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We define new analytic mixed norm spaces and integral operators in tube domains extending known spaces and operators in two directions. We provide new results on Bergman type projections in products of tubular domains over symmetric cones extending some known classical assertions. Very similar results with the same proofs may be valid in bounded strongly pseudoconvex with smooth boundary, in bounded symmetric domains and also in Siegel domains. [ABSTRACT FROM AUTHOR]

We obtain some new uniform estimates and maximal theorems in classical Hardy spaces in the unit disk related with Bergman pro jection extending some previously well-known inequalities for Hardy spaces. [ABSTRACT FROM AUTHOR]

We introduce new general spaces of subharmonic functions in the unit disk and prove some new parametric representation results for them expanding some previously known assertions. [ABSTRACT FROM AUTHOR]

We provide some new estimates and new sharp assertions for Trace operator related with embeddings in multifunctional holomorphic Herz and Bergman spaces. We note that one integral condition in Herz spaces on kernel in bounded pseudoconvex domains in Cn can be removed in the unit ball case. Some results are new even in case of holomorphic spaces of one functions. Related new sharp results with same proofs will be provided also in unbounded tubular domains over symmetric cones. [ABSTRACT FROM AUTHOR]

Although the measurement of liquids temperature is commonly used by Fiber Bragg Grating (FBG) sensor but its thermodynamic performance has interesting phenomena. This paper proposes the measurement and simulation of liquids temperature using FBG. Laser diode was launched into human blood, water, and vegetable oil, then transmitted power is measured by optical powermeter to determine its corresponding temperature. The results showed that the increasing temperature changes led to the widening of the wave shift. The largest change of wavelength is water temperature and the smallest One is vegetable oil temperature. Increase in liquid temperature causes the output power is greater. FBG simulation of sine and square function are also designed for temperature range of 30 °C to 41 °C with matrix transfer method based on coupled mode theory. Peak value of transmission spectrum of each function is shown by the change of temperature which indicates the sensor is sensitive to sine and square function variations. The peak at temperature of 30°C for each sine and square are -78.32 dB and -102.66 dB and increased to 41 °C at 46.72 dB and -79.89 dB, respectively. [ABSTRACT FROM AUTHOR]

We introduce new mixed norm analytic spaces in products of tubular domains over symmetric cones and provide new sharp embedding the-orems for them extending previously known assertions in tubular domain over symmetric cone and polydisk simultaniously. Our results extend some recent theorems of Sehba, Nana and Shamoyan in tube domain and polydisk simul-taneously. [ABSTRACT FROM AUTHOR]

We introduce new mixed norm analytic spaces in products of tubular domains over symmetric cones and provide new sharp embedding theorems for them extending previously known assertions in tubular domain over symmetric cone and polydisk simultaniously. Our proofs are heavily based on properties of recently developed r-lattices in tubular domains over symmetric cones. [ABSTRACT FROM AUTHOR]

We introduce mixed norm analytic spaces in products of strongly pseudoconvex domains and provide new sharp embedding theorems for them extending previously known assertions. [ABSTRACT FROM AUTHOR]

Objectives To investigate long-term outcome in patients with spontaneous spinal cord infarctions and secondly to compare outcome with that of patients with cerebral infarction. Material and methods The study includes 30 patients with spinal cord infarction discharged between 1995 and 2010. Surviving patients were contacted by telephone and sent a questionnaire. Data on employment, function, depression, fatigue, pain, and quality of life were obtained and compared to similar data obtained from a group of patients with cerebral infarction. Results Seven patients with spinal cord infarction had died after a mean follow-up of 7.1 years. Mortality was associated with poor functioning in the acute phase. Thirteen of 20 responding patients were able to walk. Compared to patients with cerebral infarction, patients with spinal cord infarction had significantly lower mortality, poorer functioning, higher re-employment rate, and more pain. Conclusion Many patients with spinal cord infarction experience significant improvement. Even though functional outcome is worse, the mortality rate is lower and the frequency of re-employment higher among patients with spinal cord infarction compared to patients with cerebral infarction. [ABSTRACT FROM AUTHOR]

New sharp estimates of traces of Bergman type spaces of analytic functions in bounded strictly pseudoconvex domains are obtained. These are, as far as we know, the first results of this type which are valid for any bounded strictly pseudoconvex domains with smooth boundary. [ABSTRACT FROM AUTHOR]

