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We calculate the next-to-leading order electroweak corrections for Higgs-boson production in gluon fusion and the Higgs-boson decay into two photons or gluons in the real Higgs-singlet extension of the Standard model (HSESM). For the light Higgs-boson of the HSESM the electroweak corrections for these processes are of the same order of magnitude as in the Standard model. For the heavy Higgs-boson of the HSESM the electroweak corrections can become large depending on the considered scenario. [ABSTRACT FROM AUTHOR]

Purpose: Following SARS-CoV-2 virus infection, patients may suffer from long-lasting symptoms regardless of disease severity. Preliminary results show limitations in health-related quality of life (HRQoL). The aim of this study is to show a possible change depending on the duration since infection and the accumulation of symptoms. Additionally, other possible influencing factors will be analyzed. Methods: The study population consisted of patients (18–65 years) presenting to the Post-COVID outpatient clinic of the University Hospital Jena, Germany, between March and October 2021. The HRQoL was assessed by the use of the RehabNeQ and the SF-36. Data analysis was descriptive with frequencies, means, and/or percentages. In addition, a univariate analysis of variance was performed to show the dependence of physical and psychological HRQoL on specific factors. This was finally tested for significance at an alpha level of 5%. Results: Data from 318 patients were analyzed, most of whom had 3–6 months of infection (56%) and 5–10 symptoms persisted (60.4%). Both mental (MCS) and physical sum score (PCS) of HRQoL were significantly lower than those of the German normal population (p <.001). The number of remaining symptoms (MCS p =.0034, PCS p =.000) as well as the perceived ability to work (MCS p =.007, PCS p =.000) influenced the HRQoL. Conclusion: The HRQoL of patients with Post-COVID-syndrome is still reduced months after infection and so is their occupational performance. In particular, the number of symptoms could have an influence on this deficit, which would need to be further investigated. Further research is needed to detect other factors influencing HRQoL and to implement appropriate therapeutic interventions. [ABSTRACT FROM AUTHOR]

Background: In COVID-19 survivors a relatively high number of long-term symptoms have been observed. Besides impact on quality of life, these symptoms (now called Post-COVID-Syndrome) may have an impact on functioning and may also hinder to participation in social life in affected people. However, little is known about developing such syndrome a for patients with mild and moderate COVID-19 who did not need hospitalization or intensive care. Methods: A cross-sectional study in 1027 patients with mild or moderate COVID-19 was performed in two communities in Bavaria, Germany. The Rehabilitation-Needs-Survey (RehabNeS) including the Short Form 36 Health Survey (SF-36) on health-related quality of life, was used. Descriptive statistics were calculated. Results: In all, 97.5% of patients reported one symptom in the infection stage, such as fatigue, respiratory problems, limitations of the senses of taste and smell, fear and anxiety and other symptoms. In this time period, 84.1% of the participants experienced activity limitations and participation restrictions such as carrying out daily routines, handling stress, getting household tasks done, caring for/supporting others, and relaxing and leisure concerns. In all, 61.9% of participants reported persisting symptoms more than 3 months after infection. These were fatigue, sleep disturbances, respiratory problems, pain, fear and anxiety, and restrictions in movement; 49% of the participants reported activity limitations and participation restrictions. Predominately, these were handling stress, carrying out daily routines, looking after one's health, relaxing and leisure activities and doing house work. The impacts on quality of life and vocational performance were rather low. Conclusion: The results show that long-term symptoms after mild and moderate COVID-19 are common and lead to limitations of activities and participation. However, it seems that in most cases they are not severe and do not lead to frequent or serious issues with quality of life or work ability. [ABSTRACT FROM AUTHOR]

Background: It is still difficult for people with physical impairments to be and remain equally integrated into the labour market. For this reason, the question of occupational activity has explicitly been examined by the German Spinal Cord Injury Survey (GerSCI) in order to identify barriers and facilitators for labour market participation. Methods: Cross-sectional explorative observational study. The GerSCI survey is the German part of the International Spinal Cord Injury Survey (InSCI). Using survey data from persons recruited at eight specialised SCI-centres in Germany. Participants: 1.479 persons with Spinal Cord Injury (SCI) aged 18 years and older. Results: In a self-disclosure questionnaire, persons with SCI show themselves as a professionally well-educated and highly motivated group with most of them aiming at gainful employment and considering themselves fit for work. Many changeable and non-changeable factors have been found, which showed a high correlation with the return to work after acquired SCI. Conclusion: Education and pain belong to the most critical factors and thereby possible approaches to increase the level of employment, which is essential and highly relevant not only for earning money but also for self-confidence and social integration. SCI has many dimensions in itself; support also should be multidimensional. Study results might help to improve participation. [ABSTRACT FROM AUTHOR]

