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Proxima Cen (GJ 551; dM5.5e) is one of only about a dozen fully convective stars known to have a stellar cycle, and the only one to have long-term X-ray monitoring. A previous analysis found that X-ray and mid-UV observations, particularly two epochs of data from Swift, were consistent with a well-sampled ∼7 yr optical cycle seen in All Sky Automated Survey project (ASAS) data, but not convincing by themselves. The present work incorporates several years of new ASAS-SN optical data and an additional 5 yr of Swift XRT and UVOT observations, with Swift observations now spanning 2009–2021 and optical coverage from late 2000. X-ray observations by XMM-Newton and Chandra are also included. Analysis of the combined data, which includes modeling and adjustments for stellar contamination in the optical and UV, now reveals clear cyclic behavior in all three wavebands with a period of 8.0 yr. We also show that UV and X-ray intensities are anticorrelated with optical brightness variations caused by the cycle and by rotational modulation, discuss possible indications of two coronal mass ejections, and provide updated results for the previous finding of a simple correlation between X-ray cycle amplitude and Rossby number over a wide range of stellar types and ages. [ABSTRACT FROM AUTHOR]

To use phages in a personalized therapy and industrial applications, an accurate quantification is needed. The gold standard method, namely the culture-based double agar overlay (DAO) method, provides an accurate estimate of the number of infectious phages but is laborious and time-intensive. Quantitative polymerase chain reaction (qPCR) can be used as a fast alternative but tends to overestimate the number of infectious phage particles. Here we describe the use of a DNase treatment before quantification of the Staphylococcus aureus phage ISP with qPCR to obtain a more accurate estimate of the number of infectious phage particles. We showed that DNase treatment results in a significant decrease of the concentration when measured with qPCR although for two out of three tested ISP phage stocks, there was still a significant difference with the DAO method. We also showed that the discrepancy between quantification with qPCR and the DAO method is dependent on the storage period of the phage stock, with a larger discrepancy for older stocks. Additionally, we used negative contrast immune electron microscopy to confirm the presence of DNA in the medium of the phage stock and the impact of the DNase treatment on the free DNA. [ABSTRACT FROM AUTHOR]

Analyze the burden of diseases attributable to risk factors (RF) in Brazil according to age, sex, and Brazilian states between 1990 and 2021. This study used data from the Global Burden of Disease study 1990 to 2021. The metrics used in this analysis included: mortality rates, disability-adjusted life years (DALYs) and Summary Exposure Value (SEV). A ranking of the risk factors was created by highlighting the changes between 1990 and 2021, according to sex, age group, and Brazilian state. RF were analyzed according to the Socio-Demographic Index (SDI). Decline the risk factors of tobacco (−50.2 %), environmental: water, sanitation and hand washing (−58.0 %), and air pollution (−45.0 %), as well as an increase in the burden attributable to BMI (+78.4 %), alcohol consumption (+15.7 %). High systolic blood pressure ranked first in all states in 2021, followed by high blood glucose; tobacco ranking third in most states. The burden of diseases attributable to RFs in Brazil varied considerably between men and women, age groups, and states. Trends in the period from 1990 to 2021 showed a strong correlation with the SDI, better results being observed in states with higher SDI. High blood pressure, high BMI and tobacco are the main risk factors for mortality and DALYs in 2021. The burden of disease has a high correlation with socio-economic indicator (SDI). It is important to strengthen public policies that promote healthy lifestyles, thus reducing disease and death. [ABSTRACT FROM AUTHOR]

AbstractThe unprecedented events on October 7th in Israel, characterized by little actual and perceived control over the sources of the stress, have affected virtually every household in Israel, either due to the economic and social consequences of the ensuing war or experiencing the loss of relatives and friends. The current study examined the association between traumatic loss of close friends/relatives and resilience during the initial stages of the Iron-Swords war and explored the moderating role of coping strategies for this link. Data were collected from 286 participants (age range 19-82) who completed online scales assessing loss, resilience, and coping strategies during the first weeks of the Iron-Swords war. Results demonstrated a negative association between emotion-focused coping and resilience, as well as a positive association between problem-focused coping and resilience. Moreover, coping strategies moderated the loss-resilience link, which was significant only for individuals reporting low levels of both problem-focused and emotion-focused coping. Our findings support the claim that relying on at least one dominant coping strategy (i.e., problem-focused coping/emotional-focused coping/both) is efficient to reserve resilience levels at times of adversity. The findings of the current study, based on data collected in the first weeks of the Iron-Swords war, highlight the value of different coping styles in preserving individual resilience as a protective factor against stress during adversity. [ABSTRACT FROM AUTHOR]

The aim of this study was to analyse the burden of disease due to noncommunicable diseases (NCDs) between 1990 and 2021 in Brazil. In addition, this study compared mortality from NCDs with mortality from all causes and COVID-19, analysed NCD mortality trends and projections for 2030, and analysed NCD mortality rates and risk factors attributed to these deaths among the 27 states of Brazil. Ecological studies. This study used the Global Burden of Disease study (GBD) database from 1990 to 2021. Premature deaths from four NCDs (neoplasms, cardiovascular disease, chronic respiratory diseases and diabetes mellitus) were analysed. The following metrics were used to analyse the burden of NCDs in Brazil: absolute number of deaths, proportional mortality, mortality rate, years of life lost due to premature death (YLL), years lived with disabilities (YLD) and disability-adjusted years of life lost due to premature death (DALY). For comparison between the years studied and states, age-standardised rates were used. Finding from this study showed that there was increase in the proportion of premature deaths due to NCDs between 1990 and 2019 (29.4 % in 1990, 30.8 % in 2019), and a reduction in 2021 (24.7 %). The mortality rates, DALY and YLL from NCDs declined between 1990 and 2019 (−37.7 %, −34.5 % and −38.3 %, respectively); however, a stability in mortality rates, DALY, YLD, YLL was observed between 2019 and 2021 (−0.1 %, 0.7 %, −0.1 % and 0.8 %, respectively). Between 1990 and 2021, there was a decline in mortality rates, DALY and YLL for most states and an increase in YLD rates. However, results suggest that the Sustainable Development Goal (SDG) for the reduction in mortality from NCDs by one-third by 2030 will not be achieved. The main risk factors associated with premature death from NCDs in 2021 were high blood pressure, tobacco use, dietary risks, high body mass index (BMI) and high blood glucose levels. The correlation between sociodemographic index and percentage change in mortality rates was significant for the following total NCDs, cardiovascular disease, chronic respiratory disease, diabetes and neoplasms. The current study highlights the importance of deaths from NCDs in Brazil and the worsening of mortality rates since 2016, as a result of austerity measures and the COVID-19 pandemic, which compromises the achievement of the SDG reduced mortality targets for NCDs. There was a reduction in risk factors for NCDs, mainly behavioural, although metabolic risk factors are of great concern and require new strategies to promote health, prevention and comprehensive care. [ABSTRACT FROM AUTHOR]

