52 results on '"Strasser S"'
Search Results
2. Gorbachev in America a rendezvous in...
- Author
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Strasser, S. and Cullen, R.B.
- Subjects
SOVIET Union-United States relations - Abstract
Soviet leader Mikhail Gorbachev comes to the US to sign an arms-reduction treaty with President Reagan. The majority of people in each nation see the importance of agreements on medium-range and tactical missiles, a nuclear test ban and SDI. If Gorbachev is seen as a Communist to be trusted and Reagan as a President who can lead, agreements will be more successful. See also (Time, 12/7/87, 8c, p14, 3p) See also (US News, 12/7/87, 1c, p38, 2p)
- Published
- 1987
3. Cracks in the Soviet facade.
- Author
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Watson, R. and Strasser, S.
- Subjects
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NATIONALISM - Abstract
Reports on the ethnic fighting in Azerbaijan. In the last 15 months Mikhail Gorbachev has had to cope with riots, nationalist demonstrations and protests in a nation of unrest. His openness campaign is being tested and the ensuing ethnic discontent could undermine his efforts to reform the economy and bring a little de mocracy to the Soviet Union. Examples and outlook. . See also (Time, 3/14/88, 5c, p32, 3p)
- Published
- 1988
4. The Southwest drug connection.
- Author
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Strasser, S. and Gibney, F.
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NARCOTICS , *INTERNATIONAL trade - Abstract
Roma, Texas is a small, tumbleweed town on the Mexican border, but it is dressed up and glittering, thanks to marijuana, coke and gunpowder. The town's prosperity has not gone unchallenged, but the Southwest drug connection is rivaling south Florida's in ostentatious wealth and violence. All the fresh money and manpower of Operation Alliance, Ronald Reagan's border offensive against drugs, has had little effect. Drug flow, profits, problems.
- Published
- 1987
5. Calcium intake and hypertension among obese adults in United States: associations and implications explored.
- Author
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Chen, Y, Strasser, S, Cao, Y, Wang, K-S, and Zheng, S
- Subjects
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PHYSIOLOGICAL effects of calcium , *HYPERTENSION , *ADOLESCENT obesity , *DISEASE prevalence , *REGULATION of blood pressure , *ANALYSIS of variance , *REGRESSION analysis - Abstract
The relationship between calcium intake and hypertension is receiving increased research attention. The prevalence of hypertension is high among the obese populations. Calcium is a mineral that influences blood pressure. The aim of the study was to examine the association between calcium intake and hypertension in a large nationally representative sample of obese American adults. A total of 14 408 obese adults aged 20 years or older were obtained from the 1999-2010 National Health and Nutrition Examination Survey. Analysis of variance and linear regression models were used to examine relationships between calcium intake and systolic blood pressure (SBP) as well as diastolic blood pressure (DBP). Multiple logistic regression models were used to examine the association between calcium intake and hypertension after adjusting for potential confounders and interactions, including: age, race, education level, alcohol use, smoking, diabetes status, sodium intake and potassium intake. Calcium intake was significantly lower for the hypertensive group compared with the normotensive group (P<0.0001), especially among those obese female young adults aged 20-44 years and among non-diabetic obese adults. Based on ordinary linear regression analysis, a significant inverse relationship was detected, SBP and DBP decreased if calcium intake increased (SBP: regression coefficient estimate=−0.015, P<0.0001; DBP: regression coefficient estimate=−0.028, P<0.0001). Multiple logistic regression showed that calcium intake was negatively associated with the probability of hypertension (odds ratio (OR)=0.81, 95% confidence interval (CI): 0.74-0.87, P<0.0001). In stratified analysis, calcium intake in youngest adults (age 20-44 years) had the lowest likelihood of hypertension (OR=0.77, 95% CI: 0.64-0.93, P<0.0001), the inverse relationship between calcium intake and probability of hypertension was stronger among females (OR: 0.68, 95% CI: 0.55-0.84, P<0.0001), when compared with the whole sample including all of 14 408 obese adults. The protective effect of calcium intake and hypertension was found significantly in obese non-diabetic adults (OR: OR=0.77, 95% CI: 0.67-0.89, P<0.0001) not in obese diabetic adults. SBP, DBP and calcium intake were log transformed for both ordinary linear regression analysis and logistic regression analysis. Our study findings underscore the need to explore the physiological mechanism between calcium intake and hypertension. In this study, increased calcium intake was associated with the lowest risk of hypertension. Future studies utilizing longitudinal research designs are needed to quantify therapeutic levels of calcium for control of hypertension among obese adults. Increasing calcium intake among American adults may offer promise as a cost-effective strategy to improve hypertension among obese adults; however, further scientific exploration is warranted. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
6. Severe hepatocellular injury after hematopoietic cell transplant: incidence, etiology and outcome.
- Author
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Sakai, M., Strasser, S. I., Shulman, H. M., McDonald, S. J., Schoch, H. G., and McDonald, G. B.
- Subjects
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HEMATOPOIETIC stem cell transplantation , *COMPLICATIONS from organ transplantation , *LIVER injuries , *AMINOTRANSFERASES , *HYPOXEMIA , *HEPATITIS , *DISEASE risk factors - Abstract
Hepatic complications of transplant are a common cause of mortality. Although mild elevations of serum aminotransferase enzymes (aspartate and alanine (AST, ALT)) do not carry an adverse prognosis, this is not the case with severe hepatocellular injury. We reviewed 6225 consecutive recipients to determine the incidence and outcomes of severe hepatocellular injury (AST >1500 U/l) before day 100, which occurred in 88 patients. Causes were sinusoidal obstruction syndrome (SOS) (n=46), hypoxic hepatitis (n=33), varicella zoster virus (VZV) hepatitis (n=4), drug-liver injury (n=2) and unknown (n=3). The incidence declined from 1.9% in the 1990s to 1.1% recently (owing to a fivefold decline in SOS and disappearance of VZV hepatitis). In hypoxic hepatitis, peak serum AST was 3545 U/l (range, 1380–25 246) within days of shock or prolonged hypoxemia; case fatality rate was 88%. In SOS, AST increases occurred 2–6 weeks after diagnosis; peak AST was 2252 U/l (range, 1437–8281); case fatality rate was 76%, with only serum bilirubin able to distinguish survivors (2.7 vs 11.3 mg/100 ml, P=0.0009). We conclude that circulatory insults (sinusoidal injury, hypotension and hypoxemia), and not infection, are the most common cause of severe hepatocellular injury, the frequency of which has declined because of a falling incidence of SOS and VZV hepatitis. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
7. Influence of lyophilization, fluidized bed drying, addition of protectants, and storage on the viability of lactic acid bacteria.
- Author
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Strasser, S., Neureiter, M., Geppl, M., Braun, R., and Danner, H.
