less expected to face such incognizance or ignorance within the medical community as careers in medicine offer healthcare professionals the opportunity to serve patients spanning race, ethnicity, gender, sexual orientation, religion, and other demographic differences. Unfortunately, some of the personal experiences of the primary author have prompted us to cull four personal narratives of Puerto Rican individuals (Boricuas), who comprise 20.8% of the Hispanic, Latino, or Spanish Origin applicants to U.S. medical schools, during various early stages of a medical career. Of course, these personal anecdotes, offered in response to just a few general questions about recent experiences of bias in medical applications or in early training, do not indicate pervasive bias. Similarly, these instances may be more common than people in the medical community would prefer to believe. In the brief narratives that follow, Boricuas at different junctures in their medical educations highlight the bias that they have faced and their reactions to it. We present this information with the hope of promoting awareness of potential biases at different stages of medical education. • Only 5.8% of physicians and 3.2% of medical school faculty in the U.S. were of Hispanic origin as of 2018. • We present four narratives of Puerto Rican individuals who faced bias during various early stages of their medical careers. • Puerto Rican medical student and residents should receive equal opportunities and not be treated as second-class citizens. [ABSTRACT FROM AUTHOR]

Aim: Intraspecific trait variation is fundamental to understanding a species' adaptive capacity. Assessing phenotypic variation at different ecological scales is useful for evaluating species' vulnerability to changing environmental conditions. Here, we quantify the ecological scale of variation of phenotypic functional traits for a widespread dryland tree species and evaluate the strength of trait‐environment relationships across spatial gradients and in response to interannual variability in weather conditions. Location: Western United States. Taxon: Conifer tree (Pinaceae): Pinus monophylla. Methods: Nine reproductive and foliar morphological traits were measured from 23 sampling locations in nine mountain ranges, stratified across broad‐scale gradients of precipitation timing and quantity and local gradients of elevation. We partitioned trait variation within and among nested ecological scales (mountain range, site, tree, and tree growth year). We then used multivariate methods to quantify the association between environmental variables and ecological trade‐offs associated with both reproductive and foliar traits. Results: Most variation was explained at the scale of individual trees (18%–46%) and between growth years (20%–30%), with smaller but variable contributions at the scale of sites (8%–25%) and mountain ranges (0%–15%). Trait values had low correlation with environmental variables (13%); however, 94% of the trait‐environment covariance was explained by two major axes of variation: (1) the drought‐stress gradient covarying with reproductive traits, and (2) precipitation patterns covarying with foliar morphology. Main conclusions High levels of individual trait variation indicate within‐population adaptive capacity. Consistent relationships among range‐wide patterns of foliar and reproductive traits and broad‐scale climate gradients provide indirect evidence of local adaptation and may inform seed sourcing for restoration or the potential for assisted migration efforts. Quantification of intraspecific trait variation across multiple ecological scales is important for understanding the potential climate change response of dryland tree species. [ABSTRACT FROM AUTHOR]

Wilson et al. (2025) report a failed attempt to replicate the reductive allure effect: Unlike prior work, they do not find that participants judged explanations of scientific phenomena to be higher quality when they contained irrelevant reductive language. The current commentary considers three possible reasons for this failure to replicate: (1) a change in the nature of online study participants, (2) a change in the background knowledge that people bring to judgments of scientific explanations, and (3) a change in the kinds of explanations that people find satisfying. [ABSTRACT FROM AUTHOR]

Demand for online educational tools has risen steadily as technological innovations have evolved over the past several decades. Websites were the first platform to be introduced, and eventually used for online schooling, soon after the advent of the World Wide Web. Access to information and updated content in a short period of time on a wide-screen device such as a computer made websites popular early in their development. With the technological revolution of smart phones, mobile applications have been developed on various operating systems and, through this progress, a new form of educational platform was initiated. The portable features of mobile applications represent a pioneer era of educational tools for medical professionals. Online communications have transformed into social media over the last decade and have since been adopted by much of the world. All three of these educational platforms have created a significant impact on medical education communities, specifically in radiology. We describe the relative strengths of each platform and illustrate how our experience over more than two decades guides our recommendations. • Demand for online educational tools has risen as technological innovations have evolved over the past several decades. • Websites, mobile apps, and social media have greatly influenced medical education communities, specifically in radiology. • Using two or three platforms can be a dynamic approach to expand outreach if educators have access to appropriate resources. [ABSTRACT FROM AUTHOR]

