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Pap test involves searching of morphological changes in cervical squamous epithelial cells by pathologists or cytotechnologists to identify potential cancerous cells in the cervix. Nuclear membrane irregularity is one of the morphological changes of malignancy. This paper proposes two novel techniques for the evaluation of nuclear membrane irregularity. The first technique, namely, penalty-driven smoothing analysis, introduces different penalty values for nuclear membrane contour with different degrees of irregularity. The second technique, which can be subdivided into mean- or median-type residual-based analysis, computes the number of points of nuclear membrane contour that deviates from the mean or median of the nuclear membrane contour. Performance of the proposed techniques was compared to three state-of-the-art techniques, namely, radial asymmetric, shape factor, and rim difference. Friedman and post hoc tests using Holm, Shaffer, and Bergmann procedures returned significant differences for all the three classes, i.e., negative for intraepithelial lesion or malignancy (NILM) versus low grade squamous intraepithelial lesion (LSIL), NILM versus high grade squamous intraepithelial lesion (HSIL), and LSIL versus HSIL when the span value equaled 3 was employed with linear penalty function. When span values equaled 5, 7, and 9, NILM versus LSIL and HSIL showed significant differences regardless of the penalty functions. In addition, the results of penalty-driven smoothing analysis were comparable with those of other state-of-the-art techniques. Residual-based analysis returned significant differences for the comparison among the three diagnostic classes. Findings of this study proved the significance of nuclear membrane irregularity as one of the features to differentiate the different diagnostic classes of cervical squamous epithelial cells. [ABSTRACT FROM AUTHOR]

Despite the effectiveness of Pap-smear test in reducing the mortality rate due to cervical cancer, the criteria of the reporting standard of the Pap-smear test are mostly qualitative in nature. This study addresses the issue on how to define the criteria in a more quantitative and definite term. A negative Pap-smear test result, i.e. negative for intraepithelial lesion or malignancy (NILM), is qualitatively defined to have evenly distributed, finely granular chromatin in the nuclei of cervical squamous cells. To quantify this chromatin pattern, this study employed Fuzzy C-Means clustering as the segmentation technique, enabling different degrees of chromatin segmentation to be performed on sample images of non-neoplastic squamous cells. From the simulation results, a model representing the chromatin distribution of non-neoplastic cervical squamous cell is constructed with the following quantitative characteristics: at the best representative sensitivity level 4 based on statistical analysis and human experts’ feedbacks, a nucleus of non-neoplastic squamous cell has an average of 67 chromatins with a total area of 10.827μm2; the average distance between the nearest chromatin pair is 0.508μm and the average eccentricity of the chromatin is 0.47. [ABSTRACT FROM AUTHOR]

A new approach based on Bi-Histogram Equalization is presented to enhance grayscale images. The proposed Adaptive Image Enhancement based on Bi-Histogram Equalization (AIEBHE) technique divides the input histogram into two sub-histograms, which are at the threshold of the histogram median for mean brightness preservation. Histogram clipping is performed to control the enhancement rate, and then the clipped sub-histograms are equalized and integrated to obtain the enhanced image. The novelty of AIEBHE is its flexibility in choosing the clipping limit that automatically selects the smallest value among histogram bins, mean, and median values, resulting in the conservation of a greater amount of information in the image. Automatic selection of the clipping limit addresses the issue of over-emphasizing of high frequency bins during histogram equalization. Simulation results reveal that AIEBHE technique outperforms other histogram-equalization-based enhancement techniques in terms of detail preservation and mean brightness preservation. [ABSTRACT FROM AUTHOR]

Tracking the speed and current in permanent magnet synchronous motors (PMSMs) for industrial applications is challenging due to various external and internal disturbances such as parameter variations, unmodelled dynamics, and external load disturbances. Inaccurate tracking of speed and current results in severe system deterioration and overheating. Therefore, the design of the controller for a PMSM is essential to ensure the system can operate efficiently under conditions of parametric uncertainties and significant variations. The present work proposes a PMSM speed controller using machine learning (ML) techniques for quick response and insensitivity to parameter changes and disturbances. The proposed ML controller is designed by learning fractional-order sliding mode control (FOSMC) controller behavior. The primary purpose of using ML in FOSMC is to avoid the self-tuning of the parameters and ensure the speed reaches the reference value in finite time with faster convergence and better tracking precision. Furthermore, the ML model does not require the mathematical model of the speed controller. In this work, several ML models are empirically evaluated on their estimation accuracy for speed tracking, namely ordinary least squares, passive-aggressive regression, random forest, and support vector machine. Finally, the proposed controller is implemented on a real-time hardware-in-the-loop (HIL) simulation platform from PLECS Inc. Comparative simulation and experimental results are presented and discussed. It is shown from the comparative study that the proposed FOSMC based on ML outperformed the traditional sliding mode control (SMC), which is more commonly used in industry in terms of tracking speed and accuracy. [ABSTRACT FROM AUTHOR]