We have computed the two-loop, electroweak corrections to the production of a light and a heavy neutral, scalar Higgs-boson through the important gluon fusion process in the Two-Higgs-Doublet Model. We provide our results in various renormalization schemes for different scenarios and benchmark points, which will be valuable for experimental studies at the LHC. We describe the technicalities of our two-loop calculation and augment it by a phenomenological discussion. Our results are also applicable to the gluonic neutral, scalar Higgs-boson decays. [ABSTRACT FROM AUTHOR]

We compute the decoupling function of the $$\overline{\text{ MS }}$$ renormalized fine-structure constant up to four-loop order in perturbative QCD. The results are used in order to determine the related top-quark contributions to the Higgs-boson decay into two photons in the heavy top-quark mass limit to order $$\alpha _s^{4}$$ . [ABSTRACT FROM AUTHOR]

Abstract: The running of the effective electromagnetic coupling is for many electroweak observables the dominant correction. It plays an important role for deriving constraints on the Standard Model in the context of electroweak precision measurements. We compute the four-loop QED corrections to the running of the effective electromagnetic coupling and perform a numerical evaluation of the different gauge invariant subsets. [Copyright &y& Elsevier]

Abstract: Complete electroweak two-loop corrections to the process are presented and discussed in a Standard Model with a fourth generation of heavy fermions. The latter is studied at the LHC to put exclusion limits on a fourth generation of heavy fermions. Therefore also a precise knowledge of the electroweak (EW) next-to-leading-order (NLO) corrections is important. The corrections due to the fourth generation are positive and large for a light Higgs boson, positive but relatively small around the threshold and start to become negative for a Higgs boson mass around . Increasing further the value of the Higgs boson mass, the EW NLO effects tend to become huge and negative, , around the heavy-fermion threshold, assumed at , so that gg-fusion becomes non-perturbative. Above that threshold they start to grow again and become positive around . The behavior at even larger values of shows a positive enhancement, at . [Copyright &y& Elsevier]

Abstract: The relation between physical observables measured at LHC and Tevatron and standard model Higgs pseudo-observables (production cross section and partial decay widths) is revised by extensively using the notion of the Higgs complex pole on the second Riemann sheet of the S-matrix. The extension of their definition to higher orders is considered, confronting the problems that arise when QED (QCD) corrections are included in computing realistic observables. Numerical results are presented for pseudo-observables related to the standard model Higgs boson decay and production. The relevance of the result for exclusion plots of the standard model Higgs boson for high masses (up to 600 GeV) is discussed. Furthermore, a recipe for the analytical continuation of Feynman loop integrals from real to complex internal masses and complex Mandelstam invariants is thoroughly discussed. [Copyright &y& Elsevier]

Abstract: In this Letter the complete two-loop corrections to the Higgs-boson decay, , are presented. The evaluations of both QCD and electroweak corrections are based on a numerical approach. The results cover all kinematical regions, including the WW normal-threshold, by introducing complex masses in the relevant (gauge-invariant) parts of the LO and NLO amplitudes. [Copyright &y& Elsevier]

Post-COVID syndrome is affecting many organ systems and arises as a major public health problem with millions of cases worldwide. The primary aim of this study is the analysis of health problems, activity limitations and participation restrictions (ALPR) of participants with post-COVID symptoms and the investigation of correlations between these elements to derive statements about the rehabilitation need, also depending on sex. A retrospective cohort study was performed to collect longitudinal data from January 2022 to January 2023 using the Covid-19 Rehabilitation Needs Questionnaire (RehabNeQ). Patients completed the questionnaire at the Department of Rehabilitation- and Sports Medicine at Hannover Medical School. The 1st assessment included 307 study participants, of whom 54 showed up for the 2nd, 7 for the 3rd and one for the 4th assessment. Study participants with post-COVID symptoms also experience ALPR. The results show no significant difference in symptom intensity in women and men, but in intensity of ALPR. We found many correlations of varying degrees between various factors with ALPR. We found frequent correlations between fatigue and several ALPR. While these correlations apply to both sexes, we also found different correlations in women and men, indicating the different rehabilitation need of women and men. [ABSTRACT FROM AUTHOR]