This essay calls for a more careful evaluation of the legacy of Quakerism at Haverford College by paying close attention to Isaac Sharpless, his redefinition of the college's religious mission and the practical implications of his vision on the student body. It argues that Sharpless redefined Haverford's Quaker character in a way that allowed the college to expand its religious mission to include the sons of the white Protestant elite while largely excluding young men from less socially desirable Catholic, Black, and Jewish backgrounds. Haverford gained prestige as a result of this redefinition. At the same time, however, the student body gradually became more patrician and less Friendly, so that Episcopalians and Presbyterians outnumbered Quakers by the early 1920s, if not earlier. Based on this observation, the essay calls for a more robust discussion of the extent to which it is accurate to describe Haverford as a Quaker college. [ABSTRACT FROM AUTHOR]

Acquisition of mobile genetic elements can confer novel traits to bacteria. Some integrative and conjugative elements confer upon members of Bradyrhizobium the capacity to fix nitrogen in symbiosis with legumes. These so-called symbiosis integrative conjugative elements (symICEs) can be extremely large and vary as monopartite and polypartite configurations within chromosomes of related strains. These features are predicted to impose fitness costs and have defied explanation. Here, we show that chromosome architecture is largely conserved despite diversity in genome composition, variations in locations of attachment sites recognized by integrases of symICEs, and differences in large-scale chromosomal changes that occur upon integration. Conversely, many simulated nonnative chromosome–symICE combinations are predicted to result in lethal deletions or disruptions to architecture. Findings suggest that there is compatibility between chromosomes and symICEs. We hypothesize that the size and structural flexibility of symICEs are important for generating combinations that maintain chromosome architecture across a genus of nitrogen-fixing bacteria with diverse and dynamic genomes. [ABSTRACT FROM AUTHOR]

• Self-Organizing Map analyses of satellite altimetry identify preferred states. • Two canonical transition patterns of the Gulf of Mexico Loop Current are described. • The Campeche Bank and West Florida Shelf dynamically impact the Loop Current. How the Gulf of Mexico Loop Current (LC) transitions from penetrative to ring shedding to retracted configurations remains an active research topic. Satellite altimetry suggests a set of states, some more persistent than others, identified as Campeche Bank Anchoring, West Florida Shelf Anchoring, Extended, and LC Ring, plus transitional phases. Histograms show that the most frequent states are Campeche Bank Anchoring and West Florida Shelf Anchoring. Two canonical evolutions are defined. The first is a transition from Campeche Bank Anchoring to West Florida Shelf Anchoring. The second is a transition from Campeche Bank Anchoring to Extended to LC Ring. Common to both are cyclonic eddies. The first canonical transition requires cyclones formed both east and west of the LC, acting as pincers far enough south to dislodge the LC from the Campeche Bank. The second has a single cyclone, formed on either side of the LC, that cuts through either from the east, thereby not dislodging the LC from the Campeche Bank, or from the west, but too far north to dislodge the LC. Notable is the importance of the Campeche Bank and Florida escarpments. Cyclones may generate either by instability or downslope perturbation, but whether these lead to protracted penetration, or just jostling from one anchoring state to another, depends on where they are generated and how they combine to shed a LC Ring. Thus, these findings suggest that furthering understanding and prediction requires observations and analyses over the two escarpment regions and the LC domain south of about 25°N. [ABSTRACT FROM AUTHOR]

