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Research question: Theca interna cells (TICs) are an indispensable cell source for ovarian follicle development and steroidogenesis. Recent studies have identified theca stem cells (TSCs) in both humans and animals. Interestingly, TSCs express mesenchymal stem cell (MSC)-related markers and can differentiate into mesenchymal lineages. MSCs are promising for tissue engineering and regenerative medicine due to their self-renewal and differentiation abilities. Therefore, this study investigated the potential origin of TICs from MSCs. Design: Whole ovaries from postmenopausal organ donors were obtained, and their cortex was cryopreserved prior to the isolation of stromal cells. These isolated cells were differentiated in vitro to TICs using cell media enriched with various growth factors and hormones. Immunocytochemistry, an enzyme-linked immunosorbent assay, flow cytometry, and reverse transcription–quantitative polymerase chain were employed at different timepoints. Data were analyzed using one-way ANOVA. Results: Immunocytochemistry showed an increase in TIC markers from day 0 to day 8 and a significant rise in MSC-like markers on day 2. This corresponds with rising androstenedione levels from day 2 to day 13. Flow cytometry identified a decreasing MSC-like cell population from day 2 onwards. The CD13+ cell population and its gene expression increased significantly over time. NGFR and PDGFRA expression was induced on days 0 and 2, respectively, compared to day 13. Conclusions: This study offers insights into MSC-like cells as the potential origin of TICs. Differentiating TICs from these widely accessible MSCs holds potential significance for toxicity studies and investigating TIC-related disorders like polycystic ovary syndrome (PCOS). [ABSTRACT FROM AUTHOR]

In the Atlantic Forest, species distributions are not uniform. The biome has been divided into 8 biogeographic sub-regions, such as the Pernambuco Center of Endemism (PCE), in northeastern Brazil. Nísia Floresta National Forest (Flona) is a protected area situated in the municipality of Nísia Floresta, Rio Grande do Norte state, harboring native vegetation (Atlantic Forest and "Restingas or Tabuleiros") as well regenerating areas, with experimental plots of exotic plants for timber production. Herein, we present, for the first time, a species list of the herpetofauna surveyed at Flona over the past 10 years, using a standardized, long-term sampling design along with visual encounter surveys. We conducted monthly surveys across the area using 84 pitfall traps randomly distributed in 21 arrays throughout the forest's three phytogeographic zones (Restinga, Atlantic Forest, and Regeneration). In addition, we characterized ground-dwelling herpetofauna community diversity across these three zones over the course of an entire year. We collected a total of 39 species of reptiles (among lizards, snakes, chelonians, alligators, and amphisbaenians) and 24 species of frogs. The most frequent family found for reptiles was Dipsadidae, followed by Colubridae. In frogs, Leptodactylidae was the most common, followed by Hylidae. Herpetofaunal diversity in regeneration areas is smaller than forests, which in turn are marginally less diverse than the Restinga. Community descriptors such as equity, presence of exclusive species, and differences in abundances and composition indicate that distinct management strategies for each zone are needed for this protected area. At last, albeit smaller, diversity in regenerating areas is similar to natural areas, a reassuring result considering the significant deforestation the Atlantic Forest has suffered and the urgent need for restoration initiatives. [ABSTRACT FROM AUTHOR]

Introduction: People with disabilities face many challenges on a daily basis. Despite legislative advances and inclusion policies, discrimination against people with disabilities persists in various areas of life, including access to health services. Aim: This study aims to conduct an integrative literature review to investigate the factors associated with discrimination faced by people with disabilities in health services. Materials and Methods: The search was conducted in February 2024 in the IBECS, Lilacs, BDEnf, Medline (PubMed), Scopus, and Web of Science databases. The health descriptors (DeCS) “people with disabilities,” “social discrimination,” and “health services” were used. Original articles available in full, from the last five years, and in any language were included. The exclusion criteria were duplicate articles and those that did not answer the guiding question. Results: A total of 162 records were identified, from which 17 studies were selected, resulting in a final sample of 10 articles. The main factors associated with the discriminatory experiences faced by people with disabilities when accessing and using the health system were “stigmatization,” “negligence,” “prejudice,” and “access difficulties.” Conclusions: Significant drivers of discrimination were identified, including financial barriers, lack of training for health professionals, and other gaps that generate prejudice, stigmatization, and neglect. It is essential to implement public policies to ensure service accessibility, provide financial assistance for people with disabilities, establish training programs for health professionals, and conduct more research on this subject. [ABSTRACT FROM AUTHOR]

Growth hormone (GH) receptor (GHR) is abundantly expressed in neurons that co‐release the agouti‐related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus (ARH). Since ARHAgRP/NPY neurons regulate several hypothalamic–pituitary‐endocrine axes, this neuronal population possibly modulates GH secretion via a negative feedback loop, particularly during food restriction, when ARHAgRP/NPY neurons are highly active. The present study aims to determine the importance of GHR signaling in ARHAgRP/NPY neurons on the pattern of GH secretion in fed and food‐deprived male mice. Additionally, we compared the effect of two distinct situations of food deprivation: 16 h of fasting or four days of food restriction (40% of usual food intake). Overnight fasting strongly suppressed both basal and pulsatile GH secretion. Animals lacking GHR in ARHAgRP/NPY neurons (AgRP∆GHR mice) did not exhibit differences in GH secretion either in the fed or fasted state, compared to control mice. In contrast, four days of food restriction increased GH pulse frequency, basal GH secretion, and pulse irregularity/complexity (measured by sample entropy), whereas pulsatile GH secretion was not affected in both control and AgRP∆GHR mice. Hypothalamic Ghrh mRNA levels were unaffected by fasting or food restriction, but Sst expression increased in acutely fasted mice, but decreased after prolonged food restriction in both control and AgRP∆GHR mice. Our findings indicate that short‐term fasting and prolonged food restriction differentially affect the pattern of GH secretion, independently of GHR signaling in ARHAgRP/NPY neurons. [ABSTRACT FROM AUTHOR]

