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The current study observed the histological differences of the swim bladder of the tropical eel, Anguilla bicolor bicolor, as an adaptation resulting from hydrostatic change. A total of 15 eels were collected from Pasir Puncu, Keburuhan, Purworejo and Segara Anakan, Cilacap, Indonesia in June 2017, September 2020, and April 2021. The eels were grouped into 4 stages based on the silvering stage and sex, namely: yellow undifferentiated, yellow female, silver male, and silver female. The average length and body weight of yellow undifferentiated eels were 255.07 ± 45.91 mm and 13.66 ± 8.5 g, respectively; for yellow female, the values were 374.35 ± 41.51 mm and 56.5 ± 12.02 g; for silver male, the values were 432.43 ± 15.15 mm and 140.29 ± 13.85 g; and for silver female were 702 ± 0.00 mm and 545 ± 11.31 g. The present study successfully recorded the histological structure of the swim bladder of A. bicolor bicolor in silver male and silver female stages. Silver males and females displayed a greater significant development of the swim bladder than yellow stages in the gas gland, mucosa, and submucosa layers. These results suggest that an increase in the gas gland thickness allows a greater contribution from gas to gas secretion, the mucosa exerts a mechanical effect on the newly formed gas bubbles, and the submucosa thickness reduces gas conductivity from the swim bladder wall. [ABSTRACT FROM AUTHOR]

Objectives This study aimed to analyze the global profile of the nucleotide/nucleoside analogs (NAs) for chronic hepatitis virus therapy-related research. Background NAs, which closely resemble the structure of naturally occurring nucleotides/nucleosides, function by disrupting the elongation of the nascent DNA strand. These compounds are considered safe and well-tolerated, as they specifically target viral, but not human, polymerases involved in DNA replication. NAs are crucial in treating viral infections, including hepatitis, and are widely used due to their efficacy and safety. However, a study about trends in NAs for chronic hepatitis therapy-related research was never reported before. Methods The NAs for chronic hepatitis therapy-related research bibliometric analysis was performed on articles indexed in the Scopus database from 1986 to 2022. Results The total number of articles published worldwide is 2,341 documents, with an annual average of 65 documents. The United States generated the most articles (n = 486), followed byChina (n = 454), France (n = 191), and Italy (n = 179). Since 1992, the number of publications has increased dramatically worldwide. Globally, liver cell carcinoma, antiviral therapy, hepatitis B (e) antigen, and alanine aminotransferase are becoming hot research topics in the field. Conclusions This study provides a unique composite picture of NAs for chronic hepatitis therapy-related research worldwide and evaluates research productivity from 1986 to 2022. This finding suggests that the prospects for interventions in chronic hepatitis remain promising. [ABSTRACT FROM AUTHOR]

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals. [ABSTRACT FROM AUTHOR]

OBJECTIVES: This study aimed to analyze the global profile of the literature in non-alcoholic fatty liver disease (NAFLD) research. BACKGROUND: Non-alcoholic fatty liver disease is a clinically heterogeneous condition characterized by fat accumulation in the liver and the absence of significant alcohol consumption or underlying genetic disorders. These manifestations are associated with inflammation, steatosis, and fibrosis that can develop into cirrhosis and even hepatocellular carcinoma. However, a study about the research trend in NAFLD has never been reported before. METHODS: The NAFLD bibliometric analysis was performed on articles indexed in the Scopus database from 1973 to 2022. RESULTS: The total number of articles published worldwide is 28,673 documents, with an annual average of 561 documents. The United States generated the most articles (n = 6548), followed by China (n = 6180), Italy (n = 2434), and Japan (n = 2032). Since 2013, the number of publications on NAFLD has increased dramatically worldwide. The popular topics in the field include medicine, biochemistry, genetics and molecular biology, pharmacology, toxicology and pharmaceutics, and nursing. CONCLUSIONS: This study provides a unique composite picture of NAFLD research worldwide and evaluates research productivity from 1973 to 2022. This finding suggests that the prospects for interventions in NAFLD remain promising. [ABSTRACT FROM AUTHOR]

Background: ASEAN (Association of Southeast Asian Nations) is composed of ten Southeast Asian countries bound by socio-cultural ties that promote regional peace and stability. South Asia, located in the southern subregion of Asia, includes nine countries sharing similarities in geographical and ethno-cultural factors. Chikungunya is one of the most significant problems in Southeast and South Asian countries. Much of the current chikungunya epidemic in Southeast Asia is caused by the emergence of a virus strain that originated in Africa and spread to Southeast Asia. Meanwhile, in South Asia, three confirmed lineages are in circulation. Given the positive correlation between research activity and the improvement of the clinical framework of biomedical research, this article aimed to examine the growth of chikungunya virus-related research in ASEAN and South Asian countries. Methods: The Scopus database was used for this bibliometric analysis. The retrieved publications were subjected to a number of analyses, including those for the most prolific countries, journals, authors, institutions, and articles. Co-occurrence mapping of terms and keywords was used to determine the current state, emerging topics, and future prospects of chikungunya virus-related research. Bibliometrix and VOSviewer were used to analyze the data and visualize the collaboration network mapping. Results: The Scopus search engine identified 1280 chikungunya-related documents published by ASEAN and South Asian countries between 1967 and 2022. According to our findings, India was the most productive country in South Asia, and Thailand was the most productive country in Southeast Asia. In the early stages of the study, researchers investigated the vectors and outbreaks of the chikungunya virus. In recent years, the development of antivirus agents has emerged as a prominent topic. Conclusions: Our study is the first to present the growth of chikungunya virus-related research in ASEAN and South Asian countries from 1967 to 2022. In this study, the evaluation of the comprehensive profile of research on chikungunya can serve as a guide for future studies. In addition, a bibliometric analysis may serve as a resource for healthcare policymakers. [ABSTRACT FROM AUTHOR]

Forensic entomology, the study of insects and arthropods in criminal investigations, is crucial for estimating postmortem intervals, determining changes in corpse positioning, and identifying causes of death. This study analyzes global research trends in forensic entomology using data from the Scopus database spanning 1970 to 2024, with data visualized through VOSviewer. A total of 2,261 articles were identified, with an average productivity of 42 papers per year. The leading countries in forensic entomology research are the United States (n = 444), Brazil (n = 266), China (n = 198), the United Kingdom (n = 194), and Germany (n = 156). Current hot topics in the field include pupae, feeding behavior, beetles, and genetics. These findings underscore the ongoing interest and advancements in forensic entomology, highlighting its significance and diverse applications in criminal investigations. [ABSTRACT FROM AUTHOR]