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The livelihoods of the majority of Uganda's population depend on declining environmental resources. The sustainability of the natural environment requires that the people who are interdependent with it, as well as the structures of governance and leadership around them, understand the implications of resource degradation and take deliberate steps towards restoration. The interdependency of human and environment conditions in Uganda requires multidisciplinary attention and this paper reflects a contribution to this end. Socio‐cultural perceptions and relations with a vulnerable environment are put into dialogue with the physical status of environmental resources in Alebtong District, Uganda. Southern epistemological perspectives are considered in relation to Western scientific paradigms. Culturally responsive socio‐cultural research data are related to MODIS NDVI data, using time series analyses and NDVI as a proxy for productivity. The research confirms the declining availability and condition of natural resources and the acknowledgement of local influence on this condition. Despite this, deliberate community and governance efforts towards conservation and restoration varied from non‐existent to insufficient. The causes for this inconsistency revolve around conflicting priorities. This paper demonstrates and discusses the difficult trade‐offs in decision‐making about natural resources that rural communities face, and supports new partnership models as a route to improvement. [ABSTRACT FROM AUTHOR]

The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), is an invasive pest species that has incurred massive economic damages in areas cultivating economically important crops like corn, rice, cotton and many others. Known to be a native of the Western Hemisphere, FAW has since then established itself in many parts of Africa, Asia and Australia and Oceania. The Philippines had been among the Asian countries vulnerable to FAW invasion, which was validated in June 2019. This study aims to characterize the existing strains and haplotypes of FAW and describe the genetic structure and the signature of its recent demographic history nationwide. COI sequences reveal the predominance of rice‐strain over the corn‐strain FAW, while Tpi sequences are more accurate in defining the corn‐strain found in corn and sugarcane. Discordant COI‐Tpi configurations frequently occur the most in the entire FAW population at 65.29%. Nucleotide and haplotype diversity are low with an average of 0.005976 and 0.4019 respectively. In addition to non‐significant values in neutrality tests suggesting neutral evolution, the low nucleotide and haplotype diversity indicate population contraction from founder effect. Variations are mostly found within regions, and genetic structure is moderate among regions (FST = 0.14375). These results can be attributed to low selective pressures accompanying its establishment, or more likely due to recent migration and/or human‐assisted factors such as trade. Implications on pest management and prospective studies in the future are also discussed in this study. [ABSTRACT FROM AUTHOR]

The article focuses on how iron deficiency anemia (IDA) can manifest as ischemic stroke, highlighting the importance for pediatric providers to recognize risk factors for IDA and intervene early to prevent severe clinical outcomes. Topics include the presentation of IDA as ischemic stroke in severe cases, risk factors such as excessive cow's milk consumption, and the need for early intervention to prevent critical manifestations.

GPR84 was first identified as an open reading frame encoding an orphan Class A G protein coupled receptor in 2001. Gpr84 mRNA is expressed in a limited number of cell types with the highest levels of expression being in innate immune cells, M1 polarised macrophages and neutrophils. The first reported ligands for this receptor were medium chain fatty acids with chain lengths between 9 and 12 carbons. Subsequently, a series of synthetic agonists that signal via the GPR84 receptor were identified. Radioligand binding assays and molecular modelling with site‐directed mutagenesis suggest the presence of three ligand binding sites on the receptor, but the physiological agonist(s) of the receptor remain unidentified. Here, we review the effects of GPR84 agonists on innate immune cells following a series of chemical discoveries since 2001. The development of highly biased agonists has helped to probe receptor function in vitro, and the remaining challenge is to follow the effects of biased signalling to the physiological functions of innate immune cell types. LINKED ARTICLES: This article is part of a themed issue GPR84 Pharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.10/issuetoc [ABSTRACT FROM AUTHOR]

Antibiotics have benefitted human health since their introduction nearly a century ago. However, the rise of antibiotic resistance may portend the dawn of the "post-antibiotic age." With the narrow pipeline for novel antimicrobials, we need new approaches to deal with the rise of multidrug resistant organisms. In the last 2 decades, the role of the intestinal microbiota in human health has been acknowledged and studied widely. Of the various activities carried out by the gut microbiota, colonization resistance is a key function that helps maintain homeostasis. Therefore, re-establishing a healthy microbiota is a novel strategy for treating drug resistance organisms. Preliminary studies suggest that this is a viable approach. However, the extent of their success still needs to be examined. Herein, we will review work in this area and suggest where future studies can further investigate this method for dealing with the threat of antibiotic resistance. [ABSTRACT FROM AUTHOR]

BACKGROUND: Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) share similar clinical manifestations, including cardiovascular complications, suggesting similar underlying immunopathogenic processes. Aberrant neutrophil activation may play a crucial role in the shared pathologies of KD and MIS-C; however, the associated pathogenic mechanisms and molecular drivers remain unknown. METHODS: We performed a single-cell meta-analysis of neutrophil activation with 103 pediatric single-cell transcriptomic peripheral blood mononuclear cell data across 9 cohorts, including healthy controls, KD, MIS-C, compared with dengue virus infection, juvenile idiopathic arthritis, and pediatric celiac disease. We used a series of computational analyses to investigate the shared neutrophil transcriptional programs of KD and MIS-C that are linked to systemic damage and cardiac pathologies, and suggested Food and Drug Administration-approved drugs to consider as KD and MIS-C treatment. RESULTS: We meta-analyzed 521 950 high-quality cells. We found that blood signatures associated with risks of cardiovascular events are enriched in neutrophils of KD and MIS-C. We revealed the expansion of CD177+ neutrophils harboring hyperactivated effector functions in both KD and MIS-C, but not in healthy controls or in other viral-, inflammatory-, or immune-related pediatric diseases. KD and MIS-C CD177+ neutrophils had highly similar transcriptomes, marked by conserved signatures and pathways related to molecular damage. We found the induction of a shared neutrophil expression program, potentially regulated by SPI1 (Spi-1 proto-oncogene), which confers enhanced effector functions, especially neutrophil degranulation. CD177 and shared neutrophil expression program expressions were associated with acute stages and attenuated during KD intravenous immunoglobulin treatment and MIS-C recovery. Network analysis identified hub genes that correlated with the high activation of CD177+ neutrophils. Disease-gene association analysis revealed that the KD and MIS-C CD177+ neutrophils' shared expression program was associated with the development of coronary and myocardial disorders. Last, we identified and validated TSPO (translocator protein) and S100A12 (S100 calcium-binding protein A12) as main molecular targets, for which the Food and Drug Administration-approved drugs methotrexate, zaleplon, metronidazole, lorazepam, clonazepam, temazepam, and zolpidem, among others, are primary candidates for drug repurposing. CONCLUSIONS: Our findings indicate that CD177+ neutrophils may exert systemic pathological damage contributing to the shared morbidities in KD and MIS-C. We uncovered potential regulatory drivers of CD177+ neutrophil hyperactivation and pathogenicity that may be targeted as a single therapeutic strategy for either KD or MIS-C. [ABSTRACT FROM AUTHOR]