Objective: Congenital defects/diseases Background: Bartter syndrome is a rare, inherited salt-wasting tubulopathy caused by mutations in 1 of 6 genes that express ion transport channels in the thick ascending limb of nephrons. Excessive prostaglandin E2 and associated hyperreninemic hyperaldosteronism occurs, causing polyhydramnios, polyuria, prematurity, failure to thrive, and characteristic physical features. Hypokalemia, hypochloremic metabolic alkalosis, and, depending on the affected gene, hypercalciuria and nephrocalcinosis are hallmarks of Bartter syndrome. Case Reports: A 9-month-old male infant, born prematurely due to polyhydramnios, presented in the Emergency Department with dehydration due to incoercible vomiting and significant polyuria. A 6-year-old male infant with a previous history of prematurity due to polyhydramnios was referred to the Pediatric Endocrinology Department due to short stature and notable polydipsia and polyuria. Considering these marked symptoms, both cases triggered suspicion and started workup for arginine-vasopressin insufficiency/resistance. However, during the investigations, a broader clinical revision revealed that both had dysmorphic physical features (triangularly shaped face, prominent forehead, protruding ears, drooping mouth), poor growth, impaired weight gain, and typical biochemical findings (hypokalemic metabolic alkalosis, hypercalciuria, secondary hyperaldosteronism) of Bartter syndrome. Genetic testing confirmed the diagnosis of Bartter syndrome types 1 and type 2, respectively, and this diagnosis allowed proper treatment and significant clinical improvements, personalized follow-up, and genetic counseling for parents desiring further healthy pregnancies. Conclusions: Here, we present clinical and follow-up findings of 2 patients with Bartter syndrome types 1 and 2 discovered upon a broader clinical revision of suspected arginine-vasopressin insufficiency/resistance. We also review pertinent data on diagnosis and management of this challenging syndrome. [ABSTRACT FROM AUTHOR]

• Computer simulations and the Lipinski rule evaluate the pharmacokinetic and toxicological aspects of methyl eugenol as a drug candidate. • Treatment with methyl eugenol (ME) during and after the initiation of acute respiratory distress syndrome (ARDS) can prevent the progression of acute inflammation. • In vivo and in silico tests indicate that ME oil is an orally bioavailable drug that exerts multifunctional cytoprotective activities. • ME oil can treat and prevent intestinal I/R-induced ARDS in rats. Acute respiratory distress syndrome (ARDS) is an inflammatory disease that affects the lungs with rupture of the alveolar-capillary barrier and loss of lung compliance, orchestrated by an intense inflammatory process mediated by neutrophils that culminates in diffuse alveolar data and tissue hypoxia. In this context, no specific drug has yet been applied to treat the syndrome. Therefore, finding new therapeutic targets that can treat the syndrome has become a research study. In view of this, methyl-eugenol (ME) has become the target of this study. The aim of this work was to carry out an in silico pharmacological and toxicological analysis with ADMET, as well as to determine, by means of molecular docking, the interaction affinity of the 5-LOX and COX-2 enzymes with ME and then the in vivo tests; in which male rats were distributed into five groups with five rats each, in which some groups were subjected to the process of ischemia and reperfusion (I/R). Groups G4 and G5 were treated by inhalation with ME (10 %). After completing these procedures, statistical analysis and lung histology were carried out. In the ADMET prediction, ME showed high intestinal absorption and a medium-permeability blood-brain barrier. ME had no violations of Lipinski's rule, demonstrating high potential as a drug candidate. Molecular docking showed that ME had the highest binding affinity with the 5-LOX enzyme. Finally, the statistical and histological analyses of the in vivo test showed acute and accentuated lung damage in the G1 group, while in the G4 and G5 groups, ME showed pharmacological efficacy, reducing the number of inflammatory cells, free macrophages and free radicals. The results indicate that ME oil is a favorable therapeutic approach in the treatment of ARDS. [ABSTRACT FROM AUTHOR]

This scientific article addresses the regulation of fixed odds betting in Brazil and the changes promoted by law n° 14,790 of 2023. The topic under analysis was chosen because it is an area currently widely used by the population, but little explored legally and due to the desire to expand the reflection and knowledge about the legalization of betting shops in Brazil, especially knowing your rights, thus presenting the following problem: what points are covered with the implementation of this regulation? A bibliographical survey and study on the topic was initially carried out. Studies on the topic, such as Araújo (2020), Val (2022) and others, were involved to provide theoretical support and encourage the discussion presented in the work. It can be concluded that the legislative branch took a step of great importance for the country by approving the regulation of sports betting. However, this trade requires special attention in the coming years, as it is a practice that is still little explored from a criminal point of view and its regulations must be updated frequently until the illicit acts that can occur in this sector are restricted as much as possible. [ABSTRACT FROM AUTHOR]

According to the WHO, aging is considered healthy when an individual's functional capacity and well-being are preserved. With the increase in the elderly population, there is a growing need for health policies aimed at this public. In relation to the elderly female body, there are historical and cultural disadvantages. The body image, expectations, and reflections that older women have of themselves dictate their perception of body and health. Therefore, it is important to highlight their reflections in light of reality. Understanding the perspectives of elderly women about their bodies and their awareness of ancestry regarding how this group perceives itself is crucial. This research is qualitative, cross-sectional, observational, and analytical, with a purposeful sample, comprised of elderly participants from the Open University for Seniors at the State University of Piauí, Brazil. Data collection was conducted using a semi-structured guide with open-ended questions, and the results were analyzed using Laurence Bardin's (2004) Content Analysis Technique. From the interviews, it was possible to identify the categories: "Movement, potentialities, and barriers"; "Maternal figure of reference"; "Self-learning: experience as a source of knowledge about the body"; and "Self-image, body complexes, and perspectives on body weight". [ABSTRACT FROM AUTHOR]

This article discusses the role of expert systems in supporting strategic decision-making processes. It highlights the development of novel technologies, such as machine learning and pervasive social gaming, that are changing data management processes and improving decision-making in various contexts. The article also presents six research articles that delve into different aspects of expert systems and their contributions to operational decision-making. These articles cover topics such as predicting performance metrics in machine learning, determining patent revenue odds, building pervasive social gaming experiences, forecasting based on network time series, evaluating regional innovation capabilities, and analyzing cold supply chain risk. The authors of the article express their gratitude to the reviewers and contributors of the special issue, as well as acknowledge the support of the journal and the program committee of the WorldCIST'21 conference. The article is authored by Maria José Sousa and Álvaro Rocha, who are experts in digital education, innovation, and information systems. [Extracted from the article]

Background: The concerning trend on male infertility global prevalence, together with the unexplainable causes in half of those cases, highlights that there are still aspects of this disease to be understood and solved. To address this issue, one should not only be aware of the limitations of the implemented diagnostic tools, but also understand the sperm cell in depth, structurally, biochemically, molecularly in order to develop reliable and ready‐to‐be new/improved diagnostic tools. In this sense, the sperm cells metabolism, highly related to its functionality, seems to be a promising aspect to explore. Though there is much information on the human sperm metabolism, there is still a lack of a quick integrated and comprehensive analysis that may be introduced with the potential to reveal innovative clinically relevant information. Objectives: Find metabolic details on human sperm that can be accessed easily, in real time and using few cells, relying on the bivalent potential of the Seahorse flux analyzer (SFA). Results: We have obtained standard records on human sperm cells' oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), that together with the metabolic metrics provided information on sperm cells' oxidative and glycolytic metabolism. Furthermore, a metabolic interindividual variation was observed. Discussion and conclusion: Although the comparison with other species or cell types is not linear and warrant further studies, the metabolic profile of human sperm cells seems to be similar to that of other species. Altogether our results corroborate the value of SFA for metabolic human sperm cell analysis, warranting new studies, and anticipating several applications in the male infertility field. [ABSTRACT FROM AUTHOR]