- Subjects
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MICROBIOLOGY , *LACTIC acid bacteria , *FREEZE-drying , *FUNGUS-bacterium relationships , *LACTOBACILLUS plantarum , *BACTERIAL cell surfaces , *DISACCHARIDES , *CELL culture , *ENERGY consumption - Abstract
Aims: The present study focuses on the impact of two different drying technologies and the influence of protectants on process survival and storage stability of the two lactic acid bacterial strains Enterococcus faecium and Lactobacillus plantarum. Methods and Results: After incubation with the protectants glucose, sucrose, trehalose, and maltodextrin the concentrated bacterial suspensions were subjected to fluidized bed drying and lyophilization and subsequently stored at 4, 22, and 35°C for half a year. Lactobacillus plantarum turned out to be more sensitive to both drying methods than Ent. faecium. Without the addition of a protectant cells of both strains suffered higher losses during fluidized bed drying. Elevated storage temperatures correlate with a higher decline of viable bacterial cells. Conclusions: Although survival rates varied between the strains, the nonreducing disaccharides revealed overall best protection for both investigated lactic acid bacteria during processing and storage. The addition of protective carbohydrates can prevent the decline in viability during fluidized bed drying. Significance and Impact of the Study: The influence of protectants proved to be species specific and therefore needs to be determined on a case-to-case basis. Survival rates, duration, and energy consumption appear to be the crucial parameters to evaluate the economy of production processes for industrial starter cultures. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
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8. Iron overload in bone marrow transplant recipients.
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Strasser, S I, Kowdley, K V, Sale, G E, and McDonald, G B
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IRON , *BONE marrow transplantation - Abstract
We examined the degree of hepatic iron overload in patients receiving marrow transplant for hematologic malignancy and evaluated a new method of morphometric analysis of marrow iron content as a means of estimating hepatic iron stores in these patients. The iron content of marrow and liver specimens from 10 consecutive patients who died between 50 and 100 days after transplant was determined by spectrophotometry. Their mean age was 34.9 years (range 10–59). The mean time to death from disease onset was 2.2 years (0.5–8.7). Patients had received 30.2 ± 17.4 units of red cells during the transplant period and 47.6 ± 25.9 red cell units from diagnosis to death. The median hepatic iron concentration (HIC) was 4307 μg/g dry weight (range 1832–13120; normal 530–900) and the median hepatic iron index (HIC (μmol/g dry weight/age (years)) was 3.85 (0.76–8.14). The median biochemical marrow iron content was 1999 μg/g dry weight (range 932–3942). Morphometric analysis of the marrow iron content was performed on digital photomicrographs of a single Prussian blue-stained section of marrow. Strong correlations were demonstrated between morphometric marrow iron content and (1) biochemical marrow iron content (r = 0.8, P = 0.006) and (2) biochemical hepatic iron index (r = 0.82, P = 0.004). We conclude that marrow transplant recipients have a high liver iron content at 50–100 days post transplant with the hepatic iron index in the hereditary hemochromatosis range. Computerized morphometric marrow iron determination is a readily available means of estimating hepatic iron stores in these patients. [ABSTRACT FROM AUTHOR]
- Published
- 1998
- Full Text
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9. Kuwait: Rape of a nation.
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Strasser, S. and Wilkinson, R.
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ATROCITIES - Abstract
Describes the atrocities the Iraqis committed against Kuwaiti citizens. The role of the elite Iraqi Republican Guard who spearheaded the invasion; Torture center; Volunteers of the People's Army militia often behaved without restraint; Violence against women; Thefts; Palestinians in Kuwait; Political struggle.
- Published
- 1991
10. The tougher `new Gorbachev.'
- Author
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Strasser, S. and Coleman, F.
- Subjects
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PERSIAN Gulf War, 1991 - Abstract
Examines why Soviet leader Mikhail Gorbachev tried to upstage US President George Bush in a peace initiative and rescue Iraq. Asserts that the Kremlin has always wanted to be a main player in the Middle East, or at least a spoiler. Questions if Gorbachev is a publicity seeker; `Newsweek' opinion watch on Moscow's motives; Competing for favor with regional power.
- Published
- 1991
11. The mechanics of peace.
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Strasser, S. and Waller, D.
- Subjects
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PERSIAN Gulf War, 1991 - Abstract
Considers how Washington plans to deal with Iraq when Saddam Hussein is ready to end the Persian Gulf War. Since the withdrawal will be prolonged, the Pentagon wants to dictate the order of the Iraqi retreat. Offering Saddam Hussein little more than humiliation to look forward to; Conditions if the Iraqi leader wants a cease-fire; US plan to keep pressure on Saddam Hussein throughout the final stages. INSET: A hard line against Saddam..
- Published
- 1991
12. A piece of Perestroika.
- Author
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Anderson, H. and Strasser, S.
- Subjects
- *
FOREIGN investments , *GOVERNMENT policy , *SUMMIT meetings , *PERESTROIKA , *POLITICAL attitudes ,SOVIET Union economic policy, 1986-1991 - Abstract
The good feelings from the recent United States-Soviet summit should give even more encouragement to businessmen looking to take advantage of Mikhail Gorbachev's promises of economic reform and new Soviet rules on foreign investment. Many obstacles remain to free and fair trade with the Soviets, but Americans are lining up to do business in Russia. Examples.
- Published
- 1988
13. Moscow `Afghanaizes' its war.
- Author
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Strasser, S.
- Subjects
SOVIET occupation of Afghanistan, 1979-1989 - Abstract
The first stage of the Soviet withdrawal from Afghanistan is about to begin, making residents of Kabul anxious and watchful. Moscow's support for the Kabul government will continue, but its hope for survival is unsure. Withdrawal and outlook.
- Published
- 1988
14. The mystery of Ligachev.
- Author
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Barnathan, J. and Strasser, S.
- Subjects
- LIGACHEV, E. K. (Egor Kuzmich)
- Abstract
Recent signals in Moscow point to a major power struggle behind the formal show of unity, and the big loser is said to Yegor Ligachev, 67, a brusque former Siberian leader generally considered to rank below only Gorbachev himself. He is a conservative, resisting Gorbachev's economic reforms. Recent struggles and setbacks. . See also (Time, 5/2/88, 2c, p42, 2p)
- Published
- 1988
15. One-liners and party liners.
- Author
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Alter, J. and Strasser, S.
- Subjects
- *
VOYAGES & travels - Abstract
How General Secretary Gorbachev, his aides, his press secretary, and the Soviet press as working journalists all appeared to the American television and other media, as well as to the American public, during the recent summit.
- Published
- 1987
16. Gastrointestinal: Knot the intent.
- Author
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Baars, J. E., Strasser, S. I., Kaffes, A. J., and Saxena, P.
- Subjects
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SURGICAL stents , *ALCOHOLIC liver diseases , *PANCREATITIS - Abstract
The article presents a case study of a 43-year-old man for lumen-apposing metal stent (LAMS) removal with a medical history of alcoholic liver disease and pancreatitis.