Social support is associated with positive physical and psychological health outcomes for youth. We took a qualitative approach to examine the sources, forms, and functions of social support youth receive from natural mentoring relationships in their lives. Based on in‐depth interviews with 40 adolescents participating in a study of youth–adult relationships and natural mentoring processes, we found that (1) different types of adults had the capacity to provide different types of support and were likely to provide overlapping supports; (2) emotional, informational, and instrumental support qualitatively differed depending on the adult's role (e.g., teacher), while companionship and validation were consistent across adults; and (3) youth were able to identify benefits attached to the social support received from adults. Our findings contribute to a more nuanced understanding of aspects and characteristics of effective youth–adult mentoring processes and call for fuller assessments of social support in youths' lives so we may better meet their developmental needs. [ABSTRACT FROM AUTHOR]

In economic decision-making individuals choose between items based on their perceived value. For both humans and nonhuman primates, these decisions are often carried out while shifting gaze between the available options. Recent studies in humans suggest that these shifts in gaze actively influence choice, manifesting as a bias in favor of the items that are viewed first, viewed last, or viewed for the overall longest duration in a given trial. This suggests a mechanism that links gaze behavior to the neural computations underlying value-based choices. In order to identify this mechanism, it is first necessary to develop and validate a suitable animal model of this behavior. To this end, we have created a novel value-based choice task for macaque monkeys that captures the essential features of the human paradigms in which gaze biases have been observed. Using this task, we identified gaze biases in the monkeys that were both qualitatively and quantitatively similar to those in humans. In addition, the monkeys’ gaze biases were well-explained using a sequential sampling model framework previously used to describe gaze biases in humans—the first time this framework has been used to assess value-based decision mechanisms in nonhuman primates. Together, these findings suggest a common mechanism that can explain gaze-related choice biases across species, and open the way for mechanistic studies to identify the neural origins of this behavior. [ABSTRACT FROM AUTHOR]

Moral disengagement is a social cognition people use to engage in wrongdoings even when they know it is wrong. However, little is known about the antecedents that predict moral disengagement. The current study focuses on the development of self-control and cooperation during middle childhood as two antecedents of moral disengagement among 1,103 children (50% female; 77% White, 12% Black, 6% Hispanic, and 5% other). Children's self-control at age 8 and growth in self-control from age 8 to 11 were positively linked to adolescents seeing themselves as having self-control at age 15, which then predicted less moral disengagement at age 18. Children's cooperation at age 8 also was positively linked to adolescents' self-views of cooperation at age 15, which in turn, was associated with less moral disengagement at age 18. These findings demonstrate the potential of self-control and cooperation as intrapersonal and interpersonal strengths during middle childhood for mitigating moral disengagement 10 years later. [ABSTRACT FROM AUTHOR]

Atmospheric gravity wave (AGW) characteristics were examined using Rayleigh lidar data collected over a period spanning 11 years above Logan, UT (41.7°N, 111.8°W), over an altitude range of 45–90 km. Variations of the relative density perturbations obtained with 3-km vertical resolution and 10-min temporal resolution are used to identify the presence of monochromatic gravity wave features throughout the mesosphere. The measured vertical wavelengths λ z ranged over 6–19 km with 12–14 km the most prevalent and the measured wave period τ ranged over 2–8 h with 5–6 h the most prevalent. The values of λ z , τ and mean wind velocity u were used to infer vertical phase velocities c z , horizontal wavelengths λ x , horizontal phase velocities c x and horizontal distances to the source region x. There appears to be a clear seasonal dependence in c z , τ , c x , λ x , and x but not in λ z. The c z values maximize in summer, τ and x maximize in winter whereas c x and λ x , maximize in winter and summer but minimize in spring and autumn. The values of x ranged over 1300–5000 km for waves at 60 km and ∼2000–7500 km for waves at 90 km. The source of these AGWs is, thus, far away. Furthermore, for one of these monochromatic waves to exist all night or appear to extend over 45–90 km, it has to originate from a very extended region and persist for a long time. • An extensive analysis showing the presence of monochromatic gravity wave motions throughout the mesosphere is presented. • Results showing seasonal variation of AGW vertical phase velocity in the mid-latitude mesosphere are demonstrated. • Gravity waves were observed in the mesosphere above ALO-USU propagated horizontally through a very extended region. [ABSTRACT FROM AUTHOR]

Youth-staff relationships and program activities are important elements in designing high-quality afterschool activities that promote a broad range of outcomes. Using a qualitative approach, Latinx adolescents were interviewed (n = 28, 50% girls) about their experiences in a university-based afterschool math enrichment activity. Findings under the first goal of the study suggest that Latinx adolescents perceived changes in their math-specific outcomes (e.g., problem-solving skills), future science, technology, engineering, and mathematics (STEM) pathways (e.g., envisioning a future career), and social-emotional skills (e.g., relationship skills) as a result of participating in the activity. Under the second goal of the study, findings identified the specific practices that adolescents thought promoted those outcomes, including incorporating advanced math concepts and engaging in collaborative learning, engaging in campus tours and informal conversations, and using culturally responsive practices. The findings from this study can be leveraged by scholars and educators to design, further strengthen, and evaluate high-quality afterschool activities. [ABSTRACT FROM AUTHOR]

