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We have previously shown that in vitro measurement of cytokine production prior to renal transplantation can provide predictive information on the risk of acute rejection. Our earlier studies demonstrated that patients who secreted high levels of interferon-gamma (IFN- γ) in OKT3-stimulated or mixed lymphocyte culture had a significantly increased risk of acute rejection compared with patients who secreted lower levels. In this study, we performed a retrospective analysis of the same cohort of patients in order to determine the prognostic value of cytokine profiles and other variables on long-term graft function. Our results show that high levels of IFN- γ in pretransplant mixed lymphocyte culture are a highly significant predictor of poorer creatinine levels at 18, 24 and 36 months post-transplant. [ABSTRACT FROM AUTHOR]

We report the mass and distance measurements of two single-lens events from the 2017 Spitzer microlensing campaign. The ground-based observations yield the detection of finite-source effects, and the microlens parallaxes are derived from the joint analysis of ground-based observations and Spitzer observations. We find that the lens of OGLE-2017-BLG-1254 is a 0.60 ± 0.03 M⊙ star with DLS = 0.53 ± 0.11 kpc, where DLS is the distance between the lens and the source. The second event, OGLE-2017-BLG-1161, is subject to the known satellite parallax degeneracy, and thus is either a star with DLS = 0.40 ± 0.12 kpc or a star with DLS = 0.53 ± 0.19 kpc. Both of the lenses are therefore isolated stars in the Galactic bulge. By comparing the mass and distance distributions of the eight published Spitzer finite-source events with the expectations from a Galactic model, we find that the Spitzer sample is in agreement with the probability of finite-source effects occurring in single-lens events. [ABSTRACT FROM AUTHOR]

OGLE-2014-BLG-0962 (OB140962) is a stellar binary microlensing event that was well covered by observations from the Spitzer satellite as well as ground-based surveys. Modeling yields a unique physical solution: a mid-M+M-dwarf binary with Mprim = 0.20 ± 0.01 M☉ and Msec = 0.16 ± 0.01 M☉, with projected separation of 2.0 ± 0.3 au. The lens is only DLS = 0.41 ± 0.06 kpc in front of the source, making OB140962 a bulge lens and the most distant Spitzer binary lens to date. In contrast, because the Einstein radius (θE = 0.143 ± 0.007 mas) is unusually small, a standard Bayesian analysis, conducted in the absence of parallax information, would predict a brown dwarf binary. We compare the results of Bayesian analysis using two commonly used Galactic model priors to the measured values for a set of Spitzer lenses. We find all models tested predict lens properties consistent with the Spitzer data. Furthermore, we illustrate the methodology for probing the Galactic distribution of planets by comparing the cumulative distance distribution of the Spitzer two-body lenses to that of the Spitzer single lenses. [ABSTRACT FROM AUTHOR]

Theoretical models and spectroscopic observations of newborn stars suggest that protoplantary disks have an inner “wall” at a distance set by the disk interaction with the star. Around T Tauri stars, the size of this disk hole is expected to be on a 0.1 au scale that is unresolved by current adaptive optics imaging, though some model-dependent constraints have been obtained by near-infrared interferometry. Here we report the first measurement of the inner disk wall around a solar-mass young stellar object, YLW 16B in the ρ Ophiuchi star-forming region, by detecting the light-travel time of the variable radiation from the stellar surface to the disk. Consistent time lags were detected on two nights, when the time series in H (1.6 μm) and K (2.2 μm) bands were synchronized while the 4.5 μm emission lagged by 74.5 ± 3.2 s. Considering the nearly edge-on geometry of the disk, the inner rim should be 0.084 au from the protostar on average, with an error of order 0.01 au. This size is likely larger than the range of magnetospheric truncations and consistent with an optically and geometrically thick disk front at the dust sublimation radius at ∼1500 K. The widths of the cross-correlation functions between the data in different wavebands place possible new constraints on the geometry of the disk. [ABSTRACT FROM AUTHOR]

To move one step forward toward a Galactic distribution of planets, we present the first planet sensitivity analysis for microlensing events with simultaneous observations from space and the ground. We present this analysis for two such events, OGLE-2014-BLG-0939 and OGLE-2014-BLG-0124, which both show substantial planet sensitivity even though neither of them reached high magnification. This suggests that an ensemble of low to moderate magnification events can also yield significant planet sensitivity, and therefore probability, for detecting planets. The implications of our results to the ongoing and future space-based microlensing experiments to measure the Galactic distribution of planets are discussed. [ABSTRACT FROM AUTHOR]

Space-based microlens parallax measurements are a powerful tool for understanding planet populations, especially their distribution throughout the Galaxy. However, if space-based observations of the microlensing events must be specifically targeted, it is crucial that microlensing events enter the parallax sample without reference to the known presence or absence of planets. Hence, it is vital to define objective criteria for selecting events where possible and to carefully consider and minimize the selection biases where not possible so that the final sample represents a controlled experiment. We present objective criteria for initiating observations and determining their cadence for a subset of events, and we define procedures for isolating subjective decision making from information about detected planets for the remainder of events. We also define procedures to resolve conflicts between subjective and objective selections. These procedures maximize the planet sensitivity of the sample as a whole by allowing for planet detections even if they occur before satellite observations for objectively selected events and by helping to trigger fruitful follow-up observations for subjectively chosen events. This paper represents our public commitment to these procedures, which is a necessary component of enforcing objectivity on the experimental protocol. They will be implemented for the 2015 Spitzer microlensing campaign. [ABSTRACT FROM AUTHOR]

HAT-P-20b is a giant metal-rich exoplanet orbiting a metal-rich star. We analyze two secondary eclipses of the planet in each of the 3.6 and 4.5 μm bands of Warm Spitzer. We have developed a simple, powerful, and radically different method to correct the intra-pixel effect for Warm Spitzer data, which we call pixel-level decorrelation (PLD). PLD corrects the intra-pixel effect very effectively, but without explicitly using—or even measuring—the fluctuations in the apparent position of the stellar image. We illustrate and validate PLD using synthetic and real data and comparing the results to previous analyses. PLD can significantly reduce or eliminate red noise in Spitzer secondary eclipse photometry, even for eclipses that have proven to be intractable using other methods. Our successful PLD analysis of four HAT-P-20b eclipses shows a best-fit blackbody temperature of 1134 ± 29 K, indicating inefficient longitudinal transfer of heat, but lacking evidence for strong molecular absorption. We find sufficient evidence for variability in the 4.5 μm band that the eclipses should be monitored at that wavelength by Spitzer, and this planet should be a high priority for James Webb Space Telescope spectroscopy. All four eclipses occur about 35 minutes after orbital phase 0.5, indicating a slightly eccentric orbit. A joint fit of the eclipse and transit times with extant RV data yields and establishes the small eccentricity of the orbit to high statistical confidence. HAT-P-20b is another excellent candidate for orbital evolution via Kozai migration or other three-body mechanisms. [ABSTRACT FROM AUTHOR]