The overhand throw is a complex whole-body motor skill that is fundamental to many sports and activities. When throwing properly, the momentum generated to complete the movement begins in the lower body and transfers through the trunk to the throwing arm. This proof-of-concept study's primary purpose was to evaluate the impact of the nonthrowing arm on the ball speed during an overhand throw with both the dominant and nondominant arms. Eighteen participants (age: 20.20 ± 2.90 years, nine women) were divided into two intervention groups: a pulling group taught to engage the nonthrowing arm through a pull toward the body and a nonpulling group taught the overhand throw using a component-based physical education curriculum. Each participant completed 12 total throws, six for each side (dominant and nondominant arm). Ball speed and kinematic data were collected using an eight-camera motion analysis system and were assessed using a pre–post study design. The two groups showed significant improvements pre–post when throwing with both the dominant and nondominant arms. Based on effect size comparisons, engaging the nonthrowing arm makes a meaningful difference in maximal ball velocity. [ABSTRACT FROM AUTHOR]

Collaboration and teamwork are well-established cornerstones of modern clinical and academic medicine as well as research, including radiology. Mentorship is also part and parcel of daily medical practice and training. As it is, there is a wide range of opinions on the effectiveness of standard mentorship models. In some cases, academic departments may offer mentorship to fulfill a requirement rather than as a sign of commitment to ensuring that all mentees receive the guidance they seek. Although mentor-mentee relationships might have arisen organically, and such situations are still possible, the overall lack of face-to-face interactions in many departments in the COVID era suggests the need to emphasize formal mentoring programs. We appreciate the overall successes of mentorship in medicine as well as radiology, while acknowledging that, like anything, it is not perfect. Because the processes of decision making and career planning are similar across fields, a peer-to-peer cross-specialty mentorship model could yield untold benefits to early-career radiologists who may receive valuable advice from friends or colleagues outside of medicine, or simply outside of radiology, at crucial points in their careers. There is no ideal formula or format for mentoring, however. We endorse the theory or intentions of mentorship and believe that its effectiveness can take several forms. Having a formal program in place, with built-in flexibility to address our rapidly changing times, remains highly desirable. Our proposal is to expand this notion to a "whatever works," "anything goes," or, in the spirit of the COVID era, a hybrid model. • There is a reported lack of radiology mentoring, e.g., formal programs for students, residents, fellows, or junior faculty. • The challenges of mentorship, including intergenerational communication gaps, have led some to consider other models. • We endorse formal mentorships and any approaches preferred by mentees, including peer-to-peer and non-medical friends. [ABSTRACT FROM AUTHOR]

Many people feel the pull of both creationism and evolution as explanations for the origin of species, despite the direct contradiction. Some respond by endorsing theistic evolution, integrating the scientific and religious explanations by positing that God initiated or guided the process of evolution. Others, however, simultaneously endorse both evolution and creationism despite the contradiction. Here, we illustrate this puzzling phenomenon with interviews with a diverse sample. This qualitative data reveals several approaches to coping with simultaneous inconsistent explanations. For example, some people seem to manage this contradiction by separating out ideological claims , which prioritize identity expression, from fact claims , which prioritize truth. Fitting with this interpretation, ambivalent individuals tended to call explanations "beliefs" (not knowledge), avoid mention of truth or falsity, and ground one or both beliefs in identity and personal history. We conclude with a brief discussion of the affordances of this distinction. [ABSTRACT FROM AUTHOR]

Members of the agrobacteria-rhizobia complex (ARC) have multiple and diverse plasmids. The extent to which these plasmids are shared and the consequences of their interactions are not well understood. We extracted over 4000 plasmid sequences from 1251 genome sequences and constructed a network to reveal interactions that have shaped the evolutionary histories of oncogenic virulence plasmids. One newly discovered type of oncogenic plasmid is a mosaic with three incomplete, but complementary and partially redundant virulence loci. Some types of oncogenic plasmids recombined with accessory plasmids or acquired large regions not known to be associated with pathogenicity. We also identified two classes of partial virulence plasmids. One class is potentially capable of transforming plants, but not inciting disease symptoms. Another class is inferred to be incomplete and non-functional but can be found as coresidents of the same strain and together are predicted to confer pathogenicity. The modularity and capacity for some plasmids to be transmitted broadly allow them to diversify, convergently evolve adaptive plasmids and shape the evolution of genomes across much of the ARC. [ABSTRACT FROM AUTHOR]