It is generally accepted that material inhomogeneity causes stress concentrations at the interface and thus reduces the overall strength of a composite. To overcome this reduction in strength, some groups experimented on coating the nanoinclusions with a layer of rubbery material, aiming for higher energy absorption. However, representative volume element (RVE) nanocomposite models, established with randomly distributed core–shell nanoparticles and single nanoparticle cells, show that the enhancement in strength observed in some experiments remains elusive computationally. By including a pre-existing crack in the matrix of the RVE, the stress concentration at the crack tip is reduced for cases where the nanoparticle and precrack are aligned away from the loading direction. This suggests that stress concentrations around inherent defects in materials can sometimes be reduced by adding nanoparticles to improve material strength. The effect is reversed if the crack and nanoparticle are aligned towards the loading direction. Parametric studies were also carried out in terms of the relative stiffness of the nanoparticle to the matrix and crack length. Validation tests were performed on 3D RVEs with an elliptical crack as the initial defect, and the results match with the 2D findings. [ABSTRACT FROM AUTHOR]

Recent botanical explorations in the province of Benguet, Philippines have resulted in the discovery of a new ginger species, namely Boesenbergia igorota Tad-o & Napal., which is described and illustrated here, including the information on its phenology, ecology, conservation status, distribution, habitat, and surrounding floral species. [ABSTRACT FROM AUTHOR]

Opportunities for collaborative learning reflect positive peer processes that have strong implications for adolescents' developmental experiences in afterschool programs (ASPs). However, collaborative learning, which involves considering multiple viewpoints and coordinating actions with peers to accomplish a shared goal, is often difficult for adolescents to navigate. Utilizing qualitative methods, the purpose of this study was to identify ASP mentoring strategies that promote collaborative learning among adolescent participants. Based on the experiences and perspectives of college student mentors who serve as frontline staff of a math enrichment ASP for Latino/a middle school students, we identified four mentoring strategies that promote collaborative learning: (1) nurturing personal connections with and among youth, (2) establishing positive group norms, (3) strategically splitting groups and work, and (4) modeling collaborative behaviors. These strategies reflect best practices that frontline staff can utilize to promote adolescents' collaborative learning, skill development, and engagement in ASPs. Practical implications and directions for future research are discussed. [ABSTRACT FROM AUTHOR]

The past decade has witnessed burgeoning interest and concern regarding the mental health of firefighters. This increased attention is due, in part, to research documenting higher rates of psychiatric problems, including depression, substance abuse, sleep disturbances, posttraumatic stress disorder, and suicidality in fire rescue personnel compared to civilians. Similarly, the National Institute for Occupation Safety and Health (2014) has identified disturbingly elevated rates of physical health difficulties in firefighters, most notably high blood pressure, coronary heart disease, death due heart attacks, as well as different forms of cancer. Despite the heightened awareness of the mental and physical health challenges in this population, behavioral research specifically targeting firefighters is limited. With this is mind, we asked prominent researchers and clinicians working in this area to present results of their early investigative efforts in our Special Issue on "First Responder Stress and Mental Health". In this Introduction, we provide brief summaries of the studies comprising the Issue. Articles in this issue address topics of sleep, PTSD, substance use, physical health concerns, and provide assessment and treatment considerations. A primary goal of the Issue is to stimulate further behavioral research with this group of deserving yet underserved first responders. Moreover, the Issue serves as a tribute to the men and women of the fire service who dedicate and risk their lives to serve their community. [ABSTRACT FROM AUTHOR]

The impact of occupational stress on first responders has received increased investigative attention in recent years. However, research specifically targeting firefighters and their unique responses to job related stress remains limited. Although cardiovascular disease (CVD) risk has been recognized in firefighters, behavioral and psychological contributions (e.g., posttraumatic stress) have not been adequately examined. The purpose of this study was to: (1) examine the relationship between posttraumatic stress symptoms and CVD risk in firefighters, (2) assess the effects of service time on the relationship, and (3) increase understanding of the manifestations of stress in this population. Participants were 87 firefighters from Special Operations teams. Self-report measures of posttraumatic stress symptoms, health, and length of service were administered. Data from annual physical examinations provided information regarding CVD risk (weight, height, blood pressure, cholesterol, smoking, physical exercise). Results indicated significant relationships between posttraumatic stress symptomatology and current smoking status, triglyceride levels, and the number of CVD risk factors. Findings suggest that the presence of posttraumatic stress symptoms may influence overall CVD risk and may not be moderated by years of fire service. Implications for behavioral interventions with firefighters are discussed. Suggestions for future research in this area are offered. [ABSTRACT FROM AUTHOR]

High‐quality afterschool programs (ASPs) are opportunities to diversify the ways that Latinx youth from economically underprivileged communities experience STEM learning. Utilizing qualitative methods, based on the experiences and perspectives of low‐income Latinx middle school participants of a math enrichment ASP in Southern California, we identified four culturally responsive practices: (1) the promotion of an inclusive, safe, and respectful program climate, (2) engaging in personal conversations, (3) facilitating opportunities for mutual and math learning across diverse cultures and perspectives, and (4) the promotion of math and a range of social‐emotional skills across contexts. These practices helped youth feel more connected to the program, their peers, and program staff (college mentors); provided a platform for youth voice and contribution to the processes of teaching and learning; facilitated opportunities for skill development and practice across the different contexts of youth's lives; interrelated with Latinx cultural values; and helped to promote youth's engagement and math learning. Importantly, youth's relationships with their mentors was a significant aspect of their experiences and perceptions of these practices. We argue that culturally responsive practices are necessary to achieve high‐quality programs and provide specific implications for how ASPs can implement them in the design and implementation of their programs. Highlights: Culturally responsive practices are a necessary and defining aspect of program quality.A safe, inclusive and respectful climate is fundamental for culturally responsive practices.Engaging in personal conversations, including small talk, matter and can make a difference.Mutual learning and the promotion of skills across contexts is important for youth voice and contribution.Both positive program structure and staff practices are necessary for culturally responsive programs. [ABSTRACT FROM AUTHOR]

• CFTR carrier with methylmalonic acidemia given ivacaftor for chronic pancreatitis. • Reduced lipase/ chronic pain with fewer admissions post ivacaftor suggests response. • Our case report suggests that ivacaftor may be used to treat CP in CFTR carriers. CFTR mutation carriers, numbering 1 in 25 among Caucasians, have an increased risk of developing chronic pancreatitis due to the underlying dysfunction of ion channels created by the mutant allele. Carriers do not frequently manifest disease due to the remaining wild-type CFTR protein sufficiently maintaining normal pancreatic homeostasis. However, additional risk factors for pancreatitis, such as organic acidemias (as seen in our patient) that further impact function of pancreatic acinar cells can result in the precipitation of CFTR related pancreatitis. Here we report a CFTR carrier with methylmalonic acidemia who was treated with ivacaftor and subsequently experienced resolution of her chronic pancreatitis. Our report suggests that ivacaftor may rescue the function of mutant CFTR in carriers and treat pancreatitis caused by CFTR dysfunction in situations where there are additional precipitating factors. [ABSTRACT FROM AUTHOR]

