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Ethnopharmacological relevance The rich floral and ethnic composition of eastern Nepal and the widespread utilization of locally available medicinal plants offer remarkable opportunity for ethnomedicinal research. The present paper aims to explore medicinal plant diversity and use in the remote villages of eastern Nepal. It also aims to evaluate ethnopharmacological significance of the documented use reports and identify species of high indigenous priority. Materials and methods The study was undertaken in four villages located in the Sankhuwasabha district in eastern Nepal. Ethnomedicinal information was collected through structured interviews. The homogeneity of informant's knowledge and the relative importance of documented medicinal plants were validated by informant consensus factor and use value, respectively. Species preference for treatment of particular diseases was evaluated through fidelity level. Results We reported medicinal properties of 48 species belonging to 33 families and 40 genera, for the treatment of 37 human ailments. The uses of 10 medicinal plants were previously undocumented. The informant consensus factor (F IC ) ranged between 0.38 and 1 with about 50% of values greater than 0.80 and over 75% of values greater than 0.70, indicating moderate to high consensus among the informants on the use of medicinal plants in the region. Swertia chirayita was the most preferred species with significantly high use values, followed by Paris polyphylla and Neopicrorhiza scrophulariiflora. Conclusions The remote villages in eastern Nepal possess rich floral and cultural diversity with strong consensus among informants on utilization of plants for local healthcare. The direct pharmacological evidence for medicinal properties of most species indicates high reliability of documented information. Careful and systematic screening of compounds isolated from these plants could possibly provide good opportunity for the discovery of novel medicines to treat life-threatening human diseases. We recommend prioritization of medicinal plants and reinforcement of existing cultivation practices for sustainable management of high-priority species. [ABSTRACT FROM AUTHOR]

Few seroprevalence studies have been conducted on coronavirus disease (COVID‐19) in Nepal. Here, we aimed to estimate seroprevalence and assess risk factors for infection in the general population of Nepal by conducting two rounds of sampling. The first round was in October 2020, at the peak of the first generalized wave of COVID‐19, and the second round in July–August 2021, following the peak of the wave caused by the delta variant of SARS‐CoV‐2. We used cross‐sectional probability‐to‐size (PPS)‐based multistage cluster sampling to estimate the seroprevalence in the general population of Nepal at the national and provincial levels. We tested for anti‐SARS‐CoV‐2 total antibody using the WANTAI SARS‐CoV‐2 Ab ELISA kit. In Round 1, the overall national seroprevalence was 14.4%, with provincial estimates ranging from 5.3% in Sudurpaschim to 27.3% in Madhesh Province. In Round 2, the estimated national seroprevalence was 70.7%, with the highest in the Madhesh Province (84.8%) and the lowest in the Gandaki Province (62.9%). Seroprevalence was comparable between males and females (Round 1, 15.8% vs. 12.2% and Round 2, 72.3% vs. 68.7%). The seroprevalence in the ecozones—Terai, hills, and mountains—was 76.3%, 65.3%, and 60.5% in Round 2 and 17.7%, 11.7%, and 4.6% in Round 1, respectively. In Nepal, COVID‐19 vaccination was introduced in January 2021. At the peak of the first generalized wave of COVID‐19, most of the population of Nepal remained unexposed to SARS‐CoV‐2. Towards the end of the second generalized wave in April 2021, two thirds of the population was exposed. [ABSTRACT FROM AUTHOR]

Understanding the primary drivers of species diversity patterns and identifying critical places for biodiversity protection are the two major concerns confronting the global conservation community. The Orchidaceae, which is one of the most diverse angiosperm families with over 30,000 species, is currently facing grave threats from habitat degradation, climate change, and a range of human-induced issues. However, the spatial patterns of orchid distribution and the factors influencing these patterns, both of which are crucial for developing successful orchid conservation plans, remain poorly understood. Here, using one of the most extensive distribution datasets of >500 orchid species in Nepal, we mapped the distribution of all, common, rare, epiphyte, and terrestrial species and identified important factors driving their patterns. We also assessed their protection gaps and identified key conservation regions. We discovered low spatial congruence between the diversity patterns of different groups, and the fundamental drivers underlying the richness pattern differed considerably. The key orchid conservation areas were primarily found in the mid-hills and highlands of central Nepal, with 62 % of these areas outside the protected area (PA) network. Our findings emphasize the importance of considering pollinator diversity and other climate factors when developing effective management plans to conserve orchids, as well as employing different strategies to conserve different life forms. A huge conservation gap in protecting orchids despite large PA coverage in Nepal indicates insufficiency of existing PA network in conserving plants. Therefore, our findings reiterates the need to consider plant conservation goals alongside animal conservation priorities in future conservation planning. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance The present paper documents the utilization of medicinal plants for the treatment of various human ailments in two village development committees in the Rasuwa district of central Nepal. It also evaluates the ethnopharmacological significance of the documented reports and identifies species of high indigenous priority in local therapeutics. Materials and methods The ethnobotanical information was collected by interviews and group discussions using standard ethnobotanical procedures. The homogeneity of informant׳s knowledge was validated by Informant consensus factor ( F IC ) and the relative importance of a plant species used as medicine in the study area was calculated with the help of use value (UV). Results The present study identified a total of 46 medicinal plants belonging to 26 families used for the treatment of 38 human ailments. Besides medicinal uses, the study has also documented the culinary and cultural use of 13 species of medicinal plants. The most commonly used part was root constituting about 42% of the total utilized plants. The most commonly used form of preparation was paste (31.91%). We found new usage reports for 9 medicinal plants. The F IC value in the present study ranged from 0.66 to 1 with 84.6% values greater than 0.8 indicating high consensus among the informants. The most preferred species was Neopicrorhiza scrophulariflora (UV=0.96) and the lowest used value was found for Lyonia ovalifolia (UV=0.32). Conclusions People of Rasuwa possess rich traditional knowledge in medicinal plants utilization with strong consensus among local people on the utilization of species evident by higher F IC values in different ailment categories. Strong pharmacological evidence for a majority of species being currently used as medicines shows that the plants used in local therapeutics are likely to be more effective in treating different medical ailments. The bioactive compounds extracted from these medicinal plants could subsequently be used in the creation of novel drugs to treat life threatening human diseases. The species with high use values are the ones likely to be more vulnerable because of high demand and high collection pressure. Therefore, it is imperative to prioritize such species for cultivation and sustainable management in order to ensure their long term availability. [ABSTRACT FROM AUTHOR]