1. Effects of ivermectin on cytokine and immunoglobulin levels in sheep.
- Author
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Canbar, Rahmi, Dik, Irmak, Uslu, Muhittin, Ider, Merve, Arslan, Mustafa-Sedat, and Yazar, Enver
- Subjects
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IVERMECTIN , *IMMUNOGLOBULIN E , *SHEEP , *IMMUNOGLOBULIN G , *IMMUNE system , *CYTOKINES , *IMMUNOGLOBULIN M - Abstract
Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheepspecific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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