1. Influence of the structure of substituted benzodiazepines on their pharmacokinetic properties.
- Author
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Artemenko, A. G., Kuz'min, V. E., Muratov, E. N., Polishchuk, P. G., Borisyuk, I. Yu., and Golovenko, N. Ya.
- Subjects
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BENZODIAZEPINES , *PHARMACOKINETICS , *REGRESSION analysis , *TRANQUILIZING drugs , *STATISTICS - Abstract
The influence of the structure of substituted benzodiazepines on their pharmacokinetic properties including the bioavailability, elimination half-life, clearance, and distribution volume in the human organism has been studied. The analysis was performed using the QSAR/QSPR method based on the Simplex representation of molecular structure. Completely adequate models capable of describing quantitatively the structure—pharmacokinetic properties relationship were obtained using the statistical methods of projection onto latent structures and multiple linear regression. Structural factors determining changes in the pharmacokinetic properties of substituted benzodiazepines are established on the basis of the obtained models. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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