Fever in infants presenting to pediatric emergency departments (PEDs) often results in significant return visits (RVs). This retrospective study aimed to identify factors associated with RVs in febrile infants aged 0 to 90 days. Data from infants presenting to PED between 2018 and 2021 and returning within 7 days (RV group) were compared to age-matched febrile infants without RVs (control group). Each group had 95 infants with similar demographics and medical history. RVs were primarily due to positive cultures and persistent fever. The control group had higher initial hospitalization rates, longer PED stays, and increased antibiotic treatment. Prevalence of serious bacterial infections (SBIs) did not significantly differ. Higher hospitalization, prolonged PED stays, and initial antibiotic treatment were associated with reduced RV incidence despite similar SBI rates. Return visits in infants <90 days were primarily driven by persistent fever and positive cultures. Addressing these factors through targeted parental education and improved care protocols may reduce RVs. [ABSTRACT FROM AUTHOR]

Background: Burst‐patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear. Objectives: The aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS. Methods: Six PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS‐III) and proactive inhibition (using stop‐signal task) were evaluated for each condition. Results: Burst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS‐III reduction and increased proactive inhibition relative to DBS OFF. Conclusions: This pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger‐scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Stellar photospheric inhomogeneities are a significant source of noise, which currently precludes the discovery of Earth-mass planets orbiting Sun-like stars with the radial-velocity (RV) method. To complement several previous studies that have used ground- and spaced-based facilities to characterize the RV of the Sun, here we characterize the center-to-limb variability (CLV) of solar RVs arising from various solar-surface inhomogeneities observed by the Solar Dynamics Observatory (SDO)/Helioseismic Magnetic Imager and SDO/Atmospheric Imaging Assembly. By using various SDO observables to classify pixels and calculate line-of-sight velocities as a function of pixel classification and limb angle, we show that each identified feature type, including the umbrae and penumbrae of sunspots, quiet-Sun magnetoconvective cells, magnetic network, and plage, exhibit distinct and complex CLV signatures, including a notable limb-angle dependence in the observed suppression of convective blueshift for magnetically active regions. We discuss the observed distributions of velocities by identified region type and limb angle, offer interpretations of the physical phenomena that shape these distributions, and emphasize the need to understand the RV signatures of these regions as astrophysical signals, rather than simple (un)correlated noise processes. [ABSTRACT FROM AUTHOR]

Motivated by the saturation of drag reduction effectiveness at high non-dimensional riblet spacing in turbulent boundary layer flows, this study seeks to investigate the influence of a secondary blade riblet structure on flow statistics and friction drag reduction effectiveness in comparison to the widely explored single-scale blade riblet surface. The turbulent flow dynamics and drag reduction performance over single- and multi-scale blade riblet surfaces were experimentally examined in a flow visualization channel across various non-dimensional riblet spacings. The shear velocity was quantified by the streamwise velocity distributions from the logarithmic layer via planar Particle Image Velocimetry (PIV) measurements, whereas the near-wall flow dynamics were characterized by a Micro Particle Image Velocimetry (micro-PIV) system. The results highlighted that although both riblet surfaces exhibited similar drag reduction performances at low non-dimensional riblet spacings, the presence of a secondary riblet blade structure can effectively extend the drag reduction region with the non-dimensional riblet spacing up to 32 and achieve approximately 10% lower friction drag in comparison to the single-scale riblet surface when the non-dimensional riblet spacing increases to 44.2. The average number of uniform momentum zones (UMZs) on the multi-scaled blade riblet has also reduced by 9% compared to the single-scaled riblet which indicates the reduction of strong shear layers within a turbulent boundary layer. The inspection of near-wall flow statistics demonstrated that at high non-dimensional riblet spacings, the multi-scale riblet surface produces reduced wall-normal velocity fluctuations and Reynolds shear stresses. Quadrant analysis revealed that this design allows for the suppression of both the sweep and ejection events. This experimental result demonstrated that surfaces with spanwise variations of riblet heights have the potential to maintain drag reduction effectiveness across a wider range of flow speeds. [ABSTRACT FROM AUTHOR]

Colloidal semiconductor nanoparticles (NPs) represent an emergent state of matter with unique properties, bridging bulk materials and molecular structures. Their distinct physical attributes, such as bandgap and photoluminescence, are intricately tied to their size and morphology. Ligand passivation plays a crucial role in shaping NPs and determining their physical properties. Ligand exchange (LE) offers a versatile approach to tailoring NP properties, often guided by Pearson's Hard–Soft Acid–Base theory. Lead sulfide (PbS), a semiconductor of considerable interest, exhibits size-dependent tunable bandgaps from the infrared to the visible range. Here, we present two methods for synthesizing water-soluble, polyvinylpyrrolidone (PVP)-coated PbS NPs. The first involves direct synthesis in an aqueous solution while utilizing PVP as the surfactant for the formation of nano-cubes with a crystal coherence length of ~30 nm, while the second involves LE from octadecylamine-coated PbS truncated nano-cubes to PVP-coated PbS NPs with a crystal coherence length of ~15 nm. Multiple characterization techniques, including X-ray diffraction, transmission electron microscopy, Fourier-transform infrared spectroscopy, and thermal gravimetric analysis, confirmed the results of the synthesis and allowed us to monitor the ligand exchange process. Our findings demonstrate efficient and environmentally friendly approaches for synthesizing PVP-coated PbS NPs. [ABSTRACT FROM AUTHOR]

Bio‐based, fully degradable aliphatic‐aromatic block copolymers are synthesized from ω‐pentadecalatone and cyclic oligo(3,4‐ethylene furanoate). In the first approach, the ring‐opening polymerization of the cyclic oligo(3,4‐ethylene furanoate) is initiated by a poly(pentadecalactone) macroinitiator with a terminal hydroxy group. The reaction temperatures of the melt polymerization are 210–230 °C due to the high melting points of the oligo(3,4‐ethylene furanoate). Under these conditions, transesterification is observed. The blockiness of the reaction products depends on the reaction temperature and on the ratio of pentadecalactone to 3,4‐ethylene furanoate repeat units, which is 50:50, 80:20, and 90:10. At lower temperatures and more pentadecalactone content, the blockiness is larger. The number average molar mass of the block copolymers remains smaller than 20 000 g mol−1. In the second approach, poly(pentadecalactone) is functionalized with an alkyne group, and the OH group of the oligo(3,4‐ethylene furanoate) (molar mass 1900 g mol−1) is converted into an azide group. Connecting the two polymers in a copper‐catalyzed 1,3‐dipolar addition reaction ("click reaction") yields block copolymers with a number average molar mass of 12 400 g mol−1. The mechanical properties of the polymer films are intermediate between those of the parent homopolymers. [ABSTRACT FROM AUTHOR]