Objectives: To examine the effects of acupuncture and therapeutic exercise alone and in combination on temporomandibular joint symptoms in tension-type headache and to evaluate the potential interaction of existing temporomandibular dysfunction on the success of headache treatment. Design: Pre-planned secondary analysis of a randomized controlled, non-blinded trial. Setting: Outpatient clinic of a German university hospital. Subjects: Ninety-six Participants with frequent episodic or chronic tension-type headache were randomized to one of four treatment groups. Interventions: Six weeks of acupuncture or therapeutic exercise either as monotherapies or in combination, or usual care. Follow-up at 3 and 6 months. Main measures: Subjective temporomandibular dysfunction symptoms were measured using the Functional Questionnaire Masticatory Organ, and the influence of this sum score and objective initial dental examination on the efficacy of headache treatment interventions was analyzed. Results: Temporomandibular dysfunction score improved in all intervention groups at 3-month follow-up (usual care: 0.05 [SD 1.435]; acupuncture: −5 [SD 1.436]; therapeutic exercise: −4 [SD 1.798]; combination: −3 [SD 1.504]; P = 0.03). After 6 months, only acupuncture (−6 [SD 1.736]) showed a significant improvement compared to the usual care group (P < 0.01). Subjective temporomandibular dysfunction symptoms had no overall influence on headache treatment. Conclusions: Only acupuncture had long-lasting positive effects on the symptoms of temporomandibular dysfunction. Significant dental findings seem to inhibit the efficacy of acupuncture for tension-type headache. [ABSTRACT FROM AUTHOR]

Declarative process management has emerged as an alternative solution for describing flexible workflows. In turn, the modelling opportunities with languages such as Declare are less intuitive and hard to implement. The area of process discovery covers the automatic discovery of process models. It has been shown that the performance of process mining algorithms, particularly when considering the multi-perspective declarative process models, are not satisfactory. State-of-the-art mining tools do not support multi-perspective declarative models at this moment. We address this open research problem by proposing an efficient mining framework that leverages the latest big data analysis technology and builds upon the distributed processing method MapReduce. The paper at hand further completes the research on multi-perspective declarative process mining by extending our previous work in various ways; in particular, we introduce algorithms and descriptions for the full set of commonly accepted types of MP-Declare constraints. Additionally, we provide a novel implementation concept allowing an easy introduction and discovery of customised constraint templates. We evaluated the mining performance and effectiveness of the presented approach on several real-life event logs. The results highlight that, with our efficient mining technique, multi-perspective declarative process models can be extracted in reasonable time. [ABSTRACT FROM AUTHOR]

Supplemental digital content is available in the text. Objective: The aim of this study was to investigate the interrater reliability and intrarater reliability of the flexor pollicis longus muscle stretch reflex (FPLR) and compare it with clinically established reflexes. Design: A total of 71 healthy volunteers participated. The FPLR, biceps reflex, brachioradialis reflex, and patellar tendon reflex of each participant were tested bilaterally and rated by eight examiners (four experienced, four inexperienced). For intrarater reliability evaluation, five examiners rated the reflexes of four volunteers at four different points in time. Results: Analysis of the interrater reliability with Gwet's AC1 demonstrated almost perfect agreement for FPLR (Gwet's AC1 = 0.90), biceps reflex (Gwet's AC1 = 0.90), and patellar tendon reflex (Gwet's AC1 = 0.95) when using binary data (reflex present vs. absent). Only fair agreement was found for the brachioradialis reflex (Gwet's AC1 = 0.56). Experienced raters had a higher agreement than inexperienced raters did when rating the biceps reflex and the patellar tendon reflex. The intrarater reliability was almost perfect for the patellar tendon reflex (Gwet's AC1 = 0.94), followed by the FPLR (Gwet's AC1 = 0.83) with substantial agreement and the biceps reflex (Gwet's AC1 = 0.57) with moderate agreement. Conclusion: The FPLR is a reliable diagnostic neuromuscular test and may therefore be useful in the clinical examination for C8/T1 nerve root lesions or pathologies of the interosseous anterior nerve. To Claim CME Credits: Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME Objectives: Upon completion of this article, the reader should be able to: (1) Elicit the flexor pollicis longus muscle stretch reflex; (2) Discuss the disadvantage of kappa statistics in assessing the interrater reliability when the prevalence of the studied trait is very high or very low; and (3) Name the spinal nerves involved in the innervation of the flexor pollicis longus muscle. Level: Advanced Accreditation: The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Association of Academic Physiatrists designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s) ™. Physicians should only claim credit commensurate with the extent of their participation in the activity. [ABSTRACT FROM AUTHOR]

