Search

Background: There are contradictory effects regarding the effect of NAD + precursor on glucose metabolism and liver enzymes. In order to obtain a better viewpoint from them, this study aimed to comprehensively investigate the effects of NAD + precursor supplementation on glucose metabolism, C-reactive protein (CRP), and liver enzymes. Methods: PubMed/MEDLINE, Web of Science, SCOPUS, and Embase databases were searched using standard keywords to identify all controlled trials investigating the glucose metabolism, CRP, and liver enzymes effects of NAD + precursor. Pooled weighted mean difference (WMD) and 95% confidence intervals (95% CI) were achieved by random-effects model analysis for the best estimation of outcomes. Results: Forty-five articles with 9256 participants' were included in this article. The pooled findings showed that NAD + precursor supplementation had a significant increase in glucose (WMD: 2.17 mg/dL, 95% CI: 0.68, 3.66, P = 0.004) and HbA1c (WMD: 0.11, 95% CI: 0.06, 0.16, P < 0.001) as well as a significant decrease in CRP (WMD: -0.93 mg/l, 95% CI -1.47 to -0.40, P < 0.001) compared with control group, and was not statistically significant with respect to insulin and homeostasis model assessment of insulin resistance (HOMA-IR). However, we found no systemic changes in aspartate transaminase (AST), alanine transaminase (ALT), or alkaline phosphatase (ALP) levels after NAD + precursor supplementation. The results of the subgroup analysis showed that the intake of NAD + precursor during the intervention of more than 12 weeks caused a greater increase in the glucose level. Furthermore, Nicotinic acid supplementation (NA) causes a greater increase in glucose and HbA1c levels than nicotinamide (NE) supplementation. Conclusions: Overall, these findings suggest that NAD + precursor supplementation might have an increase effect on glucose metabolism as well as a decrease in CRP. [ABSTRACT FROM AUTHOR]

Objectives: To investigate whether consumption of more diverse diets would increase the probability of nutrients adequacy among elderly women in Tehran, Iran.Methods: This cross-sectional study was conducted on 292 women aged ≥60 years who were randomly selected from 10 public health centers among 31 centers in south area of Tehran. Because of some limitations we randomly chose these 10 centers. The sample sizes provided 80% statistical power to meet the aim of study for test the relationship between Nutrient Adequacy Ratio (NAR), Mean Adequacy Ratio (MAR) as a dependent variable and total Dietary Diversity Score (DDS) as an independent variable. Dietary intakes were assessed by two 24-h recall questionnaires. The mean probability of adequacy across 12 nutrients and energy were calculated using the Dietary Reference Index (DRI). Dietary diversity Score was defined according to diet quality index revised (Haines et al. method). To investigate the relationship between MAR and DDS some demographic and socioeconomic variables were examined.Results: Mean ± SD of total dietary diversity was 4.22 ± 1.28 (range 1.07-6.93). The Fruit and vegetable groups had the highest (1.27 ± 0.65, range 0-2.0) and the lowest (0.56 ± 0.36, range 0-1.71) diversity score, respectively. We observed that total DDS has significant positive correlation with MAR (r = 0.65, P < 0.001). Total DDS was significantly associated with NAR of all 12 studied nutrients (P < 0.01); probability adequacy of vitamin B2 revealed the strongest (r = 0.63, P < 0.01) and vitamin B12 revealed the weakest (r = 0.28, P < 0.01) relationship with total DDS. When maximizing sensitivity and specificity, the best cut-off point for achieving MAR≥1 was 4.5 for DDS.Conclusion: The results of our study showed that DDS is an appropriate indicator of the probability of nutrient adequacy in Tehranian elderly women. [ABSTRACT FROM AUTHOR]

BACKGROUND: Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It imposes significant costs on health care systems. Socioeconomic status is also the root cause of healthy challenges among the elderly. Therefore, investigating the association between sarcopenia and socioeconomic status is very important to improve healthy ageing of the elderly. The aim of this study was to investigate the prevalence of sarcopenia and its association with socioeconomic status among the elderly in Tehran. METHODS: Cross-sectional and case-control studies were conducted from August 2014-July 2015 among 310 men and 334 women elderly (60 and over years old) in Tehran health centers. Randomization, restriction and matching were setting during study design to minimize selection bias. Then study participants were recruited via phone call. Participants' phone numbers were already recorded in a telephone book electronically. When there were two elderly people in the same house, only one person was invited randomly. Association between sarcopenia and socio-economic status was analyzed by SPSS version 22. RESULTS: The overall prevalence of sarcopenia in the elderly was 16.5%. Prevalenceamong the lowincome elderly was relatively higher than (20.5%) that among those with middle income status (18.2%) while in the higher income, the proportion of sarcopenia was very low (12.8%). The findings indicated that 339(52.6%) were in low-income status, 304(47.1%) were in middle-income status and 1(.2%) in high-income class. CONCLUSION: There was a significant association between socioeconomic status and sarcopenia (Pvalue <0.001). The odd risk of sarcopenia was 0.97 times more likely higher in low socioeconomic class than those who were in middle and high income classes. [ABSTRACT FROM AUTHOR]