The current consensus holds that optically‐cleared specimens are unsuitable for Magnetic Resonance Imaging (MRI); exhibiting absence of contrast. Prior studies combined MRI with tissue‐clearing techniques relying on the latter's ability to eliminate lipids, thereby fostering the assumption that lipids constitute the primary source of ex vivo MRI‐contrast. Nevertheless, these findings contradict an extensive body of literature that underscores the contribution of other features to contrast. Furthermore, it remains unknown whether non‐delipidating clearing methods can produce MRI‐compatible specimens or whether MRI‐contrast can be re‐established. These limitations hinder the development of multimodal MRI‐light‐microscopy (LM) imaging approaches. This study assesses the relation between MRI‐contrast, and delipidation in optically‐cleared whole brains following different tissue‐clearing approaches. It is demonstrated that uDISCO and ECi‐brains are MRI‐compatible upon tissue rehydration, despite both methods' substantial delipidating‐nature. It is also demonstrated that, whereas Scale‐clearing preserves most lipids, Scale‐cleared brain lack MRI‐contrast. Furthermore, MRI‐contrast is restored to lipid‐free CLARITY‐brains without introducing lipids. Our results thereby dissociate between the essentiality of lipids to MRI‐contrast. A tight association is found between tissue expansion, hyperhydration and loss of MRI‐contrast. These findings then enabled us to develop a multimodal MRI‐LM‐imaging approach, opening new avenues to bridge between the micro‐ and mesoscale for biomedical research and clinical applications. [ABSTRACT FROM AUTHOR]

Phylogenetic study of Arrhenia peltigerina revealed a complex of seven divergent clades. Type specimens of Agaricus peltigerinus and Omphalina cupulatoides fell into separate clades; the latter was recombined as Arrhenia cupulatoides. Four clades were described as new species: Arr. baltica, Arr. fennoscandica, Arr. mohniensis, and Arr. talpoides; the fifth, with only a single specimen, was left formally undescribed. These cryptic species are uncommon—more so in North America than Scandinavia—and collections are often misidentified. Spore measurements separated Arr. baltica from the others by its narrower spores; average measurements help separate some species a bit better than ranges. So far, Arr. peltigerina was found only in North America, Arr. mohniensis and Arr. talpoides in both Europe and North America, and the remainder only in Europe. The host species of Peltigera was Peltigera hymenina for Arr. cupulatoides, Peltigera rufescens for Arr. baltica, and varied for the others. All but one collection came from soil over calcareous bedrock. Small sample size does not permit assigning high confidence to noted interspecific differences; these await confirmation by greater experience from future study. [ABSTRACT FROM AUTHOR]

Objective: Parent peer advocacy, mentoring, and support programs, delivered by parents with lived child protection (CP) experience to parents receiving CP intervention, are increasingly recognized internationally as inclusive practices that promote positive outcomes, but little is known about what shared characteristics exist across these types of programs and what variations may exist in service delivery or impact. This scoping review examines 25 years (1996–2021) of empirical literature on these programs to develop a systematic mapping of existing models and practices as context for program benefits and outcome achievement. Method: Studies were selected using a systematic search process. The final sample comprised 45 publications that addressed research on 24 CP-related parent peer advocacy and support programs. Data analysis explored how programs were studied and conceptualized and examined their impact on parents, professionals, and the CP system. Results: Substantial variation in program settings, target populations, aims, advocate roles, and underlying theoretical frameworks were identified. Across program settings, existing empirical evidence on impact and outcomes also varied, though positive impacts and outcomes were evident across most settings. Conclusions: Findings from this review highlight the need to account better for parent peer advocacy and support program variations in future practice development to ensure alignment with inclusive and participatory principles and goals. Future research is also needed to address current knowledge gaps and shed light on the impact of these differences on individual, case, and system outcomes. [ABSTRACT FROM AUTHOR]

In specific contract No 13 issued under the framework agreement OC/EFSA/AMU/2019/02, EFSA requested Open Analytics to implement a web application SIGMA Kaleidoscope composed of different modules addressing the need of generating customized visualizations for African swine fever (ASF) epidemiological data with the possibility of selecting the species (wild and/or domestic), the geographical area, the time frame and many other analytical parameters of interest. These visualization components can be used to elaborate an epidemiological report with automatic text creation. The web application integrates different types of data sources and data formats in order to generate insightful tables and graphs covering surveillance activities, spatial and temporal dynamics, disease outbreaks and impact estimators. Users will be able to generate a report summarizing the results obtained throughout the application. The web application has been developed and tested using ASF data, but the 'Summary' module can also be applied to the outbreak data of other diseases. [ABSTRACT FROM AUTHOR]

Tissue development occurs through a complex interplay between many individual cells. Yet, the fundamental question of how collective tissue behavior emerges from heterogeneous and noisy information processing and transfer at the single-cell level remains unknown. Here, we reveal that tissue scale signaling regulation can arise from local gap-junction mediated cell-cell signaling through the spatiotemporal establishment of an intermediate-scale of transient multicellular communication communities over the course of tissue development. We demonstrated this intermediate scale of emergent signaling using Ca2+ signaling in the intact, ex vivo cultured, live developing Drosophila hematopoietic organ, the lymph gland. Recurrent activation of these transient signaling communities defined self-organized signaling "hotspots" that gradually formed over the course of larva development. These hotspots receive and transmit information to facilitate repetitive interactions with nonhotspot neighbors. Overall, this work bridges the scales between single-cell and emergent group behavior providing key mechanistic insight into how cells establish tissue-scale communication networks. [ABSTRACT FROM AUTHOR]

The purpose of the article is to analyze why Huntington's ideas about civilizations, which have been much criticized, misused, and abused, continue to show amazing vitality by tackling the trends of international order. His paradigm has been a good predictor of international conflicts, but at the same time a tool that allows us to accept some primordial things. Properly understood and applied, civilizational analysis, which considers one's strengths and weaknesses, can be used, like geopolitical analysis, as an indispensable component of planning a strategic approach. [ABSTRACT FROM AUTHOR]

Aim: To identify the various diagnoses associated with extremely elevated C‐reactive protein (CRP) (>30 mg/dL) among immunocompetent children and to evaluate its clinical implications during emergency department (ED) workup and hospital management. Methods: Children (3 months–18 years) with fever in ED were included, retrospectively. The cohort was divided into two groups—'extremely elevated CRP' (>30 mg/dL) and 'highly elevated CRP' (15–30 mg/dL). Results: Included were 1173 patients with CRP 15–30 mg/dL and 221 with CRP > 30 mg/dL. Bacterial infection was more prevalent among the extremely elevated CRP group (94.1% vs. 78.5%, respectively, p = 0.002). Specifically, bacterial pneumonia (52%), cellulitis (7.2%) and sepsis (4.1%) were more prevalent among this group. More of these patients were reported as 'Ill appearing' [78 (35.3%) vs. 166 (17.4%), p < 0.001]. They were more often treated with fluids [33 (14.9%) vs. 50 (5.3%), p < 0.001] and a higher portion of them required admission to an intensive care unit [11 (5.0%) vs. 16 (1.7%), p = 0.007]. Conclusion: Febrile children with extremely elevated CRP showed greater illness severity (haemodynamic instability, PICU admissions), thus careful clinical attention is desirable in these cases. More than half of them had bacterial pneumonia, which reinforces the importance of relevant investigation when diagnosis is unclear. [ABSTRACT FROM AUTHOR]

