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Background/Objectives: Itch is one of the hallmarks of atopic dermatitis (AD), which has a significant impact on the quality of life of pediatric patients with AD and their caregivers. We aimed to conduct a systematic review and meta‐analysis to evaluate the antipruritic effects of systemic AD treatments in pediatric patients with AD. Methods: PubMed, EMBASE, Cochrane, and Web of Science databases were searched, including studies providing original data on the effects of systemic treatment on pruritus in pediatric patients (<18 years) with AD. Placebo‐controlled trials reporting a Peak Pruritus Numerical Rating Scale 4 (PP‐NRS4) response were included in a meta‐analysis. Results: A total of 30 studies were included, with most evidence available for dupilumab. Overall, marked improvements of pruritus (50% or greater reduction in pruritus outcome measurements) were found for treatment with cyclosporin A (2–16 years), dupilumab (6 months–17 years), abrocitinib, and upadacitinib (both 12 and 17 years). Nemolizumab (12–17 years) may be promising in reducing pruritus in pediatric patients; however, data are limited. Only five randomized controlled trials could be included in our meta‐analysis, in which dupilumab, abrocitinib, and upadacitinib showed a significantly higher probability of achieving a PP‐NRS4 response compared with placebo. Our study was limited by a lack of homogeneity of included studies. Conclusions: Cyclosporin A, dupilumab, abrocitinib, and upadacitinib are all effective in decreasing pruritus and, therefore, in improving the quality of life in children with AD. As more systemic treatments for AD become available, it will be imperative to incorporate patient‐oriented treatment goals such as reduction of pruritus into therapeutic decision‐making. [ABSTRACT FROM AUTHOR]

Real-world evidence, directly comparing the effectiveness of interleukin (IL)17-inhibitors, IL23-inhibitors, tumour necrosis factor alpha (TNF-a)-inhibitors and an IL12/23-inhibitor in psoriasis, is scarce. The aim of this study was to directly compare the first-year effectiveness of biologic therapies for psoriasis, corrected for confounders. This prospective, multicentre cohort study assessed BioCAPTURE data on etanercept, adalimumab, ustekinumab, secukinumab, ixekizumab, and guselkumab in 1,080 treatment episodes of 700 patients with psoriasis. The course of the mean absolute Psoriasis Area and Severity Index (PASI) and the proportion of patients who achieved PASI90/PASI75 were compared using linear mixed models and mixed logistic regression models respectively, corrected for baseline PASI, biologic naivety, and weight. Patients treated with adalimumab, ustekinumab, secukinumab, ixekizumab, or guselkumab all had a significantly lower mean PASI after 12 months compared with etanercept, and significantly higher overall odds of reaching PASI90 than those treated with etanercept. Patients treated with ixekizumab or guselkumab also had higher probabilities of reaching PASI90 than adalimumab, ustekinumab, and secukinumab. Relative to randomized controlled trials, the proportions of patients who reached PASI90/75 were lower in this real-world study. [ABSTRACT FROM AUTHOR]

The article presents a study which aims to evaluate 1- and 2-year drug survival (DS) of guselkumab, split for discontinuation due to ineffectiveness or side-effects. It mentions that the study elucidate predictors for a shorter guselkumab DS. It informs that guselkumab has been registered as the first interleukin-23 (IL-23) inhibitor for treatment of psoriasis.