The present essay seeks to offer a conceptual framework for grappling with climate change from within the sources of Jewish law (halakhah), a discourse rooted in the Hebrew Bible but developed in the rabbinic literature of Late Antiquity and then in medieval and modern codes and commentaries. Halakhah reflects deeply-held intellectual, theological, ontological, and sociological values. As a modus vivendi, rabbinic law—variously interpreted by Jews of different stripes—remains a vital force that shapes the life of contemporary practitioners. We are interested in how a variety of contemporary scholars, theologians, and activists might use the full range of rabbinic legal sources—and their philosophical, jurisprudential, and moral values—to construct an alternative environmental ethic founded in a worldview rooted in obligation and a matrix of kinship relationships. Our essay is thus an exercise in decolonizing knowledge by moving beyond the search for environmental keywords or ready analogies to contemporary western discourse. We join the voices of recent scholars who have sought to revise regnant assumptions about how religious traditions should be read and interpreted with an eye to formulating constructive ethics. [ABSTRACT FROM AUTHOR]

As the event horizon of cataclysmic climate change draws nearer, we are beginning to see evident consequences in the form extreme weather patterns such as drought, flooding, and wildfire. Anat Koplowitz examines the ecopoetry of three prominent American Jewish women, arguing that each reinterpreted the Jewish traditions and theological categories through the twin lenses of Jewish feminism and ecofeminism. Religious traditions can, in our estimation, offer us a critical set of values and the vocabulary with which to begin addressing and thinking beyond the staggeringly complicated cluster of problems bound up with climate change. [Extracted from the article]

The field of Law and Literature, perhaps more than any other area of legal studies, has been touched deeply by Robert Cover's life and work.1 My interactions with Bob over the last half dozen years of his tragically short life provide an insight, recounted in a somewhat personal vein here, into his profound engagement with stories, with the most enduring part of that revitalized inter-discipline. I specify and illustrate five conversations I had with him during conferences, family interactions, or long New Haven walks beginning in 1981 and ending the day before his untimely death in the Summer of 1986. On each occasion, Bob wanted to spin out ideas we were developing together about Dostoevsky's last masterpiece, The Brothers Karamazov ("The Brothers"), and in these pages, I want to engage the largest issues provoked in Bob's mind by that text: law, religion, and the potential undermining of sound traditions through "revolutionary" interpretive distortions.2 Why, I ruminate here, did Bob delve repetitively into the pages of the text he always spoke of affectionately as "The Brothers?" I provide something of an answer in putting part of that novel together with part of the transcript of the recent trial of Derek Chauvin for the murder of George Floyd3--with occasional brief allusions to the O.J. Simpson trial of 1988. The focus is on the behavior of defense counsel, fictional and real; might the wild manipulation of reality introduced by The Brothers brilliant lawyer, Fetyukovich, have motivated Bob to crystallize misgivings about our system's epistemput differently--to find the pathway to legal accuracy and soundness that Bob insisted on during those long conversations, and during his lifetime generally? Do his favorite stories, including those he wrote about influentially, Billy Budd, Sailor4 and The Antigone,5 indicate that fictional novels, as ironic as it seems, almost uniquely provide a pathway to truthful outcomes, stories read and re-read, argued about, and integrated into a community that elevated them, Midrashically, into the status of law?6 Bob's taste in stories was highly selective, and it constantly invited him and his students to the table of Tanakh, Gemorrha, 5th Century Greek Tragedy, Melville, and the Russians. He made me an occasional guest at that table. At a 1981 Brandeis conference on "Terror in the Modern Age: The Vision of Literature, the Response of Law,"7 I first learned of his fascination with The Brothers. Illustration 1 is a photo taken at that conference8 where Bob and I are discussing, as I recall the moment, the defendant Dmitri Karamazov's terror at finding himself on trial for the murder of his father, a parricide that the reader of the novel already knows should be laid at the hands of his brother Ivan and his half-brother Smerdyakov, who are not in the dock. At that stage in our relationship, Bob knew that I was developing a manuscript about fiction writers' self-awareness when depicting in great detail lawyers, investigations, and trials, and the horror often felt by ordinary people in the face of error-prone narrative power.ological shakiness more generally? Is there a better way to resolve disputes, perhaps, or--Illustration 29 is a contemporaneous calendar marking for 1982 of the Cover family joining with mine at the beach in Guilford, Connecticut, where our conversations continued at low tide, feet in the Long Island Sound and tossing around a ball. Earlier that year, Bob had participated in what became a well-known Association of American Law Schools ("A.A.L.S.") session on Legal Interpretation that I had convened, which included Owen Fiss and Stanley Fish. At this conference, and elsewhere Bob signaled his lack of interest in the "turn" to interpretation--sometimes called Law as Literature.10 He and I never revisited, in private conversation, that component of the field of Law and Literature.11 The very next year, my calendar memorializes (Illustration 3) a crucial day for me in New Haven, when--typifying Bob's generosity to fellow scholars and his spiritual yearning for stories--he led me over to the office of Ellen Graham, the formidable literary editor of the Yale University Press.12 He was bringing to her my manuscript with the working title The Failure of the Word. Anciently, this was done in a cardboard box bearing pages of corrasable bond typing paper. Bob had read the manuscript, including significant chapters on Billy Budd, Sailor and The Brothers, and he wanted the Press to publish it, which (after peer review by law professors and Russian Literature scholars, among others) it was published.13 From his office to Ms. Graham's, we centered our thoughts on The Brothers. [ABSTRACT FROM AUTHOR]