Based on recent results on boundedness of Bergman projection with positive Bergman kernel in analytic spaces in various types of domains in ℂn, we extend our previous sharp results on distances obtained for analytic Bergman type spaces in unit disk to some new Bergman type spaces in Lie ball, bounded symmetric domains of tube type, Siegel domains, and minimal bounded homogeneous domains. [ABSTRACT FROM AUTHOR]

We extend our previous sharp results on distances obtained for analytic Bergman type spaces in unit disk to some new analytic Bergman type spaces in higher dimensions in ℂn. Also, we study the same problem in anisotropic mixed norm h(p, q, s) spaces consisting of n-harmonic functions on the unit polydisc of ℂn. [ABSTRACT FROM AUTHOR]

We prove new projection theorems involving certain Hardy-Lorentz analytic function spaces based on Lorentz classes on the unit circle which are related to p-Carleson type measures. We also study the action of fractional derivative in related analytic spaces in the unit disk partially extending previously known assertions. [ABSTRACT FROM AUTHOR]

New sharp estimates concerning distance function in certain Bergman -type spaces of analytic functions in a certain Siegel domain of first type are obtained. Related sharp new estimates for more general Siegel domains of second type are also provided. For Siegel domains of second type in Cn these are the first results of this type. [ABSTRACT FROM AUTHOR]

We give solutions to some extremal problems involving distance function in mixed normed spaces of harmonic functions on the unit ball in Rn. [ABSTRACT FROM AUTHOR]

In this paper, we introduce new Qp type spaces and mixed norm analytic function spaces on polyballs and describe completely their traces on unit ball. Also, we provide complete descriptions for analytic Bergman classes in the polyhalfplane. [ABSTRACT FROM AUTHOR]

In this article we obtain the atomic decomposition for multifunctional weighted Bergman spaces and multifunctional Bloch spaces. Also we get some new estimates for various multifunctional expressions extending the known ones. [ABSTRACT FROM AUTHOR]

In this paper we completely describe traces of holomorphic Bergman classes and Bloch-type classes on polyballs and obtain related estimates generalizing classical Bergman projection theorem. [ABSTRACT FROM AUTHOR]

We introduce and study new analytic classes on subframe and expanded disk and give complete description of their traces on the unit disk. Sharp embedding theorems and various new estimates concerning differential Rs operator in polydisk also will be presented. Practically all our results were known or obvious in the unit disk. [ABSTRACT FROM AUTHOR]

Paraneoplastic myasthenia gravis (MG) is accompanied by a neoplasm, usually thymoma. In patients with thymoma and a specific genetic make-up, the paraneoplastic immune response develops further in thymic remnant or peripheral lymphatic tissue. Paraneoplastic MG and late-onset MG (age ≥ 50 years) share a similar immunological profile with high titin and ryanodine receptor (RyR) antibody prevalence. This profile is the most important predictor of clinical outcome in paraneoplastic MG. The presence of a thymoma per se does not cause more severe MG. MG severity is linked to the patient’s immunological profile. Paraneoplastic MG causes a distinctive non-limb symptom profile at MG onset, characterized by bulbar, ocular, neck, and respiratory symptoms. When the diagnosis of paraneoplastic MG is established, the neoplasm should be removed surgically. Pre-thymectomy plasmapheresis or iv-IgG should be considered in these patients to minimize post-thymectomy MG exacerbation risk. Paraneoplastic MG usually continues after thymectomy. The pharmacological treatment of paraneoplastic MG does not differ from non-paraneoplastic MG, except for tacrolimus that should be considered in difficult cases. Tacrolimus is an immunosuppressant acting specifically in RyR antibody positive patients through enhancing RyR-related sarcoplasmic calcium release that in theory might be blocked by RyR antibodies, causing symptomatic relief in paraneoplastic MG. [ABSTRACT FROM AUTHOR]

Myasthenia gravis (MG) is an autoimmune disease caused in 85% of the patients by acetylcholine receptor (AChR) antibodies. Non-AChR muscle antibodies, against titin and ryanodine receptor (RyR) are mainly found in sera of patients with thymoma or late-onset MG. The occurrence of RyR antibodies increases the risk for severe MG and should lead to active immunomodulating treatment already at MG onset. The aim in this study was to describe the association between symptoms at MG onset and antibody profile in 152 patients. Patients with RyR antibodies had the highest rate of bulbar, respiratory and neck involvement at MG onset. They also had the highest frequency of non-limb MG symptoms. Neck weakness occurred in 40%. Respiratory difficulties at MG onset occurred in patients with titin antibodies, with and without RyR antibodies. Patients with RyR antibodies have a distinctive non-limb MG symptom profile, with bulbar, ocular, neck, and respiratory symptoms. These features, identified as early as at the first examination by a neurologist, characterize the RyR antibody positive subgroup at MG onset. [ABSTRACT FROM AUTHOR]