Through the provision of different types of social support, significant nonparental youth–adult relationships can facilitate youth's positive development across adolescence. However, despite the potential benefits of these relationships, there has been little consideration of how the relational process may vary across different adolescent stages. Utilizing qualitative methods, this study compared five types of social support processes (emotional, instrumental, companionship, validation, and informational) as reported by youth during early (n = 23) and late adolescence (n = 14). Differences emerged with regard to the general characteristics and nature of relationships between the early and late adolescent groups and additional differences emerged across the five types of social support. This study demonstrates how a developmental perspective may elucidate the processes that characterize and underlie youth's relationships with supportive nonparental adults. Findings provide implications to understand, promote and sustain these important relationships in the lives of youth. [ABSTRACT FROM AUTHOR]

Papilio chikae and P. hermeli are two endemic swallowtail butterflies in the Philippines found primarily in the Cordillera region and Mindoro Island, respectively. Their species status is still subject to debate due to opposing interpretations of their genitalia and morphological traits. This study aims to delineate these taxa through the use of mitochondrial cytochrome C oxidase subunit I (COI) gene marker, with additional information on their cytochrome C oxidase subunit II (COII) gene. The COI nucleotide sequences from our Philippine P. chikae samples were surprisingly identical to P. hermeli EF514465.1 on the GenBank, whereas our P. hermeli samples showed a 100% similarity with P. hermeli EF514464.1. Based on our phylogenetic analysis, P. chikae and P. hermeli exhibit distinct COI barcodes supported by a high bootstrap value (85%). The P. hermeli voucher specimen with GenBank Acc. No. EF514465.1 clustered with our P. chikae samples, separate from the cluster containing our P. hermeli specimens. Nonetheless, the 3.1-3.4% genetic distance observed in the COI region supported by the formation of two separate clusters suggests species status for these taxa. Moreover, species-specific molecular markers obtained from the COII region displayed a 2.4% distance between these two taxa. These molecular markers could therefore be utilized to distinguish P. chikae from P. hermeli. Nevertheless, a thorough examination of their morphology, behavior, and ecology is still imperative to firmly establish their taxonomic status. [ABSTRACT FROM AUTHOR]

GPR84 is an inflammation-induced receptor highly expressed on immune cells, yet its endogenous ligand is still unknown. This makes any interpretation of its physiological activity in vivo difficult. However, experiments with potent synthetic agonists have highlighted what the receptor can do, namely, enhance proinflammatory signaling and macrophage effector functions such as phagocytosis. Developing drugs to block these effects has attracted interest from the scientific community with the aim of decreasing disease activity in inflammatory disorders or enhancing inflammation resolution. In this review, we critically reassess the widely held belief that the major role of GPR84 is that of being a medium-chain fatty acid (MCFA) receptor. While MCFAs have been shown to activate GPR84, it remains to be demonstrated that they are present in relevant tissues at appropriate concentrations. In contrast to four other "full-time" free fatty acid receptor subtypes, GPR84 is not expressed by enteroendocrine cells and has limited expression in the gastrointestinal tract. Across multiple tissues and cell types, the highest expression levels of GPR84 are observed hours after exposure to an inflammatory stimulus. These factors obscure the relationship between ligand and receptor in the human body and do not support the exclusive physiological pairing of MCFAs with GPR84. To maximize the chances of developing efficacious drugs for inflammatory diseases, we must advance our understanding of GPR84 and what it does in vivo. [ABSTRACT FROM AUTHOR]

Introduction: Traditionally, tissue engineering techniques have largely focused on 2D cell culture models-monolayers of immortalized or primary cells growing on tissue culture plastic. Although these techniques have proven useful in research, they often lack physiological validity, because of the absence of fundamental tissue properties, such as multicellular organization, specialized extracellular matrix structures, and molecular or force gradients essential to proper physiological function. More recent advances in 3D cell culture methods have facilitated the development of more complex physiological models and tissue constructs; however, these often rely on self-organization of cells (bottom-up design), and the range of tissue construct size and complexity generated by these methods remains relatively limited. By borrowing from advances in the additive manufacturing field, 3D bioprinting techniques are enabling top-down design and fabrication of cellular constructs with controlled sizing, spacing, and chemical functionality. The high degree of control over engineered tissue architecture, previously unavailable to researchers, enables the generation of more complex, physiologically relevant 3D tissue constructs. Three main 3D bioprinting techniques are reviewed-extrusion, droplet-based, and laser-assisted bioprinting techniques are among the more robust 3D bioprinting techniques, each with its own strengths and weaknesses. High complexity tissue constructs created through 3D bioprinting are opening up new avenues in tissue engineering, regenerative medicine, and physiological model systems for researchers in the military medicine community.Materials and Methods: Recent primary literature and reviews were selected to provide a broad overview of the field of 3D bioprinting and illustrate techniques and examples of 3D bioprinting relevant to military medicine. References were selected to illustrate specific examples of advances and potential military medicine applications in the 3D bioprinting field, rather than to serve as a comprehensive review.Results: Three classes of 3D bioprinting techniques were reviewed: extrusion, droplet-based, and laser-assisted bioprinting. Advantages, disadvantages, important considerations, and constraints of each technique were discussed. Examples from the primary literature were given to illustrate the techniques. Relevant applications of 3D bioprinting to military medicine, namely tissue engineering/regenerative medicine and new models of physiological systems, are discussed in the context of advancing military medicine.Conclusions: 3D bioprinting is a rapidly evolving field that provides researchers the ability to build tissue constructs that are more complex and physiologically relevant than traditional 2D culture methods. Advances in bioprinting techniques, bioink formulation, and cell culture methods are being translated into new paradigms in tissue engineering and physiological system modeling, advancing the state of the art, and increasing construct availability to the military medicine research community. [ABSTRACT FROM AUTHOR]