- Published
- 2018
- Full Text
- View/download PDF
17. The end of the Gorbachev era.
- Author
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Strasser, S.
- Subjects
SOVIET Union politics & government, 1985-1991 ,RUSSIAN politics & government, 1991- - Abstract
Considers the state the Soviet Union was in when leader Mikhail Gorbachev came to power and what he has done to get the system working again. How Gorbachev's idea gradually developed into the heart of perestroika; From Soviet economic experiments toward acceptance of a free-market economy; Other economic changes; Assertion that last week's drama was as much Gorbachev's victory as Russian President Boris Yeltsin's; The end of the Gorbachev Era.
- Published
- 1991
18. Keeping the lid on dissent.
- Author
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Strasser, S.
- Subjects
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POLITICS & ethnic relations , *DISSENTERS , *INTERNATIONAL relations - Abstract
Although Mikhail Gorbachev has no intention of weakening Moscow's hold on Lithuania, Latvia and Estonia (Soviet territory along the Baltic Sea), his reforms have given impetus to those who want to preserve their ethnic ways of life. Anti-Russian feelings are common and growing. The Baltics' tactics of protest are peaceful but are being felt in Moscow. Gorbachev must decide if he should tighten the reign on the area or let Kremlin control be weakened.
- Published
- 1988
19. Exhuming the corpse.
- Author
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Strasser, S.
- Subjects
UNITED States history education - Abstract
Today's Soviet historians concede that American capitalism has proved resilient, viewing the Great Depression as the turning point. Most Soviet students learn a little about America in their world-history courses, but they are given only a grim view. A common assumption is that capitalism will gradually crumble under its inequities. Soviet historians don't account for America's 200 years of thriving. Soviet views.
- Published
- 1987
20. Aftermath of Chernobyl.
- Author
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Strasser, S.
- Subjects
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CHERNOBYL Nuclear Accident, Chornobyl, Ukraine, 1986 - Abstract
Soviet officials have begun to take Western journalists on tours in and around the crippled Chernobyl nuclear power plant. Reminders of the disaster, from ghost towns to radiation checkpoints, fill the area. Some communities have returned to their homes. Scheduled trial of senior plant officials next month; Possible criminal negligence charges.
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- 1987
21. Effects of Gorbachev's reform.
- Author
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Strasser, S.
- Subjects
UZBEKISTAN politics & government - Abstract
Nowhere has Mikhail Gorbachev fought harder to engineer restructuring than in Uzbekistan. So far, some 3,000 state employees have lost their jobs and high public officials have been executed. Despite Gorbachev's personal demand for economic and political changes in Uzbekistan, the reporting of false statistics is actually rising. The masses are proving to be Gorbachev's biggest obstacle.
- Published
- 1987
22. Sofosbuvir and daclatasvir therapy in patients with hepatitis C‐related advanced decompensated liver disease (MELD ≥ 15).
- Author
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the Australian Liver Association Clinical Research Network, McCaughan, G. W., Strasser, S. I., Mason, S., Thwaites, P. A., Morales, B., Gow, P., Parker, F. C., Angus, P. W., Roberts, S. K., Mitchell, J., Wigg, A., Tallis, C., Jeffrey, G., George, J., and Thompson, A. J.
- Subjects
- *
ANTIVIRAL agents , *HEPATITIS C , *LIVER diseases , *RIBAVIRIN , *PATIENTS ,SOFOSBUVIR - Abstract
Summary: Background: Antiviral therapy for hepatitis C has the potential to improve liver function in patients with decompensated cirrhosis. Aims: To examine the virological response and effect of viral clearance in patients with decompensated hepatitis C cirrhosis all with MELD scores ≥15 following sofosbuvir/daclatasvir ± ribavirin. Methods: We prospectively collected data on patients who commenced sofosbuvir/daclatasvir for 24‐weeks under the Australian patient supply program (TOSCAR) and analysed outcomes including sustained viral response at 12 weeks (SVR12), death and transplant. Results: 108 patients (M/F, 79/29; median age 56years; Child‐Pugh 10; MELD 16; genotype 1/3, 55/47) received sofosbuvir/daclatasvir and two also received ribavirin. On intention‐to‐treat, the SVR12 rate was 70% (76/108). Seventy‐eight patients completed 24‐weeks therapy. SVR12 was achieved in 56 of these patients on per‐protocol‐analysis (76%). SVR12 was 80% in genotype 1 compared to 69% in genotype 3. Thirty patients failed to complete therapy. In patients achieving SVR12, median MELD and Child‐Pugh fell from 16(IQR15‐17) to 14(12‐17) and 10(9‐11) to 8(7‐9), respectively (P<.001). In those who died, MELD increased from 16 to 23 at death (P=.036). Patients who required transplantation had a significantly higher baseline MELD (20) compared to those patients completing treatment (16) (P=.0010). The odds ratio for transplant in patients with baseline MELD ≥20 was 13.8(95%CI 2.78‐69.04). Conclusions: SVR12 rates with sofosbuvir/daclatasvir in advanced liver disease are lower than in compensated disease. Although treatment improves MELD and Child‐Pugh in most patients, a significant proportion will die or require transplantation. In those with MELD ≥20, it may be better to delay treatment until post‐transplant. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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- View/download PDF
23. O66 SOFOSBUVIR-BASED REGIMENS ARE ASSOCIATED WITH HIGH SVR RATES ACROSS GENOTYPES AND AMONG PATIENTS WITH MULTIPLE NEGATIVE PREDICTIVE FACTORS.
- Author
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Foster, G.R., Strasser, S., Christensen, C., Ma, J., Bekele, B.N., Brainard, D.M., Symonds, W.T., McHutchison, J.G., Conway, B., Crespo, I., and Zeuzem, S.
- Subjects
- *
GENETIC polymorphisms , *VIRAL nonstructural proteins , *NUCLEOTIDE sequencing , *DISEASE relapse , *CIRRHOSIS of the liver , *LIVER transplantation - Published
- 2014
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24. Accuracy of digital templating of uncemented total hip arthroplasty at a certified arthroplasty center: a retrospective comparative study.
- Author
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Dammerer, D., Keiler, A., Herrnegger, S., Putzer, D., Strasser, S., and Liebensteiner, M.
