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The aim of this study was to investigate the effects of plyometric training on vastus lateralis (VL) and patellar tendon size, quadriceps isokinetic strength, and vertical jump height in adolescent female volleyball players. Thirty players (age mean ± SD: 15.7 ± 1.1 years) participated in a 6-week Sportsmetrics™ plyometric training program. VL thickness, echo intensity, and patellar tendon cross-sectional area were assessed by real-time ultrasound. Isokinetic quadriceps strength and vertical jump were assessed. The VL thickness, quadriceps strength, and VJ height increased and VL–echo intensity decreased after training. We recommended that 6-week Sportmetrics plyometric training program may be implemented in adolescent female volleyball programs especially before the beginning of the volleyball season. [ABSTRACT FROM AUTHOR]

Background: Comparing gene expression profiles using gene expression datasets of different types of tumors is frequently used to identify molecular mechanisms of cancer. This study aimed to find shared and type specific gene expression profiles of hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL). Material and methods: Gene expression microarrays for HCC and B-CLL and RNA-sequencing expression data for liver HCC and lymphoid neoplasm diffuse large B-cell lymphoma (DLBC) were analyzed and differentially expressed probe sets or genes for each cancer type were detected. Probe sets and genes that were shared or specifically expressed in both cancer types were identified. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) terms for Biological Process (BP) annotations were performed. Results: According to our analysis shared upregulated genes were mainly annotated in cell cycle processes. Some of the genes that changed only in HCC were annotated in cell cycle and metabolic processes, and some of the genes, altered only in B-CLL, were annotated in immune response and hemopoiesis. Conclusion: These results contribute to cancer research that aim to find the conserved gene expression profiles in different cancer types and widen the knowledge of HCC and B-CLL specific mechanisms. [ABSTRACT FROM AUTHOR]

Objective: To investigate the ulnar groove (UG), extensor carpi ulnaris (ECU) tendon, and ulnar styloid process (USP) parameters in asymptomatic individuals without ulnar-sided wrist abnormalities, to determine whether these values can be anthropometric markers of age and gender and identify their correlations for use in clinical decision-making.Materials and methods: The MRI T1W axial, T2W sagittal, coronal PW and DESS sequences were evaluated in 100 cases (62 women). The UG width, depth and groove opening angle (GOA), ECU tendon width and thickness, and USP base width and length were measured.Results: For gender, the cut-off, sensitivity, specificity and accuracy values were 8.58 mm, 67, 68 and 66%, respectively, for UG width; 5.3 mm, 53, 68 and 62%, respectively, for ECU width; and 6.4 mm, 55, 74, and 67%, respectively, for USP length. There was no difference concerning age. The tendon width was 63% of the UG width and depth was approximately 51% out of the UG. UG depth was correlated with GOA and tendon thickness (p < 0.001 and 0.03, respectively); UG width with GOA, tendon thickness, and USP base width and length (p = 0.005, 0.01, 0.016, and 0.02, respectively); tendon width-thickness with USP base width and length (p = 0.05); and US base width with US length (p < 0.001).Conclusion: The gender differences in distal ulnar measurements can be beneficial for surgery and forensic science. UG is wider than ECU tendon, and this is the cause of normal subluxation. Therefore, rather than deepening UG, surgeons should focus on tendon sheath abnormalities as a physiological solution. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the sonographic characteristics, functional aspects and life quality of a group of adolescent patients 2 years after having been diagnosed with Osgood-Schlatter disease and compare them with an age-matched healthy control group. Methods: The study was conducted on eighteen Osgood-Schlatter patients with unilateral involvement and 14 age-matched healthy controls. The Flaviis classification and patellar tendon characteristics were observed using a GE Logiq 9 scanner. Broad and vertical jump tests were used for jumping performance. The coordination, proprioception, strength and endurance functions were assessed with the Functional Squat System. For the quality of life, the SF-36 questionnaire was used. The Wilcoxon test for the patients' initial and second-year assessment and Mann-Whitney U test for the comparison between the patient and control groups were used. Results: By the end of second year, 38.9 % of the patients had totally recovered. The patellar tendon lengthened, distal diameter and distal area of the tendon had lessened, and no significant difference was observed between patient and control groups (n.s). Improvements were detected for the bilateral broad jump test scores, the quality of life and coordination of the patients after 2 years ( p < 0.05). The average power of endurance and the total work of strength were significantly higher in control group ( p < 0.05). Conclusions: According to the sonography results 2 years after diagnosis, nearly half of the patients had totally recovered. Coordination was the only parameter that improved over the 2-year period. The patient group strength and endurance function remained lower than the control group. Level of evidence: III. [ABSTRACT FROM AUTHOR]

