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Presents a study which examined the effect of bradykinin on drinking and arterial blood pressure in eels. Materials and methods; Results and discussion.

Examines the antidipsogenic effect of eel bradykinins in the eel Anguilla japonica. Role of atrial natriuretic peptide on plasma sodium concentration; Alteration in the drinking and arterial blood pressure in eels; Infusion rate of angiotensin II.

Evaluates the role of the renin-angiotensin system in drinking of seawater-adapted eels. Role of angiotensin II in drinking of seawater fish; Changes in drinking rate, plasma angiotensin II concentration, and arterial blood pressure after infusion of SQ-14225; Comparison of plasma renin activity and angiotensin II levels in freshwater and seawater eels.

Presents information on a study which evaluated the role of endogenous renin-angiotensin system in copius drinking of seawater eels. Methodology; Effects of SQ-14225 and an anti-ANG II serum on drinking, plasma ANG II hormone, and blood pressure; Role of ANG II hormone in drinking of seawater fish.

Provides information on a study on the effects of eel atrial natriuretic peptide on drinking. Methodology; Materials used in the study; Results of the study; Changes in drinking rate; Conclusion.

Examines the effects of eel atrial natriuretic peptide (ANP) on drinking in both freshwater and saltwater eels. Assessment of the interaction of ANP and the plasma ANG II in the regulation of drinking; Examination of the changes in plasma sodium concentration and osmolality.

Background/Aims: Lipocalin-type prostaglandin D synthase (L-PGDS), an enzyme converting prostaglandin H[sub 2] to prostaglandin D[sub 2] , occurs particularly in the cardiovascular system. Urinary L-PGDS excretion is increased in diabetes prior to overt proteinuria, suggesting that it is a predictor of renal injury. In this study, we tested the hypothesis that L-PGDS excretion reflects renal injury in primary glomerular diseases using Adriamycin-induced nephropathy in mice. Methods: Twenty 6-week-old ICR female mice were intravenously given a dose of 25 mg Adriamycin/kg body weight through the tail vein. 24-hour urine was collected every day, and blood samples were obtained. Results: The mice developed significant albuminuria from day 3 onward (p < 0.05), which was followed by overt proteinuria from day 4 (p < 0.05). Histological examination revealed focal mesangial expansion with partial tubular atrophy. Urinary L-PGDS excretion significantly increased from day 1 onward (p < 0.05), and apparently preceded the increase in urinary albumin excretions. Either serum L-PGDS or creatinine levels were not changed by administration of Adriamycin. However, serum creatinine levels were inversely correlated to urinary L-PGDS excretions (r = –0.88, p < 0.05). Immunohistochemistry showed that L-PGDS occurred in the tubules, but not in the glomeruli in Adriamycin mice and L-PGDS mRNA paralleled urinary L-PGDS excretion. Conclusion: Urinary L-PGDS excretion is increased in Adriamycin-induced nephropathy, and this precedes overt albuminuria. Copyright © 2004 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]