- Subjects
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TOTAL hip replacement , *ARTHROPLASTY , *MANN Whitney U Test , *COMPARATIVE studies , *KRUSKAL-Wallis Test - Abstract
Introduction: To investigate the accuracy of preoperative digital templating for total hip arthroplasty (THA) at a certified arthroplasty center (EndoCert EPZmax). Materials and methods: In a retrospective study design, we analysed 620 uncemented primary THAs for templating accuracy by comparing the preoperatively planned THA component size and the implanted size as documented by the surgeon. Templating was determined to be a) exact if the planned and the implanted component were the same size and b) accurate if they were exact ± one size. Moreover, we investigated factors that potentially influence templating accuracy: overweight and obesity (WHO criteria), sex, implant design, surgeon experience, preoperative diagnosis. Digital templating was done with MediCAD software. The Mann–Whitney U test and the Kruskal–Wallis test were used for statistical analysis. Results: Templating was exact in 52% of stems and 51% of cups and was accurate in 90% of the stems and 85% of the cups. Regarding the factors potentially influencing templating accuracy, the type of cup implant had a significant influence (p = 0.016). Moreover, greater accuracy of stem templating was achieved in female patients (p = 0.004). No such effect was determined for the other factors investigated. Conclusions: We conclude that preoperative 2D templating is accurate in 90% of the stems and 85% of the cups. Greater accuracy may be achieved in female patients. In addition to gender, the type of implant used may influence planning accuracy as well. Surgeon experience, BMI and preoperative diagnosis did not influence templating accuracy. Level of evidence: Level III (retrospective comparative study with prospective cohort). [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
25. Venom and violence.
- Author
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Strasser, S.
- Subjects
- RUSSIAN Revolution, The (Book)
- Abstract
Reviews the book `The Russian Revolution' by Richard Pipes who redefines Lenin for the postcommunist era. A masterful and timely distillation of Lenin's destructive genius; Traces the start of the Russian Revolution to a mundane university uprising in 1899.
- Published
- 1990
26. Production, Characterization, and Measurement of H(D) Beams on the ORNL Merged-Beams Experiment.
- Author
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Thomas, J. D., Kvale, T. J., Strasser, S. M. Z., Seely, D. G., and Havener, C. C.
- Subjects
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PARTICLES (Nuclear physics) , *ELECTRON capture , *ELECTRIC currents , *PARTICLE range (Nuclear physics) , *COLLISIONS (Nuclear physics) , *NUCLEAR physics - Abstract
Total cross section measurements of electron capture processes are being studied for low-energy, Aq++H(D) collisions using the Ion-Atom Merged-Beams apparatus at the Multicharged Ion Research Facility (MIRF) at Oak Ridge National Laboratory (ORNL). On this apparatus, a modified Faraday cup detector is used to measure the intensity of the neutral beam. The conversion of the measured electrical current to the true neutral particle beam current is necessary to accurately determine the true cross section values. Inherent in this conversion process is the number of secondary electrons (γ) emitted from the surface of the detector upon impact of an atom. The method employed to determine γ and its role in the absolute electron capture measurements at ORNL-MIRF are presented. With a recent upgrade to the apparatus, the neutral beam H(D) production technique has been improved and is discussed in detail in this paper. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
27. Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter.
- Author
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Brendel, C, Müller-Kuller, U, Schultze-Strasser, S, Stein, S, Chen-Wichmann, L, Krattenmacher, A, Kunkel, H, Dillmann, A, Antoniou, M N, and Grez, M
- Subjects
- *
TRANSGENE expression , *LENTIVIRUSES , *EPIGENETICS , *GENE silencing , *GENE therapy , *GENETIC vectors , *PROMOTERS (Genetics) - Abstract
Protection against epigenetic silencing is a desirable feature of future gene therapy vectors, in particular for those applications in which transgene expression will not confer growth advantage to gene-transduced cells. The ubiquitous chromatin opening element (UCOE) consisting of the methylation-free CpG island encompassing the dual divergently transcribed promoters of the human HNRPA2B1-CBX3 housekeeping genes (A2UCOE) has been shown to shield constitutive active heterologous promoters from epigenetic modifications and chromosomal position effects. However, it is unclear if this element can be used to improve expression from tissue-specific enhancer/promoters, while maintaining tissue specificity in hematopoietic cells. Here, we evaluated the potential of the A2UCOE in combination with the myeloid-specific myeloid related protein 8 (MRP8) promoter to target transgene expression specifically to myeloid cells in vitro and in vivo from a self-inactivating lentiviral vector. The inclusion of the A2UCOE did not interfere with specific upregulation of MRP8 promoter activity during myeloid differentiation and mediated sustained and vector copy-dependent expression in myeloid cells. Notably, the A2UCOE did not protect the MRP8 promoter from methylation in the P19 embryonal carcinoma cell line, suggesting that this element maintains the inherent epigenetic state and transcriptional activity of cellular promoters in their native configuration. Thus, the A2UCOE could represent a useful protective genetic element in gene therapy vectors, ensuring physiological transcriptional regulation of tissue-specific promoters independent of the chromosomal integration site. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
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28. Reviews of books: United States.
- Author
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Strasser, S.
- Subjects
- MAKING America Corporate (Book)
- Abstract
Reviews the book `Making America Corporate, 1870-1920,` by Oliver Zunz.
- Published
- 1992
29. A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.
- Author
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Nevens, F., Andreone, P., Mazzella, G., Strasser, S. l., Bowlus, C., Invernizzi, P., Drenth, J. P. H., Pockros, P. J., Regula, J., Beuers, U., Trauner, M., Jones, D. E., Floreani, A., Hohenester, S., Luketic, V., Shiftman, M., van Erpecum, K. J., Vargas, V., Vincent, C., and Hirschfield, G. M.
- Abstract
Background: Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients with this disease.Methods: In this 12-month, double-blind, placebo-controlled, phase 3 trial, we randomly assigned 217 patients who had an inadequate response to ursodiol or who found the side effects of ursodiol unacceptable to receive obeticholic acid at a dose of 10 mg (the 10-mg group), obeticholic acid at a dose of 5 mg with adjustment to 10 mg if applicable (the 5-10-mg group), or placebo. The primary end point was an alkaline phosphatase level of less than 1.67 times the upper limit of the normal range, with a reduction of at least 15% from baseline, and a normal total bilirubin level.Results: Of 216 patients who underwent randomization and received at least one dose of obeticholic acid or placebo, 93% received ursodiol as background therapy. The primary end point occurred in more patients in the 5-10-mg group (46%) and the 10-mg group (47%) than in the placebo group (10%; P<0.001 for both comparisons). Patients in the 5-10-mg group and those in the 10-mg group had greater decreases than those in the placebo group in the alkaline phosphatase level (least-squares mean, -113 and -130 U per liter, respectively, vs. -14 U per liter; P<0.001 for both comparisons) and total bilirubin level (-0.02 and -0.05 mg per deciliter [-0.3 and -0.9 μmol per liter], respectively, vs. 0.12 mg per deciliter [2.0 μmol per liter]; P<0.001 for both comparisons). Changes in noninvasive measures of liver fibrosis did not differ significantly between either treatment group and the placebo group at 12 months. Pruritus was more common with obeticholic acid than with placebo (56% of patients in the 5-10-mg group and 68% of those in the 10-mg group vs. 38% in the placebo group). The rate of serious adverse events was 16% in the 5-10-mg group, 11% in the 10-mg group, and 4% in the placebo group.Conclusions: Obeticholic acid administered with ursodiol or as monotherapy for 12 months in patients with primary biliary cholangitis resulted in decreases from baseline in alkaline phosphatase and total bilirubin levels that differed significantly from the changes observed with placebo. There were more serious adverse events with obeticholic acid. (Funded by Intercept Pharmaceuticals; POISE ClinicalTrials.gov number, NCT01473524; Current Controlled Trials number, ISRCTN89514817.). [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
30. Review article: long-term safety of nucleoside and nucleotide analogues in HBV-monoinfected patients.
- Author
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Lampertico, P., Chan, H. L. Y., Janssen, H. L. A., Strasser, S. I., Schindler, R., and Berg, T.