Around 10–20% of myasthenia gravis (MG) patients do not have acetylcholine receptor (AChR) antibodies (seronegative), of whom some have antibodies to a membrane-linked muscle specific kinase (MuSK). To examine MG severity and long-term prognosis in seronegative MG compared with seropositive MG, and to look specifically at anti-AChR antibody negative and anti-MuSK antibody negative patients. Seventeen consecutive seronegative non-thymomatous MG patients and 34 age and sex matched contemporary seropositive non-thymomatous MG controls were included in a retrospective follow-up study for a total period of 40 years. Clinical criteria were assessed each year, and muscle antibodies were assayed. There was no difference in MG severity between seronegative and seropositive MG. However, when thymectomized patients were excluded from the study at the year of thymectomy, seropositive MG patients had more severe course than seronegative (P < 0.001). One seropositive patient died from MG related respiratory insufficiency. The need for thymectomy in seronegative MG was lower than in seropositive MG. None of the seronegative patients had MuSK antibodies. This study shows that the presence of AChR antibodies in MG patients correlates with a more severe MG. With proper treatment, especially early thymectomy for seropositive MG, the outcome and long-term prognosis is good in patients with and without AChR antibodies. [ABSTRACT FROM AUTHOR]

Romi F, Gilhus NE, Aarli JA. Myasthenia gravis: clinical, immunological, and therapeutic advances.Acta Neurol Scand 2005: 111: 134–141.© Blackwell Munksgaard 2005.We give an update on clinical, immunological, and therapeutic advances in the field of myasthenia gravis, including a summary of suggested therapeutic recommendations. [ABSTRACT FROM AUTHOR]

Thymomas occurring in myasthenia gravis (MG) are usually of the cortical subtype and are usually treated by thymectomy. However, the factors that influence MG outcome in thymoma MG patients are not known. In a long-term study, MG severity and treatment was observed in 24 thymoma and 24 non-thymoma MG patients for up to 30 years, and the occurrence of muscle autoantibodies was assayed. The rate of complete stable remission was low and did not differ between the two groups. There was no significant difference in MG severity between thymoma and non-thymoma MG patients at any time during the study. Titin and ryanodine receptor (RyR) antibody occurrence was significantly higher in thymoma MG patients. Four thymoma (all titin and RyR antibody positive) and two non-thymoma (both titin and one RyR antibody positive) MG patients died from MG-related respiratory insufficiency. Seventy percent of thymoma and 75% of non-thymoma MG patients were treated with immunosuppressive drugs. The number of patients who received plasmapheresis did not differ in those who were treated because of acute MG deterioration, irrespective of planned surgery .This study shows equal MG severity and outcome in thymoma and non-thymoma MG, but the presence of RyR antibodies in thymoma MG and titin/RyR in non-thymoma MG indicates a less favorable prognosis. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical effect of thymectomy in a well-defined early-onset MG subgroup and to correlate it to MG severity, the presence of circulating muscle autoantibodies, and the need for pharmacological treatment in a long-term setting. Methods: Fifty-two consecutive AChR antibody-positive early-onset MG patients (34 thymectomized and 18 nonthymectomized) were included. Severity was assessed and the pharmacological treatment monitored on a yearly basis, starting from the year of MG onset, for 5, 10, 15, and 20 consecutive years; AChR, titin, and RyR antibodies were assayed. Results: In the four follow-up groups, MG severity was significantly higher in nonthymectomized compared to thymectomized MG patients. The postthymectomy MG improvement was significant and persistent. There were 21/34 remissions in thymectomized patients and only 4/18 in the nonthymectomized group. Patients with initially high or low AChR antibody concentration had a similar thymectomy outcome. Only 6 patients had titin antibodies, and none had RyR antibodies. Conclusion: The present study indicates a benefit of thymectomy in early-onset MG. The muscle autoantibody concentration does not influence the outcome of thymectomy in early-onset MG.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Thymectomy is still widely carried out in myasthenia gravis (MG) patients, but its role, especially in late-onset MG patients, is not established. These patients are immunologically heterogeneous, some with thymoma-like and others with early onset-like features. We evaluated whether any therapeutic effects of thymectomy correlate with the presence of non-acetylcholine receptor (AChR) muscle antibodies. The severity of MG, and titin and ryanodine receptor (RyR) antibodies, were assessed yearly starting from MG onset in 21 thymectomized and 22 non-thymectomized AChR antibody positive late-onset MG patients, who were followed for 2, 3 and 5 years. Clinical or pharmacological remission were seen in six of 11 titin antibody negative but none of the 10 titin antibody positive thymectomized patients, however, the non-thymectomized cases showed an opposite trend. The three MG-related deaths were all in patients with titin antibodies. There was no significant difference in MG severity between thymectomized and non-thymectomized patients; 2 years after MG onset, both groups were significantly improved. This study showed no dramatic benefit from thymectomy in late-onset MG in general. Any limited improvement appeared less likely in cases with titin and/or RyR antibodies. [ABSTRACT FROM AUTHOR]