Purpose: Using sonographic findings to test the diagnostic accuracy of impingement versus tendon palpation tests in Neer stage I and II subacromial impingement syndrome cases and examine their clinical potential. Methods: Neer and Hawkins impingement tests and rotator cuff tendon palpation tests followed by bilateral shoulder sonography were conducted on 69 patients with a clinical diagnosis of unilateral subacromial impingement. Results: The Neer and Hawkins tests had 74 and 62 % accuracy (sensitivity 80 and 67 %, and specificity 52 and 47 %, respectively) in comparison to 79 and 62 % accuracy rates for supraspinatus and biceps tendon palpation tests (sensitivity 92 and 41 %, and specificity 41 and 48 %, respectively). Overall, the palpation tests scored better than impingement tests in the diagnosis of Neer stage I and II subacromial impingement syndrome. No tendinosis or tear was noted in patients with negative findings in the supraspinatus palpation tests (sensitivity 100 %, specificity 21 %). Conclusion: Palpation tests for supraspinatus and biceps tendons have a slightly higher accuracy than the impingement tests, and if tenderness does not exist then supraspinatus tendinopathy can be ruled out. These findings warrant the use of palpation tests in a routine physical examination for tendinopathy. Level of evidence: I. [ABSTRACT FROM AUTHOR]

Context: The scapular retraction exercises are widely used among clinicians to balance the activity of the scapular muscles as well as the rotator cuff muscles in different shoulder abduction positions. Objectives: The aim of this study was to investigate the relationship between scapular (middle and upper trapezius) and shoulder muscles (middle deltoid and infraspinatus) activation level differences and acromiohumeral distance changes during shoulder abduction with scapular retraction. Design: Cross-sectional study. Setting: University research laboratory. Participants: Nineteen asymptomatic individuals were included (mean [SD]: age = 22.4 [1.8] y). Main Outcome Measure: The acromiohumeral distance was measured at 0° and 90° shoulder abduction when the scapula was in nonretracted and retracted position with ultrasound imaging. The relationship between muscle activation level changes and acromiohumeral distance difference was analyzed with the Pearson correlation test. Results: Middle trapezius muscle activity change correlated with acromiohumeral distance difference (r =.55, P =.02) from 0° to 90° shoulder abduction when scapula was retracted. For both nonretracted and retracted scapular positions, no correlations were found between middle deltoid, infraspinatus, and upper trapezius muscle activity changes with acromiohumeral distance differences during shoulder abduction (P >.05). Conclusions: Active scapular retraction exercise, especially focusing on the middle trapezius muscle activation, seems to be an effective treatment option to optimize the acromiohumeral distance during shoulder abduction. [ABSTRACT FROM AUTHOR]

Background: The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin. Aim: This multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey. Methods: The study included 156 Crohn's disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals' gastroenterology departments. Data collection relied on the International Organization of IBD's questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models. Results: In the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14–0.55) and UC (OR 0.25; 95% CI 0.15–0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76–6.10) and CD (OR 4.40; 95% CI 2.12–9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51–35.6) and UC (OR 7.56; 95% CI 1.57–36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10–0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18–0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16–4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19–8.37). Conclusions: This study represents the first multicenter case–control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD. [ABSTRACT FROM AUTHOR]