- Subjects
- *
NUCLEOSIDES , *NUCLEOTIDES , *HEPATITIS B treatment , *HEPATITIS B virus , *VIRAL disease treatment , *PATIENTS , *THERAPEUTICS - Abstract
Background Nucleos(t)ide analogues ( NUCs) for chronic hepatitis B treatment achieve high rates of viral suppression and are generally well tolerated. Entecavir ( ETV) and tenofovir disoproxil fumarate ( TDF) are the currently preferred first-line agents. The safety of these agents in clinical practice is particularly relevant since long-term treatment is usually required. Aim To summarise and critically discuss recent real-world evidence on the safety of treatment with ETV or TDF in hepatitis B virus ( HBV)-monoinfected patients. Methods PubMed and conference proceedings up to 15th June 2015 were searched using the terms ((((Hepatitis_B) OR HBV) AND ((tenofovir) OR entecavir)) AND (((lactic_acidosis) OR bone) OR renal)). Results In selected populations included in registration studies, both ETV and TDF were well tolerated with no clinically significant renal toxicity or lactic acidosis. Growing 'real-world' clinical experience with these agents includes some reports of ETV-associated lactic acidosis and TDF-associated renal impairment; however, evidence from cohort studies appears to be conflicting. In the case of ETV-related lactic acidosis, a small number of cases have been reported, all in patients with decompensated cirrhosis. The degree of association between TDF treatment and changes in markers of renal function varies between studies: discrepancies may result from the use of different definitions and cut-offs for reporting renal toxicities, and differences in patient populations. Conclusions Pre-treatment and on-treatment monitoring of eGFR and phosphorus, with prompt appropriate dose adjustment or treatment switch can minimise the impact of NUC renal toxicity. Standardisation of measures of renal impairment and identification of early molecular markers remain an unmet need. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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31. Safety and on-treatment efficacy of telaprevir: the early access programme for patients with advanced hepatitis C.
- Author
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Colombo, M., Fernández, I., Abdurakhmanov, D., Ferreira, P. A., Strasser, S. I., Urbanek, P., Moreno, C., Streinu-Cercel, A., Verheyen, A., Iraqi, W., DeMasi, R., Hill, A., Läuffer, J. M., Lonjon-Domanec, I., and Wedemeyer, H.
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HEPATITIS C treatment , *ADVERSE health care events , *ANTIVIRAL agents , *DRUG efficacy , *TELAPREVIR , *MEDICATION safety , *MEDICAL statistics , *THERAPEUTICS - Abstract
Background and aim Severe adverse events (AEs) compromise the outcome of direct antiviral agent-based treatment in patients with advanced liver fibrosis due to HCV infection. HEP3002 is an ongoing multinational programme to evaluate safety and efficacy of telaprevir (TVR) plus pegylated-interferon-a (PEG-IFNα) and ribavirin (RBV) in patients with advanced liver fibrosis caused by HCV genotype 1 (HCV-1). Methods 1782 patients with HCV-1 and bridging fibrosis or compensated cirrhosis were prospectively recruited from 16 countries worldwide, and treated with 12 weeks of TVR plus PEG-IFN/RBV, followed by 12 or 36 weeks of PEG-IFN and RBV (PR) alone dependent on virological response to treatment and previous response type. Results 1587 patients completed 12 weeks of triple therapy and 4 weeks of PR tail (53% cirrhosis, 22% HCV-1a). By week 12, HCV RNA was undetectable in 85% of naives, 88% of relapsers, 80% of partial responders and 72% of null responders. Overall, 931 patients (59%) developed grade 1-4 anaemia (grade 3/ 4 in 31%), 630 (40%) dose reduced RBV, 332 (21%) received erythropoietin and 157 (10%) were transfused. Age and female gender were the strongest predictors of anaemia. 64 patients (4%) developed a grade 3/4 rash. Discontinuation of TVR due to AEs was necessary in 193 patients (12%). Seven patients died (0.4%, six had cirrhosis). Conclusions In compensated patients with advanced fibrosis due to HCV-1, triple therapy with TVR led to satisfactory rates of safety, tolerability and on-treatment virological response with adequate managements of AEs. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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32. Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare.
- Author
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Nguyen, V., Tan, P. K., Greenup, A.‐J., Glass, A., Davison, S., Samarasinghe, D., Holdaway, S., Strasser, S. I., Chatterjee, U., Jackson, K., Locarnini, S. A., and Levy, M. T.
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ANTIVIRAL agents , *HEPATITIS B virus , *VIRUS disease transmission , *LAMIVUDINE , *PREGNANCY - Abstract
Background Antepartum anti-viral therapy ( AVT) is often administered to prevent perinatal transmission of hepatitis B virus ( HBV) infection. Little is known about the effect of AVT on post-partum flare rates and severity. Aim To examine whether extending AVT beyond birth influences the post-partum course. Methods One hundred and one pregnancies in 91 women with HBV DNA levels ≥log 7 IU/ mL were included. AVT (initially lamivudine, later tenofovir disoproxil fumarate) was commenced from 32 weeks gestation and stopped soon after birth and at 12 weeks post-partum. Outcomes according to post-partum treatment duration were examined: Group 1 = AVT ≤4 weeks ( n = 44), Group 2 = AVT >4 weeks ( n = 43), Group 3 = no AVT ( n = 14). Results The majority of women were HBeAg+ (97%), median age 29 years, baseline HBV DNA log 8.0 IU/ mL and follow-up 48 weeks post-partum. Post-partum treatment duration was 2 weeks for Group 1 and 12 weeks for Group 2, P < 0.01. Flare rates were not significantly different: Group 1 = 22/44 (50%), Group 2 = 17/43 (40%) and Group 3 = 4/14 (29%), P = 0.32. Onset of flare was similar at 8/10/9 weeks post-partum for Groups 1/2/3 respectively, P = 0.34. The majority of flares spontaneously resolved. HBeAg seroconversion ( n = 1/5/1 in Groups 1/2/3, P = 0.27) was not associated with treatment duration or the occurrence of a post-partum flare. Conclusions Post-partum flares are common and usually arise early after delivery. They are often mild in severity and most spontaneously resolve. Extending anti-viral therapy does not protect against post-partum flares or affect HBeAg seroconversion rates. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
33. Terlipressin therapy for moderate-to-severe hyponatraemia in patients with liver failure.
- Author
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Prakoso, E., Jones, C., Koorey, D. J., Strasser, S. I., Bowen, D., McCaughan, G. W., and Shackel, N. A.