The central objective of this work is to make a comparative analysis of the fable “The Cigarra and the Form”, by Aesop, and “Sem barra”, by José Paulo Paes. In this process, analyze the similarities and distances between the works, highlighting the aspects of intertextuality, imitation, influences and marks of originality based on the theoretical perspectives discussed by Nitrini (2021), Carvalhal (2001), Ana Maria Mello (1996), Koch, Bentes, Carvalho (2008). The works bring criticism and teachings. While the fable explicitly brings its moralizing content, which aims to convey the message, merely capitalist, that “art is a waste of time” and the ants are shown as a representation of the “ideal” social model, which work to accumulate food in the summer to enjoy in the winter, Paes' poem, despite having the influence and intertextuality relative to the fable, distances itself in several aspects, such as the fact of describing the characters from another perspective, the cicada is no longer portrayed as “lazy”, but rather, as of fundamental importance for the ants’ daily lives. [ABSTRACT FROM AUTHOR]

Diapause-like features can be extended to naïve mouse embryonic stem cells (mESCs) to induce paused pluripotency by using INK128 (mTi), a mammalian target of rapamycin (mTOR) inhibitor. As a core integrative pathway, mTOR senses diverse stimuli and translates these cues to coordinate several processes. We have previously shown that the withdrawal of leucine and arginine from the culture medium of naïve mESCs can induce features of a paused-pluripotent state, including reduced cell proliferation, cell cycle arrest, and reductions in glycolytic and oxidative metabolism. However, surprisingly, although mTi did indeed provoke a paused-like state, this was distinct from and less pronounced than what resulted from leucine and arginine removal, and, according to our results, these features did not seem to necessarily be mTOR-driven. Therefore, this possibility should be considered in further experiments, and mTOR inhibition when using INK128 should always be confirmed and not merely assumed when INK128 is present in the culture medium. [ABSTRACT FROM AUTHOR]

Bactrocera carambolae Drew & Hancock (Diptera: Tephritidae), the carambola fruit fly, is a quarantine pest present in Brazil, restricted to the states of Amapá, Pará, and Roraima. Its dispersion to other regions of the country could cause serious socioeconomic damage. Fruits were collected from urban trees, residential backyards, and small orchards in rural and urban areas of the municipality of Oiapoque, Amapá, Brazil. A total of 240 samples (11,126 fruits; 288.8 kg) of 33 plant species (16 native and 17 introduced species) from 19 families were collected. Bactrocera carambolae was isolated from the fruits of 13 plant species. In addition, specimens of 8 Anastrepha species were collected in this study. Moreover, 5 parasitoid species (Hymenoptera; 3 Braconidae and 2 Figitidae species) associated with Anastrepha spp. were identified. Overall, this study adds 3 new records to the list of host plants for B. carambolae in Brazil (Artocarpus heterophyllus Lam.; Moraceae, Passiflora quadrangularis L.; Passifloraceae, and Ziziphus mauritiana Lam.; Rhamnaceae), two of them (A. heterophyllus and P. quadrangularis) new records for South America, and demonstrates new interactions between Anastrepha species and host plants in the extreme north of the state of Amapá. Notably, this is the first report of the figitid species, Aganaspis nordlanderi Wharton, in the state of Amapá. Bactrocera carambolae Drew & Hancock (Diptera: Tephritidae), a mosca-da-carambola, é uma praga quarentenária presente no Brasil, restrita aos estados do Amapá, Pará e Roraima. Sua dispersão para outras regiões do país poderia causar sérios prejuízos socioeconômicos. Os frutos foram coletados em árvores urbanas, quintais residenciais e pequenos pomares nas áreas rurais e urbanas do município de Oiapoque, Amapá, Brasil. Um total de 240 amostras (11.126 frutos; 288,8 kg) de 33 espécies vegetais (16 nativas e 17 introduzidas) de 19 famílias foram coletadas. Bactrocera carambolae foi isolada dos frutos de 13 espécies vegetais. Além de B. carambolae, foram coletados neste estudo espécimes de 8 espécies de Anastrepha. Além disso, 5 espécies de parasitoides (Hymenoptera; 3 espécies de Braconidae e 2 de Figitidae) associadas a Anastrepha spp. foram identificadas. No geral, este estudo acrescenta 3 novos registros à lista de plantas hospedeiras de B. carambolae no Brasil (Artocarpus heterophyllus Lam.; Moraceae, Passiflora quadrangularis L.; Passifloraceae e Ziziphus mauritiana Lam.; Rhamnaceae), dois deles novos registros na América do Sul (A. heterophyllus e P. quadrangularis) e demonstra novas interações entre espécies de Anastrepha e plantas hospedeiras no extremo norte do estado do Amapá. Notavelmente, este é o primeiro relato da espécie de figitídeo Aganaspis nordlanderi Wharton no estado do Amapá. [ABSTRACT FROM AUTHOR]

Predatory long-legged flies of the genus Medetera are important, but currently understudied, natural enemies of Scolytinae bark beetles such as Ips typographus. Medetera flies lay eggs on beetle-infested trees, where the developing larvae find their prey, but the chemical cues used by Medetera to locate infested trees are currently unknown. To identify odors attracting Medetera signaticornis, a species in Europe, headspace samples were collected at several time-points through different stages of I. typographus attacks on logs of Norway spruce (Picea abies). The headspace samples were analyzed using combined gas chromatography and mass spectrometry (GC–MS), and gas chromatography coupled with electroantennographic detection (GC-EAD) to determine compounds that stimulate M. signaticornis antennae. Antennae of M. signaticornis males and females were found to detect (–)-cis-verbenol, (+)-trans-verbenol and myrtenol, which are known to be produced by bark beetles. Antennal responses were also observed for verbenene, isoterpinolene, α-pinene oxide, camphor, pinocamphone, terpinene-4-ol, myrtenal, borneol, α-terpineol, geranyl acetone, and verbenone, which are primarily produced by microorganisms, and α-pinene, α-fenchene, β-pinene, camphene, 3-carene, limonene, γ-terpinene, and terpinolene, known spruce tree compounds. In field experiments testing two synthetic blends containing 18 antennal active and two additional compounds 2-methyl-3-buten-2-ol and ipsdienol we observed significant attraction of M. signaticornis within 24 h. These attractive blends can form the basis for development of Medetera monitoring lures for use in future forest and pest management. [ABSTRACT FROM AUTHOR]

