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• Modeling of Salsalate solubility in supercritical CO 2. • Analysis of influence of pressure and temperature on the solubility values. • Comparisons of the models in terms of accuracy. Salsalate solubility in supercritical carbon dioxide was studied in this research by computational simulation to correlate the solubility to input parameters including temperature and pressure. A dataset was collected from resources and the models were correlated to the data. Both training and validation steps have been performed to implement the computational tasks. Indeed, we are dealing with a dataset with two P and T inputs and one output (drug solubility), and 32 data points. We chose three models based on Gaussian Process Regression (GPR) including simple (raw) GPR, Ada-boosted GPR, and Bagged GPR as two ensemble methods for correlation of the solubility data. All hyper-parameters were tuned for more general models and models evaluated with standard metrics. The GPR, Adaboost + GPR, and Bagging + GPR have scores of 0.9779, 0.9992, and 0.9795 using R-squared, respectively. Also, in terms of RMSE models have error rates of 1.25 × 10−4, 1.20 × 10−4, and 1.29 × 10−4, respectively. Finally, considering the standard criteria and visual analysis, the boosted GPR model is selected as the main model. The optimal values found as (P = 400, T = 338.0, Y = 0.003879). [ABSTRACT FROM AUTHOR]

The decline in mechanical properties of secondary fiber upon multiple recycling iterations necessitates the incorporation of cost-effective and environmentally friendly fibers to counterbalance strength loss. In this study, an orthogonal experiment design was employed to optimize the SE process to acquire tabocco stem pulp (TSP). The study systematically investigated the influence of steam pressure, residence time, and alkali dosage employed during impregnation were investigated. Notably, the research identified alkali dosage as the most significant parameter impacting system performance. Under optimized conditions (1.2 MPa, 5 min, and 5 %), the prepared paper using 100 % TSP exhibited the capability to attain Grade C corrugated medium. TSP, subsequently, served as a compensatory material for mitigating the loss of strength observed in low-quality secondary fibers (LSF). Remarkably, the introduction of 20 wt% TSP resulted in the production of grade B products, showcasing exceptional enhancement in ring-crush strength. The breaking length of paper was increased with an additional 0.5 wt% PAE added, resulting in all criteria achieving the highest grade A. In conclusion, the study elucidated the synergistic and complementary effects of TSP and LSF, wherein stiff TSP fiber bundles formed a network that effectively supported LSF filling. This study identified the relationship between SE parameters and fiber properties, conclusively establishing waste tobacco stem as a quality fiber source conducive to producing high-quality paper. [Display omitted] • Steam explosion (SE) didn't change the inherent stiffness of the tobacco stem fiber. • Process parameters of SE influence strongly on fiber properties. • SE pulp compensates for secondary fiber's inadequate mechanical properties. • SE pulp and secondary fiber have synergistic and complementary effects. [ABSTRACT FROM AUTHOR]