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ANTIHYPERTENSIVE agents , *FISHER exact test , *HYPONATREMIA , *LIVER failure , *HEALTH outcome assessment , *SURVIVAL analysis (Biometry) , *T-test (Statistics) , *LOGISTIC regression analysis , *TREATMENT effectiveness , *DATA analysis software , *DESCRIPTIVE statistics , *KAPLAN-Meier estimator , *DISEASE complications - Abstract
Background Hyponatraemia in liver failure is associated with increased morbidity and mortality. Improving serum sodium in liver failure has been observed in patients receiving terlipressin. Methods We assessed the response of hyponatraemia in patients with liver failure to terlipressin using comparative retrospective analysis. Results Twenty-three patients received terlipressin for hyponatraemia after failed conservative management (median age 52 years (27-67), model for end-stage liver disease score 28 (16-38)). The median therapy was 7 days (1-27), with an average total dose of 25 mg (4-90) and a mean follow up of 51 days (5-1248). These patients were compared with 11 hyponatraemic patients managed conservatively during the same period with comparable age, baseline serum sodium and follow up. After 1 week of terlipressin therapy, serum sodium increased from a median of 120 (115-128) to 129 mmol/ L (121-144) ( P < 0.001), and at the end of terlipressin therapy, the serum sodium had increased significantly to 131 mmol/ L (120-148) ( P < 0.001). In comparison, in the conservatively managed group, the serum sodium did not increase significantly from the baseline of 123 (117-127) mmol/ L. Adverse events occurred in 26% of patients receiving terlipressin, which predominantly pulmonary oedema. Importantly, more hyponatraemic patients treated with terlipressin (48%) were alive compared with the conservative group (18%), despite the latter having a significantly lower baseline median MELD score of 21 (16-30) ( P = 0.008). Moreover, the transplant-free survival was higher in the terlipressin (30%) compared with the conservative group (0%). Conclusions Terlipressin is effective in treating hyponatraemia in liver failure. Importantly, terlipressin use results in better transplant-free survival but also more adverse events. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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34. Anthrax cases in pregnant and postpartum women: a systematic review.
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Meaney-Delman D, Zotti ME, Rasmussen SA, Strasser S, Shadomy S, Turcios-Ruiz RM, Wendel GD Jr, Treadwell TA, Jamieson DJ, Meaney-Delman, Dana, Zotti, Marianne E, Rasmussen, Sonja A, Strasser, Sheryl, Shadomy, Sean, Turcios-Ruiz, Reina M, Wendel, George D Jr, Treadwell, Tracee A, and Jamieson, Denise J
- Abstract
Objective: To describe the worldwide experience of Bacillus anthracis infection reported in pregnant, postpartum, and lactating women.Data Sources: Studies were identified through MEDLINE, Web of Science, Embase, and Global Health databases from inception until May 2012. The key words (["anthrax" or "anthracis"] and ["pregna*" or "matern*" or "postpartum" or "puerperal" or "lact*" or "breastfed*" or "breastfeed*" or "fetal" or "fetus" or "neonate" or "newborn" or "abort*" or "uterus"]) were used. Additionally, all references from selected articles were reviewed, hand searches were conducted, and relevant authors were contacted.Methods Of Study Selection: The inclusion criteria were: published articles referring to women diagnosed with an infection due to exposure to B anthracis during pregnancy, the postpartum period, or during lactation; any article type reporting patient-specific data; articles in any language; and nonduplicate cases. Non-English articles were professionally translated. Duplicate reports, unpublished reports, and review articles depicting previously identified cases were excluded.Tabulation, Integration, and Results: Two authors independently reviewed articles for inclusion. The primary search of the four databases yielded 1,340 articles, and the secondary crossreference search revealed 146 articles. Fourteen articles met the inclusion criteria. In total, 20 cases of B anthracis infection were found, 17 in pregnant women, two in postpartum women, and one case in a lactating woman. Among these reports, 16 women died and 12 fetal or neonatal losses were reported. Of these fatal cases, most predated the advent of antibiotics.Conclusions: Based on these case reports, B anthracis infection in pregnant and postpartum women is associated with high rates of maternal and fetal death. Evidence of possible maternal-fetal transmission of B anthracis infection was identified in early case reports. [ABSTRACT FROM AUTHOR]- Published
- 2012
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35. Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney.
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Prakoso, E., Verran, D., Dilworth, P., Kyd, G., Tang, P., Tse, C., Koorey, D. J., Strasser, S. I., Stormon, M., Shun, A., Thomas, G., Joseph, D., Pleass, H., Gallagher, J., Allen, R., Crawford, M., McCaughan, G. W., and Shackel, N. A.
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ANALYSIS of variance , *CHI-squared test , *COMPUTER software , *ORGAN donation , *LIVER transplantation , *LONGITUDINAL method , *EVALUATION of medical care , *STATISTICS , *SURVIVAL analysis (Biometry) , *DATA analysis , *RETROSPECTIVE studies , *MORTALITY - Abstract
Background: We aimed to describe the demand for liver transplantation (LTx) and patient outcomes on the waiting list at the Australian National Liver Transplantation Unit, Sydney over the last 20 years. Methods: We performed a retrospective analysis with the data divided into three eras: 1985-1993, 1994-2000 and 2001-2008. Results: The number of patients accepted for LTx increased from 320 to 372 and 548 ( P < 0.001) with the number of LTx being performed increasing from 262 to 312 and 452 respectively ( P < 0.001). The median adult recipient age increased from 45 to 48 and 52 years ( P < 0.001) while it decreased in children from 4 to 2 and 1 years respectively ( P= 0.001). In parallel, the deceased donor offers decreased from 1003 to 720 and 717 ( P < 0.001). Methods to improve access to donor livers have been used with the use of split livers, extended criteria and non-heart beating donors, resulting in increased acceptance of deceased donor offers by 65% and 115% in the second and third eras when compared with the first era ( P < 0.001). However, the adult median waiting time has increased from 23 to 41 and 120 days respectively ( P < 0.001). This was associated with increased adult mortality on the waiting list from 23 to 40 and 122 respectively ( P < 0.001). Conclusions: Despite the increasing proportion of donor offers being used, the waiting list mortality is increasing. A solution to this problem is an increase in organ donation to keep pace with the escalating demand for LTx. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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36. Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade.
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Åneman, Anders, Treggiari, M. M., Burgener, D., Laesser, M., Strasser, S., and Hadengue, A.