Objectives: There is a great need for low‐intensity, scalable treatments in primary care, where most anxious patients first present for treatment. We describe Stage IA treatment development and a Stage IB feasibility trial of cognitive bias modification (CBM) for transdiagnostic anxiety in primary care. Methods: The online intervention, Mental Habits, comprised eight sessions of a personalized CBM targeting attention and interpretation biases. Coaches assisted patients in using the website, monitored progress via a dashboard, and shared information with primary care providers. We evaluated Mental Habits in an open trial (N = 14) and a randomized controlled trial (RCT) (N = 40) in primary care patients with anxiety disorders. Results: We compared results to a priori benchmarks of clinically meaningful outcomes. In the open trial, Mental Habits met feasibility, acceptability, and efficacy benchmarks. In the pilot RCT, there was greater dropout at one study site which ultimately closed. In the intent‐to‐treat analyses, Mental Habits met the benchmark for self‐report, but not the interview measure of anxiety. Symptom Tracking did not meet the benchmark for self‐report or interview measures of anxiety. In per‐protocol analyses, Mental Habits exceeded the benchmark for both self‐report and interview measures, whereas Symptom Tracking met the benchmark for self‐report. Interpretation bias improved in the Mental Habits group, but not in Symptom Tracking. No effects were observed for attention bias. Conclusion: The online CBM intervention demonstrated good acceptability and, when delivered at a stable primary care clinic, preliminary effectiveness in primary care. A larger RCT is warranted to test effectiveness. Practitioner points: A personalized, transdiagnostic Cognitive Bias Modification (CBM) intervention for anxiety in primary care is acceptable to primary care patients with social anxiety disorder, generalized anxiety disorder, and/or panic disorder /agoraphobia.With training and supervision from licensed mental health clinicians, bachelor's‐level coaches can assist primary care patients to self‐administer CBM.Offering a low‐intensity, self‐directed anxiety intervention in primary care can greatly expand the reach of anxiety treatment, with minimal need for additional resources.Interpretation bias may be an important clinical target for primary care patients with anxiety. [ABSTRACT FROM AUTHOR]

We present the results of our study of two thin sections of Pecora Escarpment (PCA) 91020, a heavily shocked EL3 chondrite, to characterize the sizes, shapes, orientations, and mineral compositions of its chondrules and opaque nodules. We also studied the mildly shocked Queen Alexandra Range (QUE) 94594 EL3 chondrite for comparison. PCA 91020 appears to show the evidence of deformation throughout the meteorite in both the chondrules and the opaque (metal–sulfide) nodules. Aspect ratios of the chondrules in PCA 91020 are greater than in the mildly shocked QUE 94594. Aspect ratios of the more ductile metal grains are higher than those of the chondrules in both sections of PCA 91020 and in QUE 94594. The data suggest that the chondrules and metal‐rich nodules in PCA 91020 were elongated (flattened) to a greater degree and show a preferred orientation in comparison to objects in typical EL3 chondrites such as QUE 94594. The chondrule and metal‐rich nodule deformation and foliation in PCA 91020 were likely produced by an impact on the EL3 asteroid. However, there are some inconsistencies in reconciling an impact hypothesis with all of the observations. Scenarios of hot accretion and/or overburden compaction during progressive (potentially rapid, hot) accretion to explain the deformation cannot be completely ruled out. Also, heavily shocked E3 chondrites, like PCA 91020, are relatively rare, suggesting the impacts that may have compacted chondrites, although potentially frequent, were of weak magnitude. [ABSTRACT FROM AUTHOR]

Kuhn relies on a descriptivist theory of names, but when a more plausible theory is adopted, Morris argues, Kuhn's arguments fall apart. Morris also devotes considerable attention to Kuhn's cautions against (Morris would say obsessions with) Whigishness in history. This book is a self-described highly polemical discussion of Kuhn and of what Morris takes to be the dangers of Kuhn's antirealism. [Extracted from the article]

We use X‐ray microtomography (µCT) and digital data extraction techniques for the three‐dimensional (3‐D) petrographic investigation of the Tucson meteorite. Our results show that the silicate‐free metal regions in Tucson exist as discrete objects surrounded by a continuous silicate‐containing metal "matrix." Volumetric measurements of the silicate‐free metal regions in Tucson demonstrate that they are akin to the sizes of metallic nodules found in CBa chondrites. Silicate‐free metal regions have bladed or prolate shapes. Nonmetallic minerals in Tucson are predominately equant or prolate in shape. Nonmetallic mineral grains and silicate‐free metal regions in Tucson share a common orientation and are part of a petrofabric composed of a lineation. Any foliation in Tucson is weakly developed. We interpret the petrofabric as being the result of a single event on the Tucson parent body, during which Tucson experienced shearing forces. Our 3‐D petrographic investigation supports the idea that Tucson is an unusual member of the CR chondrite clan. [ABSTRACT FROM AUTHOR]

Reuben Baron significantly contributed to both the fields of personality and social psychology. In this paper, we discuss Baron's 'lock and key' metaphor, which emphasizes the mutualism and realism of individual differences, suggesting that personal traits and environmental affordances are interdependent with one another. Building on Baron's theoretical foundations, we introduce the concepts of personal coherence (the perception that our life is meaningful and comprehensible) and place coherence (the perception that an environment has congruent features and characteristics and that it affords behaviors congruent with our true selves). We then propose a hypothesis for how place and personal coherence affect one other, which we call the place resonance hypothesis. If the affordances of a place resonate with meaningful behaviors a person wants to partake in, the place itself has increased coherence based on the synergy with the person's individual needs. Thus, both place and personal coherence are both amplified. This integration not only bridges personality and social psychology but also provides new insights into the mechanisms that foster psychological well-being. [ABSTRACT FROM AUTHOR]

