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Introduction: Tocilizumab (TCZ) is a humanized antihuman interleukin (IL)-6 receptor antibody recommended for the treatment of moderate to severe active rheumatoid arthritis, adult-onset Still disease, Castleman disease and more recently, systemic juvenile idiopathic arthritis. Like anti-TNFα, rituximab and less frequently abatacept, TCZ can induce paradoxical cutaneous eruption like psoriasis with predominantly palmoplantar presentation. Case report: We report a 47-year-old woman with psoriastic arthritis who developed under anti-TNFα therapy and later under tocilizumab a paradoxical palmoplantar eruption. Conclusion: The specific underlying mechanisms of this side effect are unclear but relapse of these lesions seems to be observed with certain biological agents. [ABSTRACT FROM AUTHOR]

Research on the subfossil record and paleoecology of Olea europaea suggests a new interpretation of its history and ecology with reference to the Mediterranean climate since the Neogene. New results are based on the wood anatomy of ancient and extant Olea and a model estimating hydraulic conductance established for wild forms belonging to Olea europaea subsp. europaea. These suggest that during glacial periods wild olive populations survived in protected microenvironments, particularly riparian habitats. Thereafter, the post- glacial expansion of olive associated with climatic warming took place from these refuge areas. This new evidence suggests that the continued existence of Olea in Mediterranean areas since the Neogene was made possible either by preferential survival of Olea lineages adaptable to the Holocene climate or from enhanced adaptation to extreme environmental variation, a trait possibly originating from Tertiary predecessors and maintained in post-glacial olive populations. [ABSTRACT FROM AUTHOR]