The Albian Mauddud Formation is a prolific reservoir in Kuwait and nearby countries such as Iraq and Iran but has received far less attention than the under‐ and overlying units (the Aptian Shu'aiba and Cenomanian Mishrif Formations). Detailed reservoir characterization studies of the formation are required to support field development and improved / enhanced oil recovery (EOR) programmes. In this study, 26 wells penetrating the Mauddud Formation within the Greater Burgan area of Kuwait (Burgan and neighbouring fields) were investigated, integrating the logging of 910 ft of core with petrographic investigations of 113 stained and impregnated thin sections. In the Greater Burgan area, the Mauddud Formation can be divided into a lower Clastic Member and an upper Carbonate Member which is the main focus of this paper. The primary objective of the study was to present a new characterization of this thin, heterogeneous carbonate reservoir by integrating facies analysis and sequence stratigraphy with a detailed petrographic investigation. A second objective was to identify the relative importance of depositional characteristics and diagenesis on the distribution of reservoir properties. Sandstones in the Clastic Member of the Mauddud Formation were deposited on a delta which passed laterally to the north and east into a carbonate platform. During subsequent regional flooding, increased carbonate production resulted in the development of a larger‐scale carbonate platform covering the entire study area. The Burgan field area was part of the proximal zone of this carbonate platform. A number of depositional environments were identified by integrating core and thin section data. These range from outer platform to mid‐ and inner platform, the latter including both high‐ and low‐energy settings (shoal, shoreline; and lagoonal respectively). Mud‐supported textures characteristic of low‐energy inner‐platform and mid‐ to outer‐platform settings are volumetrically dominant in the Mauddud Carbonate Member. Sequence stratigraphic analysis suggests that the Mauddud Carbonate Member is part of a major regressive phase (or highstand systems tract) of a third‐order sequence, with the regional‐scale K110 MFS positioned close to the transition with the underlying Clastic Member. Two 4th order transgressive – regressive (TR) cycles or sequences, M1 and M2, were identified within the Carbonate Member. The top‐Mauddud surface corresponds to a sequence boundary with long‐lasting subaerial exposure during the latest Albian and is characterized by both micro‐ and macroscopic karst features (calcite dissolution vugs and recrystallization in thin sections; and cavities in cores). This study demonstrates that the Burgan field area experienced significant uplift, with increased differential erosion and/or non‐deposition of the upper M2 TR cycle towards the southwest. Eogenetic marine and meteoric calcite cements partially fill macropores close to the tops of the TR cycles and remaining macropores were occluded by shallow‐burial calcite cements. Cementation by ferroan dolomite cement, which resulted from the increased overburden and associated chemical compaction, has almost entirely occluded residual macropores in the lower part of the Mauddud Carbonate Member, close to the underlying siliciclastic deposits of the Clastic Member. As a consequence, porosity is mostly preserved in the middle part of the Carbonate Member. The predominance of mud‐supported textures in these intervals together with the effects of diagenesis explain the widespread occurrence of microporosity within both micritic matrix and grains. In the Greater Burgan area, meteoric diagenesis associated with subaerial exposure(s) of the top‐Mauddud preserved and/or enhanced micrite microporosity. Plug porosity may reach 35% or more, but permeability does not exceed 100 mD. The Mauddud Carbonate Member in the Greater Burgan area is a thin, microporous reservoir, with a dual porosity component which is linked to karst alteration and not to tectonic fracturing. The distribution of reservoir properties results from a combination of primary depositional characteristics and a multiphase diagenetic overprint. This study will guide the future development of the Mauddud reservoir in the Greater Burgan area. It also demonstrates the importance of an integrated approach to constrain sub‐seismic heterogeneities in carbonate reservoirs. [ABSTRACT FROM AUTHOR]

Introduction: Minimally invasive techniques have been suggested to achieve enhanced recovery and improved outcome after pancreaticoduodenectomy (PD). This study describes our experience and a stepwise technical implementation of the laparoscopic pancreaticoduodenectomy (LPD) during early introduction in 2016. Methods: A team of three hepatopancreaticobiliary surgeons with extensive experience in open pancreaticoduodenectomy (OPD) and with advanced laparoscopic skills started a proctor-guided program with LPD. The first 20 carefully selected cases were prospectively reviewed and compared with a matched OPD cohort. Results: In 20 months, 20 minimally invasive PDs were performed. Reviewing the first 10 LPD cases, 7 patients (70%) had anastomosis-related complications, versus 16% in OPD (P = .001). After consulting an international LPD expert, the team switched to a hybrid technique consisting of LPD followed by open reconstruction through midline minilaparotomy (LPD-OR). In the following 10 cases of LPD-OR, no anastomosis-related complications did occur (P = .342 OPD versus LPD-OR). Conclusion: Safe introduction of new techniques in minimally invasive major abdominal surgery is imperative. Based on our single-center experience, LPD-OR may be safer in the earliest phase of the learning curve of minimally invasive PD, as part of a stepwise implementation toward the fully laparoscopic technique. [ABSTRACT FROM AUTHOR]

On the basis of an extended Flory–Huggins expression for the mixing free energy of the long-chain binary polymer blend, we showed that liquid–liquid demixing can be driven solely by the propensities of crystallization differing with respect to components. Demixing prior to crystallization on cooling was demonstrated by dynamic Monte Carlo simulations of the lattice model for a symmetric polymer blend where only one component is crystallizable. We discussed the implications of this principle to several experimental observations including the (in)compatibility of polymer chains with different stereochemical compositions, the memory effect of polymer crystallization, and the spinodal decomposition at an early stage of polymer crystallization. © 2003 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Police officers encounter a variety of stressors, most of which are unique to the profession. These can exact a toll on an officer's mental health, and leave them at increased risk for experiencing psychological problems. However, due to stigma surrounding mental health, as well as traditional law enforcement culture, many officers find it difficult to report, or seek help for, difficulties due to fear of repercussions and/or distrust. Consequently, the potential value of incorporating trained peers as a "first line of defense" has received increased attention. This article describes the Peers as Law Enforcement Support (PALS) program developed in a collaboration between a local police agency and University psychology department. Results of a pilot study evaluating participants' perspectives on course content and quality of instruction are presented. Finally, the need for a broad spectrum approach to prevention and intervention of mental health issues in officers is underscored. • Police officers' unique occupational stressor's impact their mental health. • The PALS program was developed as a secondary prevention effort. • Officers viewed PALS as practical in the learning of material/skills. • Trainers were prepared, engaging, knowledgeable, and encouraging. [ABSTRACT FROM AUTHOR]