Background: Inequality in health is a prevalent and growing concern among countries where people with disabilities are disproportionately affected. Unmet healthcare needs explain a large part of the observed inequalities between and within countries; however, there are other causes, many non-modifiable, that also play a role. Aim: This article explores the difference in health across income levels in populations with spinal cord injury (SCI). SCI is of special interest in the study of health systems, as it is an irreversible, long-term health condition that combines a high level of impairment with subsequent comorbidities. Methods: We estimated the importance of modifiable and non-modifiable factors that explain health inequalities through a direct regression approach. We used two health outcomes: years living with the injury and a comorbidity index. Data come from the International Spinal Cord Injury Survey (InSCI), which has individual data on people with SCI in 22 countries around the world. Due to the heterogeneity of the data, the results were estimated country by country. Results: On average, the results exhibit a prevalence of pro-rich inequalities, i.e., better health outcomes are more likely observed among high-income groups. For the years living with the injury, the inequality is mostly explained by non-modifiable factors, like the age at the time of the injury. In contrast, for the comorbidity index, inequality is mostly explained by unmet healthcare needs and the cause of the injury, which are modifiable factors. Conclusions: A significant portion of health inequalities is explained by modifiable factors like unmet healthcare needs or the type of accident. This result is prevalent in low, middle, and high-income countries, with pervasive effects for vulnerable populations like people with SCI, who, at the same time are highly dependent on the health system. To reduce inequity, it is important not only to address problems from public health but from inequalities of opportunities, risks, and income in the population. Highlights: • Better health status is evident among high-income groups, which is reflected in pro-rich inequalities. • Age at the time of the injury is the most important factor to explain inequalities in years living with the injury. • Unmet health care needs are the most important factor to explain inequalities in comorbidities. • The inequality in health varies by country dependent upon socioeconomic factors. [ABSTRACT FROM AUTHOR]

Objectives: To compare the effects of acupuncture and medical training therapy in combination or individually with usual care on quality of life, depression, and anxiety in patients with tension-type headache. Methods: In this single-center, prospective, randomized, controlled, unblinded trial, 96 adults (38.7(+/−13.3) years of age; 75 females/20 males/one dropout) with frequent episodic or chronic tension-type headache were randomized to one of four treatment groups (n = 24). The treatment groups received six weeks of either acupuncture or medical training therapy as monotherapies or in combination (12 interventions each), or usual care. We assessed depressiveness (PHQ-9), anxiety (GAD-7), and health-related quality of life (SF-12) as secondary outcome parameters at baseline, six weeks, three months, and six months after initiation of treatment. Linear mixed models were calculated. Results: Both, acupuncture (baseline to six-weeks change scores: mean: −2(standard deviation: 2.5 points), three months: −2.4(2.4), six-months −2.7(3.6)) and the combination of acupuncture and medical training therapy (−2.7(4.9), −2.2(4.0), −2.2(4.2)) (each within-group p <.05) significantly reduced depressiveness-scores (PHQ-9) to a greater extent than medical training therapy (−0.3(2.0), −0.5(1.6), −0.9(2.6)) or usual care alone (−0.8(2.9), 0.1(2.8), 0.2(3.6)). We found similar results with anxiety scores and the physical sum scores of the SF-12. No severe adverse events occurred. Conclusions: Acupuncture and the combination of acupuncture and medical training therapy elicit positive effects on depression, anxiety, quality of life, and symptom intensity in patients with episodic and chronic tension-type headache. Acupuncture appears to play a central role in mediating the therapeutic effects, underscoring the clinical relevance of this treatment. An additive benefit of the combination of both therapies does not appear to be relevant. Trial registration: Registered on 11 February 2019. German Clinical Trials Register, DRKS00016723. [ABSTRACT FROM AUTHOR]

