Search

The shoulder joint can be considered one of the most important joints in the human body in regards to maintaining a good autonomy, due to its anatomical particularities that confer a wide range of motion. Scapulo-humeral dislocations limit the functionality of the joint and lead to an important decline in autonomy. Amongst shoulder dislocations, the posterior ones are considered rare and often lead to difficulties in diagnosis. Neglecting such lesions often leads to complications which can have a great impact on the treatment. We present a case which underlines these aspects, having particularities such as the young age of the patient (18 years old) and the rather long time of 4 months in which the lesion was neglected. Patient F. C. was admitted into our hospital with pain and functional impotence in his right shoulder, which appeared after a traumatic event 4 months ago. The clinical examination reveals limitation in range of motion for all the possible motions in the shoulder joint. Imaging studies (2 plain radiographs and a CT scan) reveal a posterior scapulo- humeral dislocation with a wedge type defect on the anterior aspect of the humeral head. Surgical treatment, chosen after a careful pre-operative planning, consisted of open reduction on a deltopectoral approach and the transposition of the subscapularis tendon into the humeral head. The patient underwent a specific postoperative rehabilitation program and was able to regain almost full range of motion in the shoulder joint. The importance of this case consists in underlining the possible complications of neglected shoulder dislocations, in the importance of pre-operative planning, which in this case dictated the surgical approach and method of stabilization, as well as the importance of a good understanding of the functional anatomy of the shoulder joint. [ABSTRACT FROM AUTHOR]

Free vascularized bone grafts were found to be very effective in segmental bone defect resulted after trauma or wide tumor resection. We present a complex case of a femoral shaft non-union, which was initially treated in other service. After two surgical interventions, both complicated with implant failure after bone non-union, the segmental bone loss was treated in our clinic using free vascularized bone graft. This method was found to be really efficient and the patient was able to walk again after a good rehabilitation program in less than 6 months. Our experience with microvascular transfer of fibular graft has shown that massive autogenous bone grafting with an intact vascular pedicle accelerates the time for bone healing and improves the rehabilitation program. Non-union in long bones after multiple surgical interventions will lead to implant failure and bone loss. The technique has proven reliable in the reconstruction of the bone defect of greater than 6 to 8 cm following defects existing in a fibrotic, avascular bed. Donor site morbidity was negligible. We managed to treat a complicated case of a femoral shaft non-union in an orthoplastic manner using both techniques and principles. Our data suggests that vascularized bone grafts represent a valuable procedure for reconstruction of large segmental bone loss. [ABSTRACT FROM AUTHOR]

Abstract: A high performance liquid chromatographic method for the determination of pipamperone in the presence of one related impurity and its degradation products is described. The method is based on the use of an amide functionalized bonded phase column (LC-ABZ+ Plus) and a mobile phase of acetonitrile-tetrahydrofuran-sodium phosphate monobasic (0.05M, pH 6.5) (16:11:73, v/v/v). All peaks are eluted in <8min. The method was demonstrated to be precise, accurate and specific. Degradation study showed that the drug is stable in acidic medium while it degrades under basic and oxidative conditions. The results indicated that the proposed method could be used in a stability assay. [Copyright &y& Elsevier]

A specific, high performance liquid chromatographic method was developed for the assay of haloperidol, together with an adequate separation of its degradation products. The method is based on the use of an octadecylsilane stationary phase column under isocratic conditions. The mobile phase consisted of 50 mM sodium phosphate monobasic pH 2.5–acetonitrile–THF–TEA (63:34:3:0.1, v/v/v/v) adjusted with o-phosphoric acid to a pH of 2.5. The degradation was performed in hydrochloric acid, sodium hydroxide and hydrogen peroxide. The main degradation products were identified. Application of the assay of haloperidol in tablet formulations is presented. [Copyright &y& Elsevier]

A specific, high performance liquid chromatographic method for the determination of droperidol in the presence of its degradation products is described. The method is based on the use of an amide functionalized bonded phase column (LC-ABZ+ Plus) and a simple mobile phase of methanol–sodium phosphate monobasic (0.05 M, pH 4.5) (40:60, v/v). It enables the resolution of eight compounds from the parent drug and from each other. The degradation was carried out in hydrochloric acid, sodium hydroxide and hydrogen peroxide. The main degradation products were identified. Application of the assay for a commercial preparation of droperidol for injection is presented. [Copyright &y& Elsevier]