1. NITROXOLINE: A POTENT ANTIMICROBIAL AGENT AGAINST MULTIDRUG RESISTANT ENTEROBACTERIACEAE.
- Author
-
Rungrot Cherdtrakulkiat, Ratana Lawung, Sunanta Nabu, Srisurang Tantimavanich, Nujarin Sinthupoom, Supaluk Prachayasittikul, and Virapong Prachayasittikul
- Subjects
- *
ENTEROBACTERIACEAE , *BETA lactamases , *ANTI-infective agents , *DRUG resistance in microorganisms , *ENTEROBACTERIACEAE diseases , *KLEBSIELLA pneumoniae , *METAL ions - Abstract
Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and antineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7 -Br-8HQ (3) were investigated for antimicrobial activity against Enterobacteriaceae including extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing strains as well as the effect of metal ions .These compounds (1-3) displayed the great antimicrobial activity against fifty-eight bacterial isolates of Escherichia coli, Providencia rettgeri and Klebsiella pneumoniae, in which NQ (2) exerted the highest antimicrobial activity with a MIC50 of 42.04 μM (8 μg/mL) and MBC50 of 168.28 μM (32 μg/mL). The MIC values of NQ (2) and 7-Br -8HQ (3) were significantly increased in the presence of Cu2+ and Fe3+. This finding reveals that NQ could be an effective compound to be further developed as an antimicrobial agent for combating Enterobacteriaceae infections. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF