1. Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma.
- Author
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Routila, E, Mahran, R, Salminen, S, Irjala, H, Haapio, E, Kytö, E, Ventelä, S, Petterson, K, Routila, J, Gidwani, K, and Leivo, J
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SQUAMOUS cell carcinoma , *GLYCOSYLATION , *HEAD & neck cancer , *NECK - Abstract
Background: Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors. Methods: Tumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens were performed. Results: Strong correlation between glycosylation profiles of all four stemness-related proteins was observed in tumor tissue, whereas glycosylation in tumor tissue, adjacent normal tissue, and serum was differential. Conclusions: A mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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