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1. Temporary contraindication to chemotherapy due to toxicity: blinatumomab's effectiveness in paediatric patients with B‐acute lymphoblastic leukaemia.

Author

Collignon, C., Domenech, C., Ducassou, S., Pluchart, C., Bruno, B., Pasquet, M., Simon, P., Petit, A., Rialland‐Battisti, F., and Brethon, B.

Subjects
*CHILD patients, *LYMPHOBLASTIC leukemia, *HEMATOPOIETIC stem cell transplantation
Abstract

Another patient had an interruption of the treatment with blinatumomab because of hyperammonemia on the second cycle, but this patient had a portocaval shunt. Only one other patient had blast after treatment with blinatumomab, but this patient did not have myelogram before treatment with blinatumomab and had a prolonged interruption of treatment. Only one patient had >5% medullary blasts, 15 patients (65%) had negative MRD and 7 (30%) patients had detectable MRD. [Extracted from the article]

Published
2023
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