Objectives – To examine myesthenia gravis (MG) severity and long-term prognosis in seronegative, seropositive, and thymoma MG. Materials and Methods – Four series of patients were studied retrospectively. Severity and treatment were assessed each year, and muscle antibodies were assayed. Results – Seropositive MG patients had a more severe course than seronegative MG patients. MG severity was higher in non-thymectomized compared to thymectomized early-onset MG patients. MG severity did not differ between thymectomized and non-thymectomized late-onset patients. There was no significant difference in MG severity between thymoma and non-thymoma MG patients. Conclusions – MG is more severe in seropositive MG patients. With proper treatment, especially early thymectomy, the long-term prognosis is good in seropositive MG patients. The present studies indicate a benefit of thymectomy in early-onset MG, but no dramatic benefit in late-onset MG. Similar MG severity and outcome was seen in thymoma and non-thymoma MG. [ABSTRACT FROM AUTHOR]

Presents a case study of an aged man who developed neuroborrelioses with vasculitis, an infection of the nervous system caused by spirochetes belonging to Borrelia burgdorferi. Clinical manifestations of the disease; Medical history of the patient; Treatment administered to the patient.

Objectives: Myasthenia gravis (MG) represents a spectrum of clinical subtypes with differences in disease mechanisms and treatment response. MG with muscle‐specific tyrosine kinase (MuSK) antibodies accounts for 1%‐10% of all MG patients. We conducted a meta‐analysis to evaluate the association between HLA genes and MuSK‐MG susceptibility. Subjects and methods: Studies were searched in Pubmed, EMBASE database and other sources between 2001 and 2018. Genotype, allele and haplotype frequencies of HLA loci in MuSK‐MG patients and healthy controls were extracted from each included study. Results: The meta‐analysis showed that HLA DQB1*05, DRB1*14 and DRB1*16 were strongly associated with an increased risk of MuSK‐MG (P < .0001), whereas HLA DQB*03 was less frequent in MuSK patients compared with healthy controls (P < .05). Haplotype analysis showed that these DQB1 and DRB1 alleles were closely linked, forming both risk (DQ5‐DR14, DQ5‐DR16, P < .0001) and protective (DQ3‐DR4, DQ3‐DR11, P < .05) haplotypes. Conclusion: The distinct genetic patterns of MuSK‐MG indicate that variation in HLA class II genes plays an important role in the pathogenesis of MuSK‐MG patients. [ABSTRACT FROM AUTHOR]

Background and purpose Myasthenia gravis ( MG) is an autoimmune disease caused by antibody mediated impairment in the neuromuscular junction. Seronegative MG ( SNMG) without antibodies against acetylcholine receptor ( AChR) and muscle-specific kinase (Mu SK) by routine assays accounts for about 20% of all MG patients. Methods Plasma from 81 Chinese MG patients previously found to be seronegative was tested by routine assays for AChR and Mu SK antibodies. These samples were screened by (i) a novel, highly sensitive radioimmunoassay for AChR antibodies; (ii) cell-based assays for clustered AChR, Mu SK and lipoprotein receptor-related protein 4 ( LRP4) antibodies; (iii) a radioimmunoassay for titin antibodies. Results Antibodies to AChR, Mu SK, LRP4 and titin were found in 25% (20/81), 4% (3/81), 7% (6/81) and 6% (5/78) of SNMG patients, respectively. In total, 37% of SNMG patients were found to be positive for at least one of the tested antibodies. AChR antibody positive patients had more severe disease ( P = 0.008) and a trend towards fewer remissions/minimal manifestations than AChR antibody negative patients. The four patients with coexistence of antibodies had more severe disease, whilst the seronegative patients had milder MG ( P = 0.015). Conclusions Detection of multiple muscle antibodies by more sensitive assays provides additional information in diagnosing and subgrouping of MG and may guide MG treatment. [ABSTRACT FROM AUTHOR]