Articular cartilage injuries are currently one of the world's top health concerns owing to its limited capacity of self-renewal, thus raising to the economic burden in the healthcare system. Cell implantation strategies resorting to a suitable delivery platform hold a great promising approach to increase cell retention to be further supplied in a sufficient amount to the cartilage defects. So far, macromolecular engineering toolboxes for designing cell-carrier devices with on-demand cell delivery efficiency are rarely reported. Herein, anisotropically patterned mussel-inspired membranes, comprising oppositely charged marine-origin biopolymers (e.g., chitosan and alginate) combined in a multilayered fashion with catechol-functionalized hyaluronic acid (DOPA-HA), through electrostatically driven layer-by-layer (LbL) assembly approach, are developed. The seamless combination of nanotopography and catechol molecular cues in one single platform significantly augments ASC/TERT1 adhesion at the patterned DOPA-HA membrane surface. These highest cell density membranes are further applied onto human chondral discs ex vivo models to evaluate their capability to act as cell delivery vehicles. Results show the successful cell migration and retention at cartilage surface, wherein they spread to inhabit both superficial empty lacunae and furrows. Therefore, the present study supplies an important strategy for designing cell delivery vehicles to be applied on cell-based therapies. [ABSTRACT FROM AUTHOR]

The development of new drugs through studies of candidate molecules is a complex undertaking; however, computational or in silico approaches aimed at optimizing molecules with greater development potential are being utilized for predictions of pharmacokinetic properties such as absorption, distribution, metabolism and excretion (ADME) as well as toxicological parameters. The objective of this study was to examine in silico and in vivo pharmacokinetic and toxicological properties of the chemical constituents present in the essential oil of Croton heliotropiifolius Kunth leaves. The following Pubchem platform as well as Software SwissADME and PreADMET software were employed for in silico studies while micronucleus (MN) testing for in vivo determination of mutagenicity, using Swiss adult male Mus musculus mice. In silico findings demonstrated that all chemical constituents presented (1) high oral absorption (2) medium cellular permeability and (3) high blood brain permeability. As for toxicity, these chemical constituents exhibited low to medium risk of occurrence of cytotoxicity. Regarding in vivo evaluation, peripheral blood samples obtained from animals tested with the oil showed no significant differences in number of MN compared to negative controls. Data indicate that further investigations are necessary to corroborate the findings of this study. Our data suggest that essential oil extracted from Croton heliotropiifolius Kunth leaves may serve as a candidate for new drug development. [ABSTRACT FROM AUTHOR]

This article is part of an investigation that aimed to develop, from conceptual nexuses and assumptions of culturalhistorical theory, the theoretical concept of computational thinking for its development in mathematics education. Therefore, a study of the logical-historical movement of the term "computational thinking" in mathematics education was carried out, seeking to explain how and under what conditions the term was used in academic and documental productions in Brazil. In summary, the results indicate that studies corresponding to computational thinking in mathematics education are still incipient in Brazil and, until then, there was no concept for this term in the area. Thus, this concept was developed in order to establish three conceptual nexuses: problem-solving, algebraic thinking, and algorithmic thinking, which are in constant motion as they are dialectical, historical, logical, and cultural. [ABSTRACT FROM AUTHOR]

Olive pomace is a by-product from olive oil production that can be further processed to obtain olive pomace paste. In this work, the influence of different time/temperature binomials (65 °C/30 min; 77 °C/1 min; 88 °C/15 s; and 120 °C/20 min) on the nutritional quality, chemical composition, and efficiency on control/elimination of natural microbial load of olive pomace paste was ascertained. The treatments significantly impacted the contents of ash, fat, vitamin E, phenolics (including hydroxytyrosol), flavonoids, and antioxidant activity, but not the fatty acids profile. The binomial 88 °C/15 s showed the greatest potential since it better preserved the phytochemical and antioxidant properties as well as the protein and fiber contents. This binomial is also faster and easy to be implemented at an industrial level, allowing the obtention of a safe functional ingredient to satisfy consumers' demands for novel sustainable products, simultaneously, responding to food safety and food security concerns. [ABSTRACT FROM AUTHOR]

The current need to diversify the global energy matrix implies introducing renewable energy sources and evaluating commercially available solutions. This study assesses a trigeneration system from thermoeconomic and environmental viewpoints, employing the Theory of Exergy Cost and Life Cycle Assessment. The location of the theoretical study case is the state of Pernambuco, Northeast Brazil. The trigeneration system operates on biogas and is comprised of four subsystems: biogas purification, molted carbon fuel cell, combined cycle, and absorption refrigeration system. The energy services produced are electricity, heat (hot water), and cooling. The results of the thermoeconomic analysis revealed that the energy system requires an electricity tariff of at least US$ 106.76/MWh to generate revenue due to the high costs associated with the purchase of biogas and capital costs of the equipment for biogas purification and fuel cell. The life cycle assessment identified that the biogas purification step presented the highest environmental impacts due to the material composition of the absorption and regeneration columns, which is interesting as this is the most critical step of the process. LCA results indicate that although methane is a vital energy vector for energy transition, further studies are required on the technical and environmental aspects of its use in energy systems. [ABSTRACT FROM AUTHOR]

In this research, we analyze the presence of linguistic variations in the Portuguese contemporary collection: dialogue, reflection and use, high school, adopted by the Aura Sampaio Parente Muniz School, located in the city of Salgueiro-Pe. The theoretical contribution was based on studies by Irande (2003), Geraldi (1984), Cesário and Votre (2013), Matellota (2003), Labov (2003), Bagno (2008), Travaglia (1996), Tarallo (2000) Sousa (2017), among others. Methodologically, the research has a qualitative, documental approach. For the analysis of the corpus, carried out in volumes (I, II and III), high school, we considered the activities arising in each volume, the texts and definitions about the theme. The results obtained through the analyzes point to a disparity between the volumes. Volume I presents a discussion based on contextualized concepts and activities, while volumes II and III do not address the subject in any section of each volume. In this sense, the textbook is the main instrument that teachers use in their daily school life, however, some required content, especially in the National Secondary Education Examination (ENEM) and entrance exams are not present in the three volumes. [ABSTRACT FROM AUTHOR]

This study seeks to answer the following research question: "What factors can explain the number of patent filing requests made by residents in Brazil at patent offices in Brazil, the United States, Europe, and triadic patent families?". The methods used in this research are quantitative, using big data from private and public investments in Science and Technology, and about patent deposit numbers in Brazil from 2000 to 2017. A model of linear regression was performed and explains how these investments in Science and Technology influence patent deposit numbers. The results of this research study point towards the importance of universities, up and beyond the traditional training and education aspect of university activity. The importance of public and private innovation investments is also shown to be important. This study shows that the patent registrations in the different regions under analysis are affected by different factors. There is thus no single formula towards the creation of innovation output and governments would do well to continue to invest in higher education while also investing in public research and development activities. Additionally, and not least important, private entities should be continually encouraged to make innovation investments and favourable government policies need to thus exist for this to happen. Finally, the low numbers regarding patent filings in Brazil may be linked to institutional deficiencies in the country. Patent breaches may be difficult to punish, and the judicial system may be slow and untrustworthy, compared to the United States and to Europe—leading to diminished patent registrations in Brazil. A set of implications and recommendations for policy derived from this study and will be strategic for policymakers. [ABSTRACT FROM AUTHOR]

