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Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis bacteria, which is more prevalent among immunocompromised individuals. According to the distribution of affected organs, this infection can be categorized as either pulmonary or extrapulmonary TB. Immunodeficiency states resulting from rheumatological disorders and the use of immunosuppressive medications, such as in Behçet's disease (BD), are potential predisposing factors for TB, particularly in cases involving multiple organs. These situations can introduce challenges in both the diagnosis and treatment of patients. We describe a 43‐year‐old man with a history of BD who presented with symptoms of weight loss, abdominal pain, and shortness of breath. His chest X‐ray revealed cavities and calcifications, while an abdominal X‐ray demonstrated signs of intestinal obstruction and adhesions. Subsequent TB diagnosis led to a 6‐month course of a TB treatment regimen. Despite treatment initiation, the patient developed a brain abscess 1 year later, necessitating surgical intervention. Following the procedure, he received another 1‐year course of a TB treatment regimen and experienced full recovery without any complications during a 2‐year follow‐up period. Notably, the patient recently received a Sinopharm COVID‐19 vaccine and subsequently developed seizures that are currently being managed with anticonvulsant therapy. This case report emphasizes the significance of including pulmonary TB in complex medical cases, especially in individuals with autoimmune diseases. Early diagnosis and treatment are crucial for improving outcomes and reducing the risk of complications. Furthermore, it highlights the possible correlation between TB and BD, along with the potential adverse reactions to COVID‐19 vaccines in this population, which necessitate special consideration by healthcare professionals. [ABSTRACT FROM AUTHOR]

Key Clinical Message: Clinicians should consider spontaneous coronary artery dissection in middle‐aged women presenting with acute coronary syndromes and a history of tamoxifen use, to ensure timely diagnosis, and appropriate management strategies. Spontaneous coronary artery dissection (SCAD) is characterized by a non‐iatrogenic, nontraumatic separation of the coronary artery wall, contributing to acute coronary syndromes (ACS), and sudden cardiac death. SCAD predominantly affects the left anterior descending artery (LAD) and is frequently observed in middle‐aged women. This condition has been associated with cancer treatment and exogenous hormones exposure. The diagnostic gold standard remains coronary angiography, management strategies include conservative measures, percutaneous coronary intervention (PCI), and coronary artery bypass graft surgery (CABG). We describe a case of a 54‐year‐old woman with breast cancer and a history of tamoxifen use, presenting with SCAD in the posterolateral branch (PLB) originating from the left circumflex artery (LCX), and right coronary artery (RCA) and managed conservatively. [ABSTRACT FROM AUTHOR]