Agency independence is understood to instil credibility in regulatory policy. This is a core tenet of regulation theory, foundational to the EU regulatory state’s own origin story. We put the assumption to rigorous testing, in addition to expanding on it theoretically. We expect that stakeholder perceptions of credibility depend not only on agencies’ institutional insulation, but also on whether regulatory outcomes are congruent with stakeholders’ prior beliefs and preferences. Focusing on EU food safety regulation and the European Food Safety Authority, we test, observationally and experimentally, whether the credibility of agency scientific outputs is enhanced when stakeholders perceive the agency as more independent. Some support for the theorised link is present observationally, yet we do not find consistent and reliable experimental causal evidence for the purported relationship. We further find that the credibility of agency outputs is greatly influenced by stakeholders’ prior positions on the issue, pointing at persistent contestation. The study advances our understanding of the factors that shape credibility perceptions, supplementing institutional accounts with individual-level considerations, namely the role of priors. Our study indicates independence is a necessary but partial solution in that it can enhance stakeholder perceptions of credibility but does not compensate for the negative effect of priors. [ABSTRACT FROM AUTHOR]

We derive the stabiliser group of the four-vector, also known as Wigner's little group, in case of massless particle states, as the maximal solvable subgroup of the proper orthochronous Lorentz group of dimension four, known as the Borel subgroup. In the absence of mass, particle states are disentangled into left- and right-handed chiral states, governed by the maximal solvable subgroups sol 2 ± of order two. Induced Lorentz transformations are constructed and applied to general representations of particle states. Finally, in our conclusions, it is argued how the spin-flip contribution might be closely related to the occurrence of nonphysical spin operators. [ABSTRACT FROM AUTHOR]

The night plays an important role in Sibylla Schwarz' self-presentation as a female poet. On the one hand, she expresses her poetic skills by using the night as a literary motif which she combines with metaphors of farewell and death. On the other hand, she presents the night as the time and place of the creation of her poetry, thereby marking it as a secondary activity accepted within the gender discourse of early modern culture. Schwarz' use of the motif of the night vividly illustrates the interplay of convention, strategy and lifeworld reference that is characteristic of her poetry. Im Zuge ihrer Selbstinszenierung als Dichterin macht sich Sibylla Schwarz die Nacht zunutze. Zum einen setzt sie die Nacht als literarisches Motiv ein, über dessen Gestaltung und Kombination mit Abschieds- und Todesmetaphorik sie ihr dichterisches Können zum Ausdruck bringt. Zum anderen inszeniert sie die Nacht als Zeitpunkt bzw. Ort der Entstehung ihrer Dichtung und markiert diese dadurch als eine innerhalb des frühneuzeitlichen Geschlechterdiskurses akzeptierte Nebentätigkeit. Anhand von Schwarz' Nachtmotivik lässt sich das für ihre Lyrik charakteristische Zusammenspiel aus Konvention, Strategie und lebensweltlichem Bezug anschaulich nachvollziehen. [ABSTRACT FROM AUTHOR]

Background: The outbreak of war in Israel on 7 October and the unique events of that day have presented unprecedented challenges to first responders (FRs), who are professionally trained to engage in providing assistance in such circumstances. Moreover, while research demonstrates the long-term psychological consequences of FRs, little is known regarding how FR’s engagement in providing assistance relates to stress and resilience levels as events continue to unfold. Objective: The current study examined the relationship between traumatic stress symptoms (TSS) and resilience levels among FRs and controls during the first weeks of the Iron Swords war, while focusing on the moderating role of active engagement in providing assistance. Method: Data were collected during the first month of the Iron Swords war from 374 participants living in Southern Israel, of whom 77 (20.6%) were FRs. All participants filled out scales assessing TSS and resilience and provided relevant background information. Results: High TSS levels were associated with reduced resilience in FRs and non-FRs. Moreover, both the study group and active engagement were significant moderators for the TSSresilience link, which was insignificant among FRs who provided assistance and for civilians who did not provide assistance. However, the TSS-resilience association remained significant for FRs who did not engage in providing assistance and for civilians who did. Conclusions: Our findings highlight the importance of examining the extent to which FRs act in line with their duties during times of adverse stress. Clinical interventions aimed towards FRs who did not engage in providing assistance are needed and should focus on the extent to which their moral values, beliefs and expectations are met, as these appear critical parameters in preserving resilience. [ABSTRACT FROM AUTHOR]

Reddit discourse surrounding treatments for autistic individuals is easily accessible. Multiple Reddit threads discuss Applied Behavior Analysis (ABA) as one option. Such content impacts decision-making despite the absence of gatekeeping mechanisms to identify misinformation. Using a cross-sectional design, this study explores perceptions of ABA-based interventions shared on Reddit by exploring posts' content, stance and evidence used to support claims. Posts examined generally lacked support of scientific evidence. Additionally, perspectives on ABA were influenced by personal experiences with the intervention. This data provides insight to support healthcare professionals and families engaged in shared decision-making regarding intervention choices. [ABSTRACT FROM AUTHOR]

Objectives: Traumatic stress has been associated with increased risk for brain alterations and development of anxiety disorders. Studies conducted in posttraumatic patients have shown white‐mater volume and diffusion alterations in the corpus‐callosum. Decreased cognitive performance has been demonstrated in acute stress disorder and posttraumatic patients. However, whether cognitive alterations result from stress related neuropathology or reflect a predisposition is not known. In the current study, we examined in healthy controls, whether individual differences in anxiety are associated with those cognitive and brain alterations reported in stress related pathologies. Methods: Twenty healthy volunteers were evaluated for anxiety using the state‐trait inventory (STAI), and were tested for memory performance. Brain imaging was employed to extract volumetric and diffusion characteristics of the corpus‐callosum. Results: Significant correlations were found between trait anxiety and all three diffusion parameters (fractional‐anisotropy, mean and radial‐diffusivity). Associative‐memory performance and corpus‐callosum volume were also significantly correlated. Conclusion: We suggest that cognitive and brain alterations, as tested in the current work and reported in stress related pathologies, are present early and possibly persist throughout life. Our findings support the hypothesis that individual differences in trait anxiety predispose individuals towards negative cognitive outcomes and brain alterations, and potentially to stress related disorders. [ABSTRACT FROM AUTHOR]

This article provides an overview of critical theory, with a specific focus on the Frankfurt School and its impact on contemporary theory. The author highlights the diverse perspectives within the Frankfurt School and emphasizes that there was no unified approach among its members. They also discuss the changing context of theory formation and political intervention over the past century, suggesting that individuals should selectively adopt elements of critical theory that align with their own interests. The article concludes by examining current debates within critical theory, including its connection to social movements and its renewed focus on the critique of political economy. Additionally, the text acknowledges the historical Eurocentrism and anthropocentrism of critical theory, but argues that it contains resources that can be used to address issues such as colonialism, imperialism, and climate change. The author suggests that critical theory should engage in self-critique and challenge existing systems of domination. [Extracted from the article]