This article addresses women's protection rights in the context of the environment. The objective is to identify, in the strategic actions of the National Plan of Policies for Women, the defense of access to efficient energy sources and the fight against forms of violence against women and girls generated by sectors of major works. The Plans consider that women and girls are most affected by the lack of access and insecurity regarding the availability and sustainable management of water and sanitation; and insecurity as to reliable, sustainable, modern and affordable access to energy for all, situations aggravated by the misuse of resources and climate change. The effects of large companies on women are the growth of prostitution and violence, due to exclusion from the labor market, leaving them without alternatives and more vulnerable. It is concluded that the defense and guarantee of the right to a healthy and sustainable environment, in relation to legislative and legal aspects, is the role of the State. Civil society can face acts that violate this right through, for example, organizational and institutional cooperation and educational actions. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the influence of Bichat's ball removal on postoperative inflammatory parameters (pain, edema, and trismus), facial volume reduction, facial esthetic satisfaction, and oral health-related quality of life. Material and methods: A single-arm clinical trial with 21 patients undergoing Bichat's ball removal. The following parameters were assessed at baseline and up to 3 months postoperatively: Visual Analogue Scale pain scores (0–10), rescue medication consumption, mouth opening, AM-Tr, AM-CEO, AM-NA, AM-CL, and AM-PM measurements, Oral Health Impact Profile (OHIP)-14 QoL scores, and satisfaction with facial esthetics (FACE-Q Satisfaction with Facial Appearance Overall Scale (SFAOS). X2, analysis of variance-repeated measures/Bonferroni, or Friedman/Dunn tests were used (p < 0.05, SPSS v20.0). Results: Peak pain occurred after 2 h and, 10 h later, the levels returned to baseline values (p < 0.001). Rescue medication consumption peaked in the first 24 h reducing significantly after 72 h (p < 0.001). Mean mouth opening decreased after 24 h and returned to baseline levels after 1 month, and all linear facial measures reduced significantly after 1 or 3 months (p < 0.05). OHIP-14 scores and FACE-Q SFAOS scores showed significant improvement after 1 month (p < 0.001), but patients aged > 25 years showed a significant reduction in FACE-Q SFAOS at the end of the study (p = 0.006). Conclusions: Surgical removal of the Bichat's ball induces a mild inflammatory process controlled by rescue medication, significantly reduces face volume, and improves QoL and satisfaction with facial esthetics 3 months postoperatively. However, the efficacy of this procedure in patients > 25 years old is questionable. Clinical relevance: Evaluate the effectiveness of bichectomy in terms of clinical effects and impact on quality of life. [ABSTRACT FROM AUTHOR]

On December 31, 2019, the World Health Organization (WHO) received the first communication about a pneumonia outbreak in the city of Wuhan, which was caused by a new coronavirus. In Brazil, the first case was registered in February 26, 2020, and after 21 days the State Health Department of Paraíba announced the first case of COVID-19 in this state. One of the options used by the population to what was considered prevention against the COVID-19 was the homeopathic medicines. This research aimed to identify the best-selling homeopathic medicines in homeopathic drugstores in the municipality of João Pessoa, in the period from January to September 2020. The data was collected in an interview with the owners of the homeopathic drugstores, which answered to a previously designed questionnaire. The study evidenced an expressive enhance in the selling of homeopathic medicines starting from March 2020 in the research drugstores. The most commercialized medicines, in order of frequency, were: Camphora, Arsenicum album, Gelsemium, Oscilococcinum, Influenzinum, Antimonium tartaricum, Carbo vegetabilis and Aviarium. The data found in this study suggest that the incidence flow of Oscilococcinum and Influenzinum was higher in the initial months of the Pandemic, probably, because of their indication as a preventive, and the expressive enhance of Camphora and Arsenicum álbum in the months of April, May and June, 2020 reflect the indication of these medicines not only as preventive, but also in the cases that the illness is confirmed. [ABSTRACT FROM AUTHOR]

Amino acids are crucial nutrients involved in several cellular and physiological processes, including fertilization and early embryo development. In particular, Leucine and Arginine have been shown to stimulate implantation, as lack of both in a blastocyst culture system is able to induce a dormant state in embryos. The aim of this work was to evaluate the effects of Leucine and Arginine withdrawal on pluripotent mouse embryonic stem cell status, notably, their growth, self-renewal, as well as glycolytic and oxidative metabolism. Our results show that the absence of both Leucine and Arginine does not affect mouse embryonic stem cell pluripotency, while reducing cell proliferation through cell-cycle arrest. Importantly, these effects are not related to Leukemia Inhibitory Factor (LIF) and are reversible when both amino acids are reconstituted in the culture media. Moreover, a lack of these amino acids is related to a reduction in glycolytic and oxidative metabolism and decreased protein translation in mouse embryonic stem cells (mESCs), while maintaining their pluripotent status. [ABSTRACT FROM AUTHOR]

The present study aims to analyze how literacy is contemplated in the Curriculum of the State of Pernambuco and what are its pedagogical impacts on elementary education. Therefore, the research is justified because many students leave this teaching stage without developing this skill. In this investiture, he referred to the theoretical postulates of authors who discuss Literacy and its important role in the lives of students. For methodological purposes, this article is of a qualitative nature of a bibliographic nature, as the discussion was deepened in books, documents and websites focused on basic education and literacy. It is concluded, therefore, the need for effective reading practices for the development of literacy, aligning the curricular regulations in force, to promote the progress of students in elementary school. [ABSTRACT FROM AUTHOR]

This study focuses on the analysis of the Treatise on Argumentation in Discourse, the New Rhetoric, in the work "I know why the bird sings in the cage", by Maya Angelou. The general objective of the research is to analyse the argumentative processes present in the work. In view, analyse the theses, values and their hierarchies in excerpts taken from the book in order to understand the social, historical, economic and cultural context of the speaker during the period of racial segregation in the south of the United States. In addition, the article seeks to understand the theses defended by the speaker in the face of adversity and experiences that make up her trajectory, such as: social injustice, poverty, sexual abuse, machismo, social inequality, among others. Methodologically, the research is of a qualitative nature and presents a documentary character and the deductive method is used to analyse the corpus of the work, since there is the use of the bibliographic contribution in theorists who discussed the theme. The corpus consists of six excerpts from the work "I know why the bird sings in the cage", by Maya Angelou. The results show that the speaker's speech presents theses, values and their hierarchies. It is observed that the speaker manages to convince the audience, having as main tool the argumentation in the speech. The research showed that argumentation composes human language, being a way of expressing, denouncing and convincing others of their reality, that is, of the context in which the speaker is inserted. In short, the role that literature played as a support for surviving the adversities for which the speaker/narrator intended the thesis in order to convince the audience is clear. [ABSTRACT FROM AUTHOR]