Key to the long‐term resilience of dryland ecosystems is the recovery of foundation plant species following disturbance. In ecosystems with high interannual weather variability, understanding the influence of short‐term environmental conditions on establishment of foundation species is essential for identifying vulnerable landscapes and developing restoration strategies. We asked how annual environmental conditions affect post‐fire establishment of Artemisia tridentata, a shrub species that dominates landscapes across much of the western United States, and evaluated the influence of episodic establishment on population recovery.We collected A. tridentata stem samples from 33 plots in 12 prescribed fire sites that burned 8–11 years before sampling. We determined individual establishment years using annual growth rings. We measured seasonal soil environmental conditions at the study sites and asked if these conditions predicted annual establishment density. We then evaluated whether establishment patterns could be predicted by site‐level climate or dominant subspecies. Finally, we tested the effect of the magnitude and frequency of post‐fire establishment episodes on long‐term population recovery.Annual post‐fire recruitment of A. tridentata was driven by the episodic availability of spring soil moisture. Annual establishment was highest with wetter spring soils (relative influence [RI] = 19.4%) and later seasonal dry‐down (RI = 11.8%) in the year of establishment. Establishment density declined greatly 4 to 5 years after fire (RI = 17.1%). Post‐fire establishment patterns were poorly predicted by site‐level mean climate (marginal R2 ≤ 0.18) and dominant subspecies (marginal R2 ≤ 0.43).Population recovery reflected the magnitude, but not the frequency, of early post‐fire establishment pulses. Post‐fire A. tridentata density and cover (measured 8–11 years after fire) were more strongly related to the magnitude of the largest establishment pulse than to establishment frequency, suggesting that population recovery may occur with a single favourable establishment year.Synthesis and applications. This study demonstrates the importance of episodic periods of favourable weather for long‐term plant population recovery following disturbance. Management strategies that increase opportunities for seed availability to coincide with favourable weather conditions, such as retaining unburned patches or repeated seeding treatments, can improve restoration outcomes in high‐priority areas. [ABSTRACT FROM AUTHOR]

Introduction: Brief action planning (BAP) is a collaborative tool to support patients' self-management goal setting and action planning. BAP facilitates patient self-reflection, and provides opportunity to establish goals of their own priority. Case presentation: A 55 year-old female with recentonset low back pain with L5 nerve root distribution, described severe pain in the low back and sharp pain and tingle-sensations down to her right foot. Pain worsened with sitting, coughing, and bending. She was diagnosed with lumbar and other intervertebral disc disorder with radiculopathy (ICD 10: M51.1). Treatment: Initial treatment included reassurance, education, promotion of movement, and manual therapies. Symptoms worsened at the eighth visit (five weeks) where she also demonstrated paincatastrophizing behaviours and an over-reliance on passive treatment strategies (i.e., psychosocial factors or yellow flags). BAP was introduced into her treatment plan to set achievable goals for her care. Outcome: Decreased pain and disability were reported after incorporating BAP into care. Reduced pain-catastrophizing and reduced over-dependence on passive strategies were also demonstrated. Clinical gains were sustained at the 10-week follow-up assessment. Key clinical message: We describe the utilization of brief action planning as a technique for improving adherence to evidence-based clinical practice guideline recommendations in a patient with acute low back pain and radiculopathy, and late-onset psychosocial factors. [ABSTRACT FROM AUTHOR]

Diseases have a significant cost to agriculture. Findings from analyses of whole-genome sequences show great promise for informing strategies to mitigate risks from diseases caused by phytopathogens. Genomic approaches can be used to dramatically shorten response times to outbreaks and inform disease management in novel ways. However, the use of these approaches requires expertise in working with big, complex data sets and an understanding of their pitfalls and limitations to infer well-supported conclusions. We suggest using an evolutionary framework to guide the use of genomic approaches in epidemiology and diagnostics of plant pathogens. We also describe steps that are necessary for realizing these as standard approaches in disease surveillance. [ABSTRACT FROM AUTHOR]