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CARDIAC output , *ANIMAL models in research , *VASOCONSTRICTION , *BLOOD flow measurement , *ENDOTHELINS , *PERFUSION , *LABORATORY swine , *THERAPEUTICS - Abstract
Background: To investigate endothelin-1 (ET-1)-dependent hepatic and mesenteric vasoconstriction, and oxygen and lactate fluxes in an acute, fixed low cardiac output (CO) state. Methods: Sixteen anesthetized, mechanically ventilated pigs were studied. Cardiac tamponade was established to reduce portal venous blood flow (QPV) to 2/3 of the baseline value. CO, hepatic artery blood flow (QHA), QPV, hepatic laser-Doppler flow (LDF), hepatic venous and portal pressure, and hepatic and mesenteric oxygen and lactate fluxes were measured. Hepatic arterial (RHA), portal (RHP) and mesenteric (Rmes) vascular resistances were calculated. The combined ETA–ETB receptor antagonist tezosentan (RO 61-0612) or normal saline vehicle was infused in the low CO state. Measurements were made at baseline, after 30, 60, 90 min of tamponade, and 30, 60, 90 min following the infusion of tesozentan at 1 mg/kg/h. Results: Tamponade decreased CO, QPV, QHA, LDF, hepatic and mesenteric oxygen delivery, while hepatic and mesenteric oxygen extraction and lactate release increased. RHA, RHP and Rmes all increased. Ninety minutes after tesozentan, QPV, LDF and hepatic and mesenteric oxygen delivery and extraction increased approaching baseline values, but no effect was seen on CO or QHA. Hepatic and mesenteric handling of lactate converted to extraction. RHA, RHP and Rmes returned to baseline values. No changes were observed in these variables among control animals not receiving tesozentan. Conclusion: In a porcine model of acute splanchnic hypoperfusion, unselective ET-1 blockade restored hepatomesenteric perfusion and reversed lactate metabolism. These observations might be relevant when considering liver protection in low CO states. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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37. Current approaches to the diagnosis and management of hepatocellular carcinoma.
- Author
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Perry, J., Poustchi, H., George, J., Farrell, G., McCaughan, G., and Strasser, S.
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DIAGNOSIS , *LIVER cancer , *LIVER metastasis , *CIRRHOSIS of the liver , *LIVER diseases - Abstract
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, and incidence rates in Western countries are on the rise. Despite many options, no ideal treatment yet exists for this highly malignant tumour, and management strategies have varied accordingly. This review summarises current strategies for the diagnosis and management of HCC. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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38. Photospheric magnetic field and surface differential rotation of the FK Com star HD 199178.
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Petit, P., Donati, J.-F., Oliveira, J.M., Aurière, M., Bagnulo, S., Landstreet, J.D., Lignières, F., Lüftinger, T., Marsden, S., Mouillet, D., Paletou, F., Strasser, S., Toqué, N., and Wade, G.A.
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STELLAR magnetic fields , *STELLAR rotation , *COSMIC magnetic fields , *DYNAMO theory (Physics) , *ASTROPHYSICAL spectropolarimetry , *GALAXIES - Abstract
We present spectropolarimetric observations of the FK Com star HD 199178 obtained between 1998 December and 2003 August at the Télescope Bernard Lyot (Observatoire du Pic du Midi, France). We report the detection of a photospheric magnetic field and reconstruct its distribution by means of Zeeman–Doppler imaging. We observe large regions where the magnetic field is mainly azimuthal, suggesting that the dynamo processes generating the magnetic activity of HD 199178 may be active very close to the stellar surface. We investigate the rapid evolution of surface brightness and magnetic structures from a continuous monitoring of the star over several weeks in 2002 and 2003. We report that significant changes occur in the distribution of cool-spots and magnetic regions on typical time-scales of the order of two weeks. Our spectropolarimetric observations also suggest that the surface of HD 199178 is sheared by differential rotation, with a difference in rotation rate between equatorial and polar regions of the order of 1.5 times that of the Sun. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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39. Magnetic topology and surface differential rotation on the K1 subgiant of the RS CVn system HR 1099.
- Author
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Petit, P., Donati, J.-F., Wade, G. A., Landstreet, J. D., Bagnulo, S., Lüftinger, T., Sigut, T. A. A., Shorlin, S. L. S., Strasser, S., Aurière, M., and Oliveira, J. M.
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MAGNETIC fields , *TOPOLOGY , *ASTROPHYSICAL spectropolarimetry , *MAGNETICS , *POLARIMETRY , *STARS - Abstract
We present here spectropolarimetric observations of the RS CVn system HR 1099 (V711 Tau) secured from 1998 February to 2002 January with the spectropolarimeter MuSiCoS at the Télescope Bernard Lyot (Observatoire du Pic du Midi, France). We apply Zeeman–Doppler imaging and reconstruct surface brightness and magnetic topologies of the K1 primary subgiant of the system, at five different epochs. We confirm the presence of large, axisymmetric regions where the magnetic field is mainly azimuthal, providing further support to the hypothesis that dynamo processes may be distributed throughout the whole convective zone in this star. We study the short-term evolution of surface structures from a comparison of our images with observations secured at close-by epochs by Donati et al. at the Anglo-Australian Telescope. We conclude that the small-scale brightness and magnetic patterns undergo major changes within a time-scale of 4–6 weeks, while the largest structures remain stable over several years. We report the detection of a weak surface differential rotation (both from brightness and magnetic tracers) indicating that the equator rotates faster than the pole with a difference in rotation rate between the pole and the equator about four times smaller than that of the Sun. This result suggests that tidal forces also affect the global dynamic equilibrium of convective zones in cool active stars. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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40. Subcellular localisation of Cdc25A determines cell fate.
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Leisser, C., Rosenberger, G., Maier, S., Fuhrmann, G., Grusch, M., Strasser, S., Huettenbrenner, S., Fassl, S., Polgar, D., Krieger, S., Cerni, C., Hofer-Warbinek, R., deMartin, R., and Krupitza, G.
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CELL division , *APOPTOSIS , *CYTOPLASM , *OVARIAN cancer , *TRANSCRIPTION factors , *CANCER cells - Abstract
Cell division cycle 25A (Cdc25A) was shown to colocalise both with nuclear and cytoplasmic proteins. Recently, we have demonstrated that overexpressed Cdc25A promoted the survival of rat 423 cells through indirect activation of PKB-protein kinase B. Using a Cdc25A:ER fusion protein, which can be shuttled from the cytoplasm into the nucleus, the present investigation evidences that the antiapoptotic effect of Cdc25A was restricted to its cytoplasmic localisation in rat 423 cells. In contrast, nuclear Cdc25A overexpression caused dephosphorylation and nuclear retention of the proapoptotic transcription factor Forkhead in rhabdomyosarcoma-like 1 (FKHRL1) in human N.1 ovarian carcinoma cells. This resulted in the increased constitutive expression of the FKHRL1 targets Fas ligand and Bim, and promoted apoptosis. Thus, the Cdc25A oncogene, which was found to be frequently overexpressed in certain human cancers, can increase or decrease the susceptibility to apoptosis depending on the cell-type-specific subcellular distribution.Cell Death and Differentiation (2004) 11, 80-89. doi:10.1038/sj.cdd.4401318 Published online 5 September 2003 [ABSTRACT FROM AUTHOR]
- Published
- 2004
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41. Rural/urban differences in access to and utilization of services among people in Alabama with sickle cell disease.
