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1. Lobular panniculitis and diffuse osteonecrosis occurring during anti‐MEK and anti‐BRAF combination therapy for metastatic melanoma.

Author

Tzoumpa, S., Villette, B., Tieng, A. C., Bejar, C., Rousset, L., Heidelberger, V., Playe, M., Desbene, C., Khalifa, B., N'Guessan‐Koffi, C., Braun, T., Le Jeune, S., Caux, F., and Maubec, E.

Subjects
*ADIPOSE tissue diseases, *LOBULAR carcinoma, *OSTEONECROSIS, *MELANOMA, *METASTASIS, *LITERATURE reviews
Abstract

Dear Editor, BRAF-V600E-targeted-therapy (TT) and immune-checkpoint-inhibitors (ICIs) have revolutionized the treatment of metastatic melanoma (MM). Subcutaneous and bone lesions in patients with MM under TT should not be immediately interpreted as disseminated metastasis, as they could also represent drug-induced TT effects. PET-CT-scan showed a partial lymph-node response, contrasting with the occurrence of hypermetabolic subcutaneous lesions and bone foci of the tibias/calcaneus/right radius and humerus (Figure 1e). [Extracted from the article]

Published
2023
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