1. Clinical Features of Presarcopenia in Elderly Colorectal Cancer Patients.
- Author
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Takahiro Shigaki, Kenji Fujiyoshi, Tomoya Sudou, Yuuya Tanaka, Naohiro Yoshida, Kenichi Koushi, Takefumi Yoshida, Fumihiko Fujita, Kenta Murotani, and Yoshito Akagi
- Subjects
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COLORECTAL cancer , *CANCER patients , *OLDER patients , *OLDER people , *NEUTROPHIL lymphocyte ratio , *WHOLE-body vibration , *SKELETAL muscle injuries - Abstract
Background Sarcopenia is defined as a decline in skeletal muscle mass and whole-body physical function associated with aging. If only a decrease in skeletal muscle mass is observed, the term used is presarcopenia (PS). In this study, we retrospectively analyzed the clinical significance of PS in older patients with colorectal cancer aged ≥75 years. Results Of the 131 older patients with colorectal cancer, 33 were classified as PS group and 98 as non-PS group. Postoperative complications were more common in the PS group (P=0.051). In addition, Alb levels were lower in the PS group (Alb: P=0.069) and CRP-Alb ratio (CAR) was higher in the PS group (CAR: P = 0.069). The neutrophil-lymphocyte ratio (NLR) was higher in the PS group (NLR: P= 0.002). Conclusion PS in older patients with colorectal cancer was associated with an increased incidence of postoperative complications and longer hospital stay. Diagnosing PS before surgery may be useful as a screening tool for identifying patients at high risk of postoperative complications. Furthermore, PS was suggested to be associated with preoperative inflammation-related factors such as CAR and NLR. [ABSTRACT FROM AUTHOR]
- Published
- 2024