- Author
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Telfair J, Haque A, Etienne M, Tang S, and Strasser S
- Abstract
OBJECTIVE: This study examined relationships between socioeconomic factors and the geographic distribution of 662 cases of sickle cell disease in Alabama in 1999-2001. METHODS: Measures of community distress, physical functioning, and medical problems were used in analyzing utilization differences between individuals with sickle cell disease living in urban and rural areas. RESULTS: Utilization of comprehensive sickle cells disease services was lower for individuals with sickle cell disease living in rural areas than for those living in urban areas. Rural clients reported significantly more limitations than urban clients on several measures of physical functioning. The results also suggest that utilization of services was higher for those with more medical problems and those who lived in high distress areas, although these findings did not meet the criterion for statistical significance. CONCLUSIONS: Conclusions based on statistical evidence that geographic location and socioeconomic factors relate to significantly different health care service experience bear important implications for medical and health care support systems, especially on the community level. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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42. Transformational leadership of clinical nutrition managers.
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Arensberg MBF, Schiller MR, Vivian VM, Johnson WA, and Strasser S
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- 1996
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43. Assessment of adult patients with chronic liver failure for liver transplantation in 2015: who and when?
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McCaughan, G. W., Crawford, M., Sandroussi, C., Koorey, D. J., Bowen, D. G., Shackel, N. A., and Strasser, S. I.
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ALCOHOLIC liver diseases , *CHRONIC diseases , *FATTY liver , *HEPATITIS C , *HEPATOCELLULAR carcinoma , *LIVER failure , *LIVER transplantation , *MEDICAL needs assessment , *SURVIVAL , *SOCIAL support - Abstract
In 2015, there are a few absolute contraindications to liver transplantation. In adult patients, survival post-liver transplant is excellent, with 1-year survival rate >90% and 5-year survival rates >80% and predicted median allograft survival beyond 20 years. Patients with a Child-Turcotte Pugh score ≥9 or a model for end-stage liver disease ( MELD) score >15 should be referred for liver transplantation, with patients who have a MELD score >17 showing a 1-year survival benefit with liver transplantation. A careful selection of hepatocellular cancer patients results in excellent outcomes, while consideration of extra-hepatic disease (reversible vs irreversible) and social support structures are crucial to patient assessment. Alcoholic liver disease remains a challenge, and the potential to cure hepatitis C virus infection together with the emerging issue of non-alcoholic fatty liver disease-associated chronic liver failure will change the landscape of the who in the years ahead. The when will continue to be determined largely by the severity of liver disease based on the MELD score for the foreseeable future. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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44. P0781 : High SVR rates despite multiple negative predictors in genotype 1 patients receiving ombitasvir/paritaprevir/R, dasabuvir with or without ribavirin for 12 and 24 weeks: Integrated analysis of six phase 3 trials.
- Author
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Reau, N., Fried, M.W, Wedemeyer, H., Cooper, C., Diago, M., Craxi, A., Strasser, S., Dufour, J.-F., Xie, W., Larsen, L., Dumas, E.O., and Bernstein, D.
- Subjects
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HEPATITIS C treatment , *ANILIDES , *MACROCYCLIC compounds , *SULFONAMIDES , *RIBAVIRIN , *CLINICAL trials - Published
- 2015
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45. O168 THE FIRST PRIMARY BILIARY CIRRHOSIS (PBC) PHASE 3 TRIAL IN TWO DECADES – AN INTERNATIONAL STUDY OF THE FXR AGONIST OBETICHOLIC ACID IN PBC PATIENTS.
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Nevens, F., Andreone, P., Mazzella, G., Strasser, S., Bowlus, C., Invernizzi, P., Drenth, J., Pockros, P., Regula, J., Hansen, B., Hooshmand-Rad, R., Sheeron, S., and Shapiro, D.
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BILIARY liver cirrhosis , *CIRRHOSIS of the liver , *CLINICAL trials , *RIBAVIRIN , *THERAPEUTIC use of interferons , *THROMBOCYTOPENIA , *PATIENTS , *DIAGNOSIS , *THERAPEUTICS - Published
- 2014
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46. Author reply.
- Author
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Prakoso, E., Jones, C., Koorey, D. J., Strasser, S. I., Bowen, D., McCaughan, G. W., and Shackel, N. A.
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HYPONATREMIA , *ANTIHYPERTENSIVE agents - Abstract
A response from the authors of the article ``Terlipressin Therapy for Moderate to Severe Hyponatraemia in Patients with Liver Failure'' in the March 2013 issue is presented.
- Published
- 2013
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47. 1418 DACLATASVIR COMBINED WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN FOR 12 OR 16 WEEKS IN PATIENTS WITH HCV GENOTYPE 2 OR 3 INFECTION: COMMAND GT2/3 STUDY.
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Dore, G.J., Lawitz, E., H'ezode, C., Shafran, S., Ramji, A., Tatum, H., Taliani, G., Tran, A., Brunetto, M., Zaltron, S., Strasser, S., Weis, N., Ghesquiere, W., Lee, S., Larrey, D., Pol, S., Harley, H., George, J., Fung, S., and de L'edinghen, V.
- Published
- 2013
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48. 806 MANAGEMENT AND OUTCOMES OF ANEMIA IN THE INTERNATIONAL TELAPREVIR EARLY ACCESS PROGRAM, FOR PATIENTS WITH HEPATITIS C GENOTYPE 1 INFECTION.
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Colombo, M., Fern, I., Abdurakhmanov, D., Ferreira, P.A., Strasser, S., Urbanek, P., Moreno, C., Streinu-Cercel, A., Beeldens, F., Iraqi, W., DeMasi, R., Hill, A., L, J.M., Lonjon-Domanec, I., and Wedemeyer, H.
- Published
- 2013
- Full Text
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49. Point-of-care tests to strengthen health systems and save newborn lives: the case of syphilis.
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Mabey DC, Sollis KA, Kelly HA, Benzaken AS, Bitarakwate E, Changalucha J, Chen XS, Yin YP, Garcia PJ, Strasser S, Chintu N, Pang T, Terris-Prestholt F, Sweeney S, Peeling RW, Mabey, David C, Sollis, Kimberly A, Kelly, Helen A, Benzaken, Adele S, and Bitarakwate, Edward
- Published
- 2012
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50. 21 TWO YEARS SAFETY AND EFFICACY OF TENOFOVIR DISOPROXIL FUMARATE (TDF) IN PATIENTS WITH HBV-INDUCED CIRRHOSIS
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Buti, M., Hadziyannis, S., Mathurin, P., Urbanek, P., Sherman, M., Strasser, S., Wang, C., Petersen, J., Heathcote, E.J., Marcellin, P., Sorbel, J., Mondou, E., Anderson, J., and Rousseau, F.
- Published
- 2009
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