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Background: The extraperitoneal rectal dissection via a transanal approach facilitates the mesorectal dissection. The retroperitoneal approach for mesocolic excision may also offer some similar advantages. To complete the lymphadenectomy of extraperitoneal mesorectal resection, we developed an innovative approach for upper rectal and mesocolic excision via an exclusive retroperitoneal dissection using a single-port access at the site of the future stomy.Methods: This study was a prospective pilot study and was conducted between 2013 and 2015 at two oncologic centers. Five consecutive patients, with ano-rectal cancer requiring permanent stoma, underwent this procedure.Results: The bowel was never touched or mobilized to perform the lymphadenectomy, and no Trendelenburg was required. The median operative duration was 300 min (range 205-310). The quality of the surgical plane was classified as good (mesorectal) in the five patients. The median circumferential and distal margins were, respectively, 5 mm (range 1-20) and 20 mm (range 5-25). The median number of harvested lymph nodes was 11 (range 5-18). No laparotomy or multiport laparoscopy was required. There was no death. Two patients had perineal wound dehiscence (one minor and one major).Conclusions: The mesocolic excision via a retroperitoneal approach is feasible, completes naturally the transanal mesorectal excision and may confer several advantages including no morbidity of small bowel manipulation or Trendelenburg position. Further studies are required to analyze this approach. [ABSTRACT FROM AUTHOR]

Previous methods of measuring high velocities, e.g., during electromagnetic forming (EMF) and magnetic pulse welding processes where the workpiece is deforming, include photon Doppler velocimetry (PDV), laser micrometers, and high speed photography. In this paper, an alternative method is presented, implementing a fiber optic, reflectance dependent sensor. The sensor is shown to be an attractive, low purchase cost solution to measure high velocities. Data are shown with respect to sensor characterization including various surface reflectivity values, curvatures, and misalignments; implementation in two EMF/welding processes; and verification with high velocity PDV measurements. The sensor system is one twentieth the purchase cost of a PDV system, and yet measures velocities accurately (using PDV measurements as the reference) to at least 150 m/s provided that local curvature is not extreme and the displacement is less than approximately 27 mm. Sensor performance is also enhanced by the use of retroreflective tape, which is shown to increase the displacement range by 9×, decrease sensitivity to misalignment, and increase repeatability and ease of implementation. [ABSTRACT FROM AUTHOR]

Background. HPV is a positive prognostic factor in HNSCC. We studied the prevalence and prognostic impact of HPV on survival parameters and treatment toxicity in patients with locally advanced HNSCC treated with concomitant chemoradiation therapy. Methods. Data on efficacy and toxicity were available for 560 patients. HPV was detected by PCR. Analysis was performed using Kaplan-Meier survival curves, Fisher's test for categorical data, and log-rank statistics for failure times. Results. Median follow-up was 4.7 years. DNA extraction was successful in 255 cases. HPV prevalence was 68.6%, and 53.3% for HPV 16. For HPV+ and HPV-,median LRC was 8.9 and 2.2 years (P = 0.0002),median DFS was 8.9 and 2.1 years (P = 0.0014), and median OS was 8.9 and 3.1 years (P = 0.0002). Survival was different based on HPV genotype, stage, treatment period, and chemotherapy regimen. COX adjusted analysis for T, N, age, and treatment remained significant (P = 0.004). Conclusions. Oropharyngeal cancer is increasingly linked to HPV. This study confirms that HPV status is associated with improved prognosis among H&N cancer patients receiving CRT and should be a stratification factor for clinical trials including H&N cases. Toxicity of CRT is not modified for the HPV population. [ABSTRACT FROM AUTHOR]

Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a long and complex procedure. A minimal invasive approach is rarely performed. The feasibility of laparoscopic CRS and HIPEC via a single port (SP) approach is unknown. The aim of this study was to assess the feasibility of CRS and HIPEC with a SP approach.Methods: This study is IDEAL stage I-IIa. Patients with low grade and limited peritoneal malignancy were included in a tertiary care cancer center. Intra- and post-operative adverse events were recorded and classified according to medical and surgical dedicated classifications. The main objective measurement to assess feasibility was the conversion to open or multiport surgery.Results: A total of 12 highly selected patients were assessed. The median operating time was 240 min (range, 180-360) and two near miss events were reported. Two conversions to open and multiport surgery occurred. The median comprehensive complication index was 0 (range, 0-42.6) with two severe adverse events (Clavien-Dindo or CTC-AE ≥ 3). The median length of stay was 8.5 days (range, 5-13).Conclusion: CRS and HIPEC via a laparoscopic SP approach are feasible and safe in the short term. The next step should be a prospective development study. [ABSTRACT FROM AUTHOR]

The article presents a case study on the diagnosis of solitary fibrous tumour (SFT) of the mesorectum to an 83 year old man in Great Britain. The colonoscopy, endoscopic ultrasound, and the pelvic magnetic resonance imaging have revealed the retrorectal tumour. The radical procedure consisting of abdominoperineal resection was performed in the removal of the tumor.