• Hippocampal volume has been associated with impaired and expert navigation. • Large pre-registered studies found no such correlation in healthy adults. • Theoretical mechanisms supporting structure-behavior associations are tenuous. • Navigation is a complex cognitive function, involving multiple brain networks. • Network models offer greater explanatory power for flexibility and individual differences. A critical question regards the neural basis of complex cognitive skill acquisition. One extensively studied skill is navigation, with evidence suggesting that humans vary widely in navigation abilities. Yet, data supporting the neural underpinning of these individual differences are mixed. Some evidence suggests robust structure-behavior relations between hippocampal volume and navigation ability, whereas other experiments show no such correlation. We focus on several possibilities for these discrepancies: 1) volumetric hippocampal changes are relevant only at the extreme ranges of navigational abilities; 2) hippocampal volume correlates across individuals but only for specific measures of navigation skill; 3) hippocampal volume itself does not correlate with navigation skill acquisition; connectivity patterns are more relevant. To explore this third possibility, we present a model emphasizing functional connectivity changes, particularly to extra-hippocampal structures. This class of models arises from the premise that navigation is dynamic and that good navigators flexibly solve spatial challenges. These models pave the way for research on other skills and provide more precise predictions for the neural basis of skill acquisition. [ABSTRACT FROM AUTHOR]

Although access to technology has substantially increased in U.S. schools, inequities in technology usage persist, especially in classrooms serving disproportionately higher numbers of minoritized students. Driven by expert recommendations for increased teacher preparation focused on addressing this phenomenon, we sought to cultivate preservice teachers' (PSTs') digital equity mindsets in a stand-alone technology integration course. A qualitative analysis of pre- and post-course drawings and written reflections where PSTs indicated their intentions to build digital equity in the curriculum showed a significant evolution of their mindsets in five related dimensions of digital equity. This study provides novel insight into how PSTs' digital equity mindsets can be effectively cultivated, and how doing so might engender more equitable technology integration practices in the K-12 curriculum. • A technology integration course was redesigned to cultivate preservice teachers (PSTs) "digital equity mindsets". • Through qualitative analysis, the authors identified five "dimensions of digital equity" in which PSTs' mindsets evolved. • Each dimension features contrasting perspectives about teaching with technology on a least-to most-equitable continuum. • This study provides insight and guidance for cultivating PSTs' digital equity mindsets within these five key dimensions. [ABSTRACT FROM AUTHOR]

Development of a laboratory accreditation program to ensure competency of laboratories performing analytical measurements is a key step in adopting new analytical measurement methods for regulatory decision-making. Here, we describe California's three-part accreditation process for spectroscopically measuring microplastics in drinking water, and show how data from a multi-laboratory method comparison study informed development of accreditation programs for the resulting methods, which can inform analogous future work for other analytes. The first part is periodic performance evaluation (PE) samples, in which laboratories are provided blind samples of known composition to quantify within acceptable performance limits. The second is inspection, or audit, assessing whether the laboratory has the proper equipment to conduct the work and whether it is correctly employing proper procedures. The third is implementation of a quality management system providing documentation that protocols demonstrated during inspection are continuously maintained. These fell into three broad categories: instrument maintenance; laboratory cleanliness, especially important for microplastics and one that must be accompanied by a blanks measurement and correction process; and training so samples are being processed by qualified analysts. An intercomparison exercise among 22 laboratories was necessary to determine what parameter permutations were important for PE samples, and expected accuracy from competent laboratories. The recommended PE sample composition was two size categories (20-50um and 500um-1mm), two polymer types, and two morphologies (fibers and non-fibers). Discussions among intercomparison exercise participants were key in determining the factors that most contributed to laboratory variability, and the focus for both on-site inspections and quality management systems. [Display omitted] • Accreditation of analytical methods needed for regulatory and compliance purposes. • Microplastics analysis accreditation required for California drinking water. • Intercalibration study provided method performance capabilities and limitations. • Performance evaluation sample requirements to certify labs quantified. • Data and insights from study formed first accredited methods for microplastics. [ABSTRACT FROM AUTHOR]