Aiming to identify the role of communication in health and health promotion in the Family Health Strategy, this work was developed, anchored in a qualitative approach, with a design of multiple cases. The focus group technique was used, guided by a semi-structured script, containing three guiding questions. For data analysis, the Collective Subject Discourse technique was used. In all, ten focus groups were held in five large Brazilian municipalities. Fifty-five professionals from the Family Health Strategy participated, from 21 Family Health teams, located in 15 Basic Health Units. Among the contributions, the professionals highlighted health promotion to guarantee well-being and health communication favoring the planning of actions and the exchange of experiences, being considered by them as a tool to work with health-promoting practices. It was also highlighted that, in addition to being essential, these fields complement each other and, together, contribute to improving the quality of life. As main challenges, they reported the need for greater involvement of professionals to work on education for promotion, overcome the health-disease vision still present in the community and the lack of time to work more on health communication. [ABSTRACT FROM AUTHOR]

Objective: COVID-19 vaccines have shown efficacy and safety in healthy people. However, cancer patients under active immunosuppressive treatment were not included in the clinical trials conducted to test vaccines' efficacy and safety. This study aimed to evaluate the COVID-19 vaccine acceptance in cancer patients undergoing immunosuppressive therapy. Methods: A total of 200 adult cancer patients received a questionnaire between March 8 and April 2, 2021, before the beginning of cancer patients' vaccination in Portugal. The questionnaire adapted from previously conducted studies included 11 close-ended items, evaluating variables such as patient sociodemographic and clinical characteristics, and the acceptance and underlying reasons to be or not to be vaccinated. The primary outcome was the intended acceptance of the COVID-19 vaccine in cancer patients. Multiple logistic regression was performed to identify factors associated with intended acceptance. Results: Among the 200 delivered questionnaires, only 169 were included in this study. From those, 142 (84%) patients intended to be vaccinated against COVID-19. Only 27 participants (16%) had not yet decided or were reluctant to COVID-19 vaccination. High school degree (odds ratio (OR) 0.133, 95% confidence interval (C.I.) 0.031–0.579, p = 0.007], rural residence (OR 0.282, 95% C.I. 0.081–0.984, p = 0.047), and reluctance in believing in the vaccine efficacy (OR 0.058, 95% C.I. 0.016–0.204, p < 0.001] were identified predictors factor for COVID-19 vaccine hesitancy. Conclusion: Most patients intended to be vaccinated against COVID-19, and specific factors such as education level, rural residence and the belief in vaccine efficacy were related to vaccine acceptance. [ABSTRACT FROM AUTHOR]

Studies on fruit fly species are incipient in the Mato Grosso state. To obtain data on fruit flies, their host plants and parasitoids in this Brazilian state, samplings were carried out in 11 municipalities, in two periods (October to November 2018 and February to October 2019). The collections were carried out in traps and in fruits from several commercial sites. Nine species of Anastrepha were collected, in addition to Ceratitis capitata (Wiedemann, 1824) and three species of parasitoids. Anastrepha bahiensis Lima, 1937, A. undosa Stone, 1942 and the parasitoid Opius bellus Gahan, 1930 are being recorded for the first time in the Mato Grosso state. Additionally, new host plant records are presented for 11 fruit fly species. This is the second survey of fruit flies carried out in a large area of the Mato Grosso state. [ABSTRACT FROM AUTHOR]

To the Editor, In order to predict mortality in septic patients, several biomarkers are investigated. Patients with I IL-1R1 i rs6755229 AG/GG genotype presented higher mortality at 28 days than patients with AA genotype by Kaplan-Meier analysis, but the difference did not reach statistical significance ( I p i =.083; Figure 1). Survival probabilities (Kaplan-Meier product-limit method) and risk of death in septic shock patients who underwent major cardiac or abdominal surgery according to IL-1R1 rs6755229 polymorphism. [Extracted from the article]

The main objective of this study was to analyze the mediating effect of perceived employability (internal and external) and the organizational commitment in the relationship between the organizational practices of competencies development (OPCD) and the turnover intentions. The sample consists of 2099 participants, all of them working in organizations based in Portuguese territory. The existence of a significant and negative effect of the OPCD, of perceived internal employability and the organizational commitment in the turnover intentions, has been proven. There was also a significant and positive effect of perceived external employability on turnover intentions. Finally, the serial mediating effect of perceived employability and organizational commitment in the relationship between OPCD and turnover intentions was proven. [ABSTRACT FROM AUTHOR]

Background: Amyotrophic lateral sclerosis (ALS) is an incurable and disabling progressive neurodegenerative disease, where the caregiver plays a key role in meeting the patient's needs. Objective: To analyze the association between caregivers' sociodemographic and professional characteristics and their burden and between the sociodemographic and clinical characteristics of individuals with ALS and caregivers' burden. Methodology: Descriptive-correlational study. Sample of 30 patients and 30 caregivers. The Informal Caregiver Burden Assessment Questionnaire was used. Parametric and non-parametric tests were used for data analysis. Results: The sample of patients had a mean age of 66.4 ± 11.17 years and homogeneous gender distribution. The majority of caregivers were women, spouses, with moderate levels of burden (56.7%), less affected by "reactions to demands" and more affected by "efficacy and control mechanisms" (mean 25.67 ± 21.76 and mean 66.39 ± 21.50). The caregiver's sociodemographic characteristics, the patient's functional status, the number of care hours, and the use of non-invasive ventilation were associated with burden levels (sig < 0.05). Conclusion: Caregivers have moderate levels of burden, highlighting the importance of proximity care. [ABSTRACT FROM AUTHOR]

The Pampulha Modern Ensemble is an urban complex located in Belo Horizonte, Brazil, whose metropolitan context is highly problematic due to the pressures of urban dynamics, impacts from urban development and the need to manage changes and preserve architectural and landscape attributes that have led to its recognition as World Heritage. This article is part of a larger study that investigates the community's recognition of the values conferred by experts on that complex's cultural landscape as a world heritage site. Due to the restrictive conditions imposed by the COVID 19 pandemic, an online questionnaire with open access to the general public was used as an instrument for the field research to collect primary data from the community. The analysis of the answers obtained from the questionnaire pre-test, object of this article, demonstrates the recognition of landscape elements and of the Pampulha Modern Ensemble that contribute to its enjoyment and that characterize it as a differentiated landscape in the context of the city. [ABSTRACT FROM AUTHOR]

