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Objective: Studies about obsessive-compulsive disorder (OCD) during the postmenopausal period have been insufficient. The purpose of the current study was therefore to examine the prevalence rate, clinical characteristics, and comorbidity of OCD in postmenopausal women. Methods: A total of 269 consecutive postmenopausal women admitted to a gynaecology outpatient clinic were included in the study. OCD and comorbid disorders was diagnosed by means of the Structured Clinical Interview for DSM-IV. The Yale-Brown Obsessive- Compulsive Scale was used to determine the types of obsessions and compulsions. Results: The prevalence rate of OCD was 7.1% in the sample. Two women (0.7%) reported that OCD developed during the postmenopausal period. The most common obsessions were contamination and symmetry/exactness, whereas the most common compulsions were cleaning/washing and checking. OCD was unrelated to variables examined in the present study. The comorbidity rate of other psychiatric disorders was 63.2% in OCD patients. The most common comorbid disorder was generalized anxiety disorder. Conclusions: OCD was not rare in postmenopausal women admitted to a gynaecology outpatient clinic. In addition, OCD appears to be frequently comorbid with depressive or other anxiety disorders in the postmenopausal period. [ABSTRACT FROM AUTHOR]

Objective: There are three aims of this study:- 1) to examine the incidence of interferon alpha (IFN-a) induced major depression, 2) to examine theassociations between IFN-a induced major depression and clinical and sociodemographic characteristics and 3) to examine the impact of IFN-a on the quality of life in patients with chronic hepatitis C virus infection.Method: Thirty-six patients with chronic hepatitis C virus infection were evaluated by using the Structured Clinical Interview for DSM-IV, the Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS) and the World Health Organization Quality of Life Scale-Brief (WHOQOL-BREF) before the treatment and 8 weeks after interferon alpha treatment.Results: Major depression developed in 10 (27.8%) of 36 patients during treatment with IFN-a. During the IFN-a treatment, HDRS and HARS scoressignificantly increased, and WHOQOL-BREF subscale scores of physical health, psychological health and environment significantly decreased. It was found that HDRS scores significantly increased in patients receiving IFN-a even if major depression did not develop at 8 weeks after the treatment. IFN-a induced major depression was associated with higher basal scores of HDRS and HARS, and lower basal scores of WHOQOL-BREF.Conclusion: IFN-a treatment is associated with an increased risk for major depression and it has a negative effect on the quality of life in patients with chronic hepatitis C virus infection. The mental status of all patients were evaluated before and after the IFN-a treatment. [ABSTRACT FROM AUTHOR]

Objective. This study aims to investigate the current prevalences of mood and anxiety disorders, as well as the sociodemographic and clinical features associated with these disorders in multiple sclerosis (MS). Method. A total of 74 patients with relapsing-remitting MS (42 patients in exacerbation phase, 32 patients in remission phase) were included in the study. Mood and anxiety disorders were diagnosed by means of the Structured Clinical Interview for DSM-IV (SCID-I). The Expanded Disability Status Scale (EDSS) was used to determine degree of disability due to MS. Results. Forty-five (60.8%) patients met the criterion of at least one mood or anxiety disorder. Major depression (33.8%) was the most common psychiatric diagnosis. Generalized anxiety disorder (18.9%), specific phobia (18.9%) and obsessive-compulsive disorder (OCD) (14.9%) were other frequent psychiatric disorders. Major depression, panic disorder and OCD were significantly more common among patients in the exacerbation phase compared to patients in the remission phase. The predictors of any depressive disorder were presence of exacerbation phase of MS and higher disability level, and the predictors of any anxiety disorder were presence of exacerbation phase of MS and shorter disease duration. Conclusions. Our results suggest that the patients with relapsing-remitting MS, particularly during exacerbation phase have high prevalence of mood and anxiety disorders. [ABSTRACT FROM AUTHOR]

Background Chronic idiopathic urticaria (CIU) is associated with severely impaired quality of life (QoL). Objective To determine the levels of depression, anxiety and QoL in CIU patients. Patients and methods This study included 73 patients with CIU, and 34 healthy subjects matched for age and sex were used as controls. The levels of depression, anxiety and QoL were assessed with the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI) and the World Health Organization Quality of Life Assessment-Brief (WHOQOL-BREF), respectively. The reliability and validity of the Turkish versions of these instruments have been examined. Results When compared with healthy controls, patients with CIU had significantly higher BDI and BAI scores and significantly lower physical health and psychological health subscale scores of the WHOQOL-BREF. BDI, BAI and all domains of WHOQOL-BREF were unrelated to age, duration of illness, urticaria activity score (UAS) and visual analogue score (VAS). There was a negative significant correlation between all domains of WHOQOL-BREF and BDI and BAI. Conclusion Our data confirm that QoL is markedly reduced in CIU patients. Physical health and psychological health were found to be the areas QoL most affected in CIU patients. And also we have found that CIU patients frequently suffer from depression and anxiety. The severity of these parameters was found to be positively correlated with the extent of QoL decrease. [ABSTRACT FROM AUTHOR]

Introduction The relationship between oligohydramnios and psychiatric disturbances is unclear. Objective This study examined the prevalence of major depression and generalized anxiety disorder in pregnant women with and without a diagnosis of oligohydramnios. Methods The study sample included 53 pregnant women with a diagnosis of oligohydramnios and 80 healthy pregnant women subjects. Oligohydramnios was defined as an amniotic fluid index of 8cm or less. Major depression and generalized anxiety disorder were diagnosed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID-I). The severity of depressive and anxiety symptoms were assessed with the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI), respectively. Results Pregnant women with oligohydramnios had higher scores of depressive and anxiety symptom scores, and a higher prevalence rate of major depression (24.5% vs 6.2%) and generalized anxiety disorder (30.2% vs 3.2%). In addition, patients with deep oligohydramnios had a higher prevalence rate of major depression (40.7% vs 7.7%, P=0.009) and GAD (44.4% vs 15.4%, P=0.035) compared to patients with moderate oligohydramnios. Conclusions The results of the present study suggest that oligohydramnios appears to be associated with both major depression and generalized anxiety disorder in pregnant women. [ABSTRACT FROM AUTHOR]