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15 renal dialysis patients have been identified with a skin condition characterised by tickening and hardening of the skin of the extremities and an increase in dermal fibroblast- like cells associated with collagen remodelling and mucin deposition. The disease closely resembles scleromyxoedema, yet has significant enough clinical and histopathological differences to warrant its designation as a new clinicopathological entity. [ABSTRACT FROM AUTHOR]

A 69-year-old man presented with a malignant gastrointestinal stromal tumor associated with secondary amyloidosis. The tumor had classic features of a malignant gastrointestinal stromal tumor with interlacing fascicles and whorls of spindled cells, numerous and conspicuous mitotic figures, and extensive coagulative necrosis. The cells stained diffusely for CD117 (c-Kit), confirming the diagnosis of gastrointestinal stromal tumor. The spleen, 1 adrenal gland, and part of the pancreas were removed en block with the stomach. By microscopy, the spleen and adrenal gland were partially replaced with amyloid deposits confirmed by Congo red staining, electron microscopy, and immunohistochemistry. In contrast, neither the tumor nor the surrounding vasculature showed amyloid deposition. To our knowledge, this represents only the second case of systemic amyloidosis associated with a gastrointestinal stromal tumor. This case is unique in that extensive, diffuse amyloid deposits were observed in the spleen, adrenal gland, and liver. [ABSTRACT FROM AUTHOR]

Presents a case of hypersensitivity and pulmonary vasculitis associated with eosinophilia in a patient taking an L-tryptophan preparation. Cause of the eosinophilia-myalgia syndrome; Phatogenesis of a peripheral eosinophilia with pneumonitis; Factor which could contribute to a decrease in the incidence of the syndrome.