This study aimed to estimate the prevalence of possible cases of FH and analyze associated factors in the adult Brazilian population. Cross-sectional study with laboratory data from the Brazilian National Health Survey, with 8521 participants. Possible cases of FH were defined according to the Dutch Lipid Clinic Network criteria. The prevalence and 95% confidence intervals (95% CI) of possible cases of FH were estimated according to sociodemographic variables, lifestyle, diabetes, hypertension, altered tests, treatment and self-rated health. Logistic regression was used to analyze the associations. The prevalence of possible cases of FH was 0.96%, higher in women, between 45 and 59 years, white race/skin color and others, less education, people with diabetes, hypertension and total cholesterol ≥ 310 mg/dL. The presence of FH was positively associated with regular self-rated health (OR 1.96; 95% CI 0.99–3.84), poor/very poor (OR 3.02; 95% CI 1.30–7.03) and negatively with black race/skin color (OR 0.10; 95% CI 0.02–0.46) and complete elementary school, incomplete high school (OR 0.47; 95% CI 0.23–0.98) and complete high school and more (OR 0.45; 95% CI 0.21–0.95). FH affects 1:104 Brazilian adults, these findings contribute to understanding the burden of disease in Brazil. Due to the scarcity of studies on FH in low- and middle-income countries, further studies are desirable. [ABSTRACT FROM AUTHOR]

In mammals, O2 and CO2 levels are tightly regulated and are altered under various pathological conditions. While the molecular mechanisms that participate in O2 sensing are well characterized, little is known regarding the signaling pathways that participate in CO2 signaling and adaptation. Here, we show that CO2 levels control a distinct cellular transcriptional response that differs from mere pH changes. Unexpectedly, we discovered that CO2 regulates the expression of cholesterogenic genes in a SREBP2-dependent manner and modulates cellular cholesterol accumulation. Molecular dissection of the underlying mechanism suggests that CO2 triggers SREBP2 activation through changes in endoplasmic reticulum (ER) membrane cholesterol levels. Collectively, we propose that SREBP2 participates in CO2 signaling and that cellular cholesterol levels can be modulated by CO2 through SREBP2. In mammals, oxygen and carbon dioxide levels are tightly regulated and are altered under various pathological conditions, but little is known regarding the pathways involved in CO2 signaling and adaptation. This study provides new insight into the interaction between carbon dioxide, SREBP2 activation and regulation of cholesterol levels, suggesting that cellular cholesterol levels can be modulated by carbon dioxide through SREBP2. [ABSTRACT FROM AUTHOR]

Summary: In religious philosophy, the concept of karma represents the effect of one's past and present actions on one's future. Macrophages are highly plastic cells with myriad roles in health and disease. In the setting of cancer, macrophages are among the most plentiful members of the immune microenvironment where they generally support tumor growth and restrain antitumor immunity. However, macrophages are not necessarily born bad. Macrophages or their immediate progenitors, monocytes, are induced to traffic to the tumor microenvironment (TME) and during this process they are polarized toward a tumor‐promoting phenotype. Efforts to deplete or repolarize tumor‐associated macrophages (TAM) for therapeutic benefit in cancer have to date disappointed. By contrast, genetic engineering of macrophages followed by their transit into the TME may allow these impressionable cells to mend their ways. In this review, we summarize and discuss recent advances in the genetic engineering of macrophages for the treatment of cancer. [ABSTRACT FROM AUTHOR]

Sexual assault (SA) can induce a negative impact on victims' mental health. Specialised SA services generally offer medical care and a forensic examination to SA victims. However, there is a large variation in how these services provide mental health support. This study aims to assess mental health problems of SA victims attending the Belgian Sexual Assault Care Centres (SACCs) and identify predictors for victims' use of support from in-house psychologists. Health records of victims ≥ 16 years who presented within one week post-SA to one of the three Belgian SACCs between 25 October 2017 and 31 October 2019 were reviewed. An AIC-based stepwise backward binary logistic regression was used to analyse the association between victim, assault, service use and mental health characteristics and follow-up by a SACC-psychologist. Of the 555 victims, more than half had a history of mental health problems. Of those assessed, over 70% showed symptoms of posttraumatic stress disorder (PTSD), depression and/or anxiety disorder. One in two victims consulted a SACC-psychologist. Victims with a mental health history (OR 1.46, p =.04), victims accompanied by a support person during acute care (OR 1.51, p =.04), and victims who were assaulted by an acquaintance in comparison to those assaulted by a stranger (OR 1.60, p =.039) were more likely to attend their appointment with the SACC-psychologist. The study reaffirms the high mental health burden among victims attending specialised SA services, stressing the need to provide effective mental health interventions at these services and improve their longer-term use by victims. Prescheduling of appointments with an in-house psychologist in combination with phone reminders may improve the uptake of such services. Health care providers must be vigilant about potential barriers faced by victims without a mental health history or social support in attending appointments with mental health professionals. The mental health burden is high among victims attending Belgian Sexual Assault Care Centres. Half of the victims use the support of an in-house psychologist. Victims with a history of mental health problems, those accompanied by a support person during acute care, and those assaulted by an acquaintance in comparison to those assaulted by a stranger, are more likely to use this support. Effective mental health support should be recognised as an integral and essential part of care for SA victims. Uptake and longer-term engagement with this mental health support should be improved for those victims diagnosed with PTSD. [ABSTRACT FROM AUTHOR]

Acute bronchiolitis is a leading cause of hospitalization in infants. In this retrospective study, 645 patients with acute bronchiolitis diagnosed as respiratory syncytial virus (RSV; n = 538) or human metapneumovirus (HMPV; n = 107) were compared in terms of demographic, clinical, and laboratory findings. The HMPV patients presented later in the winter, were older (20 vs 7.55 months; P <.001)), had higher levels of C-reactive protein (4.55 vs 3.03 mg/dL; P =.007), and a higher prevalence of complications (43.9% vs 32.7%; P =.03). This study highlights the similarities and differences between these 2 common respiratory viral pathogens and shows that HMPV has a slightly more severe disease course than RSV. These findings can help guide approaches to these 2 common viruses that cause bronchiolitis. [ABSTRACT FROM AUTHOR]

Genetic engineering to block immune destruction of transplanted cells succeeds in macaques. [ABSTRACT FROM AUTHOR]

Ensuring the integrity of scientific literature is essential for advancing knowledge and research. However, the credibility and trustworthiness of scholarly publications are compromised by manipulated citations. Traditional methods, such as manual inspection and basic statistical analyses, have limitations in detecting intricate patterns and subtle manipulations of citations. In recent years, network-based approaches have emerged as promising techniques for identifying and understanding citation manipulation. This study introduces a novel method to identify potential citation manipulation in academic papers using perturbations of a deep embedding model. The key idea is to reconstruct meaningful connections represented by citations within a network by exploring, to some extent, longer alternative paths. These indirect pathways enable the recovery of reliable citations while estimating their trustworthiness. The investigation takes a comprehensive approach to link prediction, leveraging the consistent behavior of prominent connections when exposed to network perturbations. Through numerical experiments, the method demonstrates a high capability to identify reliable citations as the core of the analyzed data and to raise suspicions about unreliable references that may have been manipulated. This research presents a refined method for tackling the urgent problem of citation manipulation in academic papers. It harnesses statistical sampling and graph-embedding techniques to evaluate the credibility of scholarly publications with a substantial assessment of the whole citation graph. [ABSTRACT FROM AUTHOR]