The Pampulha Modern Ensemble is an urban complex located in Belo Horizonte, Brazil, whose metropolitan context is highly problematic due to the pressures of urban dynamics, impacts from urban development and the need to manage changes and preserve architectural and landscape attributes that have led to its recognition as World Heritage. This article is part of a larger study that investigates the community's recognition of the values conferred by experts on that complex's cultural landscape as a world heritage site. Due to the restrictive conditions imposed by the COVID 19 pandemic, an online questionnaire with open access to the general public was used as an instrument for the field research to collect primary data from the community. The analysis of the answers obtained from the questionnaire pre-test, object of this article, demonstrates the recognition of landscape elements and of the Pampulha Modern Ensemble that contribute to its enjoyment and that characterize it as a differentiated landscape in the context of the city. [ABSTRACT FROM AUTHOR]

This research aims to analyze how Portuguese-speaking African Literature is presented in the Contemporary Portuguese collection dialogue, reflection and use, secondary education by the authors Cereja; Vienna; Damien (2016), adopted by the Anisio Veras Reference School, in the city of Verdejante-PE. The research is based on studies that address African Literature and its context of teaching in textbooks in high school, as we can highlight in Brazil (2008); Abdala Júnior (2006), Souza (2006), Machado (2010) Silva (2003), Sidrim (2019), Lopes (2010), Chaves (2006), Honwana (2006), Fonseca; Moreira (2017), Ferreira (1987), among others. The methodology used in the research was qualitative, documental and deductive method, Fachin (2006), Prodanov; Freitas (2013) and Cardano (2017). The results indicate that the teaching of African literature in the analyzed collection is little explored, since in volume I we hardly found any content; in volume II there is only a quote due to an interview carried out with the singer Emicida about racism and in volume III we are faced with only one chapter that presents a small discussion of texts and authors. In this way, we see that textbooks do not fully include studies aimed at African literatures. [ABSTRACT FROM AUTHOR]

The main aim of the article is to emphasize indiscipline in the EJA modality among its causes and consequences. The theme brings with it a very enriching approach on how to observe and deal with these certain situations present in everyday school life. The EJA modality is a teaching proposal that caters to a very adverse audience, as they are students who, in one way or another, did not finish their studies at the right time. And indiscipline has been frequently explained in the teaching groups, but without any perspective of methodologies to get around this issue about teaching. The theoretical bases for the construction of the article are based on citations and arguments in theorists who are quite influential in the perspective addressed, coming to the meeting of authors such as FREIRE (2001), MATOS (2012), SANTOS (2012) among others, as well as truthful information in above the educational laws such as the LDB and CNE, in addition to statements of my authorship about everything studied through the research. The methodological process for the construction is based on an analytical study and critical observation about the content to be researched through qualitative research in a bibliographical study about the subject. The results presented around the article appear as possible answers and hypotheses to the problem presented, among its acquisitions, a new perspective of training for teachers with current problems in the classroom, as well as observing the different types of school indiscipline presented in the EJA modality. Upon completing the study, there is the opportunity to seek more information on the topic in order to further deepen the knowledge and transform it into methodologies for better teaching and learning in EJA. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to compare the strategies of companies with data science practices and methodologies and the data specificities/variables that can influence the definition of a data science strategy in pharma companies. The current paper is an empirical study, and the research approach consists of verifying against a set of statistical tests the differences between companies with a data science strategy and companies without a data science strategy. We have designed a specific questionnaire and applied it to a sample of 280 pharma companies. The main findings are based on the analysis of these variables: overwhelming volume, managing unstructured data, data quality, availability of data, access rights to data, data ownership issues, cost of data, lack of pre-processing facilities, lack of technology, shortage of talent/skills, privacy concerns and regulatory risks, security, and difficulties of data portability regarding companies with a data science strategy and companies without a data science strategy. The paper offers an in-depth comparative analysis between companies with or without a data science strategy, and the key limitation is regarding the literature review as a consequence of the novelty of the theme; there is a lack of scientific studies regarding this specific aspect of data science. In terms of the practical business implications, an organization with a data science strategy will have better direction and management practices as the decision-making process is based on accurate and valuable data, but it needs data scientists skills to fulfil those goals. [ABSTRACT FROM AUTHOR]

Introduction: Syphilis is an infectious disease of bacterial nature, acting on organs and/or systems. The increase in the number of cases worldwide has been of concern and the infection has been considered a public health problem. Given this scenario, this study evaluates the epidemiological profile, spatial distribution, and time series of the cases of acquired syphilis, syphilis in pregnant women, and congenital syphilis in a Brazilian municipality. Methodology: This is a cross-sectional and descriptive study with second data of the notified cases. For the definition of the population universe, an initial survey of syphilis cases notified in the municipality was carried out, from January 1, 2013 to December 31, 2017. Results: There was an increase in the notified cases and the detection/incidence rates of syphilis. The epidemiological profile was composed of men (76.7%), adults (24.8%), white (60.4%), with eight or more years of study (53.7%) in addition to pregnant adolescents (36.7%) and young adults (26.0%), with inadequate treatment and untreated partners. A concentration of cases was identified in the regions with the lowest monthly income and the time series showed an increasing trend (p-value < 0.001). Conclusions: Health actions should continue to improve access to diagnosis and to notification, focusing on treatment, cure and health education actions to control and prevent new cases. [ABSTRACT FROM AUTHOR]

Background: The changes observed in nursing documentation prompted a historical study on the evolution of nursing records between 1958, when the Ministry of Health and Assistance was created, and 1998, when the Ordem dos Enfermeiros (Portuguese Nursing and Midwifery Regulator) was established. Thus, the analysis of publications on nursing records in Portuguese journals during this period was considered relevant. Objective: To identify and analyze the scientific production on nursing records published in Portuguese nursing journals between 1958 and 1998. Methodology: A bibliometric study was conducted by consulting 504 Portuguese nursing journals published between 1958 and 1998, using descriptors and inclusion criteria. Results: A final sample of 22 articles related to different aspects of nursing records was obtained. Conclusion: Nursing records have been a publication subject in Portuguese journals since 1984. The number of publications increased as changes occurred in the nursing profession. Nursing records have accompanied the nursing career’s professional reconfiguration and are essential for the profession’s autonomy. [ABSTRACT FROM AUTHOR]