The protein Yju3p is the orthologue of monoglyceride lipases in the yeast Saccharomyces cerevisiae. A soluble variant of this lipase termed s-Yju3p (38.3 kDa) was generated and purified to homogeneity by affinity and size-exclusion chromatography. s-Yju3p was crystallized in a vapour-diffusion setup at 293 K and a complete data set was collected to 2.4 Å resolution. The crystal form was orthorhombic (space group P212121), with unit-cell parameters a = 77.2, b = 108.6, c = 167.7 Å. The asymmetric unit contained four molecules with a solvent content of 46.4%. [ABSTRACT FROM AUTHOR]

Abstract: A large set of techniques needed to compute decay rates at the two-loop level are derived and systematized. The main emphasis of the paper is on the two Standard Model decays and . The techniques, however, have a much wider range of application: they give practical examples of general rules for two-loop renormalization; they introduce simple recipes for handling internal unstable particles in two-loop processes; they illustrate simple procedures for the extraction of collinear logarithms from the amplitude. The latter is particularly relevant to show cancellations, e.g. cancellation of collinear divergencies. Furthermore, the paper deals with the proper treatment of non-enhanced two-loop QCD and electroweak contributions to different physical (pseudo-)observables, showing how they can be transformed in a way that allows for a stable numerical integration. Numerical results for the two-loop percentage corrections to are presented and discussed. When applied to the process , the results show that the electroweak scaling factor for the cross section is between −4% and +6% in the range , without incongruent large effects around the physical electroweak thresholds, thereby showing that only a complete implementation of the computational scheme keeps two-loop corrections under control. [Copyright &y& Elsevier]

Abstract: Results for the complete NLO electroweak corrections to Standard Model Higgs production via gluon fusion are included in the total cross section for hadronic collisions. Artificially large threshold effects are avoided working in the complex-mass scheme. The numerical impact at LHC (Tevatron) energies is explored for Higgs mass values up to 500 GeV (200 GeV). Assuming a complete factorization of the electroweak corrections, one finds a +5% shift with respect to the NNLO QCD cross section for a Higgs mass of 120 GeV both at the LHC and the Tevatron. Adopting two different factorization schemes for the electroweak effects, an estimate of the corresponding total theoretical uncertainty is computed. [Copyright &y& Elsevier]

Abstract: The effect of threshold singularities induced by unstable particles on two-loop observables is investigated and it is shown how to cure them working in the complex-mass scheme. The impact on radiative corrections around thresholds is thoroughly analyzed and shown to be relevant for two selected LHC and ILC applications: Higgs production via gluon fusion and decay into two photons at two loops in the Standard Model. Concerning Higgs production, it is essential to understand possible sources of large corrections in addition to the well-known QCD effects. It is shown that NLO electroweak corrections can incongruently reach a 10% level around the WW vector-boson threshold without a complete implementation of the complex-mass scheme in the two-loop calculation. [Copyright &y& Elsevier]

Abstract: New data for the total cross section in the charm and bottom threshold region are combined with an improved theoretical analysis, which includes recent four-loop calculations, to determine the short distance charm and bottom quark masses. A detailed discussion of the theoretical and experimental uncertainties is presented. The final result for the -masses, and , can be translated into and . This analysis is consistent with but significantly more precise than a similar previous study. [Copyright &y& Elsevier]

Objectives: The aim of this study was to compare the effects of acupuncture and medical training therapy alone and in combination with those of usual care on the pain sensation of patients with frequent episodic and chronic tension-type headache. Design: This was a prospective single-centre randomised controlled trial with four balanced treatment arms. The allocation was carried out by pre-generated randomisation lists in the ratio 1:1:1:1 with different permutation block sizes. Setting: The study was undertaken in the outpatient clinic of Rehabilitation Medicine of the Hannover Medical School. Participants and interventions: Ninety-six adult patients with tension-type headache were included and randomised into usual care (n = 24), acupuncture (n = 24), medical training (n = 24), and combination of acupuncture and medical training (n = 24). One patient was excluded from analysis because of withdrawing her/his consent, leaving 95 patients for intention to treat analysis. Each therapy arm consisted of 6 weeks of treatment with 12 interventions. Follow-up was at 3 and 6 months. Main outcome measures: Pain intensity (average, maximum and minimum), frequency of headache, responder rate (50% frequency reduction), duration of headache and use of headache medication. Clinical results: The combination of acupuncture and medical training therapy significantly reduced mean pain intensity compared to usual care (mean = −38%, standard deviation = 25%, p = 0.012). Comparable reductions were observed for maximal pain intensity (−25%, standard deviation = 20%, 0.014) and for minimal pain intensity (−35%, standard deviation = 31%, 0.03). In contrast, neither acupuncture nor medical training therapy differed significantly from usual care. No between-group differences were found in headache frequency, mean duration of headache episodes, and pain medication intake. At 3 months, the majority of all patients showed a reduction of at least 50% in headache frequency. At 6 months, significantly higher responder rates were found in all intervention groups compared to usual care. Conclusions: In contrast to monotherapy, only the combination of acupuncture and medical training therapy was significantly superior in reduction of pain intensity compared to usual care. Trial registration: Registered on 11 February 2019. German Clinical Trials Register, DRKS00016723. [ABSTRACT FROM AUTHOR]