Aspasia of Miletus (470? - 400?) is a figure whose history for us is nebulous and at the same time very clear. Nebulous because, as Marta Andrade (2022, p. 24) suggests, it is an existence, whose memory, like many others, posterity has rarely devoted attention or simply forgotten. But also clear because Aspasia has a persona constituted by what we call "tradition". Pericles' mistress. Socrates' teacher. Lysicles' wife. Her figure is often rescued in the shadow of the male figures with whom she was involved. Largely because the sources that rescue Aspasia mention her name in the margins, but also partly due to a methodological posture that sometimes ignores the names of women. In this article, I aim to resort to sources to bring out Aspasia's protagonism with regard to education and her pioneering rhetorical thoughts. In the first section, I will sketch a brief biography about the author, her political influence and her pedagogical skills. In the second section, I will deal especially with her contributions to rhetoric, addressing the speech attributed to her in Plato's Menexenus and the Funeral Oration attributed to Pericles by Thucydides. Finally, in the conclusion, in view of the theses developed, we will arrive at a more dignified image of Aspasia, glimpsing the portrait of a woman who pays tribute to courage and whose opinion directly affects her social and political body. In this way, we will better understand her advances in the pedagogical and rhetorical fields, seen as crucial for the development of Greek citizens. [ABSTRACT FROM AUTHOR]

Parental presence during invasive pediatric procedures is controversial, and its benefits are under-researched. The objective of this study was to assess the effects of parental presence during invasive procedures on the parents themselves and the physician performing the procedure. This prospective study was conducted at a single tertiary center in Jerusalem, Israel. During 10 shifts, all physicians and the families of patients who underwent invasive procedures in the pediatric emergency department (PED) were asked to fill in questionnaires related to their experiences. A total of 98 parental questionnaires and 101 physician questionnaires were collected. The most commonly performed procedures were laceration repair (65%) and abscess drainage (18%). Sedation was required in 75% of cases. In total, 73% of the cited family members were present during these procedures. The main reason for refusing to allow family members access was the physicians' concern that the procedure would be hard for parents to watch. However, in more than 85% of cases, the physicians felt that the presence of a family member contributed to the success of the procedure, augmented the child's sense of safety and lessened the family members' feelings of anxiety. All parents who opted to be present during the procedure felt very satisfied, compared to 67% of parents who were not present (p < 0.0001). When asked if, in retrospect, they would have made the same decision, 100% of the parents who were present during the procedure indicated that they would have made the same decision, compared to only 68% of the parents who were not present (p < 0.001). Overall, these findings highlight the positive effects of parental presence during invasive procedures performed in the PED, even when procedures were performed under sedation. Encouraging parental attendance during invasive procedures may, thus, enhance family-centered practices in the PED. [ABSTRACT FROM AUTHOR]

Background: Laparoscopic appendectomy (LA) is the standard treatment for acute appendicitis (AA) in general population. However, the safety of LA during pregnancy has remained a matter of debate. The purpose of this study was to compare surgical and obstetrical outcomes in pregnant women who underwent LA vs. open appendectomy (OA) for AA. We hypothesized that LA results in improved surgical and obstetric outcomes during pregnancy. Methods: Using a nationwide claim-based database in Estonia, a retrospective review of all cases of pregnant women undergoing OA or LA for AA from 2010 to 2020 was performed. Patient characteristics, surgical and obstetrical outcomes were analyzed. Primary outcomes were preterm delivery, fetal loss and perinatal mortality. Secondary outcomes included operative time, hospital length of stay (HLOS) and 30-day postoperative complications. Results: Overall, 102 patients were included of whom 68 (67%) underwent OA and 34 patients (33%) LA, respectively. Patients in LA cohort had a significantly shorter length of pregnancy in terms of gestational weeks when compared to OA cohort (12 weeks versus 17 weeks, p = 0.002). Most of the patients in their 3rd trimester pregnancy were subjected to OA. Operative time in LA cohort was shorter than in OA cohort (34 min. versus 44 min., p = 0.038). HLOS in LA cohort was shorter than in OA cohort (2.1 days versus 2.9 days, p = 0.016). There were no differences between OA and LA cohorts in terms of surgical complications or obstetrical outcomes. Conclusions: Laparoscopic appendectomy for acute appendicitis was associated with a significantly shorter operative time and a shorter hospital length of stay while open and laparoscopic appendectomy cohorts experienced comparable obstetrical outcomes. Our findings support the laparoscopic approach for acute appendicitis in pregnancy. [ABSTRACT FROM AUTHOR]

This paper presents a detailed review of the use of 87Sr/86Sr isotope systematics for wine provenance studies. The method is based on the principle that the Sr isotope ratio in wine reflects that of the labile fraction of the vineyard soil from which the wine is produced. The review encompasses 87Sr/86Sr data from wine samples published between 1993 and 2021 from terroirs in 22 different countries. The analytical procedures and techniques adopted by the different authors and the range of isotope ratios obtained in the different studies are discussed and evaluated. This study provides a bibliometric analysis of the 87Sr/86Sr isotope approach for wine authentication at different scales. Although limitations are evident when implemented at large (global) scales, we demonstrate that the 87Sr/86Sr isotope tracing technique remains a powerful and reliable tool for determining the geographical origin of wine when combined with detailed knowledge of the geological and soil characteristics of the substrata. For example, this combination of data allows the wines grown in the volcanic soils of Central and Southern Italy to be unambiguously fingerprinted. We present a detailed protocol for the application of the Sr isotope technique to wine authentication. [ABSTRACT FROM AUTHOR]

The construction of parents' cannabis use in the context of child protection has far‐reaching implications for how their parenting is perceived and assessed and for the decisions made regarding their children's lives. Yet little is known about the meanings various stakeholders in child protection processes attribute to parents' cannabis use. This paper aims to explore constructions of parents' cannabis use in child protection court proceedings and position them within a political and social context. A qualitative data mining method was used to examine 32 Family Court judgements in care proceedings that involved parents using cannabis in England and Wales. The analysis of the judgements revealed that most portrayed parents' cannabis use as a negative, deviant and harmful activity. Three constructions of cannabis use were identified: cannabis use as a risk to children, cannabis use as proof of parents' deficits, and cannabis use as (responsible) self‐medication. The discussion considers the findings in light of two social and political processes that underpin child protection policy and practice: the adoption of a risk perspective and the manifestation of othering processes. Implications for policy and practice highlight the importance of developing a critical framework for responding to parental cannabis use. [ABSTRACT FROM AUTHOR]

Objective: Rare coexistence of disease or pathology Background: Many patients experiencing acute coronary syndrome (ACS) present in cardiac arrest. Mechanical chest compressions are a common tool in cardiopulmonary resuscitation (CPR) and have their benefits as well as disadvantages and reported complications. In recent years, veno-arterial extracorporeal oxygenation membrane (VAECMO) has proven to be a promising tool in these circumstances and is now considered part of the treatment algorithm in emergent and refractory cases. The combination of mechanical compressions and the ECMO lead to "new" complicated situations in the patients. We discuss such a patient, who required emergent surgery due to complications from his resuscitation, while under ECMO. Case Report: A 56-year-old man, with medical history of cardiovascular risk factors, presented to our facility due to ST segment elevation myocardial infarction. During his catheterization, he went into cardiac arrest and needed cardiopulmonary resuscitation (CPR) using a LUCAS3™ device. Because no rhythm was restored, he was promptly placed on VA-ECMO support with immediate, albeit transient, stabilization. After transportation to our Intensive Care Unit (ICU), he quickly deteriorated again hemodynamically and after imaging workup it was discovered he had a major laceration to his liver and was rushed emergently to the operating room where he underwent partial hepatectomy, while on full anticoagulation due to the ECMO support. Conclusions: Complications from mechanical CPR are common, including liver laceration. Patients who are placed on ECMO following such measures should be carefully evaluated for such complications as they might affect the treatment and prognosis. [ABSTRACT FROM AUTHOR]

