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2 results on '"Van Loc, Tran"'

1. Two New Glycosides from the Water Extract of Lepisanthes rubiginosa Collected in Vietnam.

Author

Van Loc, Tran, Ninh, Pham Thi, Thao, Tran Thi Phuong, and Anh, Tran Tuan

Subjects
*GLYCOSIDES, *TRADITIONAL medicine
Abstract

In this attempt to seek promising compounds from Lepisanthes rubiginosa, a widely used folk medicine in the middle of Vietnam, we isolated four compounds from the water extracts of the leaves and the barks, including a new oleanane glycoside lepisantheside C (1), a new farnesyl glycoside lepisantheside D (2), and two known compounds. Their structures were elucidated using spectroscopic methods (HR-ESI-MS, 1D and 2D NMR) and by comparison with the reported data. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Synthesis of madecassic acid derivatives and their cytotoxic activity.

Author

Van Loc, Tran, Nhu, Vo Thi Quynh, Van Chien, Tran, Ha, Le Thi Thu, Thao, Tran Thi Phuong, and Van Sung, Tran

Subjects
*AMIDE derivatives, *CELL-mediated cytotoxicity, *CENTELLA asiatica, *HYDROXYL group, *AMIDATION, *CHEMICAL synthesis
Abstract

Fifteen new 28-amide derivatives of madecassic acid, isolated from the tropical medicinal herb Centella asiatica (Apiaceae), have been synthesised, and their cytotoxicity on three cancer cell lines, KB (carcinoma cancer), HepG2 (liver cancer) and Lu-1 (lung cancer), was evaluated. The results showed that acetylation of the 2,3,23-hydroxyl group and/or amidation of the 28-COOH group strongly increased the cytotoxicity of the synthesised compounds. [ABSTRACT FROM AUTHOR]

Published
2018
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