The purpose of this mixed methods study was to examine the relationship between attachment, supportive nonparental youth‐adult relationships, and self‐esteem during adolescence. First, in a quantitative path analysis, we found that perceived social support from nonparental adults partially mediated the relationship between adolescent attachment and self‐esteem. In our follow‐up mixed methods analysis, we analyzed youth reflections of support experienced in relationships with significant non‐parental adults (VIPs). As compared to youth with positive attachment models, youth with negative attachment models reported fewer instances of emotional support but more instances of validation support. The youth with negative attachment models described (1) the importance of trust and (2) receiving emotional support specific to their needs. In instances of validation support, these youth described how their VIPs (1) provided them with honest and realistic feedback, (2) challenged their negative thinking and (3) created opportunities for them to recognize and showcase their strengths. Our findings underscore the importance of considering youths' individual attributes in the context of their ongoing relationships in order to gain a more nuanced understanding of the role and dynamics of supportive nonparental youth‐adult relationships in youths' lives. [ABSTRACT FROM AUTHOR]

The status of woody seedling colonization gives clues about the self‐sustainability of restored forests, a tenet of restoration success. Little is known about woody seedling colonization in restored afrotropical forests. We evaluated effects of restoration methods (active vs. passive), sampling year, restoration age, and distance from old‐growth forests on seedling colonization in restored afrotropical moist forests. Seedlings were measured in 2011 and 2014 in 71 clusters of 284 permanent sampling plots (12.6 m2 each) in actively (initially 3–16 years old) and 21 clusters of 63 plots in passively restored forests (initially 16 years old) in Kibale National Park, western Uganda. Seedlings were also measured in nearby old‐growth forests in three clusters of five plots in 2014. We determined species diversity, richness, abundance per plot, and species composition as measures of seedling colonization in restored and old‐growth forests. We found that diversity, richness, and abundance of seedlings were significantly higher in passively than actively restored forests. Diversity and richness but not abundance significantly increased between sampling years and with restoration age. Distance from old‐growth forests did not significantly affect diversity, richness, and abundance. Species composition of actively and passively restored forests was different from that of old‐growth forests after 19 years since restoration started. Our results show that passive restoration should be the preferred method for recovering afrotropical forests, and highlight the effect of continued management on biodiversity of restored forests. [ABSTRACT FROM AUTHOR]

Background: Hiatal Hernia (HH) is a common structural defect of the diaphragm. Laparoscopic repair with suturing of the hiatal pillars followed by fundoplication has become standard practice. In an attempt to lower HH recurrence rates, mesh reinforcement, commonly located at the posterior site of the esophageal hiatus, has been used. However, effectiveness of posterior mesh augmentation is still up to debate. There is a lack of understanding of the mechanism of recurrence requiring further investigation. We investigated the anatomic location of HH recurrences in an attempt to assess why HH recurrence rates remain high despite various attempts with mesh reinforcement. Methods: A retrospective case series of prospectively collected data from patients with hiatal hernia repair between 2012 and 2020 was performed. In total, 54 patients with a recurrent hiatal hernia operation were included in the study. Video clips from the revision procedure were analyzed by a surgical registrar and senior surgeon to assess the anatomic location of recurrent HH. For the assessment, the esophageal hiatus was divided into four equal quadrants. Additionally, patient demographics, hiatal hernia characteristics, and operation details were collected and analyzed. Results: 54 patients were included. The median time between primary repair and revision procedure was 25 months (IQR 13–95, range 0–250). The left-anterior quadrant was involved in 43 patients (80%), the right-anterior quadrant in 21 patients (39%), the left-posterior quadrant in 21 patients (39%), and the right-posterior quadrant in 10 patients (19%). Conclusion: In this study, hiatal hernia recurrences occured most commonly at the left-anterior quadrant of the hiatus, however, posterior recurrences were not uncommon. Based on our results, we hypothesize that both posterior and anterior hiatal reinforcement might be a suitable solution to lower the recurrence rate of hiatal hernia. A randomized controlled trial using a circular, bio-absorbable mesh has been initiated to test our hypothesis. [ABSTRACT FROM AUTHOR]

The golden potato cyst nematode, Globodera rostochiensis (Wollenweber, 1923) Behren, is an economically important pest of potatoes worldwide. In the Philippines, although potato cultivation in the northern part of Luzon has been reported to be plagued by this nematode, no intensive study on its characterization has been done yet. In this study, morphological and molecular analyses were employed to characterize the golden potato cyst nematode present in the country, particularly those collected from Bauko, Mt. Province. Morphological verification through perineal region analysis showed a circumfenestrate vulval and a non-fenestrate anal region, typical of Globodera spp. Morphometrics of second-stage juveniles is also consistently identified with published descriptions of Globodera rostochiensis including the type specimen. Here, the DNA barcodes based on the ITS rDNA, 28S rDNA, and COI gene of the local population of G. rostochiensis were generated. Identity mining of the barcode sequences revealed an identical match to deposited ITS1, 28S, and COI gene sequences of G. rostochiensis with GenBank accession numbers, LC310801.1, MK311329.1, and MT240262.1, respectively. The generated barcode sequences from this study were deposited in NCBI GenBank Database with accession numbers ON739171-ON739173 for ITS, ON739174-ON739176 for 28S, and OQ195126-OQ195128 for COI. Phylogenetic analyses based on three markers yielded phylograms that grouped BMP isolates with other G. rostochiensis accessions in one clade. This study is the first to generate comprehensive morphological data and DNA barcodes for G. rostochiensis in the Philippines. [ABSTRACT FROM AUTHOR]

GPR84 is an orphan G-protein coupled receptor (GPCR) linked to inflammation. Strategies targeting GPR84 to prevent excessive inflammation in disease are hampered by a lack of understanding of its precise functional role. We have developed heterologous cell lines with low GPR84 expression levels that phenocopy the response of primary cells in a label-free cell electrical impedance (CEI) sensing system that measures cell morphology and adhesion. We then investigated the signalling profile and membrane localisation of GPR84 upon treatment with 6-OAU and DL-175, two agonists known to differentially influence immune cell function. When compared to 6-OAU, DL-175 was found to exhibit a delayed impedance response, a delayed and suppressed activation of Akt, which together correlated with an impaired ability to internalise GPR84 from the plasma membrane. The signalling differences were transient and occurred only at early time points in the low expressing cell lines, highlighting the importance of receptor number and kinetic readouts when evaluating signalling bias. Our findings open new ways to understand GPR84 signalling and evaluate the effect of newly developed agonists. [Display omitted] [ABSTRACT FROM AUTHOR]