Biomolecular condensation processes are increasingly recognized as a fundamental mechanism that living cells use to organize biomolecules in time and space. These processes can lead to the formation of membraneless organelles that enable cells to perform distinct biochemical processes in controlled local environments, thereby supplying them with an additional degree of spatial control relative to that achieved by membrane-bound organelles. This fundamental importance of biomolecular condensation has motivated a quest to discover and understand the molecular mechanisms and determinants that drive and control this process. Within this molecular viewpoint, computational methods can provide a unique angle to studying biomolecular condensation processes by contributing the resolution and scale that are challenging to reach with experimental techniques alone. In this Review, we focus on three types of dry-lab approaches: theoretical methods, physics-driven simulations and data-driven machine learning methods. We review recent progress in using these tools for probing biomolecular condensation across all three fields and outline the key advantages and limitations of each of the approaches. We further discuss some of the key outstanding challenges that we foresee the community addressing next in order to develop a more complete picture of the molecular driving forces behind biomolecular condensation processes and their biological roles in health and disease. [ABSTRACT FROM AUTHOR]

Background: Blast-explosion may cause traumatic brain injury (TBI), leading to post-concussion syndrome (PCS). In studies on military personnel, PCS symptoms are highly similar to those occurring in post-traumatic stress disorder (PTSD), questioning the overlap between these syndromes. In the current study we assessed PCS and PTSD in civilians following exposure to rocket attacks. We hypothesized that PCS symptomatology and brain connectivity will be associated with the objective physical exposure, while PTSD symptomatology will be associated with the subjective mental experience. Methods: Two hundred eighty nine residents of explosion sites have participated in the current study. Participants completed self-report of PCS and PTSD. The association between objective and subjective factors of blast and clinical outcomes was assessed using multivariate analysis. White-matter (WM) alterations and cognitive abilities were assessed in a sub-group of participants (n = 46) and non-exposed controls (n = 16). Non-parametric analysis was used to compare connectivity and cognition between the groups. Results: Blast-exposed individuals reported higher PTSD and PCS symptomatology. Among exposed individuals, those who were directly exposed to blast, reported higher levels of subjective feeling of danger and presented WM hypoconnectivity. Cognitive abilities did not differ between groups. Several risk factors for the development of PCS and PTSD were identified. Conclusions: Civilians exposed to blast present higher PCS/PTSD symptomatology as well as WM hypoconnectivity. Although symptoms are sub-clinical, they might lead to the future development of a full-blown syndrome and should be considered carefully. The similarities between PCS and PTSD suggest that despite the different etiology, namely, the physical trauma in PCS and the emotional trauma in PTSD, these are not distinct syndromes, but rather represent a combined biopsychological disorder with a wide spectrum of behavioral, emotional, cognitive and neurological symptoms. [ABSTRACT FROM AUTHOR]

The objective of the present study was to explore differences between males and females on mindfulness, spirituality, and thriving. A sample of 202 young adults (18-25 years) was selected through the technique of convenience sampling. Method: Each participant filled out three questionnaires that contained questions from the Five Facets Mindfulness Questionnaire (FFMQ) by Baer et al. (2000); the Daily Spiritual Experiences Scale (DSES) by Underwood (2002); and the Comprehensive Inventory of Thriving (CIT) by Su et al. (2014). FFMQ measures mindfulness in people in five different domains. DSES takes into consideration normal daily activities and how they are connected to the spiritual experiences of individuals. CIT comprises of 18 other subscales assessing thriving in these areas. The mean and standard deviation of the sample were calculated on all main scales. SPSS was used to administer the t-test. Statistically significant differences emerged on the skills dimension of CIT, indicating males thrive more in this area; it was suggested through scores that women act with awareness and mean do not react to internal experiences on the scale of FFMQ. DSES revealed that males experience spirituality more than females. This study has implications for planning intervention programs for the positive growth of individuals respective to their gender, aiming at improving psychological health. [ABSTRACT FROM AUTHOR]

Immune checkpoint inhibitors are increasingly used in combination with chemotherapy for the treatment of non-small cell lung cancer, yet the success of combination therapies is relatively limited. Thus, more detailed insight regarding the tumor molecular markers that may affect the responsiveness of patients to therapy is required. Here, we set out to explore the proteome of two lung adenocarcinoma cell lines (HCC-44 and A549) treated with cisplatin, pemetrexed, durvalumab, and the corresponding mixtures to establish the differences in post-treatment protein expression that can serve as markers of chemosensitivity or resistance. The mass spectrometry study showed that the addition of durvalumab to the treatment mixture resulted in cell line- and chemotherapeutic agent-dependent responses and confirmed the previously reported involvement of DNA repair machinery in the potentiation of the chemotherapy effect. Further validation using immunofluorescence also indicated that the potentiating effect of durvalumab in the case of cisplatin treatment was dependent on the tumor suppressor RB-1 in the PD-L1 weakly positive cells. In addition, we identified aldehyde dehydrogenase ALDH1A3 as the general putative resistance marker. Further studies in patient biopsy samples will be required to confirm the clinical significance of these findings. [ABSTRACT FROM AUTHOR]

Drawing on retrospective data from the Estonian Family and Fertility Survey, this article examines the impact of grandfathers, who reached adulthood in the Estonian Republic before World War II, on their grandchildren's educational attainment in the late Soviet and post-Soviet Estonia. The article argues that despite the Sovietization policies, the high social position of grandfathers had a positive effect on their grandchildren's educational attainment, net of parental education and resources. Our results show that the multiplication effect (i.e. the advantage of having highly educated parents is strengthened by grandparents' resources) prevails over the compensatory one (i.e. the use of advantageous grandparents' resources to overcome shortage of parental resources), suggesting that social hierarchies and advantages of the pre-Soviet period contribute to the overall and increasing intergenerational inequality in the late Soviet and post-Soviet Estonian society. This conclusion is also supported by finding that respondents with persistently high (across two familial generations and political regimes) social background have the highest probability to attain higher education, while offspring of parents characterized by the loss of grandparents' high pre-WWII status has very low (and practically non-different from that of descendants of persistently low social background) probability to attain higher education. [ABSTRACT FROM AUTHOR]