Context: Sport-specific adaptations at the glenohumeral joint could occur in adolescent athletes because they start participating in high-performance sports in early childhood. Objective: To investigate shoulder-rotator strength, internal-rotation (IR) and external-rotation (ER) range of motion (ROM), and acromiohumeral distance (AHD) in asymptomatic adolescent volleyball attackers to determine if they have risk factors for injury. Design: Cross-sectional study. Setting: University laboratory. Participants: Thirty-nine adolescent high school-aged vol-leyball attackers (22 boys, 17 girls; age = 16.0 ± 1.4 years, height = 179.2 ± 9.0 cm, mass = 67.1 ± 10.9 kg, body mass index = 20.7 ± 2.6 kg/m²). Main Outcome Measure(s): Shoulder IR and ER ROM, total-rotation ROM, glenohumeral IR deficit, AHD, and concen-tric and eccentric strength of the shoulder internal and external rotators were tested bilaterally. Results: External-rotation ROM was greater (t38 = 4.92, P < .001), but IR ROM (t38 =-8.61, P < .001) and total ROM (t38 = -3.55, P = .01) were less in the dominant shoulder, and 15 athletes had a glenohumeral IR deficit (IR ROM loss > 18°). We observed greater concentric internal-rotator (t38 = 2.89, P = .006) and eccentric external-rotator (t38 = 2.65, P = .01) strength in the dominant than in the nondominant shoulder. The AHD was less in the dominant shoulder (t38 = -3.60, P < .001). Conclusions: Adolescent volleyball attackers demonstrat-ed decreased IR ROM, total ROM, and AHD and increased ER ROM in their dominant shoulder. Therefore, routine screening of adolescent athletes and designing training programs for hazardous adaptive changes could be important in preventing shoulder injuries. [ABSTRACT FROM AUTHOR]

Objective: The objectives of this study were to determine sinus measurements specific for the Turkish population using CT sagittal thin-slice reconstruction images and to clarify the three-dimensional anatomical features of the sphenoid sinus, along with its surrounding structures, that are relevant to performing an endoscopic sphenoidotomy. Materials and Methods: ımages of 300 patients (165 female, 135 male) were studied. The research was conducted on the axial plane with a 1 mm slice thickness and a 0.6 mm slice interval, and sagittal reconstruction was performed with a 0.4 mm slice interval. Measurements of the sinus were obtained, and the presence of Onodi cells was researched. Results: Line 1 was found to be significantly shorter in the Turkish patients of this study compared to studies of other populations. Lines 4 and 6 were found to be longer on the left side (Line 4 right: 18.8±3.6 mm, left: 19.3±3.4 mm, p=0.027; Line 6 right: 24.1±6.8 mm, left: 24.3±6.8 mm, p=0.008). Lines 2, 3, 4 and 6 were longer in men than in women (p<0.05). Conclusion: ın the Turkish population, Line 1 is shorter, so the risk of skull base perforation is greater. Lines 4 and 6 are longer on the left side; thus, choosing the left ostium in sinus dilation is safer. Because of sex differences regarding Lines 2, 3, 4 and 6, sex should be considered in sphenoid sinus procedures. [ABSTRACT FROM AUTHOR]

A 58-year-old female patient presented to the hospital with hearing loss. In the chest radiography obtained before her ear surgery, volume decrease in the right hemithorax, elevation of the right diaphragm, and increase of ventilation in the right lung were detected. At the thorax CT-CT angiography, hypoplasia of the main pulmonary artery and its branches and arteriovenous malformation localized in the middle lobe of the right lung were detected. Thus, diagnosis of Swyer-James-Macleod syndrome associated with right lung middle lobe hypoplasia and arteriovenous malformation was made. This kind of association has not been reported earlier, so we are presenting it in the light of the literature knowledge. [ABSTRACT FROM AUTHOR]

Aim: To investigate the common flexor tendon (CFT) thickness and the frequency of ultrasound (US) pathological alterations in its structure in a healthy population and to evaluate if these findings can be correlated with dominant hand, age, gender, body mass index, workload, menopause status.Material and Methods: The study population consisted of 111 healthy volunteers. Bilateral CFT thicknesses were measured at 5 mm, 10 mm and 15 mm distance to medial epicondyle. Tendon echotexture, tears, calcification, enthesophyte, and neovascularization were also evaluated.Results: The CFT was thicker on the dominant side at all three locations (2.1 versus 1.9 mm proximal, 4.0 versus 3.7 mm in the middle and 7.0 versus 6.6 mm distal, all p<0.05). Thickness correlated negatively with postmenopausal duration in all landmarks, except for the nondominant side distal part and positive with body mass index, significantly on the dominant side proximal and middle parts. A statistically significant correlation was found between heavy workers group and tendon thicknesses on the proximal and middle parts of the dominant side and the distal part of the non-dominant sides. US tendinosis was detected in 24/222 tendons, calcification in 11/222 tendons and enthesophyte in 33/222 tendons. The threshold age was 46.5 years for enthesophytes and 51.5 years for calcifications. The prevalence of calcification and enthesophyte tended to be higher in blue-collar workers and on the dominant side.Conclusions: The CFT thickness varies depending on measurement locations, handedness, body mass index, postmenopausal duration and workload. The US signs of tendinosis may be encountered in a symptom-free population. Calcification and enthesophyte tended to be more frequent in blue-collar workers. [ABSTRACT FROM AUTHOR]

Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating, and rapidly progressive disorder of the central nervous system. This condition is also known as postinfectious encephalomyelitis, and it is characterized by multifocal lesions in the brain and spinal cord with widespread neurological findings. High doses of intravenous (IV) methylprednisolone, intravenous immunoglobulin (IVIG), and plasma exchange (PLEX) treatments comprise the first-line therapy. There are limited pediatric case reports refractory to standard treatment. Here, we present the case of a 17-year-old girl diagnosed with ADEM associated with Salmonella infection, which was treated with rituximab. [ABSTRACT FROM AUTHOR]

ObjectivesThis study evaluated whether diffusion-weighted magnetic resonance imaging (DW-MRI) can be used to diagnose secondary renal amyloidosis looking specifically at the diagnostic efficacy of two apparent diffusion coefficient (ADC) measurement methods as they were used with DW-MRI.MethodsThe study included 24 amyloid nephropathy (AN) patients, 20 chronic kidney disease (CKD) patients, and 20 healthy volunteers (HV). ADC values were measured using two different methods: 1) the method of the region of interest indicators (ROIs) and 2) the method of drawing whole renal parenchyma (WP). The correlation between the two methods was evaluated.ResultsROIs could differentiate AN-CKD (p = 0.007). ROIs and WP could differentiate AN-HV (p < 0.05). However, none of the methods could differentiate CKD-HV (p > 0.05). The sensitivity and specificity of the ROIs method in differentiating AN from CKD patients for 1.8 × 10−3cutoff ADC values were 79% and 60% and for AN-HV patients 79% and 70%. ADC values of AN patients with GFR > 60 mL/min were lower than that of HV (p < 0.01).ConclusionDW-MRI is a useful and non-invasive diagnostic tool in diagnosing secondary renal amyloidosis and differentiating renal amyloidosis from other CKDs. ROIs had the highest sensitivity and specificity for assessing the involvement of renal amyloidosis. MRI diagnosis of AN may obviate a renal biopsy for diagnosis. [ABSTRACT FROM PUBLISHER]

We evaluated the efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) in patients with distal ureteral stone. In addition, we tried to determine the predictive value of Hounsfield Unit (HU) of the stone in the success of MET. A total of 75 patients with a distal ureteral stone of 5-10 mm diameter were randomly divided into three groups. Group 1 ( n = 25) received tamsulosin 0.4 mg/d; group 2 ( n = 25) received nifedipine 10 mg/day p.o and group 3 ( n = 25) received diclofenac sodium 50 mg p.o. when required. At the beginning of each treatment, the HU of the stone was also measured using a non-contrast computerized tomography in all the patients. The results were evaluated at week four. The mean age of the patients was 36.8 (range, 16-68) years. Stone expulsion was observed in 19 (76%) patients in group 1, 16 (64%) patients in group 2 and 9 (36%) patients in group 3 (pgroup1-3 = 0.004, pgroup2-3 = 0.048 and pgroup1-2 = 0.355). The mean expulsion time was 9, 9.1 and 10.3 d, respectively (pgroup1-3 < 0.001, pgroup2-3 < 0.001 and pgroup1-2 = 0.619). The mean diclofenac sodium dose per patient was 544, 602 and 1408 mg in groups 1, 2 and 3, respectively (pgroup1-3 < 0.001, pgroup2-3 < 0.001 and pgroup1-2 = 0.977). The mean HU of the stone in patients with and without a successful MET was 363 and 389, respectively ( p = 0.462). Our results showed that MET with both nifedipine and tamsulosin provided a similar increase in the expulsion rate for distal ureteral stones. HU does not seem to be a predictive parameter for stone expulsion. [ABSTRACT FROM AUTHOR]

Intestinal lipomatosis also known as lipohyperplasia is a rare disease. Diffuse infiltration of the fatty tissue mainly in the submucosal layer is characteristic. It is usually asymptomatic and found incidentally. We report a case of lipomatosis in the terminal ileum and ileocecal valve. Multidetector computed tomography (MDCT) with contrast enhancement showed fatty infiltration of the terminal ileum and ileocecal valve. [ABSTRACT FROM AUTHOR]