1. Use of Nicergoline as Adjunctive Treatment of Neurotrophic Keratitis in Routine Clinical Practice: A Case Series.
- Author
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Miguel-Escuder, L., Rocha-de-Lossada, C., Sabater-Cruz, N., Sánchez-González, José-María, Spencer, F., Marín-Martínez, S., Batlle-Ferrando, S., Carreras Castañer, X., Torras, J., and Peraza-Nieves, J.
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KERATITIS , *PATIENT safety , *CORNEA , *HEALING ,CORNEAL ulcer - Abstract
To describe the effectiveness and safety of nicergoline in patients with epithelial corneal defect or corneal ulcer due to neurotrophic keratitis (NK). A prospective case series review was performed in 14 patients with NK who started treatment with nicergoline as an off-label prescription from January to November 2020. Patients with a epithelial defect or corneal ulcer due to NK were treated with oral nicergoline. Complete corneal healing was observed in 10 (71.4%) of the 14 patients after 25.6 ± 26.60 days (range 7–90) with nicergoline. In three (21.5%) patients wound healing was not achieved, and one patient (7.1%) was lost to follow-up. The mean time between diagnosis and the starting of nicergoline was 10.92 ± 8.85 days (0–28). No adverse effects of nicergoline were observed. Nicergoline as an adjunctive treatment for NK showed a potential use in the healing of epithelial defect in real-life clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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