Summary: Whereas some studies have addressed the conditions and practices required to infuse critical notions into the organizational context of public social services, there is a paucity of knowledge on what a critical public service can look like in actual practice. This article explores the possibility of applying critical theory and practice at the organizational level of public social services. It focuses on one social services department in Israel that underwent a six-year process of learning and implementing the Poverty-Aware Paradigm. Findings: Based on an in-depth case study that combines ethnographic and participatory methods, we outline how critical ideas are translated to four organizational principles: developing a critical learning culture, acknowledging services users' knowledge and skills, leading a critical discourse in the community, and poverty-proofing services and allocating resources to tackle poverty. Each of these principles is presented with derivative organizational practices and a detailed account of their implementation. Applications: By broadening the framing of critical practice as an individual, street-level endeavor, the findings offer policymakers and public social services professionals an organizational model that mitigates the negative consequences of current neoliberal and managerial policies around the world. [ABSTRACT FROM AUTHOR]

We propose a new three-dimensional (3D) perfusion zone algorithm to plan selective clamping during partial nephrectomies. The study shows that the algorithm is sufficiently accurate in 92% of the cases. Multicentric validation should assess its value compared with 3D models only. Selective clamping during robot-assisted partial nephrectomy (RAPN) requires extensive knowledge on patient-specific renal vasculature, obtained through imaging. To validate an in-house developed perfusion zone algorithm that provides patient-specific three-dimensional (3D) renal perfusion information. Between October 2020 and June 2022, 25 patients undergoing RAPN at Ghent University Hospital were included. Three-dimensional models, based on preoperative computed tomography (CT) scans, showed the clamped artery's ischemic zone, as calculated by the algorithm. All patients underwent selective clamping during RAPN. Indocyanine green (ICG) was administered to visualize the true ischemic zone perioperatively. Surgery was recorded for a postoperative analysis. The true ischemic zone of the clamped artery was compared with the ischemic zone predicted by the algorithm through two metrics: (1) total ischemic zone overlap and (2) tumor ischemic zone overlap. Six urologists assessed metric 1; metric 2 was assessed objectively by the authors. In 92% of the cases, the algorithm was sufficiently accurate to plan a selective clamping strategy. Metric 1 showed an average score of 4.28 out of 5. Metric 2 showed an average score of 4.14 out of 5. A first limitation is that ICG can be evaluated only at the kidney surface. A second limitation is that mainly patients with impaired renal function are expected to benefit from this technology, but contrast-enhanced CT is required at present. The proposed new tool demonstrated high accuracy when planning selective clamping for RAPN. A follow-up prospective study is needed to determine the tool's clinical added value. In partial nephrectomy, the surgeon has no information on which specific arterial branches perfuse the kidney tumor. We developed a surgeon support system that visualizes the perfusion zones of all arteries on a three-dimensional model and indicates the correct arteries to clamp. In this study, we validate this tool. [ABSTRACT FROM AUTHOR]

• Spread of human β-amyloid protein from olfactory epithelium to the olfactory bulb in OMP-hAPP mice. • Reduced olfactory bulb volume in OMP-hAPP mice due to APP-mediated disruption of development. • Progressive accumulation of human β-amyloid protein in the piriform cortex and hippocampus of OMP-hAPP mice. • β-amyloid deposition was not accompanied by regional atrophy in OMP-hAPP mice. Years before Alzheimer's disease (AD) is diagnosed, patients experience an impaired sense of smell, and β-amyloid plaques accumulate within the olfactory mucosa and olfactory bulb (OB). The olfactory vector hypothesis proposes that external agents cause β-amyloid to aggregate and spread from the OB to connected downstream brain regions. To reproduce the slow accumulation of β-amyloid that occurs in human AD, we investigated the progressive accumulation of β-amyloid across the brain using a conditional mouse model that overexpresses a humanized mutant form of the amyloid precursor protein (hAPP) in olfactory sensory neurons. Using design-based stereology, we show the progressive accumulation of β-amyloid plaques within the OB and cortical olfactory regions with age. We also observe reduced OB volumes in these mice when hAPP expression begins prior-to but not post-weaning which we tracked using manganese-enhanced MRI. We therefore conclude that the reduced OB volume does not represent progressive degeneration but rather disrupted OB development. Overall, our data demonstrate that hAPP expression in the olfactory epithelium can lead to the accumulation and spread of β-amyloid through the olfactory system into the hippocampus, consistent with an olfactory system role in the early stages of β-amyloid-related AD progression. [ABSTRACT FROM AUTHOR]

Objective: Studies of Australian health workforce demographics tend to be limited to single professions, a set geographic area, or based on incomplete data. This study aims to comprehensively describe changes to the demographic characteristics of Australia's regulated health professions over 6 years. Methods: Data were sourced from the Australian Health Practitioner Regulation Agency (Ahpra) registration database, and a retrospective analysis of 15 of the 16 regulated health professions between 1 July 2015 and 30 June 2021 was conducted. Variables including profession, age, gender and state/territory locations for the practitioners' principal places of practice were analysed descriptively and via appropriate statistical tests. Results: Changes in age, gender representation, and place of practice varied significantly and in different ways across the 15 professions. The total number of registered health practitioners increased by 141 161 (22%) from 2016 to 2021. The number of registered health practitioners per 100 000 population increased by 14% from 2016, with considerable variation across the professions. In 2021, women accounted for 76.3% of health practitioners across the 15 health professions, a significant increase of 0.5% points since 2016. Conclusions: Changes to demographics, especially in ageing workforces and feminising professions, can have implications for workforce planning and sustainability. Future research could build on this demographic trend data by investigating causes or undertaking workforce supply or demand modelling. What is known about the topic? Several studies have demonstrated changes in the demography of the Australian health workforce, they tend to focus on individual professions, prescribed geographic areas, or are based on data that are dated or incomplete. What does this paper add? This study presents a national picture of 15 regulated health professions' demographic changes in Australia across a 6-year period and allows for comparisons between professions. What are the implications for practitioners? Future research could build on this demographic trend data by investigating causes or undertaking workforce supply or demand modelling. [ABSTRACT FROM AUTHOR]

Objective: One explanation for the relationship between TV viewing and obesity is that people may (over)eat while watching TV. The current study investigated associations between TV viewing and the time spent on (concurrent) eating in a naturalistic setting among a general population sample. Design: Preregistered secondary data analyses were performed of a diary survey in which respondents reported their time use in 10-min blocks for 7 d. Setting: Concurrent TV viewing and eating was operationalised as all blocks in which TV viewing and eating occurred simultaneously. Furthermore, the TV content respondents watched was coded as food-related (i.e. culinary content) or non-food related. Participants: The sample composed of 2292 adults (58·9 % female) in the Netherlands, aged ≥ 20 years, from all educational levels (18·1 % low, 29·8 % middle and 51·4 % high). Results: More than half of the respondents (51·3 %) reported concurrent TV viewing and eating at least once during the 7-d diary period. The average eating occasion was longer in duration while watching TV (v. without media use), and the total time spent on eating was longer on days of concurrent TV viewing and eating (v. days of eating without media use). The percentage of TV viewing time spent on concurrent eating did not differ between food-related and non-food-related TV content. Conclusions: Eating while watching TV was related to an increased time spent on eating. Even though energy intake was not assessed, these findings from a naturalistic setting provide further evidence that concurrent TV viewing and eating may contribute to overeating. [ABSTRACT FROM AUTHOR]