Abstract Posttraumatic stress disorder (PTSD) may develop after exposure to an event in which death, severe physical harm, or violence occurred or was threatened. First responders, including police, fire rescue personnel, and emergency dispatchers, have been viewed as populations at high risk for developing PTSD symptoms. Indeed, over 80% of first responders report experiencing traumatic events on the job, and it is estimated that 10–15% have been diagnosed with PTSD. However, to date, limited research has reviewed the impact and services available following these traumatic events across first responders. This review examines research regarding PTSD in police officers, firefighters, and emergency dispatchers with particular attention to the prevalence, comorbid diagnoses, risk and protective factors, and resources available to each group. A discussion of limitations of the available research in this area, and suggestions for directions that future work might take, are offered. [ABSTRACT FROM AUTHOR]

The soils of sub-Saharan Africa are characterized by their poverty in nutrients along with low clay and organic carbon content and low exchange capacity. There is high pressure on land resources with the quick growth of population and demand for food. Maintaining the fertility of cultivated soils and land resources is a challenge. Since the paradigm of "external input" in the 1960s and 1970s, to the latest concept of integrated soil fertility management, most of the approaches remain crop oriented or livestock oriented with less attention to local communities (LC), which are at the heart of land resource management. This chapter suggests a new integrated and holistic approach involving LC for land resources management, including cultivated soils and rangelands. A global framework is proposed for development of management options of land resources with LC. It is a dynamic process of participative management of lands as providers of services for the entire community. [ABSTRACT FROM AUTHOR]

Interpersonal relationships during adolescence can be powerful avenues for personal development. As school is a universal context for youth, positive teacher-student relationships (TSRs) are one potential source for such developmentally promotive relationships. Unfortunately, research has shown a decline in the quality of teacher-student interactions as students progress through PK-12, which suggests a missed developmental opportunity. More research is needed to identify factors that contribute to positive TSRs, especially during adolescence. Utilizing qualitative methods, this study explores adolescent perceptions of TSRs in order to identify and understand key interactions and characteristics of high-quality, positive TSRs. We identified two overarching themes that emerged from our qualitative analysis: teacher noticing and teacher investment. Within these themes, we also examined the role of “free” and “same-level” conversations in promoting positive TSRs. Our findings contribute to research aimed at understanding specific processes that occur within positive youth-adult relationships. Specifically, we find promise in key teacher-student interactions that fulfill adolescents’ developmental needs including autonomy, competence and connection. Our findings emphasize the importance of the student perspective and that capitalizing on positive TSRs during adolescence can be a powerful way to promote positive youth development. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic led to reduced services of private dental practices. The public emergency clinic of Rutgers School of Dental Medicine (RSDM) (Newark, NJ) faced changing demands during various periods of the pandemic. Records of patients visiting the emergency clinic at RSDM during 3 distinct periods (prelockdown, lockdown, teledentistry) from January 10, 2020, through June 30, 2020, were retrospectively reviewed. Qualitative and quantitative attributes pertaining to patient encounters were reviewed and analyzed. A total of 1,799 records were included in this study. Patient visits increased during the early lockdown but were reduced after the implementation of teledentistry. Trends were noted in patient volume, reasons for visits, treatment needs, symptoms, diagnostic methodology, prescription use, and final disposition of patients. The lockdown affected emergency dental clinic services at RSDM. Teledentistry visits played a key role in screening patients and in facilitating the delivery of oral health care and timely follow-ups to patients who needed urgent in-person emergency visits. Data gathered will lead to a better understanding of patients seen in the emergency clinic and can help with long-term planning for both institutional and smaller outpatient clinics during public health emergencies. [ABSTRACT FROM AUTHOR]

This article reports on the characterization of a laboratory model 100 A-class hollow cathode with a sintered lanthanum hexaboride ( LaB 6) emitter for high-power Hall thrusters. The cathode has been fired up to 70 A with xenon as working gas. The cathode architecture, test setup, ignition procedure, and power consumption are described first. The second part of this contribution comments on the current–voltage characteristics and the discharge modes obtained for discharge currents in the 30–70 A range and flow rates in the 15–30 SCCM range. The cathode operates in a spot mode at high discharge currents and in a plume mode with large oscillations at low currents and low gas flow rate. Spectral analysis shows that most frequencies reside in the 10–200 kHz range with flat and sharp distributions in plume and spot modes, respectively. Finally, we present electron temperatures and densities measured in the cathode plasma plume by means of incoherent Thomson scattering. The two quantities decrease along the axis. The density is large (up to ∼ 10 19 m − 3 ) and increases with both the ion current and the gas flow rate. The electron temperature increases with the current and decreases with the gas flow rate. The temperature remains relatively low (<1.5 eV) in spite of large currents and applied powers. [ABSTRACT FROM AUTHOR]

The nucleus accumbens (NAc) has often been described as a "limbic-motor interface," implying that the NAc integrates the value of expected rewards with the motor planning required to obtain them. However, there is little direct evidence that the signaling of individual NAc neurons combines information about predicted reward and behavioral response. We report that cue-evoked neural responses in the NAc form a likely physiological substrate for its limbic-motor integration function. Across task contexts, individual NAc neurons in behaving rats robustly encode the reward-predictive qualities of a cue, as well as the probability of behavioral response to the cue, as coexisting components of the neural signal. In addition, cue-evoked activity encodes spatial and locomotor aspects of the behavioral response, including proximity to a reward-associated target and the latency and speed of approach to the target. Notably, there are important limits to the ability of NAc neurons to integrate motivational information into behavior: in particular, updating of predicted reward value appears to occur on a relatively long timescale, since NAc neurons fail to discriminate between cues with reward associations that change frequently. Overall, these findings suggest that NAc cue-evoked signals, including inhibition of firing (as noted here for the first time), provide a mechanism for linking reward prediction and other motivationally relevant factors, such as spatial proximity, to the probability and vigor of a reward-seeking behavioral response. NEW & NOTEWORTHY The nucleus accumbens (NAc) is thought to link expected rewards and action planning, but evidence for this idea remains sparse. We show that, across contexts, both excitatory and inhibitory cue-evoked activity in the NAc jointly encode reward prediction and probability of behavioral responding to the cue, as well as spatial and locomotor properties of the response. Interestingly, although spatial information in the NAc is updated quickly, finegrained updating of reward value occurs over a longer timescale. [ABSTRACT FROM AUTHOR]

