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Background: Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores the association between PFAS exposure and RA prevalence. Methods: This research utilized data from the NHANES, encompassing a sample of 10,496 adults from the 2003–2018 cycles, focusing on serum levels of several PFAS. The presence of RA was determined based on self-reports. This study used multivariable logistic regression to assess the relationship between individual PFAS and RA risk, adjusting for covariates to calculate odds ratios (ORs). The combined effects of PFAS mixtures were evaluated using BKMR, WQS regression, and quantile g-computation. Additionally, sex-specific associations were explored through stratified analysis. Results: Higher serum PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS (OR = 0.91, 95% CI: 0.83, 1.00), PFNA (OR = 0.87, 95% CI: 0.77, 0.98), and PFDA (OR = 0.89, 95% CI: 0.81, 0.99) concentration was related to lower odds of RA. Sex-specific analysis in single chemical models indicated the significant inverse associations were only evident in females. BKMR did not show an obvious pattern of RA estimates across PFAS mixture. The outcomes of sex-stratified quantile g-computation demonstrated that an increase in PFAS mixture was associated with a decreased odds of RA in females (OR: 0.76, 95% CI: 0.62, 0.92). We identified a significant interaction term of the WQS*sex in the 100 repeated hold out WQS analysis. Notably, a higher concentration of the PFAS mixture was significantly associated with reduced odds of RA in females (mean OR = 0.93, 95% CI: 0.88, 0.98). Conclusions: This study indicates potential sex-specific associations of exposure to various individual PFAS and their mixtures with RA. Notably, the observed inverse relationships were statistically significant in females but not in males. These findings contribute to the growing body of evidence indicating that PFAS may have immunosuppressive effects. [ABSTRACT FROM AUTHOR]

Hypertensive disorders of pregnancy (HDP), including gestational hypertension (GH) and preeclampsia (PE), cause significant morbidity and mortality among pregnant women. Several environmental toxins, particularly those that affect the normal function of the placenta and the endothelium, are emerging as potential risk factors for HDP. Among them, per- and polyfluoroalkyl substances (PFAS), widely used in a variety of commercial products, have been related to a variety of adverse health effects including HDP. This study was conducted by searching three databases for observational studies reporting associations between PFAS and HDP, all of which were published before December 2022. We used random-effects meta-analysis to calculate pooled risk estimates, and assessing each combination of exposure and outcome for quality and level of evidence. In total, 15 studies were included in the systematic review and meta-analysis. The results from meta-analyses showed that risk of PE was increased with exposure to PFOA (perfluorooctanoic acid) (RR = 1.39, 95% CI = 1.05, 1.85; N = 6 studies; exposure = 1 ln-unit increment; low certainty), PFOS (perfluorooctane sulfonate) (RR = 1.51, 95% CI = 1.23, 1.86; N = 6 studies; exposure = 1 ln-unit increment; moderate certainty), and PFHxS (perfluorohexane sulfonate) (RR = 1.39, 95% CI = 1.10, 1.76; N = 6 studies; exposure = 1 ln-unit increment; low certainty). PFOS was also associated with an increased risk of HDP (RR = 1.39, 95% CI = 1.10, 1.76; exposure = 1 ln-unit increment; low certainty). Exposure to legacy PFAS (PFOA, PFOS, PFHxS) is associated with an increased risk of PE, and PFOS is further associated with HDP. In view of the limitations of meta-analysis and quality of evidence, these findings should be interpreted with caution. Further research is required that assesses exposure to multiple PFAS in diverse and well-powered cohorts. • Exposure to per- and polyfluoroalkyl substances (PFAS) potentially linked to hypertensive disorders of pregnancy (HDP). • Comprehensive meta-analysis examining the association between PFAS exposure and HDP. • Legacy PFAS (PFOA, PFOS, PFHxS) exposure found to increase the risk of pre-eclampsia. • Perfluorooctane sulfonate (PFOS) exposure associated with elevated risk of HDP. • Further research is needed to explore the mechanisms and strengthen the evidence of these associations. [ABSTRACT FROM AUTHOR]

The potential effects of air pollution on the ocular surface environment have not been fully evaluated, and even fewer studies have been conducted on the lagged effects of air pollution on dry eye disease (DED). The data of 9970 DED outpatients between 1 January 2013 and 31 December 2020, and data for six air pollutants, including PM10, PM2.5, carbon monoxide (CO), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3), were obtained from 11 standard urban background stationary air quality monitors in Urumqi, Xinjiang, China. Time series analysis design and quasi-Poisson generalized linear regression models combined with distributed lagged nonlinear models (DLNM) were used. Single- and multi-pollutant model results suggest that each additional per 10 μg/m3 of PM10, NO2, and SO2 is associated with an increased risk of outpatient DED on lag day 0 and PM2.5, NO2, and SO2 with other cumulative lag days; R software version 4.0.4 (15 February 2021) was used for the analysis. We conducted first time series analysis with a large sample size in northwest China (Xinjiang) and confirmed, for the first time, the impact of air pollution including particulate pollutants (PM10, PM2.5) and acidic gasses (SO2, NO2) on DED risk in the Urumqi region, and suggested the potential lagged effects of PM2.5, SO2, and NO2. [ABSTRACT FROM AUTHOR]