Automated process discovery is a technique that extracts models of executed processes from event logs. Logs typically include information about the activities performed, their timestamps and the resources that were involved in their execution. Recent approaches to process discovery put a special emphasis on (human) resources, aiming at constructing resource-aware process models that contain the inferred resource assignment constraints. Such constraints can be complex and process discovery approaches so far have missed the opportunity to represent expressive resource assignments graphically together with process models. A subsequent verification of the extracted resource-aware process models is required in order to check the proper utilisation of resources according to the resource assignments. So far, research on discovering resource-aware process models has assumed that models can be put into operation without modification and checking. Integrating resource mining and resource-aware process model verification faces the challenge that different types of resource assignment languages are used for each task. In this paper, we present an integrated solution that comprises (i) a resource mining technique that builds upon a highly expressive graphical notation for defining resource assignments; and (ii) automated model-checking support to validate the discovered resource-aware process models. All the concepts reported in this paper have been implemented and evaluated in terms of feasibility and performance. [ABSTRACT FROM AUTHOR]

Measurements of kaon production at subthreshold energies in heavy-ion collisions point to a soft nuclear equation of state for densities up to two to three times nuclear matter saturation density. We apply these results to study the implications on compact star properties, especially in the context of the recent measurement of the two solar mass pulsar PSR J1614-2230. The implications are twofold: First, the heavy-ion results constrain nuclear matter at densities relevant to light neutron stars. Hence, a radius measurement could provide information about the density dependence of the symmetry energy which is a crucial quantity in nuclear physics. Second, the information on the nucléon potential obtained from the analysis of the heavy-ion data can be combined with restrictions from causality on the nuclear equation of state. From this we can derive a limit for the highest allowed compact star mass of three solar masses. [ABSTRACT FROM AUTHOR]

Abstract: Monoacylglycerol lipases (MGLs) catalyse the hydrolysis of monoacylglycerol into free fatty acid and glycerol. MGLs have been identified throughout all genera of life and have adopted different substrate specificities depending on their physiological role. In humans, MGL plays an integral part in lipid metabolism affecting energy homeostasis, signalling processes and cancer cell progression. In bacteria, MGLs degrade short-chain monoacylglycerols which are otherwise toxic to the organism. We report the crystal structures of MGL from the bacterium Bacillus sp. H257 (bMGL) in its free form at 1.2Å and in complex with phenylmethylsulfonyl fluoride at 1.8Å resolution. In both structures, bMGL adopts an α/β hydrolase fold with a cap in an open conformation. Access to the active site residues, which were unambiguously identified from the protein structure, is facilitated by two different channels. The larger channel constitutes the highly hydrophobic substrate binding pocket with enough room to accommodate monoacylglycerol. The other channel is rather small and resembles the proposed glycerol exit hole in human MGL. Molecular dynamics simulation of bMGL yielded open and closed states of the entrance channel and the glycerol exit hole. Despite differences in the number of residues, secondary structure elements, and low sequence identity in the cap region, this first structure of a bacterial MGL reveals striking structural conservation of the overall cap architecture in comparison with human MGL. Thus it provides insight into the structural conservation of the cap amongst MGLs throughout evolution and provides a framework for rationalising substrate specificities in each organism. [Copyright &y& Elsevier]

We determine the gravitational interaction between two compact bodies up to the sixth power in Newton's constant, GN, in the static limit. This result is achieved within the effective field theory approach to general relativity, and exploits a manifest factorization property of static diagrams which allows us to derive static post Newtonian (PN) contributions of (2n+1) order in terms of lower order ones. We recompute in this fashion the 1PN and 3PN static potential, and present the novel 5PN contribution. [ABSTRACT FROM AUTHOR]