There has been an explosion of interest in studying the indigenous microbiota, which plays an important role in human health and disease. Traditionally, the study of microbes in relationship to human health involved consideration of individual microbial species that caused classical infectious diseases. With the interest in the human microbiome, an appreciation of the influence that complex communities of microbes can have on their environment has developed. When considering either individual pathogenic microbes or a symbiotic microbial community, researchers have employed a variety of model systems with which they can study the host-microbe interaction. With the use of studies of infections with the toxin-producing bacterium Clostridium difficile as a model for both a pathogen and beneficial bacterial communities as an example, this review will summarize and compare various model systems that can be used to gain insight into the host-microbe interaction. [ABSTRACT FROM AUTHOR]

Micro-computed tomography (microCT) is a common tool for the visualization of the internal composition of organic tissues. Collagen comprises approximately 25–35% of the whole-body protein content in mammals, and the structure and arrangement of collagen fibers contribute significantly to the integrity of tissues. Collagen type I is also frequently used as a key structural component in tissue-engineered and bioprinted tissues. However, the imaging of collagenous tissues is limited by their inherently low X-ray attenuation, which makes them indistinguishable from most other soft tissues. An imaging contrast agent that selectively alters X-ray attenuation is thus essential to properly visualize collagenous tissue using a standard X-ray tube microCT scanner. This review compares various contrast-enhanced techniques reported in the literature for MicroCT visualization of collagen-based tissues. An ideal microCT contrast agent would meet the following criteria: (1) it diffuses through the tissue quickly; (2) it does not deform or impair the object being imaged; and (3) it provides sufficient image contrast for reliable visualization of the orientation of individual fibers within the collagen network. The relative benefits and disadvantages of each method are discussed. Lugol's solution (I3K), phosphotungstic acid (H3PW12O40), mercury(II) chloride (HgCl2), and Wells–Dawson polyoxometalates came closest to fitting the criteria. While none of the contrast agents discussed in the literature met all criteria, each one has advantages to consider in the context of specific lab capabilities and imaging priorities. [ABSTRACT FROM AUTHOR]

Model building and refinement, and the validation of their correctness, are very effective and reliable at local resolutions better than about 2.5 Å for both crystallography and cryo‐EM. However, at local resolutions worse than 2.5 Å both the procedures and their validation break down and do not ensure reliably correct models. This is because in the broad density at lower resolution, critical features such as protein backbone carbonyl O atoms are not just less accurate but are not seen at all, and so peptide orientations are frequently wrongly fitted by 90–180°. This puts both backbone and side chains into the wrong local energy minimum, and they are then worsened rather than improved by further refinement into a valid but incorrect rotamer or Ramachandran region. On the positive side, new tools are being developed to locate this type of pernicious error in PDB depositions, such as CaBLAM, EMRinger, Pperp diagnosis of ribose puckers, and peptide flips in PDB‐REDO, while interactive modeling in Coot or ISOLDE can help to fix many of them. Another positive trend is that artificial intelligence predictions such as those made by AlphaFold2 contribute additional evidence from large multiple sequence alignments, and in high‐confidence parts they provide quite good starting models for loops, termini or whole domains with otherwise ambiguous density. [ABSTRACT FROM AUTHOR]

Summary In the natural world, monkeys and humans judge the economic value of numerous competing stimuli by moving their gaze from one object to another, in a rapid series of eye movements. This suggests that the primate brain processes value serially, and that value-coding neurons may be modulated by changes in gaze. To test this hypothesis, we presented monkeys with value-associated visual cues and took the unusual step of allowing unrestricted free viewing while we recorded neurons in the orbitofrontal cortex (OFC). By leveraging natural gaze patterns, we found that a large proportion of OFC cells encode gaze location and, that in some cells, value coding is amplified when subjects fixate near the cue. These findings provide the first cellular-level mechanism for previously documented behavioral effects of gaze on valuation and suggest a major role for gaze in neural mechanisms of valuation and decision-making under ecologically realistic conditions. [ABSTRACT FROM AUTHOR]

Samples of locally sourced UK Diesel fuel spiked with the two organic compounds 2-(butan-2-yl)-1-(decyloxy)-4-(triphenylmethyl)benzene (TPMB) and 1,3-dibromotetrafluorobenzene (BFB) were subjected to laboratory-scale distillations to assess the suitability of TPMB and BFB as effective markers of Diesel fuel. Industrial-scale distillations of these spiked Diesel samples were performed to establish whether TPMB and BFB could be successfully and cost-effectively separated from Diesel on a significantly larger scale. Diesel distillate does not contain any TPMB; newly formulated performance criteria of an ideal, distillation resistant fuel marker clearly reject TPMB as a marker suitable for the tagging of Diesel. In contrast, BFB is retained in all fractions of distilled Diesel and largely satisfies the performance criteria of a distillation resistant fuel marker. BFB consequently functions as a significantly better fuel marker than TPMB for the tagging of Diesel. It is demonstrated that distillation is also a highly effective means of removing current overt dye markers. Conservative estimates suggest that an appropriately equipped laundering facility for the distillative removal of fuel markers or vice versa fuel from marked Diesel offers the potential of generating a vastly lucrative, multi-million pound annual profit. [ABSTRACT FROM AUTHOR]

Recent advances in developmental and stem cell biology have resulted in techniques that enable the generation and maintenance of complex epithelium in vitro. While these models have been utilized to study host development and disease, a renewed appreciation of host–microbe interactions has sparked interest in employing these new techniques to study microbes at the epithelial interface. Here we review the current advances in host–microbe interactions that have resulted from experiments using these complex epithelia. Furthermore we highlight aspects of these techniques that warrant further development to facilitate the study of host–microbe interactions. [ABSTRACT FROM AUTHOR]