This research has as its object of analysis the Democratic Management in public schools, seeking to understand how this process takes place. Every school is governed by a manager, who plays a key role in terms of its organization, especially in terms of teaching. However, the concept of Democratic Management implies exactly the division of this responsibility among all the components of the school premises. Thus, the choice of this theme for the writing of the work is based on observations made during the Pedagogical Residency at the Dr Severino Alves de Sá school, aiming to analyze how the process of Democratic Management in schools takes place and how this form of management implies improvements in public education. Democratic Management is understood as the act of managing a school through the participation of all, avoiding assigning only the manager the responsibility of guiding the school institution, although he is the most active figure, as he is responsible for managing the administrative part, financial and pedagogical, in addition to being a mediator in the relationship between all members of the school, the family and the general community. Within the school environment, there is a need for a document that contains the rights and duties of all those who make up that space, which should be developed together with everyone involved, being exposed in a place where everyone can have access. This document is the Pedagogical Political Plan (PPP), which aims to establish the guidelines that will permeate the school year, and in the educational context. Thus, the present study started from the principle established in the current legislation, based on ideas from different scholars on the subject, who defend, among other things, its application as essential for the improvement of teaching in public schools. Therefore, the theoretical support came from Lima (2018), Paro (2006), Luck (2005, 2009), Gadotti (2004) and Souza (2018), among others. Methodologically, the research is qualitative and bibliographical in nature. Thus, it was possible to see that democratic management is done through actions that make it possible to divide the responsibility of the educational process between the manager and everyone who makes up the school, thus seeking quality education for all, based on Art:206 and the LDB (Law No. 9,394/96), in addition to the Pedagogical Political Project, a document that guides actions and decisions regarding school institutions. [ABSTRACT FROM AUTHOR]

To describe the impacts on the mental health of health professionals in the face of the pandemic by COVID-19. An integrative literature review study, searching for articles in the LILACS, SciELO, MEDLINE, SciVerse Scopus databases published in 2020. 169 articles were found, of which 18 met the eligibility criteria. The most prevalent impacts on mental health for health professionals due to the COVID-19 pandemic were anxiety, depression, followed by feelings of fear, stress and insomnia. Nurses are the most affected health professionals followed by doctors. Health professionals experience a unique moment due to the COVID-19 pandemic, in which their mental health has been a concern. Studies are suggested to increase the visibility of collaborative problems for illness in mental health of professionals, their importance and the high rate of causing damage to mental integrity, which may be in effect in the short to long term. [ABSTRACT FROM AUTHOR]

The search for new materials that can be applied in the treatment of injured human tissues has led to the development of new dressings. Membranes have potential as dressing materials because they can be fitted to and interact with the tissue surface. In this study, we analyze the morphological properties and wettability of latex membranes, along with the incorporation of the photosensitizer methylene blue, in the context of the utility of the membranes in curative applications involving photodynamic therapy (PDT). It was observed that deposition of the photosensitizer into latex membranes increased both the surface roughness and wettability. Antifungal testing indicated that antimicrobial PDT assisted by the latex membranes incorporating methylene blue effectively inactivated Candida albicans. [ABSTRACT FROM AUTHOR]

The objective of this study was to investigate the impact of health literacy (HL) on health practices and oral health outcomes in an adult and elderly population in Brazil. A cross-sectional study nested in a cohort study was followed up over a period of four years (2011 and 2015) and assessed individuals between 23 and 69 years old from Piracicaba, São Paulo, Brazil. Data were collected by means of oral examinations (coronal caries, periodontal disease and visible biofilm) and interviews (socioeconomic, demographic, oral health-related quality of life, health practices and HL). The 14-item Health Literacy Scale (HLS) was used for HL data, which was the main explanatory variable. The result of the sum of the HLS-14 questionnaire for each participant was dichotomized into the median (46 points): 'high' and 'low' HL. Binary/multinomial logistic regressions were performed on health practice and oral health outcomes, controlled by age and sex (Model 1) and age, sex and socioeconomic status (Model 2; p  < 0.05). The final sample consisted of 137 subjects and 43.8% (n  = 60) presented low HL (LHL). LHL was associated with health practices, such as use of public dental services in Model 1 (odds ratio [OR] = 0.34, 95% CI: 0.14–0.87) and use of dental services for emergency in Model 1 (OR = 2.69, 95% CI: 1.29–5.51) and Model 2 (OR = 2.93, 95% CI: 1.17–7.30). Based on age and sex, LHL was associated with use of public dental service and use of emergency dental visits. Based on age, sex and socioeconomic status, LHL was associated with use of emergency dental visits. [ABSTRACT FROM AUTHOR]

This work aimed to assess the potential of Geissospermum argenteum Woodson (Apocynaceae) as a reservoir of fruit fly (Diptera: Tephritidae) parasitoids (Hymenoptera) in an upland forest in Brazil.The study was conducted in a remnant of primary upland forest, in which were distributed 10 plots (0.5 ha each). All individuals of G. argenteum with diameters greater than 5 cm at a height of 1.3 m were inventoried. Two trees per plot were selected to assess the total production of fruit. Collectors were installed under the canopy projection of each tree. The fruits were counted and weighed in the field and were transported to the laboratory, to determine the dry mass. Samples of fruits were collected to investigate their infestation by fruit flies and percentage of parasitism.A total of 394 specimens of G. argenteum were identified in the 5 ha investigated area, of which only 126 produced fruits during the 12 months of the assessment. Production ranged from 59 to 2478 fruits per plant (0.59 and 19.73 kg of fresh mass, respectively). Fifty‐nine fruit samples were collected from 44 plants, from which 7703 puparia were obtained. Only Anastrepha atrigona Hendel emerged from the puparia. The mean infestation rate was 554.9 puparia/kg of fruit (0.4–1628.6 puparia/kg). Four species of parasitoids were obtained, with mean percentage of parasitism of 2.27% (0.23–9.01%).Our results show that G. argenteum is a reservoir of fruit fly parasitoids, highlighting the importance of its conservation in native habitats, as well as its multiplication in areas close to commercial orchards. [ABSTRACT FROM AUTHOR]

Objective: To reflect on the complexity of Nursing practices in the context of Primary Health Care in Brazil. having the Family Health Strategy as the structuring basis for a new model of care. Methods: This is a theoretical-reflective rehearsal. developed between June and July 2021. based on the authors' knowledge and experiences. both academic and professional, which analyze. reflect and contextualize the contribution of Brazilian Nursing in the extension and depth of essential attributes and derivatives of PHC. rooted in the values. principles and guidelines of promotion. prevention. treatment. rehabilitation and cure in health-disease processes. Caution. Results: It points out the contemporary challenges to overcoming the constituent elements of the medical-hospital model. characterized by inefficiency. low effectiveness and population dissatisfaction. in territories with deep social. economic. political and health inequalities. Conclusion: In summary. it indicates that it is necessary to follow printed active movements that expand political decisions to ensure health as a right of full citizenship. therefore as a fundamental good of human beings. [ABSTRACT FROM AUTHOR]